MA30266B1 - Utilisation de deferiprone et methodes de traitement prophylactique et/ou therapeutique de la maladie de friedreich resultant d'un dysfonctionnement du traitement intracellulaire du fer - Google Patents

Utilisation de deferiprone et methodes de traitement prophylactique et/ou therapeutique de la maladie de friedreich resultant d'un dysfonctionnement du traitement intracellulaire du fer

Info

Publication number
MA30266B1
MA30266B1 MA31216A MA31216A MA30266B1 MA 30266 B1 MA30266 B1 MA 30266B1 MA 31216 A MA31216 A MA 31216A MA 31216 A MA31216 A MA 31216A MA 30266 B1 MA30266 B1 MA 30266B1
Authority
MA
Morocco
Prior art keywords
treatment
iron
deferiprone
dysfunction
intracellular
Prior art date
Application number
MA31216A
Other languages
English (en)
Inventor
Arnold Munnich
Michael Spino
Ioav Cabantchik
Original Assignee
Arnold Munnich
Michael Spino
Ioav Cabantchik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arnold Munnich, Michael Spino, Ioav Cabantchik filed Critical Arnold Munnich
Publication of MA30266B1 publication Critical patent/MA30266B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une quantité thérapeutiquement active de défériprone ou de déférasirox ou de sels de qualité physiologique desdits composés pour la prévention, la stabilisation, le traitement ou la guérison d'une maladie de Friedreich induite par le fer chez des patients, ladite maladie résultant de dégâts aux mitochondries induits par le fer, et le but de ladite quantité thérapeutiquement active étant préférentiellement de réduire les réserves de fer des mitochondries. La présente invention concerne également le traitement d'autres états pathologiques affectant le cerveau lorsque l'un des éléments clés de l'apparition de la pathologie est un dysfonctionnement du traitement intracellulaire du fer.
MA31216A 2006-02-22 2008-09-08 Utilisation de deferiprone et methodes de traitement prophylactique et/ou therapeutique de la maladie de friedreich resultant d'un dysfonctionnement du traitement intracellulaire du fer MA30266B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77532006P 2006-02-22 2006-02-22

Publications (1)

Publication Number Publication Date
MA30266B1 true MA30266B1 (fr) 2009-03-02

Family

ID=38436879

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31216A MA30266B1 (fr) 2006-02-22 2008-09-08 Utilisation de deferiprone et methodes de traitement prophylactique et/ou therapeutique de la maladie de friedreich resultant d'un dysfonctionnement du traitement intracellulaire du fer

Country Status (24)

Country Link
US (3) US20090023784A1 (fr)
EP (1) EP1991225B1 (fr)
JP (1) JP5730466B2 (fr)
KR (1) KR20080104329A (fr)
CN (1) CN101420954A (fr)
AU (1) AU2007219009B2 (fr)
BR (1) BRPI0708211A2 (fr)
CA (1) CA2642778A1 (fr)
DK (1) DK1991225T3 (fr)
ES (1) ES2441065T3 (fr)
IL (1) IL193598A (fr)
MA (1) MA30266B1 (fr)
MX (1) MX2008010824A (fr)
MY (1) MY151412A (fr)
NZ (1) NZ570730A (fr)
PL (1) PL1991225T3 (fr)
PT (1) PT1991225E (fr)
RS (1) RS53225B (fr)
RU (1) RU2008137604A (fr)
SG (1) SG170020A1 (fr)
SI (1) SI1991225T1 (fr)
TN (1) TNSN08338A1 (fr)
UA (1) UA95099C2 (fr)
WO (1) WO2007095728A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY151412A (en) * 2006-02-22 2014-05-30 Munnich Arnold The use of deferiprone and methods to treat and/or prevent friedreich ataxia resulting from intracellular mishandling of iron
AU2008232262B2 (en) 2007-03-28 2013-02-14 Apotex Inc. Fluorinated derivatives of deferiprone
US8703156B2 (en) * 2008-04-25 2014-04-22 Apotex Technologies Inc. Liquid formulation for deferiprone with palatable taste
SG173145A1 (en) 2009-01-26 2011-08-29 Michael Spino Use of deferiprone for treatment and prevention of iron-related eye disorders
MX2012000247A (es) 2009-07-03 2012-03-26 Apotex Technologies Inc Derivados fluorados de 3-hidroxipiridin-4-onas.
WO2011009890A2 (fr) 2009-07-23 2011-01-27 Novartis Ag Utilisation de dérivés de azabicycloalkyle ou de dérivés de pyrrolidine-2-one
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
SI2611457T1 (sl) * 2010-08-30 2014-09-30 Roberto Testi Sestavki in postopki za zdravljenje Friedreichove ataksije z interferonom gama
CN102861017A (zh) * 2011-07-08 2013-01-09 辽宁省计划生育科学研究院 一种化合物在防治老年痴呆的应用
WO2013139931A1 (fr) * 2012-03-21 2013-09-26 Icm (Institut Du Cerveau Et De La Moelle Épinière) Composition destinée à être utilisée dans le traitement de maladies neurodégénératives ayant des syndromes parkinsoniens
US10442779B2 (en) 2014-09-22 2019-10-15 Fratagene Therapeutics S.R.L. Compositions and methods for treating Friedreich's ataxia
US10426775B2 (en) 2017-09-11 2019-10-01 Fratagene Therapeutics Srl Methods for treating Friedreich's ataxia with etravirine
NZ763555A (en) 2017-10-25 2022-07-01 Chiesi Farm Spa Delayed release deferiprone tablets and methods of using the same
US12016850B2 (en) 2022-04-11 2024-06-25 Chiesi Farmaceutici S.P.A. Modified release pharmaceutical formulations comprising deferiprone
US12016851B2 (en) 2022-04-11 2024-06-25 Chiesi Farmaceutici S.P.A. Modified release pharmaceutical formulations comprising deferiprone

