KR900004325A - 유핵 과립 및 그의 제조방법 - Google Patents

유핵 과립 및 그의 제조방법 Download PDF

Info

Publication number
KR900004325A
KR900004325A KR1019890013906A KR890013906A KR900004325A KR 900004325 A KR900004325 A KR 900004325A KR 1019890013906 A KR1019890013906 A KR 1019890013906A KR 890013906 A KR890013906 A KR 890013906A KR 900004325 A KR900004325 A KR 900004325A
Authority
KR
South Korea
Prior art keywords
granules
dispersion
core
active ingredient
spraying
Prior art date
Application number
KR1019890013906A
Other languages
English (en)
Other versions
KR0143424B1 (ko
Inventor
히로요시 고야마
순이찌 이또오
신이찌로 히라이
Original Assignee
우메모또 요시마사
다께다야꾸힝고오교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우메모또 요시마사, 다께다야꾸힝고오교 가부시끼가이샤 filed Critical 우메모또 요시마사
Publication of KR900004325A publication Critical patent/KR900004325A/ko
Application granted granted Critical
Publication of KR0143424B1 publication Critical patent/KR0143424B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

유핵 과립 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 중심과립들에 저치환 히드록시프로필셀룰로오스의 분산액을 분무하는 것을 포함함을 특징으로 하는 유핵 과립의 제조방법.
  2. 제1항에 있어서, 저치완 히드록시프로필셀룰로오스가 약 4∼20%, 바람직하게는, 5∼16%, 보다 바람직하게는 10∼13%의 비율로 히드록시프로폭실기를 함유함을 특징으로 하는 방법.
  3. 제1항에 있어서, 과립에 분산액을 분무하는 동안 분말형태의 살포제를 살포함을 특징으로 하는 방법.
  4. 제1항에 있어서, 분산액에 활성 성분을 첨가 배합함을 특징으로 하는 방법.
  5. 제3항에 있어서, 분말형태의 살포제에 활성 성분을 첨가 배합함을 특징으로 하는 방법.
  6. 제4항 또는 제5항에 있어서, 활성 성분이 약물임을 특징으로 하는 방법.
  7. 제1항 내지 제6항중 어느 한항에서 청구한 방법에 의해 수득되는 유핵 과립.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890013906A 1988-09-27 1989-09-27 유핵 과립 및 그의 제조방법 KR0143424B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP24354388 1988-09-27
JP63-243543 1988-09-27
JP243543/1988 1988-09-27

Publications (2)

Publication Number Publication Date
KR900004325A true KR900004325A (ko) 1990-04-12
KR0143424B1 KR0143424B1 (ko) 1998-07-15

Family

ID=17105442

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890013906A KR0143424B1 (ko) 1988-09-27 1989-09-27 유핵 과립 및 그의 제조방법

Country Status (11)

Country Link
US (1) US5855914A (ko)
EP (1) EP0361874B1 (ko)
KR (1) KR0143424B1 (ko)
AT (1) ATE97317T1 (ko)
AU (1) AU626584B2 (ko)
CA (1) CA1338596C (ko)
DE (1) DE68910773T2 (ko)
DK (1) DK473889A (ko)
ES (1) ES2060784T3 (ko)
IE (1) IE63039B1 (ko)
NZ (1) NZ230763A (ko)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9114374D0 (en) * 1991-07-03 1991-08-21 Smithkline Beecham Plc Novel process
SE9402422D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New beads for controlled release and a pharmaceutical preparation containing the same
SE9600046D0 (sv) * 1996-01-05 1996-01-05 Astra Ab New pharmaceutical formulation
DE59710349D1 (de) * 1996-04-04 2003-07-31 Felix Specht Verfahren zur herstellung von gering dosierten freifliessenden und/oder direktkomprimierbaren pulversystemen
TW580397B (en) * 1997-05-27 2004-03-21 Takeda Chemical Industries Ltd Solid preparation
FR2771291B1 (fr) * 1997-11-21 2000-02-25 Ethypharm Lab Prod Ethiques Spheroides, procede de preparation et compositions pharmaceutiques
FR2771292B1 (fr) * 1997-11-21 2000-02-18 Ethypharm Lab Prod Ethiques Spheroides contenant de la tiagabine, procede de preparation et compositions pharmaceutiques
US6328994B1 (en) 1998-05-18 2001-12-11 Takeda Chemical Industries, Ltd. Orally disintegrable tablets
EP1561458B1 (en) * 1998-07-28 2010-09-15 Takeda Pharmaceutical Company Limited Rapidly disintegrable solid preparation
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
CA2313504C (en) 1999-07-12 2007-05-29 Douglas P. Debernardi Folic acid in solid dosage forms
FR2796840B1 (fr) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques Comprimes faiblement doses et procede de preparation
EP1238662B1 (en) * 2001-03-07 2006-05-31 Dainippon Sumitomo Pharma Co., Ltd. Method for manufacturing drug granules, the drug granules and pharmaceutical preparation containing the drug granules
US20070059368A1 (en) * 2005-05-31 2007-03-15 Cherukuri S R Modified release formulations of anti-irritability drugs
MY148466A (en) * 2001-10-26 2013-04-30 Merck Frosst Canada Ltd Granule formulation
US20030220351A1 (en) * 2002-05-24 2003-11-27 Gilbert Gonzales Enteric coated caffeine tablet
US20050054611A1 (en) * 2002-09-13 2005-03-10 Mats Lake Composition and method for use in intestinal cleansing procedures
WO2004064810A1 (ja) * 2003-01-21 2004-08-05 Nippon Shinyaku Co., Ltd. 口腔内速崩性錠剤
FR2861990B1 (fr) 2003-11-10 2006-02-10 Nouveaux Produits Pharma Comprimes faiblement doses a reseau de polymeres
US7670624B2 (en) * 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
CA2561700A1 (en) * 2004-04-16 2005-12-15 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and prokinetic agent
WO2006045152A1 (en) * 2004-10-29 2006-05-04 Mayne Pharma International Pty Ltd Improved tabletting process
EP2275088B2 (en) * 2005-02-25 2018-09-26 Takeda Pharmaceutical Company Limited Method for producing granules
US20090017110A1 (en) * 2005-05-31 2009-01-15 Capricorn Pharma Inc. Modified release formulations of anti-irritability drugs
US11266607B2 (en) * 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9095512B2 (en) * 2006-08-11 2015-08-04 Asahi Kasei Chemicals Corporation Method for producing spherical base granules comprising hardly water-soluble drug
WO2008057802A2 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
US20080194307A1 (en) * 2007-02-13 2008-08-14 Jeff Sanger Sports-based game of chance
US7994183B2 (en) * 2007-03-13 2011-08-09 Takeda Pharmaceutical Company Limited Solid preparation comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile
CA2615137A1 (en) * 2007-12-17 2009-06-17 Pharmascience Inc. Single layered controlled release therapeutic system
CN101980700A (zh) 2008-02-20 2011-02-23 密苏里大学董事会 包含奥美拉唑和兰索拉唑以及缓冲剂的组合的组合物及其使用方法
US8303868B2 (en) * 2009-01-26 2012-11-06 Shin-Etsu Chemical Co., Ltd. Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose
CN103096880B (zh) * 2010-09-13 2016-08-24 大鹏药品工业株式会社 不愉快味道被掩蔽的含药膜包覆的颗粒
EP2674149B1 (en) * 2012-06-15 2017-10-04 Shin-Etsu Chemical Co., Ltd. Method of preparing composite granule comprising low-substituted hydroxypropyl cellulose and rapid release preparation
US20170182070A1 (en) 2014-10-08 2017-06-29 Mayne Pharma International Pty Ltd. Controlled Release Doxycycline
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
CN110200935B (zh) * 2019-06-03 2021-03-02 浙江得恩德制药股份有限公司 一种胶体果胶铋胶囊及其制备工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3664963A (en) * 1969-10-22 1972-05-23 Balchem Corp Encapsulation process
SE426548B (sv) * 1978-12-05 1983-01-31 Haessle Ab Fast farmaceutisk beredning innehallande en terapeutiskt effektiv hjertglykosid och en polymer
JPS5826816A (ja) * 1981-08-11 1983-02-17 Teisan Seiyaku Kk 球形顆粒からなる持続性複合顆粒剤
DK150008C (da) * 1981-11-20 1987-05-25 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
GB8507779D0 (en) * 1985-03-26 1985-05-01 Fujisawa Pharmaceutical Co Drug carrier
GB8518301D0 (en) * 1985-07-19 1985-08-29 Fujisawa Pharmaceutical Co Hydrodynamically explosive systems
US4704285A (en) * 1985-11-18 1987-11-03 The Dow Chemical Company Sustained release compositions comprising hydroxypropyl cellulose ethers
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
JP2536109B2 (ja) * 1988-12-19 1996-09-18 ライオン株式会社 毛髪化粧料

