KR900008137B1 - 스페르구알린-관련 화합물의 제조방법 - Google Patents

스페르구알린-관련 화합물의 제조방법 Download PDF

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Publication number
KR900008137B1
KR900008137B1 KR1019830004071A KR830004071A KR900008137B1 KR 900008137 B1 KR900008137 B1 KR 900008137B1 KR 1019830004071 A KR1019830004071 A KR 1019830004071A KR 830004071 A KR830004071 A KR 830004071A KR 900008137 B1 KR900008137 B1 KR 900008137B1
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KR
South Korea
Prior art keywords
group
triazadecan
compound
guanidino
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019830004071A
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English (en)
Korean (ko)
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KR840006332A (ko
Inventor
하마오 우머쟈와
도미오 다께우찌
린죠오 니시쟈와
가쓰도시 다까하시
데루야 나까무라
요시히사 우메다
Original Assignee
자이단호오진 비세이부쓰 가가꾸 겡뀨우가이
이찌가와 도꾸지
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Filing date
Publication date
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Publication of KR840006332A publication Critical patent/KR840006332A/ko
Application granted granted Critical
Publication of KR900008137B1 publication Critical patent/KR900008137B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019830004071A 1982-09-02 1983-08-30 스페르구알린-관련 화합물의 제조방법 Expired KR900008137B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP57151698A JPS5942356A (ja) 1982-09-02 1982-09-02 スパガリン関連化合物およびその製造法
JP151698 1982-09-02

Publications (2)

Publication Number Publication Date
KR840006332A KR840006332A (ko) 1984-11-29
KR900008137B1 true KR900008137B1 (ko) 1990-10-31

Family

ID=15524303

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830004071A Expired KR900008137B1 (ko) 1982-09-02 1983-08-30 스페르구알린-관련 화합물의 제조방법

Country Status (14)

Country Link
US (1) US4529549A (enExample)
EP (1) EP0105193B1 (enExample)
JP (1) JPS5942356A (enExample)
KR (1) KR900008137B1 (enExample)
AR (1) AR241650A1 (enExample)
AT (1) ATE36701T1 (enExample)
AU (1) AU560073B2 (enExample)
CA (1) CA1199641A (enExample)
CS (1) CS235341B2 (enExample)
DE (1) DE3377795D1 (enExample)
DK (1) DK160089C (enExample)
ES (1) ES8506267A1 (enExample)
HU (1) HU190730B (enExample)
MX (1) MX8257A (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
JPH075538B2 (ja) * 1985-08-27 1995-01-25 財団法人微生物化学研究会 フエニレン基を有するスパガリン関連ニトリル化合物及びその製造法
ES2039213T3 (es) * 1986-04-04 1993-09-16 Microbial Chemistry Research Foundation Procedimiento para producir nuevos compuestos relacionados con espergualina.
US4873253A (en) * 1987-03-30 1989-10-10 Shosuke Okamoto Phenylalanine derivative and proteinase inhibitor
JPH0794424B2 (ja) * 1987-09-30 1995-10-11 財団法人微生物化学研究会 新スパガリン関連化合物およびその製造法
US5061787A (en) * 1988-06-24 1991-10-29 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compounds and compositions
JPH0776204B2 (ja) * 1988-07-01 1995-08-16 寳酒造株式会社 スパガリン類の精製法
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
DE69104291T2 (de) * 1990-07-20 1995-05-18 Nippon Kayaku Kk Spergulinähnliche Verbindungen und ihre Verwendung.
WO1994004140A1 (fr) * 1992-08-19 1994-03-03 Nippon Kayaku Kabushiki Kaisha Medicament anti-protozoose
FR2698628B1 (fr) * 1992-12-02 1995-02-17 Fournier Ind & Sante Analogues de 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR2716452B1 (fr) * 1994-02-24 1996-05-10 Fournier Ind & Sante Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR2716451B1 (fr) * 1994-02-24 1996-04-26 Fournier Ind & Sante Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR2730488B1 (fr) * 1995-02-10 1997-04-30 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur utilisation en therapeutique et leur procede de preparation
WO1996024579A1 (fr) * 1995-02-10 1996-08-15 Fournier Industrie Et Sante Analogues de la 15-deoxyspergualine, leur utilisation en therapeutique et leur procede de preparation
FR2737891B1 (fr) * 1995-08-17 1997-10-24 Fournier Ind & Sante Analogues chiraux de la 15-deoxyspergualine, procede de preparation et utilisation en therapeutique
FR2734263B1 (fr) * 1995-05-17 1997-06-20 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2015650A1 (de) * 1969-04-02 1970-10-15 Taiho Pharmaceutical Company Ltd., Tokio omega-Guanidinosäureamid-Derivate und deren Oniumsalze
JPS507057B1 (enExample) * 1970-10-28 1975-03-20
US3937805A (en) * 1971-11-10 1976-02-10 Colgate-Palmolive Company Method of making dentifrice compositions containing insolubilized salts of 1,6-di-(p-chlorophenyl biguanido) hexane
JPS5748957A (en) * 1980-09-08 1982-03-20 Microbial Chem Res Found Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient
IT8248390A0 (it) * 1981-05-11 1982-05-11 Zaidan Hojin Biseidutsu Kagaku N-[4-(3-amminopropil)amminobutil]2,2-diidrossiotanammide come immuno -stimolante ed intermedio per laproduzione di sostanze carcinostati che, e procedimento per la sua preparazione

Also Published As

Publication number Publication date
AU560073B2 (en) 1987-03-26
EP0105193B1 (en) 1988-08-24
EP0105193A2 (en) 1984-04-11
KR840006332A (ko) 1984-11-29
ES525278A0 (es) 1985-07-01
US4529549A (en) 1985-07-16
MX8257A (es) 1994-01-31
CA1199641A (en) 1986-01-21
JPS5942356A (ja) 1984-03-08
DK398583A (da) 1984-03-03
DK398583D0 (da) 1983-09-01
ATE36701T1 (de) 1988-09-15
EP0105193A3 (en) 1985-04-03
DE3377795D1 (en) 1988-09-29
AU1807483A (en) 1984-03-08
AR241650A1 (es) 1992-10-30
JPH0149256B2 (enExample) 1989-10-24
ES8506267A1 (es) 1985-07-01
CS235341B2 (en) 1985-05-15
DK160089C (da) 1991-06-24
HU190730B (en) 1986-10-28
DK160089B (da) 1991-01-28

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