KR920000648B1 - α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 분리방법 - Google Patents

α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 분리방법 Download PDF

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Publication number
KR920000648B1
KR920000648B1 KR1019840003108A KR840003108A KR920000648B1 KR 920000648 B1 KR920000648 B1 KR 920000648B1 KR 1019840003108 A KR1019840003108 A KR 1019840003108A KR 840003108 A KR840003108 A KR 840003108A KR 920000648 B1 KR920000648 B1 KR 920000648B1
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apm
water
solution
solubility
solvent
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Korean (ko)
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KR850000465A (ko
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시니지 기시모또
가드수미 수기야마
Original Assignee
아지노모도 가부시끼가이샤
우따다 가쯔히로
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Publication of KR850000465A publication Critical patent/KR850000465A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019840003108A 1983-06-08 1984-06-04 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 분리방법 Expired KR920000648B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58102327A JPS59227849A (ja) 1983-06-08 1983-06-08 Ｌ―α―アスパルチル―Ｌ―フェニルアラニンメチルエステル束状晶の晶析分離法
JP102327/83 1983-06-08

Publications (2)

Publication Number Publication Date
KR850000465A KR850000465A (ko) 1985-02-27
KR920000648B1 true KR920000648B1 (ko) 1992-01-20

Family

ID=14324442

Family Applications (1)

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KR1019840003108A Expired KR920000648B1 (ko) 1983-06-08 1984-06-04 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 분리방법

Country Status (6)

Country Link
US (1) US4994605A (enExample)
EP (1) EP0128694A3 (enExample)
JP (1) JPS59227849A (enExample)
KR (1) KR920000648B1 (enExample)
CA (1) CA1299813C (enExample)
IE (1) IE58987B1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
AU586669B2 (en) * 1985-03-29 1989-07-20 Mitsui Toatsu Chemicals Inc. Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPH0832719B2 (ja) * 1986-12-19 1996-03-29 三井東圧化学株式会社 吸湿性の小さいα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
AU600176B2 (en) * 1987-10-13 1990-08-02 Mitsui Toatsu Chemicals Inc. Preparation method of alpha-l-aspartyl-l-phenylalanine methyl ester having improved solubilization
CA2017137A1 (en) * 1989-05-22 1990-11-22 Shigeaki Irino Method for crystallizing &-l-aspartyl-l-phenylalanine methyl ester
JPH0327398A (ja) * 1989-06-26 1991-02-05 Mitsui Toatsu Chem Inc α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの晶析方法
US5591886A (en) * 1990-11-05 1997-01-07 Mitsui Toatsu Chemicals, Incorporated Process for the crystallizing L-α-aspartyl-L-phenylalanine methyl ester from the solution
DE69211756T3 (de) * 1991-04-24 2001-04-19 Mitsui Chemicals, Inc. Verfahren zur Herstellung von alpha-L-aspartyl-L-phenylalaninmethylester
JP2946853B2 (ja) * 1991-05-09 1999-09-06 味の素株式会社 アスパルテームの晶析法
JP2927070B2 (ja) * 1991-05-23 1999-07-28 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造方法
JP2979761B2 (ja) * 1991-05-23 1999-11-15 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステル塩酸塩の製造法
US5391810A (en) * 1991-05-23 1995-02-21 Ajinomoto Co., Inc. Method of crystallizing α-L-aspartyl-L-phenylalanine methyl ester
US5473097A (en) * 1991-05-24 1995-12-05 Ajinomoto Company, Inc. Granules of α-L-aspartyl-L-phenylalanine methyl ester
JPH05178889A (ja) * 1991-10-30 1993-07-20 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの晶析方法
JPH05286994A (ja) * 1992-04-13 1993-11-02 Tosoh Corp α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの晶析法
JP3239452B2 (ja) * 1992-08-05 2001-12-17 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステル塩酸塩の製造法
US5728862A (en) * 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
US6657073B1 (en) 1999-08-18 2003-12-02 Daesang Corporation Crystallization of α-L-aspartyl-L-phenylalanine methyl ester
KR100464559B1 (ko) * 2002-03-22 2005-01-03 정남교 벨크로 테이프 제조장치

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309605A (en) * 1970-01-31 1973-03-14 Ajinomoto Kk Process for producing alpha-dipeptide esters of l-aspartic acid
CA1027112A (en) * 1973-03-05 1978-02-28 Willard M. Hoehn Process for isolation of dipeptide esters
US4017472A (en) * 1973-03-05 1977-04-12 G. D. Searle & Co. Process for isolation of aspartyl dipeptide esters
US3901871A (en) * 1973-09-21 1975-08-26 American Cyanamid Co Process of preparing ' -l-aspartyl-l-phenylalanine methyl ester
US4394308A (en) * 1980-05-27 1983-07-19 Chimicasa Gmbh Method of producing α-L-aspartyl-L-phenylalanine methylesters

Also Published As

Publication number Publication date
IE841326L (en) 1984-12-08
EP0128694A2 (en) 1984-12-19
JPH0377199B2 (enExample) 1991-12-09
US4994605A (en) 1991-02-19
JPS59227849A (ja) 1984-12-21
EP0128694A3 (en) 1986-11-26
IE58987B1 (en) 1993-12-15
CA1299813C (en) 1992-04-28
KR850000465A (ko) 1985-02-27

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