ES2574557T3 - Miméticos dopaminérgicos - Google Patents
Miméticos dopaminérgicos Download PDFInfo
- Publication number
- ES2574557T3 ES2574557T3 ES05799591.2T ES05799591T ES2574557T3 ES 2574557 T3 ES2574557 T3 ES 2574557T3 ES 05799591 T ES05799591 T ES 05799591T ES 2574557 T3 ES2574557 T3 ES 2574557T3
- Authority
- ES
- Spain
- Prior art keywords
- hydroxybutyrate
- ketosis
- symptoms
- symptomatic relief
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Abstract
Un material cetógeno seleccionado de entre (R)-3-hidroxibutirato, (R)-3-hidroxibutirato oligómero y ésteres de (R)-3-hidroxibutirato con glicerol o (R)-butano-1,3-diol, para su uso en el suministro de un alivio sintomático agudo para los síntomas de la enfermedad de Parkinson resultantes de un déficit de dopamina en el encéfalo por administración a una dosis de 50 a 1.000mg/kg de peso corporal al día para producir una cetosis de tal manera que la concentración total de acetoacetato y (R)-3-hidroxibutirato en la sangre se eleva a entre 0,5 y 8mM; caracterizado porque la administración proporciona una dosis terapéuticamente efectiva del material cetógeno para el alivio sintomático agudo de uno o más de los síntomas del síndrome motor de bradicinesia (movimientos lentos), discinesia (movimientos anómalos), acinesia (rigidez), temblor en reposo, inestabilidad postural y déficits del habla; donde estos síntomas se reducen durante este periodo de cetosis, con la instauración de alivio sintomático en un máximo de dos horas desde el inicio de la cetosis.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61130204P | 2004-09-21 | 2004-09-21 | |
US611302P | 2004-09-21 | ||
PCT/US2005/033860 WO2006034361A2 (en) | 2004-09-21 | 2005-09-21 | Dopaminergic mimetics |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2574557T3 true ES2574557T3 (es) | 2016-06-20 |
Family
ID=36090656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES05799591.2T Active ES2574557T3 (es) | 2004-09-21 | 2005-09-21 | Miméticos dopaminérgicos |
Country Status (5)
Country | Link |
---|---|
US (7) | US20070281892A1 (es) |
EP (1) | EP1796658B1 (es) |
DK (1) | DK1796658T3 (es) |
ES (1) | ES2574557T3 (es) |
WO (1) | WO2006034361A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2146711A4 (en) | 2007-04-12 | 2011-10-26 | Univ Minnesota | PROTECTIVE COMPOSITIONS AGAINST ISCHEMIA / REPERFUSION AND METHODS OF USE |
US11229364B2 (en) * | 2013-06-14 | 2022-01-25 | Medtronic, Inc. | Patient motion analysis for behavior identification based on video frames with user selecting the head and torso from a frame |
US10307398B2 (en) | 2016-09-20 | 2019-06-04 | Regents Of The University Of Minnesota | Resuscitation composition and methods of making and using |
CN113329990A (zh) * | 2019-01-17 | 2021-08-31 | Ioi油脂化学品有限责任公司 | 羟基羧酸甘油酯的生产方法 |
TWI804037B (zh) * | 2021-11-02 | 2023-06-01 | 長庚醫療財團法人高雄長庚紀念醫院 | 生酮飲食之評估系統及其運作方法 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE637726A (es) * | 1962-09-26 | |||
US3665075A (en) * | 1970-08-07 | 1972-05-23 | American Cyanamid Co | Thozalinone as an antiparkinson agent |
US4363815A (en) * | 1975-07-23 | 1982-12-14 | Yu Ruey J | Alpha hydroxyacids, alpha ketoacids and their use in treating skin conditions |
DE2733202A1 (de) * | 1976-08-04 | 1978-02-09 | Agroferm Ag | Verfahren zur herstellung der d(-)-3-hydroxybuttersaeure |
US4067999A (en) * | 1976-12-15 | 1978-01-10 | Food Technology Products | Control of hemorrhagic enteritis in turkeys |
US4234599A (en) * | 1978-10-04 | 1980-11-18 | Scott Eugene J Van | Treatment of skin keratoses with α-hydroxy acids and related compounds |
US4346107A (en) * | 1979-02-12 | 1982-08-24 | Claudio Cavazza | Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism |
US4351835A (en) * | 1981-04-01 | 1982-09-28 | Montefiore Hospital | Method for preventing body fat deposition in mammals |
FR2521857B1 (fr) * | 1982-02-23 | 1985-10-31 | Solvay | Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee |
US4701443A (en) * | 1983-03-22 | 1987-10-20 | Baxter Travenol Laboratories, Inc. | Nutrient polyesters |
US5100677A (en) * | 1985-12-18 | 1992-03-31 | Veech Richard L | Fluid therapy with various organic anions |
EP0215138B1 (fr) * | 1985-09-06 | 1991-01-16 | Societe Des Produits Nestle S.A. | Préservation des tissus vivants |
GB8525666D0 (en) * | 1985-10-17 | 1985-11-20 | Ici Plc | Chemical process |
US5719119A (en) * | 1985-12-18 | 1998-02-17 | British Technology Group, Ltd. | Parenteral nutrition therapy with amino acids |