Also Published As

Publication number Publication date
DE68910773T2 (de) 1994-05-11
EP0361874A3 (en) 1991-01-30
IE63039B1 (en) 1995-03-22
US5855914A (en) 1999-01-05
DE68910773D1 (de) 1993-12-23
AU626584B2 (en) 1992-08-06
AU4233289A (en) 1990-04-05
KR0143424B1 (ko) 1998-07-15
EP0361874A2 (en) 1990-04-04
ATE97317T1 (de) 1993-12-15
IE893075L (en) 1990-03-27
ES2060784T3 (es) 1994-12-01
EP0361874B1 (en) 1993-11-18
CA1338596C (en) 1996-09-17
DK473889D0 (da) 1989-09-26
NZ230763A (en) 1991-10-25
DK473889A (da) 1990-03-28

Similar Documents

Publication Publication Date Title
KR900004325A (ko) 유핵 과립 및 그의 제조방법
AU690588B2 (en) Novel pyrazine carboxamide derivatives, their production and their use in medicaments
ATE421318T1 (de) Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben
ATE143830T1 (de) Mikrokapseln mit wänden aus primären alkoholfunktionen enthaltenden polysacchariden, und zusammensetzungen daraus
MX169329B (es) Composicion con bajo contenido de sal de sodio y metodo para su preparacion
ATE102044T1 (de) Stabilisiertes fgf-mittel und dessen herstellung.
EP0214647A3 (en) Inclusion complexes of 7-isopropoxy-isoflavone and cyclodextrins, process for their preparation and pharmaceutical preparations containing these complexes
KR880010757A (ko) 제약정제, 제약과립 및 그의 제조방법
ATE200024T1 (de) Verfahren zur herstellung von medizinischem kaugummi mit einem guten geschmack, enthaltend eine einschlussverbindung
HUT51269A (en) Process for producing benzimidazole derivatives and pharmaceutical compositions comprising same
EP0141300A3 (en) An occulusion compound of 2-nitroxymethyl-6-chloropyridine with beta-cyclodextrin and process for preparation thereof
FI940696A (fi) Uudet pyratsiinijohdannaiset, niiden valmistus ja käyttö
ATE100095T1 (de) 2,2-dimethylchromenderivate, verfahren zur herstellung und diese enthaltende pharmazeutische zusammenstellungen.
ES2062145T3 (es) 1,8-naftiridinas substituidas.
DK0436252T3 (da) Farmaceutisk præparat til oral administration i flydende form
KR890007745A (ko) 약학조성물 및 그의 제조방법
KR930021206A (ko) 시타라빈 옥포스페이트 경질 캡슐제
EP0362731A3 (de) Verfahren zur Herstellung von Arzneimittelwirkstoff-Partikeln mit verbesserten Fliess-, Lager- und Formulierungseigenschaften sowie Arzneimittel, die diese Arzneimittelwirkstoff-Partikeln enthalten
ATE132877T1 (de) Emulgatorfreie emulsionspolymere in pharmazeutischen zubereitungen mit verzögerter wirkstofffreigabe und ihre herstellung
KR890003380A (ko) 피부에 축적하는 외용의 항 바이러스성 약학적 조성물 및 그 제조방법
SU1517173A1 (ru) Антисептическое средство
KR880008809A (ko) 안정화된 중아황산염 메나디온 제제 및 이들의 제조
JPS565412A (en) Pharmaceutical composition
KR910004092A (ko) 달팽이 구제제용 입상제형
KR940021082A (ko) 생체조직보전형성조성물

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20120322

Year of fee payment: 15

EXPY Expiration of term