ATE117302T1 - 2-(2-vinylpyrrolidinylthio)carbapenem-derivate. - Google Patents
2-(2-vinylpyrrolidinylthio)carbapenem-derivate.Info
- Publication number
- ATE117302T1 ATE117302T1 AT90114980T AT90114980T ATE117302T1 AT E117302 T1 ATE117302 T1 AT E117302T1 AT 90114980 T AT90114980 T AT 90114980T AT 90114980 T AT90114980 T AT 90114980T AT E117302 T1 ATE117302 T1 AT E117302T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen atom
- vinylpyrrolidinylthio
- lower alkyl
- carbapenem derivatives
- Prior art date
Links
- VNDKHPSGHISURR-QVDQXJPCSA-N (5S)-3-(2-ethenylpyrrolidin-1-yl)sulfanyl-1-azabicyclo[3.2.0]hept-2-en-7-one Chemical class C(=C)C1N(CCC1)SC=1C[C@H]2N(C=1)C(C2)=O VNDKHPSGHISURR-QVDQXJPCSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002393 azetidinyl group Chemical group 0.000 abstract 1
- 125000004069 aziridinyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20256889 | 1989-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE117302T1 true ATE117302T1 (de) | 1995-02-15 |
Family
ID=16459655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90114980T ATE117302T1 (de) | 1989-08-04 | 1990-08-03 | 2-(2-vinylpyrrolidinylthio)carbapenem-derivate. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5095013A (de) |
| EP (1) | EP0411664B1 (de) |
| JP (1) | JP2707811B2 (de) |
| KR (1) | KR910004622A (de) |
| AT (1) | ATE117302T1 (de) |
| AU (1) | AU631671B2 (de) |
| CA (1) | CA2022681C (de) |
| DE (1) | DE69016121D1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3048196B2 (ja) * | 1991-06-20 | 2000-06-05 | 第一製薬株式会社 | カルバペネム誘導体 |
| WO1993001192A1 (en) * | 1991-07-09 | 1993-01-21 | Banyu Pharmaceutical Co., Ltd. | 2-(2-substituted pyrrolidinylthio)carbapenem derivatives |
| KR950014111A (ko) * | 1993-11-23 | 1995-06-15 | 유충식 | 새로운 카바페넴 유도체 및 그 제조방법 |
| KR100551853B1 (ko) * | 2000-07-19 | 2006-02-13 | 에프. 호프만-라 로슈 아게 | 피리미딘 유도체 |
| WO2011080736A1 (en) | 2009-12-29 | 2011-07-07 | Mapi Pharma Hk Limited | Intermediate compounds and processes for the preparation of tapentadol and related compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1281720C (en) * | 1984-11-08 | 1991-03-19 | Makoto Sunagawa | Carbapenem compounds and production thereof |
| EP0243686B1 (de) * | 1986-03-27 | 1992-07-15 | Sumitomo Pharmaceuticals Company, Limited | Beta-Lactam-Verbindungen und deren Herstellung |
| EP0272455B1 (de) * | 1986-11-24 | 1993-02-10 | Fujisawa Pharmaceutical Co., Ltd. | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-en-2-carbonsäure-Derivate |
| US4925838A (en) * | 1988-03-18 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds |
| CA2036941A1 (en) * | 1990-02-23 | 1991-08-24 | Isao Kawamoto | Carbapenem derivatives having antibiotic activity, their preparation and their use |
| TW198034B (de) * | 1990-03-27 | 1993-01-11 | Manyu Seiyaku Kk |
-
1990
- 1990-08-02 AU AU60122/90A patent/AU631671B2/en not_active Ceased
- 1990-08-03 CA CA002022681A patent/CA2022681C/en not_active Expired - Fee Related
- 1990-08-03 DE DE69016121T patent/DE69016121D1/de not_active Expired - Lifetime
- 1990-08-03 AT AT90114980T patent/ATE117302T1/de not_active IP Right Cessation
- 1990-08-03 EP EP90114980A patent/EP0411664B1/de not_active Expired - Lifetime
- 1990-08-03 US US07/562,564 patent/US5095013A/en not_active Expired - Fee Related
- 1990-08-03 JP JP2205984A patent/JP2707811B2/ja not_active Expired - Lifetime
- 1990-08-04 KR KR1019900011988A patent/KR910004622A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2707811B2 (ja) | 1998-02-04 |
| DE69016121D1 (de) | 1995-03-02 |
| US5095013A (en) | 1992-03-10 |
| EP0411664B1 (de) | 1995-01-18 |
| KR910004622A (ko) | 1991-03-29 |
| CA2022681C (en) | 1996-06-18 |
| EP0411664A2 (de) | 1991-02-06 |
| AU631671B2 (en) | 1992-12-03 |
| AU6012290A (en) | 1991-02-07 |
| JPH04154782A (ja) | 1992-05-27 |
| CA2022681A1 (en) | 1991-02-05 |
| EP0411664A3 (en) | 1991-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |