KR910000143B1 - 3-히드록시부탄산 또는 이 산으로 부터 유도된 염의 제조방법 - Google Patents

3-히드록시부탄산 또는 이 산으로 부터 유도된 염의 제조방법 Download PDF

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Publication number
KR910000143B1
KR910000143B1 KR1019830000728A KR830000728A KR910000143B1 KR 910000143 B1 KR910000143 B1 KR 910000143B1 KR 1019830000728 A KR1019830000728 A KR 1019830000728A KR 830000728 A KR830000728 A KR 830000728A KR 910000143 B1 KR910000143 B1 KR 910000143B1
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KR
South Korea
Prior art keywords
hydroxybutanoic acid
experiment
salts derived
salts
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
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KR1019830000728A
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English (en)
Korean (ko)
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KR840003414A (ko
Inventor
라머란트 자케스
클라노브스키 자로슬라브
Original Assignee
솔베이 앤드 시에 (소시에떼 아노님)
클라우디 라우트렐
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Publication of KR840003414A publication Critical patent/KR840003414A/ko
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Publication of KR910000143B1 publication Critical patent/KR910000143B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1019830000728A 1982-02-23 1983-02-23 3-히드록시부탄산 또는 이 산으로 부터 유도된 염의 제조방법 Expired KR910000143B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8203100A FR2521857B1 (fr) 1982-02-23 1982-02-23 Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee
FR82-03100 1982-02-23
FR82.03100 1982-02-23

Publications (2)

Publication Number Publication Date
KR840003414A KR840003414A (ko) 1984-09-08
KR910000143B1 true KR910000143B1 (ko) 1991-01-21

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Family Applications (1)

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KR1019830000728A Expired KR910000143B1 (ko) 1982-02-23 1983-02-23 3-히드록시부탄산 또는 이 산으로 부터 유도된 염의 제조방법

Country Status (21)

Country Link
US (2) US4579955A (https=)
EP (1) EP0087192B1 (https=)
JP (1) JPS58201746A (https=)
KR (1) KR910000143B1 (https=)
AT (1) ATE24478T1 (https=)
AU (2) AU560757B2 (https=)
CA (1) CA1203242A (https=)
DE (1) DE3368601D1 (https=)
DK (1) DK163235C (https=)
ES (2) ES8500240A1 (https=)
FI (1) FI79523C (https=)
FR (1) FR2521857B1 (https=)
GR (1) GR77934B (https=)
IE (1) IE54561B1 (https=)
IL (1) IL67965A0 (https=)
MX (1) MX156855A (https=)
NO (1) NO161909C (https=)
NZ (1) NZ203279A (https=)
PH (1) PH21561A (https=)
PT (1) PT76267A (https=)
ZA (1) ZA831019B (https=)