EP0258273A1 (en) * | 1985-12-20 | 1988-03-09 | VEECH, Richard L. | Preparation of electrolyte solutions and containers |
US4997976A (en) * | 1988-11-15 | 1991-03-05 | Henri Brunengraber | Use of 1,3-butanediol acetoacetate in parenteral oral nutrition |
US5126373A (en) * | 1987-11-19 | 1992-06-30 | Henri Brunengraber | Composition for parenteral and oral nutrition |
US5292774A (en) * | 1988-07-26 | 1994-03-08 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Substitution fluid preparation comprising 3-hydroxy-butyric acid (β-hydroxybutric acid) and its salts |
US5116868A (en) * | 1989-05-03 | 1992-05-26 | The Johns Hopkins University | Effective ophthalmic irrigation solution |
EP0522422A3 (en) * | 1991-07-01 | 1993-03-17 | Mitsubishi Kasei Corporation | Process for producing a biodegradable polymer |
US5654266A (en) * | 1992-02-10 | 1997-08-05 | Chen; Chung-Ho | Composition for tissues to sustain viability and biological functions in surgery and storage |
US5348979A (en) * | 1992-12-23 | 1994-09-20 | Iowa State University Research Foundation Inc. | Method of promoting nitrogen retention in humans |
WO1995009144A1 (en) * | 1993-09-30 | 1995-04-06 | Eastman Chemical Company | Nutritive water soluble glycerol esters of hydroxy butyric acid |
US5912269A (en) * | 1996-04-30 | 1999-06-15 | Vertex Pharmaceuticals, Inc. | Butyrate prodrugs derived from lactic acid |
JP4598203B2 (ja) * | 1995-12-01 | 2010-12-15 | ビーティージー・インターナショナル・リミテッド | 脳機能改善剤 |
US6323237B1 (en) * | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
DE69903792T2 (de) * | 1998-01-07 | 2003-08-14 | Metabolix Inc | Tierfutterzusammensetzungen |
US6417210B1 (en) * | 1998-01-09 | 2002-07-09 | Mor-Research Applications Ltd. | Treatment of dyskinesias and Parkinson's disease with riluzole and levodopa |
ATE239464T1 (de) * | 1998-01-21 | 2003-05-15 | Fideline | Pheromone enthaltende zusammensetzung zur minderung von stress, angst und streitsucht in schweinen |
WO2002051395A1 (en) * | 1998-05-28 | 2002-07-04 | Codon Pharmaceuticals, Inc. | Treatment of neurodegenerative diseases |
ATE283056T1 (de) * | 1998-07-22 | 2004-12-15 | Metabolix Inc | Nahrungs- und therapeutische verwendung von hydroxyalkanoat oligomere |
KR100805490B1 (ko) * | 1998-09-15 | 2008-02-20 | 비티지 인터내셔널 리미티드 | 치료 조성물 (ⅱ) |
GB9901809D0 (en) * | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
AU2001257451A1 (en) * | 2000-05-01 | 2001-11-12 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism |
US6835750B1 (en) * | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
US20020132846A1 (en) * | 2001-02-26 | 2002-09-19 | Caleb Stone | Use of gamma substituted gamma-butyrolactones to increase levels of their corresponding substituted gamma-hydroxybutyrate derivatives in humans |
US6670378B2 (en) * | 2001-05-08 | 2003-12-30 | Pharmacia & Upjohn Company | Method of treating Parkinson's disease |
CA2517929A1 (en) * | 2003-03-06 | 2004-09-16 | Accera Inc. | Novel-chemical entities and methods for their use in treatment of metabolic disorders |
WO2006012490A2 (en) * | 2004-07-23 | 2006-02-02 | Ketocytonyx Inc. | Ketogenic saccharides |
GB201002983D0 (en) * | 2010-02-22 | 2010-04-07 | Tdeltas Ltd | Nutritinal composition |
-
2005
- 2005-09-21 WO PCT/US2005/033860 patent/WO2006034361A2/en active Application Filing
- 2005-09-21 DK DK05799591.2T patent/DK1796658T3/en active
- 2005-09-21 ES ES05799591.2T patent/ES2574557T3/es active Active
- 2005-09-21 US US11/663,342 patent/US20070281892A1/en not_active Abandoned
- 2005-09-21 EP EP05799591.2A patent/EP1796658B1/en active Active
-
2010
- 2010-09-22 US US12/888,222 patent/US20110065656A1/en not_active Abandoned
-
2015
- 2015-01-26 US US14/604,812 patent/US20150141511A1/en not_active Abandoned
- 2015-10-06 US US14/875,999 patent/US20170035712A1/en not_active Abandoned
-
2018
- 2018-08-07 US US16/057,080 patent/US20180338938A1/en not_active Abandoned
-
2020
- 2020-08-26 US US17/003,531 patent/US20210077440A1/en not_active Abandoned
-
2022
- 2022-07-12 US US17/811,956 patent/US20230165817A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1796658B1 (en) | 2016-03-30 |
US20070281892A1 (en) | 2007-12-06 |
EP1796658A4 (en) | 2007-12-12 |
EP1796658A2 (en) | 2007-06-20 |
US20180338938A1 (en) | 2018-11-29 |
DK1796658T3 (en) | 2016-06-27 |
US20150141511A1 (en) | 2015-05-21 |
US20170035712A1 (en) | 2017-02-09 |
WO2006034361A2 (en) | 2006-03-30 |
US20110065656A1 (en) | 2011-03-17 |
US20210077440A1 (en) | 2021-03-18 |
US20230165817A1 (en) | 2023-06-01 |
WO2006034361A3 (en) | 2006-11-16 |
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