KR910002845A - 크로만 유도체 - Google Patents
크로만 유도체 Download PDFInfo
- Publication number
- KR910002845A KR910002845A KR1019900011156A KR900011156A KR910002845A KR 910002845 A KR910002845 A KR 910002845A KR 1019900011156 A KR1019900011156 A KR 1019900011156A KR 900011156 A KR900011156 A KR 900011156A KR 910002845 A KR910002845 A KR 910002845A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- general formula
- carbon atoms
- chromen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 일반식(I)의 크로만 유도체 및 그의 염상기식에서, R¹은 A이고, R²은 각각 H 또는 A이고, R¹과R²는 함께 탄소수 3내지 6의 알킬렌이고, R³는 CHO 또는 CH2OH이고, R4는 A, F, Cl, Br, I, OH, OA, OAC, SH, NO2, NH2, AcNH, COOH 및 또는 COOA로 일치환 또는 이치환 또는 비치환된 피리딜, 피리다진일, 피리미딘일, 피라진일, 옥소디히드로피리딜, 옥소디히드로피리다진일, 옥소디히드로피리미딘일, 옥소디히드로피라진일, 2-피롤리디논-1-일 또는 3-옥소시클로펜텐-1-일이고, R5와 R6은 각각 H, A, HO, CHO, ACO, ACS, HOOC, AOOC, AO-CS, ACOO, A-CS-O, 히드록시알킬, 머르캅토알킬, NO2, NH2, NHA, NA2, CN, F, Cl, Br, I, CF3, ASO, ASO2, AO-SO, AO-SO2, AcNH, AO-CO-NH, H2NSO, HANSO, A2NSO, HANSO2, A2NSO2, H2NCO, HANCO, A2NCO, H2NCS, HANCS, A2NCS, ASONH, ASO2NH, AOSONH, AOSO2NH, ACO-알킬, 니트로알킬, 시아노알킬, A-C(=NOH) A-C(=NNH2)이고 Z는 O, S, NH 또는 결합이고, A는 탄소수 1내지 6의 알킬이고, -알킬은 탄소수 1내지 6의 알킬렌이고, Ac는 탄소수 1내지 8의 알칸오일 또는 탄소수 7내지 11의 아로일이다.
- a)2,2-디메틸-3-포르밀-4-(1.2-디히드로-2-옥소-1-피리딜)-6-시아노-3-크로멘, b)2,2-디메틸-3-히드록시메틸-4-(1,2-히드로-2-옥소-1-피리딜)-6-시아노-3-크로멘, c)2,2-디메틸-3-프로밀-4-(6-옥소-1,6-디히드로-3-피리다진일옥시)-6-시아노-3-크로멘, 3.일반식(I)의 크로만 유도체를 제조하는 방법에 있어서, 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시키거나,(상기식에서, E는 Cl, Br, I 또는 반응성 에스테르화 OH 그룹이고, R1, R2, R3, R4, R5, R6및 Z는 일반식(Ⅰ)에서 정의한 바와같다), 또는 R3가 CH2OH인 일반식(Ⅰ)의 화합물을 제조하기 위해서는, R3가 CHO인 일반식(Ⅰ)의 화합물을 환제로 처리하고/하거나, 일반식(Ⅰ)의 R4, R5및/또는 R6기로 전환시키고/시키거나, 일반식(Ⅰ)의 염기성 또는 산성 화합물을 산 또는 염기로 처리하여 그의 염으로 전환시킴을 특징으로 하는 방법.
- 내용 없음.
- 일반식(Ⅰ)의 화합물및/또는 이의 생리학적으로 허용되는 염의 하나를 적어도 하나의 고체, 액체 또는 반액체 부형제 또는 보조제와 함께 투여에 적합한 형태로 제조하는 것을 특징으로 하는 약학적 제제의 제조방법.
- 적어도 하나의 일반식(Ⅰ)의 화합물 및/또는 이의 생리학적으로 허용되는 염의 하나를 함유하는 약학적 제제.
- 약품의 제조를 위한 일반식(Ⅰ) 화합물의 용도.