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* Cited by examiner, † Cited by third party
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FR2521857B1 (fr) * 1982-02-23 1985-10-31 Solvay Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee
USRE38604E1 (en) 1984-06-22 2004-09-28 Btg International Limited Fluid therapy with L-lactate and/or pyruvate anions
US6020007A (en) * 1984-06-22 2000-02-01 Btg International Limited Fluid therapy with l-lactate and/or pyruvate anions
US4777288A (en) * 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
BE1001209A3 (fr) * 1987-11-19 1989-08-22 Solvay Compositions pharmaceutiques contenant un derive de l'acide 3-hydroxybutanoique choisi parmi les oligomeres de cet acide et les esters de cet acide ou de ces oligomeres avec du 1,3-butanediol.
US5292774A (en) * 1988-07-26 1994-03-08 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Substitution fluid preparation comprising 3-hydroxy-butyric acid (β-hydroxybutric acid) and its salts
DE4113984C2 (de) * 1991-04-29 2002-05-08 Koehler Chemie Dr Franz Salze der 4-Hydroxy-Buttersäure
ES2051222B1 (es) * 1992-03-12 1995-02-16 Sanmiguel Gabriel Serrano Procedimiento de neutralizacion de acido alfa-hidroxietanoico.
JP4598203B2 (ja) * 1995-12-01 2010-12-15 ビーティージー・インターナショナル・リミテッド 脳機能改善剤
CN1315473C (zh) * 1997-03-17 2007-05-16 英国技术集团国际有限公司 治疗组合物
US6316038B1 (en) 1997-03-17 2001-11-13 Btg International Limited Therapeutic compositions
US20090253781A1 (en) * 2002-05-24 2009-10-08 Btg International Limited Therapeutic compositions
US6323237B1 (en) * 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
US6613356B1 (en) 2000-10-10 2003-09-02 Victor Vlahakos Weight loss medication and method
GB0420856D0 (en) * 2004-09-20 2004-10-20 Ketocytonyx Inc Cns modulators
WO2006020137A2 (en) * 2004-07-16 2006-02-23 Ketocytonyx Inc. Oligomeric compounds
EP1778615A4 (en) * 2004-07-20 2010-01-06 Btg Int Ltd OLIGOMERE KETONE COMPOUNDS
US20070225252A1 (en) * 2004-07-23 2007-09-27 Gross Richard A Ketogenic Saccharides
EP1793813A4 (en) * 2004-09-21 2011-05-18 Btg Int Ltd TREATMENT OF HYPERACTIVITY DISORDER WITH DEFICIT ATTENTION (ADHD)
ES2574557T3 (es) * 2004-09-21 2016-06-20 Btg International Limited Miméticos dopaminérgicos
RU2302239C1 (ru) * 2006-07-14 2007-07-10 Михаил Владимирович Покровский Способ фармакологической коррекции ишемии конечности
JPWO2008053982A1 (ja) 2006-10-30 2010-02-25 株式会社オフテクス アレルギー治療用組成物
DK2914251T3 (da) 2012-11-05 2019-11-04 Us Health Ketonlegemer til beskyttelse af væv mod beskadigelse som følge af ioniseringsstråling
HK1258020A1 (zh) 2015-11-19 2019-11-01 株式会社大塚制药工场 3-羟基异戊酸的一价阳离子盐的晶体及该晶体的制造方法
US11103470B2 (en) 2017-11-22 2021-08-31 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US11241403B2 (en) 2016-03-11 2022-02-08 Axcess Global Sciences, Llc Beta-hydroxybutyrate mixed salt compositions and methods of use
US11806324B2 (en) 2018-04-18 2023-11-07 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
US12109182B2 (en) 2016-04-19 2024-10-08 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate and related compounds in humans
US11202769B2 (en) 2017-11-22 2021-12-21 Axcess Global Sciences, Llc Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function
US12521378B2 (en) 2016-04-19 2026-01-13 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans
US12496283B2 (en) 2016-04-19 2025-12-16 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate and related compounds in humans
US12533346B2 (en) 2016-04-19 2026-01-27 Axcess Global Sciences, Llc Administration of berberine metabolites
US12329734B2 (en) 2017-12-19 2025-06-17 Axcess Global Sciences, Llc Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow
US10925843B2 (en) 2018-04-18 2021-02-23 Axcess Global Sciences, Llc Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate
US12599579B2 (en) 2016-04-19 2026-04-14 Axcess Global Sciences, Llc Compositions and compounds containing ketone bodies and/or ketone body precursors and one or more amino acids
US11944598B2 (en) 2017-12-19 2024-04-02 Axcess Global Sciences, Llc Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer
US20230346721A1 (en) 2018-04-18 2023-11-02 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies
JP6710098B2 (ja) * 2016-05-10 2020-06-17 大阪瓦斯株式会社 栄養剤組成物及び栄養補助食品
EP3476825A4 (en) 2016-06-24 2020-02-26 Kyowa Hakko Bio Co., Ltd. CRYSTAL OF BETA-HYDROXY-BETA-METHYLBUTTERIC ACID-AMINO ACID SALT AND PRODUCTION METHOD THEREFOR
US12090129B2 (en) 2017-11-22 2024-09-17 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US12472200B2 (en) 2019-05-15 2025-11-18 Axcess Global Sciences, Llc Autobiotic compositions and method for promoting healthy gut microbiome
US11950616B2 (en) 2019-06-21 2024-04-09 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
US12167993B2 (en) 2019-06-21 2024-12-17 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
US11969430B1 (en) 2023-03-10 2024-04-30 Axcess Global Sciences, Llc Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance
CN112341331B (zh) * 2019-08-07 2023-04-07 辽宁科硕营养科技股份有限公司 一种3-羟基丁酸盐及其制备方法与应用
US12186297B2 (en) 2020-08-26 2025-01-07 Axcess Global Sciences, Llc Compositions and methods for increasing lean-to-fat mass ratio
WO2024192165A1 (en) * 2023-03-14 2024-09-19 The Board Of Trustees Of The Leland Stanford Junior University N-beta-hydroxybutyryl-amino acids and related compositions and methods
AU2024343036A1 (en) * 2023-09-11 2026-02-12 Societe Des Produits Nestle S.A. Polymorphs and compositions comprising same