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624807A (en) 1992-07-22 1997-04-29 The Mclean Hospital Corporation Methods for detecting Alzheimer's disease by measuring ratios of calcium-activated neutral protease isoforms
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
US6133322A (en) 1998-10-29 2000-10-17 Institut National De La Sante Et De La Recherche Medicale (Inserm) Quinone derivatives for treating or preventing diseases associated with iron overload
US6933104B1 (en) * 1999-04-23 2005-08-23 Shiva Biomedical, Llc Diagnosis and treatment of human kidney diseases
AUPQ262499A0 (en) 1999-09-02 1999-09-23 University Of Queensland, The Novel iron chelators
CA2313270C (fr) * 2000-06-30 2011-09-13 Apotex Inc. Utilisation de deferiprone pour le traitement et la prevention de maladies cardiaques induites par le fer
WO2004006856A2 (fr) * 2002-07-12 2004-01-22 The Buck Institute For Research On Aging Sequestration ou elimination du fer pour reduire la neurodegenerescence ou la progression de la maladie de parkinson
EP1565185A4 (fr) * 2002-11-07 2011-01-05 Technion Res & Dev Foundation Chelateurs du fer et compositions pharmaceutiques les renfermant
WO2005115379A2 (fr) * 2004-05-24 2005-12-08 New York University Methode de traitement ou de prevention d'effets pathologiques d'augmentations aigues de l'hyperglycemie et/ou d'augmentations aigues de flux d'acides gras libres
US9737511B2 (en) * 2004-05-24 2017-08-22 Geoffrey C. GURTNER Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
US7728038B2 (en) 2004-08-04 2010-06-01 University Of Utah Research Foundation Methods for chelation therapy
US20070197469A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V Fluoroquinolone carboxylic acid salt compositions
MY151412A (en) * 2006-02-22 2014-05-30 Munnich Arnold The use of deferiprone and methods to treat and/or prevent friedreich ataxia resulting from intracellular mishandling of iron

Also Published As

Publication number Publication date
RS53225B (en) 2014-08-29
US20130190365A1 (en) 2013-07-25
JP5730466B2 (ja) 2015-06-10
IL193598A (en) 2012-08-30
BRPI0708211A2 (pt) 2011-05-17
AU2007219009A1 (en) 2007-08-30
MY151412A (en) 2014-05-30
TNSN08338A1 (en) 2009-12-29
KR20080104329A (ko) 2008-12-02
PT1991225E (pt) 2014-02-13
PL1991225T3 (pl) 2014-04-30
AU2007219009B2 (en) 2012-12-20
US20070197649A1 (en) 2007-08-23
EP1991225B1 (fr) 2013-11-06
RU2008137604A (ru) 2010-03-27
EP1991225A1 (fr) 2008-11-19
ES2441065T3 (es) 2014-01-31
WO2007095728A1 (fr) 2007-08-30
NZ570730A (en) 2013-05-31
IL193598A0 (en) 2009-08-03
EP1991225A4 (fr) 2009-07-29
SG170020A1 (en) 2011-04-29
DK1991225T3 (da) 2013-12-16
CA2642778A1 (fr) 2007-08-30
MX2008010824A (es) 2009-06-08
US20090023784A1 (en) 2009-01-22
JP2009527506A (ja) 2009-07-30
UA95099C2 (ru) 2011-07-11
SI1991225T1 (sl) 2014-02-28
CN101420954A (zh) 2009-04-29

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