AU7139791A - New 15-dehydroxy-16-oxoprostaglandins - Google Patents
New 15-dehydroxy-16-oxoprostaglandinsInfo
- Publication number
- AU7139791A AU7139791A AU71397/91A AU7139791A AU7139791A AU 7139791 A AU7139791 A AU 7139791A AU 71397/91 A AU71397/91 A AU 71397/91A AU 7139791 A AU7139791 A AU 7139791A AU 7139791 A AU7139791 A AU 7139791A
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- hydrogen atom
- unsubstituted
- substituted
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A compound of the formula: <CHEM> wherein L and M are hydrogen atom, hydroxy, lower alkyl, hydroxy(lower)alkyl or oxo, provided that at least one of L and M is not hydrogen atom and that the five-membered ring may have one or two double bonds, X1 and X2 are hydrogen atom, halogen atom or lower alkyl, Y is -CH2-CH2-, -CH=CH-, -C=C- or -CO-CH2-, Z is -CH2-CH2-CH2-, -CH=CH-CH2 or -CH2-CH=CH-, R is hydrogen atom, lower alkyl, lower cycloalkyl, monocyclic aryl, monocyclic aryl(lower)alkyl or monocyclic aroyl(lower)alkyl, R2 is single bond or lower alkylene, R3 is lower alkyl which is unsubstituted or substituted with halogen, lower cycloalkyl which is unsubstituted or substituted with lower alkyl, monocyclic aryl which is unsubstituted or substituted with halogen or halo(lower)alkyl, or monocyclic aryloxy which is unsubstituted or substituted with halogen or halo(lower)alkyl, or a pharmaceutically acceptable salt when R1 is hydrogen atom.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2-46932 | 1990-02-26 | ||
| JP4693290 | 1990-02-26 | ||
| JP2-241938 | 1990-09-11 | ||
| JP24193890 | 1990-09-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU7139791A true AU7139791A (en) | 1991-08-29 |
| AU633697B2 AU633697B2 (en) | 1993-02-04 |
Family
ID=26387096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU71397/91A Ceased AU633697B2 (en) | 1990-02-26 | 1991-02-26 | New 15-dehydroxy-16-oxoprostaglandins |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0444844B1 (en) |
| JP (1) | JP2511579B2 (en) |
| KR (1) | KR960008667B1 (en) |
| AT (1) | ATE117290T1 (en) |
| AU (1) | AU633697B2 (en) |
| CA (1) | CA2037009C (en) |
| DE (1) | DE69106744T2 (en) |
| DK (1) | DK0444844T3 (en) |
| ES (1) | ES2069821T3 (en) |
| TW (1) | TW202430B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU640767B2 (en) * | 1990-03-08 | 1993-09-02 | Shionogi & Co., Ltd. | 15-deoxyprostaglandin derivative |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5221799A (en) * | 1990-02-26 | 1993-06-22 | K.K. Ueno Seiyaku Oyo Kenkyujo | New 15-dehydroxy-16-oxoprostaglandins |
| US5302617A (en) * | 1990-04-27 | 1994-04-12 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyuio | Biochemical treatment with 15-dehydroxy-16-oxoprostaglandin compounds |
| ATE148344T1 (en) * | 1990-04-27 | 1997-02-15 | R Tech Ueno Ltd | USE OF 15-DEHYDROXY-16-OXOPROSTAGLANDIN IN THE TREATMENT OF ALLERGY DISEASES |
| US7321057B2 (en) * | 2004-08-02 | 2008-01-22 | R-Tech Ueno, Ltd. | Method for manufacturing prostaglandin analogue |
| JP5147404B2 (en) | 2005-01-27 | 2013-02-20 | スキャンポ・アーゲー | Methods and compositions for the treatment of central nervous system disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4170709A (en) * | 1977-10-03 | 1979-10-09 | American Home Products Corporation | 16-Keto PGE2 methyl esters |
| US4312994A (en) * | 1981-03-25 | 1982-01-26 | G. D. Searle & Co. | α Chain dienic prostanoic acid derivatives |
| US4499296A (en) * | 1983-11-14 | 1985-02-12 | G. D. Searle & Co. | Omega cycloalkyl prostaglandins |
| JPS60181068A (en) * | 1984-02-29 | 1985-09-14 | Teijin Ltd | 6-substituted prostaglandin e1 and its preparation |
-
1991
- 1991-02-25 DE DE69106744T patent/DE69106744T2/en not_active Expired - Fee Related
- 1991-02-25 DK DK91301480.9T patent/DK0444844T3/en active
- 1991-02-25 ES ES91301480T patent/ES2069821T3/en not_active Expired - Lifetime
- 1991-02-25 CA CA002037009A patent/CA2037009C/en not_active Expired - Lifetime
- 1991-02-25 EP EP91301480A patent/EP0444844B1/en not_active Expired - Lifetime
- 1991-02-25 AT AT91301480T patent/ATE117290T1/en not_active IP Right Cessation
- 1991-02-26 KR KR1019910003104A patent/KR960008667B1/en not_active IP Right Cessation
- 1991-02-26 AU AU71397/91A patent/AU633697B2/en not_active Ceased
- 1991-02-26 TW TW080101480A patent/TW202430B/zh active
- 1991-02-26 JP JP3055930A patent/JP2511579B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU640767B2 (en) * | 1990-03-08 | 1993-09-02 | Shionogi & Co., Ltd. | 15-deoxyprostaglandin derivative |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69106744T2 (en) | 1995-05-18 |
| CA2037009A1 (en) | 1991-08-27 |
| CA2037009C (en) | 1998-01-27 |
| ATE117290T1 (en) | 1995-02-15 |
| KR910021372A (en) | 1991-12-20 |
| JPH04211053A (en) | 1992-08-03 |
| DE69106744D1 (en) | 1995-03-02 |
| TW202430B (en) | 1993-03-21 |
| DK0444844T3 (en) | 1995-04-03 |
| KR960008667B1 (en) | 1996-06-28 |
| EP0444844A2 (en) | 1991-09-04 |
| EP0444844B1 (en) | 1995-01-18 |
| ES2069821T3 (en) | 1995-05-16 |
| EP0444844A3 (en) | 1992-05-13 |
| JP2511579B2 (en) | 1996-06-26 |
| AU633697B2 (en) | 1993-02-04 |
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