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US2101097A (en) * 1934-07-26 1937-12-07 Wm S Merrell Co Products for rendering the urine bacteriostatic
US2799684A (en) * 1954-06-18 1957-07-16 Food Chemical And Res Lab Inc Crystalline compounds of tryptophane and methods of manufacturing them
NL279760A (https=) * 1961-06-17
US3830931A (en) * 1972-11-06 1974-08-20 Felice S De Carnitine and its use in the treatment of arrhythmia and impaired cardiac function
US3879537A (en) * 1973-09-04 1975-04-22 Scott Eugene J Van Treatment of ichthyosiform dermatoses
DE2733202A1 (de) * 1976-08-04 1978-02-09 Agroferm Ag Verfahren zur herstellung der d(-)-3-hydroxybuttersaeure
US4412943A (en) * 1981-02-23 1983-11-01 Kao Soap Co., Ltd. Liquid detergent composition
FR2521857B1 (fr) * 1982-02-23 1985-10-31 Solvay Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee

Also Published As

Publication number Publication date
DK163235C (da) 1992-06-29
US4771074A (en) 1988-09-13
ZA831019B (en) 1983-11-30
JPS58201746A (ja) 1983-11-24
ES519991A0 (es) 1984-10-01
FI79523B (fi) 1989-09-29
IL67965A0 (en) 1983-06-15
NO830618L (no) 1983-08-24
FI830603L (fi) 1983-08-24
NO161909C (no) 1989-10-11
FI830603A0 (fi) 1983-02-23
EP0087192B1 (fr) 1986-12-30
IE830366L (en) 1983-08-23
FR2521857B1 (fr) 1985-10-31
DK163235B (da) 1992-02-10
AU1162483A (en) 1983-09-01
PT76267A (fr) 1983-03-01
EP0087192A1 (fr) 1983-08-31
ES8500240A1 (es) 1984-10-01
IE54561B1 (en) 1989-11-22
ATE24478T1 (de) 1987-01-15
GR77934B (https=) 1984-09-25
NZ203279A (en) 1985-04-30
PH21561A (en) 1987-12-11
CA1203242A (fr) 1986-04-15
AU602329B2 (en) 1990-10-11
AU6916187A (en) 1987-05-21
DE3368601D1 (en) 1987-02-05
DK81583A (da) 1983-08-24
DK81583D0 (da) 1983-02-23
FI79523C (fi) 1990-01-10
ES532880A0 (es) 1985-07-01
AU560757B2 (en) 1987-04-16
KR840003414A (ko) 1984-09-08
US4579955A (en) 1986-04-01
NO161909B (no) 1989-07-03
MX156855A (es) 1988-10-07
FR2521857A1 (fr) 1983-08-26
ES8506283A1 (es) 1985-07-01

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