KR850004579A - D-아미노산 옥시다제 기질의 제조방법 - Google Patents
D-아미노산 옥시다제 기질의 제조방법 Download PDFInfo
- Publication number
- KR850004579A KR850004579A KR1019840007675A KR840007675A KR850004579A KR 850004579 A KR850004579 A KR 850004579A KR 1019840007675 A KR1019840007675 A KR 1019840007675A KR 840007675 A KR840007675 A KR 840007675A KR 850004579 A KR850004579 A KR 850004579A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- sch
- hydrogen
- amino acid
- lower alkyl
- Prior art date
Links
- 102000004674 D-amino-acid oxidase Human genes 0.000 title claims 2
- 108010003989 D-amino-acid oxidase Proteins 0.000 title claims 2
- 239000000758 substrate Substances 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical group CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000006242 amine protecting group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical group CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 하기 일반식(Ⅶ)의 화합물을, 염기의 존재하에서 0내지 100℃에서 1내지 24시간 동안 하기 일반식(Ⅷ)의 D-산유도체로 N-알킬화시킨후 에스테르 및 아민 보호그룹을 제거시킴을 특징으로 하는, 하기 일반식(I)의 D-아미노산 옥시다제기질 및 이의 약제학적으로 허용될 수 있는 염의 제조방법.상기식에서, R은 H, -CH3,CH3CH2-, CH3CH2CH2-, CH3(CH2)2CH2-, (CH3)2CH-,-CH2OH, CH3CH2SCH2CH2-, CH3SCH2-, CH3SCH2CH2-, C6H5CH2-, 4-OH-C6H4CH2-, 3,4-디하이드록시-C6H3CH2- 또는이며, R1은 아미노-함유 치료제의 데스-아미노잔기기며, R7은 수소,또는 R8SO2(여기서, R6는 탄소수 1내지 4의 저급알킬이며, R8은 아릴이다)이며, R4는 수소이거나 탄소수 1내지 6의 직쇄 또는 측쇄저급알킬 그룹이고, X는 할로겐, 토실레이트 또는 메실레이트이다.
- 제1항에 있어서, R이 수소, -CH3또는 (CH3)2CH-인 방법.
- 제1항에 있어서, R1이 다음 구조식의 그룹인 방법.
- 제1항에 있어서, R1이 하기화합물의 데스아미노 잔기인 방법.상기식에서, R1은 (CH2)2C6H5또는이며, R2는 (CH2)4NH2이고, R3는 H 또는 저급알킬 (C1-4)이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55864383A | 1983-12-06 | 1983-12-06 | |
US558643 | 1983-12-06 | ||
US66934284A | 1984-11-09 | 1984-11-09 | |
US669342 | 1984-11-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR850004579A true KR850004579A (ko) | 1985-07-25 |
KR900004397B1 KR900004397B1 (ko) | 1990-06-25 |
Family
ID=27071801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840007675A KR900004397B1 (ko) | 1983-12-06 | 1984-12-05 | D-아미노산 옥시다제 기질의 제조방법 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0146067A3 (ko) |
KR (1) | KR900004397B1 (ko) |
AU (1) | AU575602B2 (ko) |
DK (1) | DK580884A (ko) |
ES (1) | ES538309A0 (ko) |
FI (1) | FI844793L (ko) |
GR (1) | GR81170B (ko) |
HU (1) | HU192086B (ko) |
IL (1) | IL73795A0 (ko) |
NO (1) | NO844858L (ko) |
NZ (1) | NZ210420A (ko) |
PT (1) | PT79623A (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4694082A (en) * | 1985-09-23 | 1987-09-15 | Monsanto Company | Compound 1,4-diisopropyl-2,5-diketopiperazine |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1074480A (en) * | 1964-07-29 | 1967-07-05 | Pfizer & Co C | Amino acid derivatives and method of preparation |
US3856857A (en) * | 1970-02-13 | 1974-12-24 | En Nom Collectif Science Union | Amino acids and their derivatives |
DE2021620C3 (de) * | 1970-05-02 | 1980-02-07 | Boehringer Sohn Ingelheim | Neue Phenylaminoalkane und Verfahren zu deren Herstellung |
GB1406993A (en) * | 1971-10-09 | 1975-09-24 | Beecham Group Ltd | Amino acid derivatives |
GB1360457A (en) * | 1972-10-02 | 1974-07-17 | Beecham Group Ltd | Amino acid derivatives |
JPS5251333A (en) * | 1975-10-22 | 1977-04-25 | Tanabe Seiyaku Co Ltd | Process for prepaation of bezylalcohol derivatives |
EP0035868A1 (en) * | 1980-03-07 | 1981-09-16 | Takeda Chemical Industries, Ltd. | Bicyclic compounds, their production and use |
US4425280A (en) * | 1981-03-30 | 1984-01-10 | Ferro Corporation | Metal amino acids |
US4399121A (en) * | 1981-11-04 | 1983-08-16 | Miles Laboratories, Inc. | Iodothyronine immunogens and antibodies |
JPS58150562A (ja) * | 1982-03-03 | 1983-09-07 | Takeda Chem Ind Ltd | N−置換グリシン誘導体 |
US4555503A (en) * | 1982-05-05 | 1985-11-26 | Merck & Co., Inc. | N2 -(Substituted)carboxymethyl-N6 -(substituted)-lysyl-and αε-aminoalkyl)glycyl amino acid antihypertensive agents |
-
1984
- 1984-12-03 NZ NZ210420A patent/NZ210420A/en unknown
- 1984-12-03 EP EP84114651A patent/EP0146067A3/en not_active Withdrawn
- 1984-12-04 GR GR81170A patent/GR81170B/el unknown
- 1984-12-04 AU AU36284/84A patent/AU575602B2/en not_active Expired - Fee Related
- 1984-12-05 DK DK580884A patent/DK580884A/da not_active Application Discontinuation
- 1984-12-05 ES ES538309A patent/ES538309A0/es active Granted
- 1984-12-05 HU HU844526A patent/HU192086B/hu not_active IP Right Cessation
- 1984-12-05 FI FI844793A patent/FI844793L/fi not_active Application Discontinuation
- 1984-12-05 NO NO844858A patent/NO844858L/no unknown
- 1984-12-05 KR KR1019840007675A patent/KR900004397B1/ko active IP Right Grant
- 1984-12-06 PT PT79623A patent/PT79623A/pt unknown
- 1984-12-11 IL IL73795A patent/IL73795A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
FI844793A0 (fi) | 1984-12-05 |
ES8600390A1 (es) | 1985-09-16 |
FI844793L (fi) | 1985-06-07 |
DK580884D0 (da) | 1984-12-05 |
ES538309A0 (es) | 1985-09-16 |
PT79623A (en) | 1985-01-01 |
AU575602B2 (en) | 1988-08-04 |
EP0146067A2 (en) | 1985-06-26 |
EP0146067A3 (en) | 1987-03-04 |
HU192086B (en) | 1987-05-28 |
NZ210420A (en) | 1988-04-29 |
AU3628484A (en) | 1985-06-13 |
NO844858L (no) | 1985-06-07 |
GR81170B (en) | 1985-04-03 |
HUT36082A (en) | 1985-08-28 |
KR900004397B1 (ko) | 1990-06-25 |
DK580884A (da) | 1985-06-07 |
IL73795A0 (en) | 1985-03-31 |
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