- 질병을 치료하는데 있어서, 일반식(Ⅰ)의 화합물의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP3924417.2 | 1989-07-24 | ||
DE3924417A DE3924417A1 (de) | 1989-07-24 | 1989-07-24 | Chromanderivate |
Publications (1)
Publication Number | Publication Date |
---|---|
KR910002845A true KR910002845A (ko) | 1991-02-26 |
Family
ID=6385695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900011156A KR910002845A (ko) | 1989-07-24 | 1990-07-23 | 크로만 유도체 |
Country Status (20)
Country | Link |
---|---|
US (1) | US5143924A (ko) |
EP (1) | EP0410208B1 (ko) |
JP (1) | JPH0358983A (ko) |
KR (1) | KR910002845A (ko) |
AR (1) | AR245938A1 (ko) |
AT (1) | ATE107640T1 (ko) |
AU (1) | AU623544B2 (ko) |
CA (1) | CA2021684A1 (ko) |
DE (2) | DE3924417A1 (ko) |
DK (1) | DK0410208T3 (ko) |
ES (1) | ES2055830T3 (ko) |
FI (1) | FI95250C (ko) |
HU (1) | HU206707B (ko) |
IE (1) | IE63917B1 (ko) |
IL (1) | IL95167A (ko) |
NO (1) | NO176100C (ko) |
NZ (1) | NZ234609A (ko) |
PT (1) | PT94792B (ko) |
TW (1) | TW210337B (ko) |
ZA (1) | ZA905773B (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5387587A (en) * | 1986-12-23 | 1995-02-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
US5284838A (en) * | 1987-06-23 | 1994-02-08 | Elf Sanofi | Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma |
DE3922392A1 (de) * | 1989-07-07 | 1991-01-17 | Merck Patent Gmbh | Chromanderivate |
TW257762B (ko) * | 1991-06-14 | 1995-09-21 | Nippon Chemicals Pharmaceutical Co Ltd | |
US5250547A (en) * | 1991-08-29 | 1993-10-05 | Syntex (U.S.A.) Inc. | Benzopyran derivatives |
US5837702A (en) * | 1993-10-07 | 1998-11-17 | Bristol-Myers Squibb Co. | 4-arylamino-benzopyran and related compounds |
EP0677519A4 (en) * | 1993-11-10 | 1996-04-03 | Japan Tobacco Inc | CHROMAN DERIVATIVE AND THERAPEUTIC USE THEREOF. |
US5482942A (en) * | 1994-06-28 | 1996-01-09 | American Home Products Corporation | (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants |
US5470861A (en) * | 1994-08-04 | 1995-11-28 | Hoffmann-La Roche Inc. | Method of promoting hair growth |
US5869478A (en) * | 1995-06-07 | 1999-02-09 | Bristol-Myers Squibb Company | Sulfonamido substituted benzopyran derivatives |
US5612370A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phenylglycine and phenylalaninen amido benzopyran derivatives |
US5612323A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phosphinic ester substituted benzopyran derivatives |
US5629429A (en) * | 1995-06-07 | 1997-05-13 | Bristol-Myers Squibb Company | Process for preparing 4-arylamino-benzopyran and related compounds |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1770171C3 (de) * | 1967-04-14 | 1979-08-30 | Beecham Group Ltd., Brentford, Mddlesex (Grossbritannien) | 2,2-Dimethyl-7-alkyl-4-(4-pyridyl)-2H-chromen-5-ole, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneipräparate |
US3973023A (en) * | 1972-01-26 | 1976-08-03 | Beecham Group Limited | Anti-hypertensive polycyclic compounds for treating hypertension |
GB1417745A (en) * | 1973-07-07 | 1975-12-17 | Beecham Group Ltd | Chromene compounds |
US3947462A (en) * | 1974-05-22 | 1976-03-30 | Abbott Laboratories | 2,4,7-substituted 5-hydroxy benzopyrans and esters |
DE2745305A1 (de) * | 1977-10-07 | 1979-04-19 | Bayer Ag | Insektizide und akarizide mittel |
US4486428A (en) * | 1982-03-16 | 1984-12-04 | Pfizer Inc. | Bicyclic benzo fused compounds |
ATE56007T1 (de) * | 1984-06-22 | 1990-09-15 | Beecham Group Plc | Wirksame benzopyranverbindungen. |
GB8521857D0 (en) * | 1985-09-03 | 1985-10-09 | Beecham Group Plc | Active compounds |
