ES2069821T3 - Nuevas 15-deshidroxi-16-oxoprostaglandinas. - Google Patents

Nuevas 15-deshidroxi-16-oxoprostaglandinas.

Info

Publication number
ES2069821T3
ES2069821T3 ES91301480T ES91301480T ES2069821T3 ES 2069821 T3 ES2069821 T3 ES 2069821T3 ES 91301480 T ES91301480 T ES 91301480T ES 91301480 T ES91301480 T ES 91301480T ES 2069821 T3 ES2069821 T3 ES 2069821T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen atom
unsubstituted
substituted
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91301480T
Other languages
English (en)
Inventor
Ryuji Ueno
Tomio Oda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
R Tech Ueno Ltd
Original Assignee
R Tech Ueno Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Tech Ueno Ltd filed Critical R Tech Ueno Ltd
Application granted granted Critical
Publication of ES2069821T3 publication Critical patent/ES2069821T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN COMPUESTO DE LA FORMULA: DONDE, L Y M SON ATOMOS DE HIDROGENO, HIDROXI, ALQUILO BAJO, HIDROXI(BAJO)ALQUILO O OXO, CON LA SALVEDAD DE QUE AL MENOS UNO DE LOS L Y M NO SEA UN ATOMO DE HIDROGENO Y QUE EL ANILLO NUMERADO-CINCO PUEDA TENER UNO O DOS ENLACES DOBLES, X SUB 1 Y X SUB 2 SON ATOMOS DE, ATOMOS DE HALOGENO O ALQUILO BAJO, Y ES -CH SUB 2-CH SUB 2-, -CH=CH-, -C=C SUB 2 O -CH SUB 2-CH=CH-, R ES UN ATOMO DE HIDROGENO, ALQUILO BAJO, CICLOALQUILO BAJO, ARLY MONOCICLICO, MONOCICLICO ARLY(BAJO)ALQUILO O MONOCICLICO AROYL(BAJO) ALQUILO, R SUB 2 ES EN ENLACE SIMPLE O BAJO CICLOALQUILO, R SUB 3 ES ALQUILO BAJO QUE ES NOSUSTITUIDO O SUSTITUIDO CON HALOGENO, BAJO CICLOALQUILO QUE ES NO SUSTITUIDO O SUSTITUIDO CON ALQUILO BAJO, ARLY MONOCICLICO, QUE ES NOSUSTITUIDO O SUSTITUIDO CON HALOGENO O HALO(BAJO) ALQUILO, O MONOCICLICO ARYOXY QUE ES NOSUSTITUIDO O SUSTITUIDO CON HALOGENO O HALO(BAJO)ALQUILO, O UNA SAL ACEPTABLE FARMACOLOGICAMENTE DONDE R SUB 1 ES UN ATOMO DE HIDROGENO.
ES91301480T 1990-02-26 1991-02-25 Nuevas 15-deshidroxi-16-oxoprostaglandinas. Expired - Lifetime ES2069821T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4693290 1990-02-26
JP24193890 1990-09-11

Publications (1)

Publication Number Publication Date
ES2069821T3 true ES2069821T3 (es) 1995-05-16

Family

ID=26387096

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91301480T Expired - Lifetime ES2069821T3 (es) 1990-02-26 1991-02-25 Nuevas 15-deshidroxi-16-oxoprostaglandinas.

Country Status (10)

