KR900009061A - 치아질환을 경감시키는데 유용한 개선된 상분리-미소봉입된 제약학적 조성물 - Google Patents

치아질환을 경감시키는데 유용한 개선된 상분리-미소봉입된 제약학적 조성물 Download PDF

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KR900009061A
KR900009061A KR1019890019157A KR890019157A KR900009061A KR 900009061 A KR900009061 A KR 900009061A KR 1019890019157 A KR1019890019157 A KR 1019890019157A KR 890019157 A KR890019157 A KR 890019157A KR 900009061 A KR900009061 A KR 900009061A
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poly
therapeutic agent
microparticles
weight
agent
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KR1019890019157A
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KR0138651B1 (ko
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로널드 로터 제임즈
제럴드 란질로티 마이클
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

내용 없음.

Description

치아질환을 경감시키는데 유용한 개선된 상분리-미소봉입된 제약학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 생체에 적합하고 생분해가능한 중합체로 구성된 매트릭스(ii)에 분산되 유효량의 적어도 한 치료제(i)로 구성되고, 상분리 방법에 의해 제조되고 잔류 경화제 함량 3중량% 이하를 갖는 치아질환을 경감시키기 위한 치료제-함유 미소입자.
  2. 제1항에 있어서, 상기 치아질환이 치근막염인 치료제-함유 미소입자.
  3. 제1항에 있어서, 상기 치료제가 항균제, 항진균제, 항생제, 항-염제, 면역억제제, 면역촉진제, 치질 제감작(齒質 除感作)제, 냄새은폐제, 면역시약, 마취제, 소독제, 영양제, 항산화제, 리포폴리 사카라이드 복합제, 과산화물, 조직 성장 인자 또는 이들중 임의의 혼합물중에서 선택된 치료제-함유 미소입자.
  4. 제3항에 있어서, 상기 치료제가 항생 활성을 갖는 약품으로 구성되고 테트라시클린 또는 제약학적으로 허용가능한 그들의 염 또는 그들의 수화물, 톡시시클린 또는 제약학적으로 허용가능한 그들의 염 또는 그들의 수화물, 미노시클린 또는 제약학적으로 허용가능한 그들의 염 또는 그들의 수화물, 및 이들중 하나이상의 혼합물로 구성된 군 중에서 선택된 치료제-함유미소입자.
  5. 제1항에 있어서, 상기 치료제가 상기 미소입자 100중량 부당 약 0.0001-약 50중량부로 구성된 치료제-함유 미소입자.
  6. 제4항에 있어서, 상기 치료제가 상기 미소입자 100 중량부당 약 5-약 40중량부로 구성된 치료제-함유 미소입자.
  7. 제1항에 있어서, 상기 미소입자가 상기 미소입자 100중량 부당 미노시클린 HCl 약 20-약 30중량부 및 폴리(글리콜리드-코-dl-락티드) 약 80-약 70중량부로 구성된 치료제-함유 미소입자.
  8. 제1항에 있어서, 상기 중합체가 폴리글리콜리드, 폴리락티드(d 또는 1), 폴리(글리콜리드-코-1-락티드), 폴리(글기콜리드-코-d1-락티드), 폴리(p-디옥사는), 폴리(글리콜리드-코-트리에틸렌 카르보네이트), 폴리글리콜리드, 트리메틸렌 카르보네이트 및 폴리에틸렌 산화물의 블록 공중합체, 폴리(알킬렌 디클리콜레이트), 폴리(알킬렌숙시네이트), 폴리(알킬렌 옥살레이트), 폴리(카프로락톤), 폴리(알파-히드록시부티르산), 폴리(오르토 에스테르), 폴리(언히드리드), 폴리(아미드 에스테르), 폴리(알킬렌 타르트레이트), 폴리(푸마레이트) 및 이들중 임의의 혼합물 중에서 선택된 치료제-함유 미소입자.
  9. 제1항에 있어서, 상기 중합체가 물과 접촉시 끈적끈적해지고 폴리(글리콜리드-코-d1-락티드), 폴리글리콜리드, 트리메틸렌카르보네이트 및 폴리에틸렌 산화물의 블록 공중합체, 및 이들의 혼합물로 구성된 군중에서 선택된 중합체로 구성되며, 상기 미소입자가 직경 약 1-약 1000미크론을 갖는 치료제-함유 미소입자.
  10. 제1항, 제4항, 제7항, 제8항 또는 제9항에 있어서, 상기 잔류 경화제가 상기 미소입자의 약 1중량% 이하로 구성된 치료제-함유 미소입자.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890019157A 1988-12-22 1989-12-21 치아질환을 경감시키는데 유용한 개선된 상분리-미소봉입된 제약학적 조성물 KR0138651B1 (ko)

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US28907688A 1988-12-22 1988-12-22
US7/289,076 1988-12-22

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KR0138651B1 KR0138651B1 (ko) 1998-05-15

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KR1019890019474A KR0143912B1 (ko) 1988-12-22 1989-12-21 치아질환 치료용 조성물 및 그 조성물의 투여장치
KR1019890019157A KR0138651B1 (ko) 1988-12-22 1989-12-21 치아질환을 경감시키는데 유용한 개선된 상분리-미소봉입된 제약학적 조성물

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US (1) US5366733A (ko)
EP (1) EP0374531B1 (ko)
JP (1) JP2901674B2 (ko)
KR (2) KR0143912B1 (ko)
AT (1) ATE105177T1 (ko)
AU (1) AU635912B2 (ko)
CA (1) CA2006105C (ko)
DE (1) DE68915132T2 (ko)
DK (1) DK174915B1 (ko)
ES (1) ES2051968T3 (ko)
IE (1) IE63952B1 (ko)
IL (1) IL92700A (ko)
NO (1) NO178605C (ko)
NZ (1) NZ231791A (ko)
PT (1) PT92614B (ko)
ZA (1) ZA899857B (ko)

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IL92700A0 (en) 1990-09-17
IE63952B1 (en) 1995-06-28
EP0374531B1 (en) 1994-05-04
NO895167L (no) 1990-06-25
CA2006105C (en) 2000-03-14
DE68915132D1 (de) 1994-06-09
CA2006105A1 (en) 1990-06-22
DK655889A (da) 1990-06-23
ATE105177T1 (de) 1994-05-15
IL92700A (en) 1994-05-30
PT92614A (pt) 1990-06-29
NO178605C (no) 1996-05-02
KR0143912B1 (ko) 1998-07-15
DK174915B1 (da) 2004-02-23
ZA899857B (en) 1990-10-31
JP2901674B2 (ja) 1999-06-07
AU4707789A (en) 1990-06-28
KR900009045A (ko) 1990-07-02
AU635912B2 (en) 1993-04-08
NO178605B (no) 1996-01-22
KR0138651B1 (ko) 1998-05-15
DE68915132T2 (de) 1994-12-08
JPH02184620A (ja) 1990-07-19
EP0374531A3 (en) 1991-07-31
ES2051968T3 (es) 1994-07-01
DK655889D0 (da) 1989-12-21
NO895167D0 (no) 1989-12-21
NZ231791A (en) 1992-05-26
IE894145L (en) 1990-06-22
PT92614B (pt) 1995-09-12
EP0374531A2 (en) 1990-06-27

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