DE3835011A1 (de) * | 1988-10-14 | 1990-04-19 | Merck Patent Gmbh | Chromanderivate |
DE3726261A1 (de) * | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
CH674984A5 (ko) * | 1987-05-16 | 1990-08-15 | Sandoz Ag | |
FI90343C (fi) * | 1987-06-23 | 1994-01-25 | Merck Patent Gmbh | Menetelmä korkeaa verenpainetta alentavien ja rytmihäiriöitä vastustavien trans-2,2-dimetyylikroman-3-olijohdannaisten valmistamiseksi |
US4971982A (en) * | 1987-07-06 | 1990-11-20 | Hoffmann-La Roche Inc. | Benzopyran derivatives |
JPH0753725B2 (ja) * | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
FR2621587B1 (fr) * | 1987-10-12 | 1990-02-09 | Sanofi Sa | Derives du dimethyl-2,2 chromene, procede pour leur preparation et composition pharmaceutiques les contenant |
DE3811017A1 (de) * | 1988-03-31 | 1989-10-19 | Hoechst Ag | Ungesaettigte n-benzopyranyllactame |
AU628331B2 (en) * | 1988-05-06 | 1992-09-17 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
DE3918041A1 (de) * | 1989-06-02 | 1990-12-06 | Merck Patent Gmbh | Chromanderivate |
-
1989
- 1989-07-24 DE DE3924417A patent/DE3924417A1/de not_active Withdrawn
-
1990
- 1990-07-11 DE DE59006189T patent/DE59006189D1/de not_active Expired - Fee Related
- 1990-07-11 EP EP90113218A patent/EP0410208B1/de not_active Expired - Lifetime
- 1990-07-11 DK DK90113218.3T patent/DK0410208T3/da active
- 1990-07-11 ES ES90113218T patent/ES2055830T3/es not_active Expired - Lifetime
- 1990-07-11 AT AT90113218T patent/ATE107640T1/de not_active IP Right Cessation
- 1990-07-20 CA CA002021684A patent/CA2021684A1/en not_active Abandoned
- 1990-07-20 TW TW079106032A patent/TW210337B/zh active
- 1990-07-23 KR KR1019900011156A patent/KR910002845A/ko not_active Application Discontinuation
- 1990-07-23 IL IL9516790A patent/IL95167A/en not_active IP Right Cessation
- 1990-07-23 ZA ZA905773A patent/ZA905773B/xx unknown
- 1990-07-23 PT PT94792A patent/PT94792B/pt not_active IP Right Cessation
- 1990-07-23 IE IE267690A patent/IE63917B1/en not_active IP Right Cessation
- 1990-07-23 NZ NZ234609A patent/NZ234609A/en unknown
- 1990-07-23 FI FI903704A patent/FI95250C/fi not_active IP Right Cessation
- 1990-07-23 NO NO903275A patent/NO176100C/no unknown
- 1990-07-23 US US07/555,700 patent/US5143924A/en not_active Expired - Fee Related
- 1990-07-24 AU AU59751/90A patent/AU623544B2/en not_active Ceased
- 1990-07-24 AR AR90317448A patent/AR245938A1/es active
- 1990-07-24 JP JP2194116A patent/JPH0358983A/ja active Pending
- 1990-07-24 HU HU904594A patent/HU206707B/hu not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ZA905773B (en) | 1991-05-29 |
HUT59130A (en) | 1992-04-28 |
DE59006189D1 (de) | 1994-07-28 |
JPH0358983A (ja) | 1991-03-14 |
AU5975190A (en) | 1991-01-24 |
FI903704A0 (fi) | 1990-07-23 |
IL95167A (en) | 1995-11-27 |
EP0410208B1 (de) | 1994-06-22 |
FI95250C (fi) | 1996-01-10 |
HU206707B (en) | 1992-12-28 |
ATE107640T1 (de) | 1994-07-15 |
ES2055830T3 (es) | 1994-09-01 |
CA2021684A1 (en) | 1991-01-25 |
IL95167A0 (en) | 1991-06-10 |
NO176100C (no) | 1995-02-01 |
AU623544B2 (en) | 1992-05-14 |
IE63917B1 (en) | 1995-06-14 |
PT94792B (pt) | 1997-03-31 |
US5143924A (en) | 1992-09-01 |
DE3924417A1 (de) | 1991-01-31 |
PT94792A (pt) | 1991-03-20 |
NZ234609A (en) | 1991-04-26 |
TW210337B (ko) | 1993-08-01 |
FI95250B (fi) | 1995-09-29 |
DK0410208T3 (da) | 1994-07-25 |
NO176100B (no) | 1994-10-24 |
NO903275L (no) | 1991-01-25 |
AR245938A1 (es) | 1994-03-30 |
IE902676A1 (en) | 1991-02-27 |
NO903275D0 (no) | 1990-07-23 |
EP0410208A1 (de) | 1991-01-30 |
HU904594D0 (en) | 1990-12-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |