MA30266B1 - Utilisation de deferiprone et methodes de traitement prophylactique et/ou therapeutique de la maladie de friedreich resultant d'un dysfonctionnement du traitement intracellulaire du fer - Google Patents
Utilisation de deferiprone et methodes de traitement prophylactique et/ou therapeutique de la maladie de friedreich resultant d'un dysfonctionnement du traitement intracellulaire du ferInfo
- Publication number
- MA30266B1 MA30266B1 MA31216A MA31216A MA30266B1 MA 30266 B1 MA30266 B1 MA 30266B1 MA 31216 A MA31216 A MA 31216A MA 31216 A MA31216 A MA 31216A MA 30266 B1 MA30266 B1 MA 30266B1
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- iron
- deferiprone
- dysfunction
- intracellular
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne une quantité thérapeutiquement active de défériprone ou de déférasirox ou de sels de qualité physiologique desdits composés pour la prévention, la stabilisation, le traitement ou la guérison d'une maladie de Friedreich induite par le fer chez des patients, ladite maladie résultant de dégâts aux mitochondries induits par le fer, et le but de ladite quantité thérapeutiquement active étant préférentiellement de réduire les réserves de fer des mitochondries. La présente invention concerne également le traitement d'autres états pathologiques affectant le cerveau lorsque l'un des éléments clés de l'apparition de la pathologie est un dysfonctionnement du traitement intracellulaire du fer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77532006P | 2006-02-22 | 2006-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30266B1 true MA30266B1 (fr) | 2009-03-02 |
Family
ID=38436879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31216A MA30266B1 (fr) | 2006-02-22 | 2008-09-08 | Utilisation de deferiprone et methodes de traitement prophylactique et/ou therapeutique de la maladie de friedreich resultant d'un dysfonctionnement du traitement intracellulaire du fer |
Country Status (24)
Country | Link |
---|---|
US (3) | US20070197649A1 (fr) |
EP (1) | EP1991225B1 (fr) |
JP (1) | JP5730466B2 (fr) |
KR (1) | KR20080104329A (fr) |
CN (1) | CN101420954A (fr) |
AU (1) | AU2007219009B2 (fr) |
BR (1) | BRPI0708211A2 (fr) |
CA (1) | CA2642778A1 (fr) |
DK (1) | DK1991225T3 (fr) |
ES (1) | ES2441065T3 (fr) |
IL (1) | IL193598A (fr) |
MA (1) | MA30266B1 (fr) |
MX (1) | MX2008010824A (fr) |
MY (1) | MY151412A (fr) |
NZ (1) | NZ570730A (fr) |
PL (1) | PL1991225T3 (fr) |
PT (1) | PT1991225E (fr) |
RS (1) | RS53225B (fr) |
RU (1) | RU2008137604A (fr) |
SG (1) | SG170020A1 (fr) |
SI (1) | SI1991225T1 (fr) |
TN (1) | TNSN08338A1 (fr) |
UA (1) | UA95099C2 (fr) |
WO (1) | WO2007095728A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2008137604A (ru) * | 2006-02-22 | 2010-03-27 | Арнольд МЮННИК (FR) | Применение деферипрона и способ лечения и/или профилактики атаксии фридрейха, возникающей вследствие внутриклеточного нарушения обмена железа |
NZ600874A (en) | 2007-03-28 | 2013-01-25 | Apotex Technologies Inc | Fluorinated derivatives of deferiprone |
AP2010005454A0 (en) | 2008-04-25 | 2010-12-31 | Apotex Technologies Inc | Liquid formulation for deferiprone with palatable taste. |
BRPI0920492A2 (pt) * | 2009-01-26 | 2019-07-09 | Lawrence Dunaief Joshua | uso de deferiprona para o tratamento e prevenção de doenças oftalmológicas relacionadas ao ferro. |
CN102712591B (zh) | 2009-07-03 | 2014-06-25 | 阿普泰克斯科技公司 | 3-羟基吡啶-4-酮的氟化衍生物 |
WO2011009890A2 (fr) | 2009-07-23 | 2011-01-27 | Novartis Ag | Utilisation de dérivés de azabicycloalkyle ou de dérivés de pyrrolidine-2-one |
JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
DK2611457T3 (da) * | 2010-08-30 | 2014-05-12 | Roberto Testi | Sammensætninger og fremgangsmåder til behandling af Friereichs ataxia med interferon gamma |
CN102861017A (zh) * | 2011-07-08 | 2013-01-09 | 辽宁省计划生育科学研究院 | 一种化合物在防治老年痴呆的应用 |
WO2013139931A1 (fr) * | 2012-03-21 | 2013-09-26 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Composition destinée à être utilisée dans le traitement de maladies neurodégénératives ayant des syndromes parkinsoniens |
US10442779B2 (en) | 2014-09-22 | 2019-10-15 | Fratagene Therapeutics S.R.L. | Compositions and methods for treating Friedreich's ataxia |
US10426775B2 (en) | 2017-09-11 | 2019-10-01 | Fratagene Therapeutics Srl | Methods for treating Friedreich's ataxia with etravirine |
US10940116B2 (en) | 2017-10-25 | 2021-03-09 | Chiesi Farmaceutici S.P.A. | Delayed release deferiprone tablets and methods of using the same |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5624807A (en) | 1992-07-22 | 1997-04-29 | The Mclean Hospital Corporation | Methods for detecting Alzheimer's disease by measuring ratios of calcium-activated neutral protease isoforms |
US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
CA2272971C (fr) * | 1998-10-29 | 2008-01-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Derives de la quinone pour le traitement ou la prevention de maladies associees a une surcharge en fer |
US6933104B1 (en) * | 1999-04-23 | 2005-08-23 | Shiva Biomedical, Llc | Diagnosis and treatment of human kidney diseases |
AUPQ262499A0 (en) * | 1999-09-02 | 1999-09-23 | University Of Queensland, The | Novel iron chelators |
CA2313270C (fr) * | 2000-06-30 | 2011-09-13 | Apotex Inc. | Utilisation de deferiprone pour le traitement et la prevention de maladies cardiaques induites par le fer |
WO2004006856A2 (fr) * | 2002-07-12 | 2004-01-22 | The Buck Institute For Research On Aging | Sequestration ou elimination du fer pour reduire la neurodegenerescence ou la progression de la maladie de parkinson |
EP1565185A4 (fr) * | 2002-11-07 | 2011-01-05 | Technion Res & Dev Foundation | Chelateurs du fer et compositions pharmaceutiques les renfermant |
EP1755579A4 (fr) * | 2004-05-24 | 2009-06-10 | Univ New York | Methode de traitement ou de prevention d'effets pathologiques d'augmentations aigues de l'hyperglycemie et/ou d'augmentations aigues de flux d'acides gras libres |
US9737511B2 (en) * | 2004-05-24 | 2017-08-22 | Geoffrey C. GURTNER | Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux |
US7728038B2 (en) | 2004-08-04 | 2010-06-01 | University Of Utah Research Foundation | Methods for chelation therapy |
US20070197469A1 (en) * | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V | Fluoroquinolone carboxylic acid salt compositions |
RU2008137604A (ru) * | 2006-02-22 | 2010-03-27 | Арнольд МЮННИК (FR) | Применение деферипрона и способ лечения и/или профилактики атаксии фридрейха, возникающей вследствие внутриклеточного нарушения обмена железа |
-
2007
- 2007-02-21 RU RU2008137604/14A patent/RU2008137604A/ru not_active Application Discontinuation
- 2007-02-21 BR BRPI0708211-8A patent/BRPI0708211A2/pt not_active IP Right Cessation
- 2007-02-21 MX MX2008010824A patent/MX2008010824A/es active IP Right Grant
- 2007-02-21 PT PT77018000T patent/PT1991225E/pt unknown
- 2007-02-21 US US11/708,322 patent/US20070197649A1/en not_active Abandoned
- 2007-02-21 JP JP2008555581A patent/JP5730466B2/ja not_active Expired - Fee Related
- 2007-02-21 UA UAA200810608A patent/UA95099C2/ru unknown
- 2007-02-21 CN CNA2007800132579A patent/CN101420954A/zh active Pending
- 2007-02-21 MY MYPI20083186 patent/MY151412A/en unknown
- 2007-02-21 DK DK07701800.0T patent/DK1991225T3/da active
- 2007-02-21 PL PL07701800T patent/PL1991225T3/pl unknown
- 2007-02-21 EP EP07701800.0A patent/EP1991225B1/fr active Active
- 2007-02-21 US US12/279,930 patent/US20090023784A1/en not_active Abandoned
- 2007-02-21 SG SG201101266-3A patent/SG170020A1/en unknown
- 2007-02-21 SI SI200731386T patent/SI1991225T1/sl unknown
- 2007-02-21 WO PCT/CA2007/000252 patent/WO2007095728A1/fr active Application Filing
- 2007-02-21 AU AU2007219009A patent/AU2007219009B2/en not_active Ceased
- 2007-02-21 KR KR1020087023077A patent/KR20080104329A/ko not_active Application Discontinuation
- 2007-02-21 CA CA002642778A patent/CA2642778A1/fr not_active Abandoned
- 2007-02-21 NZ NZ570730A patent/NZ570730A/xx not_active IP Right Cessation
- 2007-02-21 ES ES07701800.0T patent/ES2441065T3/es active Active
- 2007-02-21 RS RS20140006A patent/RS53225B/en unknown
-
2008
- 2008-08-21 IL IL193598A patent/IL193598A/en not_active IP Right Cessation
- 2008-08-22 TN TNP2008000338A patent/TNSN08338A1/en unknown
- 2008-09-08 MA MA31216A patent/MA30266B1/fr unknown
-
2013
- 2013-01-31 US US13/755,048 patent/US20130190365A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BRPI0708211A2 (pt) | 2011-05-17 |
CA2642778A1 (fr) | 2007-08-30 |
EP1991225B1 (fr) | 2013-11-06 |
IL193598A0 (en) | 2009-08-03 |
AU2007219009B2 (en) | 2012-12-20 |
EP1991225A4 (fr) | 2009-07-29 |
JP2009527506A (ja) | 2009-07-30 |
AU2007219009A1 (en) | 2007-08-30 |
UA95099C2 (ru) | 2011-07-11 |
CN101420954A (zh) | 2009-04-29 |
PL1991225T3 (pl) | 2014-04-30 |
US20130190365A1 (en) | 2013-07-25 |
MY151412A (en) | 2014-05-30 |
ES2441065T3 (es) | 2014-01-31 |
US20070197649A1 (en) | 2007-08-23 |
JP5730466B2 (ja) | 2015-06-10 |
WO2007095728A1 (fr) | 2007-08-30 |
DK1991225T3 (da) | 2013-12-16 |
RU2008137604A (ru) | 2010-03-27 |
KR20080104329A (ko) | 2008-12-02 |
MX2008010824A (es) | 2009-06-08 |
SG170020A1 (en) | 2011-04-29 |
SI1991225T1 (sl) | 2014-02-28 |
EP1991225A1 (fr) | 2008-11-19 |
RS53225B (en) | 2014-08-29 |
TNSN08338A1 (en) | 2009-12-29 |
NZ570730A (en) | 2013-05-31 |
IL193598A (en) | 2012-08-30 |
US20090023784A1 (en) | 2009-01-22 |
PT1991225E (pt) | 2014-02-13 |
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