KR910006229A - 5-알콕시-치환된(=)-1,3-디메틸옥스인돌릴에틸 아민의 화학적 분할방법 - Google Patents

5-알콕시-치환된(=)-1,3-디메틸옥스인돌릴에틸 아민의 화학적 분할방법 Download PDF

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Publication number
KR910006229A
KR910006229A KR1019900014730A KR900014730A KR910006229A KR 910006229 A KR910006229 A KR 910006229A KR 1019900014730 A KR1019900014730 A KR 1019900014730A KR 900014730 A KR900014730 A KR 900014730A KR 910006229 A KR910006229 A KR 910006229A
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South Korea
Prior art keywords
enantiomers
acid
mixture
tartaric acid
precipitate
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KR1019900014730A
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English (en)
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KR0165670B1 (ko
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빙 킨 리 토마스
에스.케이.윌 죠오지
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원본미기재
훽스트-러셀 파마슈티칼즈 인코포레이티드
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Publication of KR910006229A publication Critical patent/KR910006229A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

내용 없음

Description

5-알콕시-치환된(=)-1,3-디메틸옥스인돌릴에틸 아민의 화학적 분할방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. (A)필수적으로 하기 일반식의 에난티오머들의 혼합물로 이루어지는 용액을 제조하고, (B)혼합물을 에난티오머들중 하나와 키랄산의 염을 선택적으로 침전시키기에 충분한 양으로, 디벤조일-D-타르타르산, 디벤조일-L-타르타르산, 디불루오일-D-타르타르산, 및 디불루오일-L-타르타르산으로 이루어진 그룹으로 부터 선택된 키랄산과 접촉시키고, (C)생성된 침전물을 회수하고, (D)임의로 생성된 타르타르산염을 염기화시켜 상응하는 유리염기를 제조함을 특징으로 하여, 에난티오머들의 혼합물로부터 에난티오머들중 하나를 침전시키기 위해 혼합물을 처리하는 방법.
    상기식에서, R1은 탄소수 1 내지 3의 직쇄 또는 측쇄 알킬 그룹 또는 벤질이다.
  2. 제1항에 있어서, 에난티오머들을 함유하는 모액으로부터 침전물을 회수한 후, 모액을 키랄산중 하나와 접촉시켜 에난티오머들중 하나의 산의 염을 포함하는 다른 침전물을 선택적으로 생성시키는 방법.
  3. 제1항 또는 2항에 있어서, 키랄산이 에난티오머 1당량당 산 약 0.5내지 0.5약 1당량의 양으로 사용되는 방법.
  4. 제1항 내지 3항 중 어느 한 항에 있어서, 에난티오머들의 혼합물이 라세미 혼합물인 방법.
  5. 제1항 내지 4항 중 어느 한 항에 있어서, 키랄산이 디벤조일-D-타르타르산 또는 디틀루오일-D-타르타르산인 방법.
  6. 제1항 내지 5항 중 어느 한 항에 있어서, 에난티오머들의 혼합물이 하기 구조식을 갖는 방법.
  7. 제1항 내지 6항중 어느 한 항에 있어서, 침전물이 하기 구조식(2a)의 염을 포함하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900014730A 1989-09-19 1990-09-18 5-알콕시-치환된(±)-1,3-디메틸옥신돌릴에틸아민의 화학적 분할방법 KR0165670B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40921389A 1989-09-19 1989-09-19
US409,213 1989-09-19
US409213 1989-09-19

Publications (2)

Publication Number Publication Date
KR910006229A true KR910006229A (ko) 1991-04-27
KR0165670B1 KR0165670B1 (ko) 1999-01-15

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ID=23619520

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900014730A KR0165670B1 (ko) 1989-09-19 1990-09-18 5-알콕시-치환된(±)-1,3-디메틸옥신돌릴에틸아민의 화학적 분할방법

Country Status (17)

Country Link
US (1) US5387695A (ko)
EP (1) EP0418770B1 (ko)
JP (1) JPH0757746B2 (ko)
KR (1) KR0165670B1 (ko)
AT (1) ATE125254T1 (ko)
AU (1) AU626458B2 (ko)
CA (1) CA2025593A1 (ko)
DE (1) DE69020989T2 (ko)
DK (1) DK0418770T3 (ko)
ES (1) ES2075102T3 (ko)
FI (1) FI95030C (ko)
IE (1) IE67640B1 (ko)
IL (1) IL95717A (ko)
NO (1) NO174252C (ko)
NZ (1) NZ235333A (ko)
PT (1) PT95340B (ko)
ZA (1) ZA907424B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
EP0438796B1 (en) * 1990-01-22 1998-08-26 HOECHST MARION ROUSSEL, Inc. Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine
US5840915A (en) * 1990-01-22 1998-11-24 Hoechst Marion Roussel, Inc. Process for the enatioselective synthesis of intermediates used
US5521320A (en) * 1990-01-22 1996-05-28 Hoechst-Roussel Pharmaceuticals Incorporated Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
US5665880A (en) * 1996-10-31 1997-09-09 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) * 1996-12-19 1997-10-14 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseroline ethers
BR112017001516B1 (pt) * 2015-02-17 2023-10-31 Amorepacific Corporation Método de ressolubilização quiral, estereoisômero, método para preparar um composto, composto, composição, e kit de ressolubilização quiral

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
EP0438796B1 (en) * 1990-01-22 1998-08-26 HOECHST MARION ROUSSEL, Inc. Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine
US5274117A (en) * 1990-01-22 1993-12-28 Hoechst-Roussel Pharmaceuticals, Inc. Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine

Also Published As

Publication number Publication date
JPH03167172A (ja) 1991-07-19
DE69020989T2 (de) 1996-02-08
NO904067L (no) 1991-03-20
US5387695A (en) 1995-02-07
EP0418770A2 (en) 1991-03-27
ATE125254T1 (de) 1995-08-15
IE67640B1 (en) 1996-04-17
EP0418770A3 (en) 1991-11-27
DE69020989D1 (de) 1995-08-24
FI904562A0 (fi) 1990-09-17
EP0418770B1 (en) 1995-07-19
NO904067D0 (no) 1990-09-18
NO174252C (no) 1994-04-06
FI95030C (fi) 1995-12-11
IL95717A (en) 1994-10-21
IL95717A0 (en) 1991-06-30
NO174252B (no) 1993-12-27
DK0418770T3 (da) 1995-10-30
PT95340B (pt) 1997-06-30
CA2025593A1 (en) 1991-03-20
AU6262990A (en) 1991-03-28
ES2075102T3 (es) 1995-10-01
ZA907424B (en) 1991-06-26
NZ235333A (en) 1992-03-26
KR0165670B1 (ko) 1999-01-15
JPH0757746B2 (ja) 1995-06-21
AU626458B2 (en) 1992-07-30
FI95030B (fi) 1995-08-31
PT95340A (pt) 1991-05-22
IE903374A1 (en) 1991-04-10

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