KR910021372A - 신규 15-데히드록시-16-옥소프로스타글란딘류 - Google Patents

신규 15-데히드록시-16-옥소프로스타글란딘류 Download PDF

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Publication number
KR910021372A
KR910021372A KR1019910003104A KR910003104A KR910021372A KR 910021372 A KR910021372 A KR 910021372A KR 1019910003104 A KR1019910003104 A KR 1019910003104A KR 910003104 A KR910003104 A KR 910003104A KR 910021372 A KR910021372 A KR 910021372A
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South Korea
Prior art keywords
alkyl
hydrogen atom
compound
substituted
halogen
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KR1019910003104A
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KR960008667B1 (ko
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류지 우에노
도미오 오다
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우에노 류조
가부시끼가이샤우에노세이야꾸오오요겡뀨쇼
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

신규 15-데히드록시-16-옥소프로스타글란딘류
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 일반식(Ⅰ)의 화합물 또는 R1이 수소원자인 경우에는 약학적으로 허용 가능한 염.
    〔식중, L 및 M은, L과 M중 최소 하나가 수소원자가 아니고 5각형 고리가 1 또는 2개의 이중결합을 가진다면, 수소원자, 히드록시, 저급알킬, 히드록시(저급)알킬 또는 옥소이고, X1및 X2는 수소원자, 할로겐원자 또는 저급알킬이고, Y는 -CH2-CH2-, -CH＝CH-, -C≡C-또는 -CO-CH2-이며 Z는 -CH2-CH2-CH2-, -CH＝CH-CH2또는 -CH2-CH＝CH이고 R1은 수소원자, 저급알킬, 저급시클로 알킬, 모노시클릭아릴, 모노시클릭아릴(저급)알킬 또는 모노시클릭아로일(저급)알킬이며, R2는 단일결합 또는 저급알킬렌이고, R3는 비치환 또는 할로겐으로 치환된 저급알킬로 치환된 저급시클로알킬, 비치환 또는 할로겐또는 할로(저급)알킬로 치환된 모노시클릭아릴, 또는 할로겐 또는 할로(저급)알킬로 치환된 모노시클릭아릴옥시이다〕.
  2. 제1항에 있어서, X1이 불소원자인 화합물.
  3. 제2항에 있어서, X2이 불소원자인 화합물.
  4. 제1항에 있어서, Y가 -CH＝CH 인 화합물.
  5. 제1항에 있어서, Z가 -CH2-CH2-CH2-인 화합물.
  6. 제1항에 있어서, R2는 단일결합이고, R3는 저급알킬인 화합물.
  7. 제1항에 있어서, L 및 M은 수소원자, 히드록시또는 옥소이고, 5-각형고리는 하나의 이중결합을 가질 수 있고, X1및 X2는 수소원자, 불소원자 또는 메틸이고, Y는 -CH2-CH2-, -CH＝CH-, -C≡C- 또는 -CO-CH2-이며, Z는 -CH2-CH2-CH2- 또는 -CH＝CH-CH2이고, R1은 수소원자, 메틸, 에틸, 이소프로필, 벤질, 또는 펜아실이며, R2-R3는 부틸 또는 헥실인 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910003104A 1990-02-26 1991-02-26 신규 15-데히드록시-16-옥소프로스타글란딘류 KR960008667B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP46932/1990 1990-02-26
JP4693290 1990-02-26
JP2-241938 1990-09-11
JP241938/1990 1990-09-11
JP24193890 1990-09-11
JP2-46932 1990-09-11

Publications (2)

Publication Number Publication Date
KR910021372A true KR910021372A (ko) 1991-12-20
KR960008667B1 KR960008667B1 (ko) 1996-06-28

Family

ID=26387096

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Application Number Title Priority Date Filing Date
KR1019910003104A KR960008667B1 (ko) 1990-02-26 1991-02-26 신규 15-데히드록시-16-옥소프로스타글란딘류

Country Status (10)

Country Link
EP (1) EP0444844B1 (ko)
JP (1) JP2511579B2 (ko)
KR (1) KR960008667B1 (ko)
AT (1) ATE117290T1 (ko)
AU (1) AU633697B2 (ko)
CA (1) CA2037009C (ko)
DE (1) DE69106744T2 (ko)
DK (1) DK0444844T3 (ko)
ES (1) ES2069821T3 (ko)
TW (1) TW202430B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221799A (en) * 1990-02-26 1993-06-22 K.K. Ueno Seiyaku Oyo Kenkyujo New 15-dehydroxy-16-oxoprostaglandins
ES2069881T3 (es) * 1990-03-08 1995-05-16 Shionogi & Co Derivado de 15-desoxiprostaglandina.
US5302617A (en) * 1990-04-27 1994-04-12 Kabushikikaisha Ueno Seiyaku Oyo Kenkyuio Biochemical treatment with 15-dehydroxy-16-oxoprostaglandin compounds
ATE148344T1 (de) * 1990-04-27 1997-02-15 R Tech Ueno Ltd Verwendung von 15-dehydroxy-16-oxoprostaglandin bei der behandlung von allergischen erkrankungen
US7321057B2 (en) * 2004-08-02 2008-01-22 R-Tech Ueno, Ltd. Method for manufacturing prostaglandin analogue
ES2375082T3 (es) 2005-01-27 2012-02-24 Sucampo Ag Composición para el tratamiento de trastornos del sistema nervioso central.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4170709A (en) * 1977-10-03 1979-10-09 American Home Products Corporation 16-Keto PGE2 methyl esters
US4312994A (en) * 1981-03-25 1982-01-26 G. D. Searle & Co. α Chain dienic prostanoic acid derivatives
US4499296A (en) * 1983-11-14 1985-02-12 G. D. Searle & Co. Omega cycloalkyl prostaglandins
JPS60181068A (ja) * 1984-02-29 1985-09-14 Teijin Ltd ６−置換プロスタグランジンｅ↓１類およびその製造法

Also Published As

Publication number Publication date
TW202430B (ko) 1993-03-21
KR960008667B1 (ko) 1996-06-28
ATE117290T1 (de) 1995-02-15
EP0444844A2 (en) 1991-09-04
CA2037009C (en) 1998-01-27
AU7139791A (en) 1991-08-29
CA2037009A1 (en) 1991-08-27
EP0444844A3 (en) 1992-05-13
DK0444844T3 (da) 1995-04-03
AU633697B2 (en) 1993-02-04
JPH04211053A (ja) 1992-08-03
DE69106744T2 (de) 1995-05-18
JP2511579B2 (ja) 1996-06-26
DE69106744D1 (de) 1995-03-02
ES2069821T3 (es) 1995-05-16
EP0444844B1 (en) 1995-01-18

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