KR910001062A - L-트립토판의 제조방법 - Google Patents

L-트립토판의 제조방법 Download PDF

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Publication number
KR910001062A
KR910001062A KR1019900008280A KR900008280A KR910001062A KR 910001062 A KR910001062 A KR 910001062A KR 1019900008280 A KR1019900008280 A KR 1019900008280A KR 900008280 A KR900008280 A KR 900008280A KR 910001062 A KR910001062 A KR 910001062A
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South Korea
Prior art keywords
anthranilate
tryptophan
brevibacterium
phosphate synthase
corynebacterium
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KR1019900008280A
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English (en)
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KR970001238B1 (ko
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료이찌 가쓰마따
마사또 이께다
게이꼬 나까니시
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가또 미끼오
교오와학꼬 고오교 가부시끼가이샤
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Publication of KR910001062A publication Critical patent/KR910001062A/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine

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  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Zoology (AREA)
  • Wood Science & Technology (AREA)
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  • Biomedical Technology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

내용 없음.

Description

L-트립토판의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 pCDtrp157의 제한 효소에 대한 절단지도 및 이 플라스미드의 제작 과정을 나타내고
제2도는 pDTS9901의 제한 효소에 대한 절단지도 및 이 플라스미드의 제작 과정을 나타낸다.

Claims (4)

  1. 코리네박테리움 또는 브레비박테리움 속에 속하고, 3-데옥시-D-아라비노-헵툴로소네이트-7-포스페이트 신타제, 안트라닐레이트 산타제, 안트라닐레이트 포스포리보실 트란스페라제, N-5'-포스포리보실 안트라닐레이트 이소메라제, 인들-3-글리세롤 포스페이트 신타제, 트립토판 신타제 및 3-포스포글리세레이트 데히드로게나재의 합성에 관여하는 유전정보를 전부 함유하는 DNA 단편과 벡터 DNA로 구성된 재조합 DNA를 보유하는 미생물을 배지에서 배양하고 : 배양물중에 L-트립토판을 축적시키고 : 그 배양물로 부터 L-트립토판을 회수함을 특징으로 하는 L-트립토판의 제조방법.
  2. 제1항에 있어서, DNA 단편이 코리네박테리움 또는 브레비박테리움속 미생물에서 유래되는 방법.
  3. 코리넥박테리움 또는 브레비박테리움 속에 속하는 미생물에서 유래된 3-데옥시-D-아라비노-헵롤로소네이트-7-포스페이트 신타제, 안트라닐레이트 산타제, 안트라닐레이트 포스포리보실 트란스페라제, N-5'-포스포리보실 안트라닐레이트 이소메타제, 인들-3-글리세롤 포스페이트 신타제, 트립토판 산타제 및 3-포스포글리세레이트 대히드로게나제의 합성에 관여하는 유전정보를 전부 함유하고, 코리네박테리움 또는 브레비박테리움 속 미생물에 트립로판 유사화합물에 대한 내성을 부여할 수 있는 DNA 단편과 벡터 DNA로 구성된 재조합 DNA.
  4. 코리네박테리움 또는 브레비박테리움 속에 속하고, 코리네박테리움 또는 브레비박테리움 속 미생물 유래의 3-데옥시-D-아라비노-헵룰로소네이트-7-포스페이트 신타제, 안트라닐레이트 산타제, 안트라닐레이트 포스포리보실 트란스페라제, N-5'-포스포리보실 안트라닐레이트 이소메라제, 인들-3-글리세롤 포스페이트 신타제, 트립토판 신타제 및 3-포스포글리세레이트 데히드로계나제의 합성에 관여하는 유전정보를 전부 함유하는 DNA 단편과 벡터 DNA로 구성된 재조합 DNA를 보유하는 미생물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900008280A 1989-06-06 1990-06-05 L-트립토판의 제조방법 KR970001238B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1143693A JP2967996B2 (ja) 1989-06-06 1989-06-06 Ｌ―トリプトファンの製造法
JP143693/89 1989-06-06
JP143693/1989 1989-06-06

Publications (2)

Publication Number Publication Date
KR910001062A true KR910001062A (ko) 1991-01-30
KR970001238B1 KR970001238B1 (ko) 1997-02-04

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Country Status (5)

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US (2) US5407824A (ko)
EP (1) EP0401735B1 (ko)
JP (1) JP2967996B2 (ko)
KR (1) KR970001238B1 (ko)
DE (2) DE401735T1 (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3078312B2 (ja) * 1990-11-22 2000-08-21 協和醗酵工業株式会社 物質の製造法
TW313589B (ko) * 1991-12-12 1997-08-21 Wacker Chemie Gmbh
US5856148A (en) * 1991-12-12 1999-01-05 Wacker Chemie Gmbh Materials and methods for biosynthesis of serine and serine-related products
DE4232468A1 (de) 1992-09-28 1994-03-31 Consortium Elektrochem Ind Mikroorganismen für die Produktion von Tryptophan und Verfahren zu ihrer Herstellung
US5776736A (en) * 1992-12-21 1998-07-07 Purdue Research Foundation Deblocking the common pathway of aromatic amino acid synthesis
US6118047A (en) 1993-08-25 2000-09-12 Dekalb Genetic Corporation Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction
JP4035855B2 (ja) * 1996-06-05 2008-01-23 味の素株式会社 Ｌ−リジンの製造法
JP4066543B2 (ja) * 1998-01-12 2008-03-26 味の素株式会社 発酵法によるｌ−セリンの製造法
JP3997631B2 (ja) 1998-01-12 2007-10-24 味の素株式会社 発酵法によるｌ−セリンの製造法
KR100878332B1 (ko) * 1999-06-25 2009-01-14 백광산업 주식회사 막 합성 및 막 운반 관련 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자
AU783706B2 (en) * 1999-06-25 2005-11-24 Paik Kwang Industrial Co., Ltd. Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation
CA2383865A1 (en) * 1999-06-25 2001-01-04 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding metabolic pathway proteins
JP2008166071A (ja) * 2006-12-27 2008-07-17 Toshiba Corp アダプタ
JP6177995B2 (ja) * 2013-04-16 2017-08-09 シージェイ チェイルジェダン コーポレーションＣｊ Ｃｈｅｉｌｊｅｄａｎｇ Ｃｏｒｐｏｒａｔｉｏｎ Ｌ−トリプトファン産生能を有する微生物およびこれを用いてｌ−トリプトファンを産生する方法
KR102221040B1 (ko) * 2019-05-09 2021-03-03 씨제이제일제당 주식회사 L-아미노산을 생산하는 미생물 및 이를 이용한 l-아미노산을 생산하는 방법

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Also Published As

Publication number Publication date
US5447857A (en) 1995-09-05
EP0401735A1 (en) 1990-12-12
DE69022631D1 (de) 1995-11-02
JPH037591A (ja) 1991-01-14
DE69022631T2 (de) 1996-03-21
JP2967996B2 (ja) 1999-10-25
EP0401735B1 (en) 1995-09-27
KR970001238B1 (ko) 1997-02-04
DE401735T1 (de) 1991-06-13
US5407824A (en) 1995-04-18

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