Country Link
EP (1) EP0444844B1 (es)
JP (1) JP2511579B2 (es)
KR (1) KR960008667B1 (es)
AT (1) ATE117290T1 (es)
AU (1) AU633697B2 (es)
CA (1) CA2037009C (es)
DE (1) DE69106744T2 (es)
DK (1) DK0444844T3 (es)
ES (1) ES2069821T3 (es)
TW (1) TW202430B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221799A (en) * 1990-02-26 1993-06-22 K.K. Ueno Seiyaku Oyo Kenkyujo New 15-dehydroxy-16-oxoprostaglandins
EP0471856B1 (en) * 1990-03-08 1995-03-22 Shionogi & Co., Ltd. 15-deoxyprostaglandin derivative
US5302617A (en) * 1990-04-27 1994-04-12 Kabushikikaisha Ueno Seiyaku Oyo Kenkyuio Biochemical treatment with 15-dehydroxy-16-oxoprostaglandin compounds
ATE148344T1 (de) * 1990-04-27 1997-02-15 R Tech Ueno Ltd Verwendung von 15-dehydroxy-16-oxoprostaglandin bei der behandlung von allergischen erkrankungen
JP4690814B2 (ja) * 2004-08-02 2011-06-01 株式会社アールテック・ウエノ プロスタグランジン誘導体の製造法
EP1841433B1 (en) 2005-01-27 2011-11-30 Sucampo AG Composition for treating central nervous system disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4170709A (en) * 1977-10-03 1979-10-09 American Home Products Corporation 16-Keto PGE2 methyl esters
US4312994A (en) * 1981-03-25 1982-01-26 G. D. Searle & Co. α Chain dienic prostanoic acid derivatives
US4499296A (en) * 1983-11-14 1985-02-12 G. D. Searle & Co. Omega cycloalkyl prostaglandins
JPS60181068A (ja) * 1984-02-29 1985-09-14 Teijin Ltd ６−置換プロスタグランジンｅ↓１類およびその製造法

Also Published As

Publication number Publication date
EP0444844A2 (en) 1991-09-04
ATE117290T1 (de) 1995-02-15
DE69106744D1 (de) 1995-03-02
KR960008667B1 (ko) 1996-06-28
KR910021372A (ko) 1991-12-20
EP0444844B1 (en) 1995-01-18
DK0444844T3 (da) 1995-04-03
AU633697B2 (en) 1993-02-04
AU7139791A (en) 1991-08-29
EP0444844A3 (en) 1992-05-13
JP2511579B2 (ja) 1996-06-26
DE69106744T2 (de) 1995-05-18
TW202430B (es) 1993-03-21
JPH04211053A (ja) 1992-08-03
CA2037009A1 (en) 1991-08-27
CA2037009C (en) 1998-01-27

Similar Documents

Publication Publication Date Title
PL233786A1 (es)
CA2039420A1 (en) Treatment of cataract with 15-keto-prostaglandin compounds
MX9203032A (es) Una solucion farmaceutica.
ES2048109A1 (es) Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
FI953710A (fi) Uusia pyrrolokarbatsoleja
NO944371L (no) Kjemisk forbindelse med blodplateaggregeringsinhibiotoraktivitet
ES2069821T3 (es) Nuevas 15-deshidroxi-16-oxoprostaglandinas.
ES8503678A1 (es) Proceso para producir un ester de benzoilpiperazina.
EP0663392A4 (en) BENZOLSULPHONAMIDE DERIVATIVE AND ITS USE.
AU8452591A (en) 2-thio-1-aminocarbonyl cyclo alk-1-enes
MY102440A (en) Fungicidal pyridyl cyclopropane carboxamides.
CA1228067A (en) 3,4-DIAMINO-1,2,5-THIADIAZOLE SUBSTITUTION DERIVATIVES, ANTAGONISTS FOR H.SUB.2 HISTAMINE RECEPTORS
ES2014041A6 (es) Un procedimiento para preparar un derivado de amina.
ES8106144A1 (es) Procedimiento para la preparacion de derivados de aroilete- nilpiperidinobutirofenona
ZA906445B (en) New 1,3-oxazines
GB1510107A (en) Benzimidazolyl-furan derivatives and use thereof as optical brighteners
ITMI931728A1 (it) Composti eterociclici ad attivita' cardiovascolare
GB1187200A (en) 2-[(Halophenoxy) Methyl]-2-Imidazolines
KR800001280B1 (en) Process for the preparation of 2-(indolin-1-yl)guanidine
SU1499898A1 (ru) СОЛИ 9-ДИАЛКИЛАМИНОЭТИЛ-2-МЕТИЛ-3-ТЕНОИЛИМИДАЗО[1,2-а]БЕНЗИМИДАЗОЛА, ОБЛАДАЮЩИЕ АНТИРАДИОМИМЕТИЧЕСКИМ ДЕЙСТВИЕМ
TH10814EX (th) " อนุพันธ์อมิโนอัลคิลเบนซิน "
ES416222A1 (es) Procedimiento para la preparacion de un derivado de benzo- xacepina.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 444844

Country of ref document: ES