KR910016736A - 피페라지닐 퀴놀론 유도체의 제조방법 - Google Patents

피페라지닐 퀴놀론 유도체의 제조방법 Download PDF

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Publication number
KR910016736A
KR910016736A KR1019900004115A KR900004115A KR910016736A KR 910016736 A KR910016736 A KR 910016736A KR 1019900004115 A KR1019900004115 A KR 1019900004115A KR 900004115 A KR900004115 A KR 900004115A KR 910016736 A KR910016736 A KR 910016736A
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KR
South Korea
Prior art keywords
group
methyl
ethyl
general formula
formula
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KR1019900004115A
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English (en)
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KR920003605B1 (ko
Inventor
박상우
김유승
이진화
Original Assignee
박원희
한국과학기술연구원
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Application filed by 박원희, 한국과학기술연구원 filed Critical 박원희
Priority to KR1019900004115A priority Critical patent/KR920003605B1/ko
Priority to US07/561,811 priority patent/US5051505A/en
Priority to JP2252044A priority patent/JPH075562B2/ja
Priority to DE4100855A priority patent/DE4100855A1/de
Publication of KR910016736A publication Critical patent/KR910016736A/ko
Application granted granted Critical
Publication of KR920003605B1 publication Critical patent/KR920003605B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

피페라지닐 퀴놀론 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 일반식(Ⅱ)의 디할로퀴놀론과 일반식(Ⅲ)의 피페라진 유도체를 극성용매와 일반식(Ⅳ)의 테트라알킬암모늄 할라이드 존재하에 60∼80℃에서 2∼3시간 반응시키는 것을 특징으로 하는 일반식(I)의 피페라지닐 퀴놀론 유도체의 제조방법.
    일반식(I)에 있어서, R1은 메틸, 에틸, 시클로프로필등의 탄소수 1∼6의 저급알킬기 또는 3-옥소-2-프로파닐기를 표시한다. 다만 3-옥소-2-프로파닐기에 있어서, 이의 산소가 일반식(I)로 표시되는 퀴놀론의 8위치에 치환되어 고리 화합물을 형성한다. R2는 수소, 메틸 또는 에틸기를 표시한다. 일반식(Ⅱ)에 있어서, R1는 메틸, 에틸, 시클로프로필 등의 탄소수 1∼6의 저급알킬기 또는 3-옥소-2-프로파닐기를 표시한다. X는 염소 또는 플로오르를 표시한다.
    일반식(Ⅲ)에 있어서, R2는 수소, 메틸 또는 에틸기를 표시한다. R3,R4및 R5는 각각 메틸, 에틸, t-부틸기를 표시하는데 서로 같거나 다를수 있다. 일반식(Ⅳ)에 있어서, R6는 메틸, 에틸 또는 부틸기를 표시한다. X는 염소 또는 플루오르기를 표시한다.
  2. 제1항에 있어서, 극성 용매로 아세토니트릴, 디메틸포름아미드, 파리딘, 설포란 및 디메틸설폭사이드 중에서 선택하는 것을 특징으로 하는 일반식(I)의 피페라지닐 퀴놀론 유도체의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900004115A 1990-03-27 1990-03-27 피페라지닐 퀴놀론 유도체의 제조방법 KR920003605B1 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1019900004115A KR920003605B1 (ko) 1990-03-27 1990-03-27 피페라지닐 퀴놀론 유도체의 제조방법
US07/561,811 US5051505A (en) 1990-03-27 1990-08-02 Process for preparing piperazinyl quinolone derivatives
JP2252044A JPH075562B2 (ja) 1990-03-27 1990-09-25 ピペラジニルキノロン誘導体の製造方法
DE4100855A DE4100855A1 (de) 1990-03-27 1991-01-14 Verfahren zur herstellung von piperazinylchinolon-derivaten

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019900004115A KR920003605B1 (ko) 1990-03-27 1990-03-27 피페라지닐 퀴놀론 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR910016736A true KR910016736A (ko) 1991-11-05
KR920003605B1 KR920003605B1 (ko) 1992-05-04

Family

ID=19297401

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900004115A KR920003605B1 (ko) 1990-03-27 1990-03-27 피페라지닐 퀴놀론 유도체의 제조방법

Country Status (4)

Country Link
US (1) US5051505A (ko)
JP (1) JPH075562B2 (ko)
KR (1) KR920003605B1 (ko)
DE (1) DE4100855A1 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003028665A2 (en) * 2001-10-03 2003-04-10 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
US7425628B2 (en) * 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EP2172192A1 (en) * 2001-12-24 2010-04-07 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder of granular material, and process and tooling for producing it
EP1478642A1 (en) 2002-08-14 2004-11-24 Teva Pharmaceutical Industries Ltd. Synthesis of gatifloxacin
JP5699990B2 (ja) * 2012-06-14 2015-04-15 信越化学工業株式会社 ピペラジニル基を有するオルガノキシシラン化合物の製造方法及びピペラジン化合物
JP6201957B2 (ja) * 2014-10-28 2017-09-27 信越化学工業株式会社 Ｎ−シリルピペラジンの製造方法
CN111579633B (zh) * 2020-05-28 2023-03-10 山东省分析测试中心 一种基于原位衍生化的脂肪酸maldi质谱成像方法及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460587A (en) * 1981-12-07 1984-07-17 Ciba-Geigy Corporation 5-Diazacycloalkyl imidazo[1,2-c][1,3]benzodiazepines
DE3420116A1 (de) * 1984-05-30 1985-12-05 Bayer Ag, 5090 Leverkusen Immunstimulierende mittel

Also Published As

Publication number Publication date
US5051505A (en) 1991-09-24
JPH03279361A (ja) 1991-12-10
DE4100855A1 (de) 1991-10-02
JPH075562B2 (ja) 1995-01-25
KR920003605B1 (ko) 1992-05-04

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