KR880008809A - 안정화된 중아황산염 메나디온 제제 및 이들의 제조 - Google Patents

안정화된 중아황산염 메나디온 제제 및 이들의 제조 Download PDF

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Publication number
KR880008809A
KR880008809A KR1019880000214A KR880000214A KR880008809A KR 880008809 A KR880008809 A KR 880008809A KR 1019880000214 A KR1019880000214 A KR 1019880000214A KR 880000214 A KR880000214 A KR 880000214A KR 880008809 A KR880008809 A KR 880008809A
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South Korea
Prior art keywords
acid
formulation
sodium bisulfite
menadione
physiologically acceptable
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KR1019880000214A
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English (en)
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KR950013449B1 (ko
Inventor
키퍼 한스
뷜러 볼프강
우. 쉬나이더 요아힘
예디케 하겐
Original Assignee
원본미기재
바스프 악티엔게젤샤프트
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Publication of KR880008809A publication Critical patent/KR880008809A/ko
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Publication of KR950013449B1 publication Critical patent/KR950013449B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

안정화된 중아황산염 메나디온 제제 및 이들의 제조
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 생리학적으로 수용가능한 유기 또는 무기산을 부가적으로 함유하는 분제화된 및/또는 입제화된 중아황산나트륨 메나디온 제제.
  2. 제1항에 있어서, 제제에 대한 퍼센티지로서 90 내지 99중량％의 중아황산나트륨 메나디온 및 1내지 10중량％의 생리학적으로 수용가능한 유기 또는 무기산을 함유함을 특징으로 하는 분제화된 및/또는 입제화된 중아황산나트륨 메나디온 제제.
  3. 제2항에 있어서, 생리적으로 수용 가능한 유기 또는 무기산을 소량 함유하는 중아황산나트륨 메나디온 수용액을 분무 조립함으로써 제조됨을 특징으로 하는 분제화된 및/또는 입제화된 제제.
  4. 제1항에 있어서, 제제에 대한 퍼센티지로서 50 내지 80중량％의 중아황산나트륨 메나디온, 1 내지 20중량％의 부가적인 생리적으로 수용가능한 유기 또는 무기산 및 1 내지 50중량％의 점도부여제를 함유함을특징으로 하는 분제화된 및/또는 입제화된 중아황산나트륨 메나디온 제제.
  5. 제4항에 있어서, 생리학적으로 수용가능한 유기 또는 무기산과 점도 부여제를 함유하는 중아황산나트륨 메나디온의 농축된 수용액 또는 현탁액을 유동층에서 건조시키거나 또는 분무 및 건조시켜 제조됨을 특징으로 하는 제제.
  6. 제1항에 있어서, 푸말산, 소르브산, 시트르산, 락트산, 인산, 타르타르산 및 제일인산칼슘으로 이루어지는 그룹으로부터 산이 선택됨을 특징으로 하는 제제.
  7. 제4항에 있어서, 점도부여제 또는 결합제가 탄수화물 및/또는 단백질임을 특징으로 하는 제제.
  8. 제7항에 있어서, 점도부여제가 전분 또는 젤라틴임을 특징으로 하는 제제.
  9. 제1항에 있어서, 산이 타르타르산임을 특징으로 하는 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880000214A 1987-01-14 1988-01-14 안정학된 중아황산염 메나디온제제 및 이들의 제조 KR950013449B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873700812 DE3700812A1 (de) 1987-01-14 1987-01-14 Stabilisierte menadionbisulfit-formulierungen und verfahren zu deren herstellung
DEP3700812.9 1987-01-14

Publications (2)

Publication Number Publication Date
KR880008809A true KR880008809A (ko) 1988-09-13
KR950013449B1 KR950013449B1 (ko) 1995-11-08

Family

ID=6318774

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880000214A KR950013449B1 (ko) 1987-01-14 1988-01-14 안정학된 중아황산염 메나디온제제 및 이들의 제조

Country Status (8)

Country Link
US (1) US5128151A (ko)
EP (1) EP0275880B1 (ko)
JP (1) JPH0774191B2 (ko)
KR (1) KR950013449B1 (ko)
CA (1) CA1305059C (ko)
DE (2) DE3700812A1 (ko)
ES (1) ES2038698T3 (ko)
IL (1) IL85052A (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2281465A1 (en) * 2009-08-05 2011-02-09 Lonza Ltd. Vitamin K3 derivative / NSA formulation
US20140370151A1 (en) * 2013-06-12 2014-12-18 Bob J. Dull Method for Producing Sweet Bran and the Resultant Product

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2808361A (en) * 1955-03-09 1957-10-01 Russell R Bavouset Solubilizer for preparing an aqueous soluble menadione
US3079261A (en) * 1960-04-11 1963-02-26 Heterochemical Corp Vitamin k premix
DE1202624B (de) * 1961-10-19 1965-10-07 Heterochemical Corp Stabilisierte Vitamin-K-Vormischung fuer die Bereitung von Tierfutterfertiggemischen
IT1097391B (it) * 1978-07-21 1985-08-31 Stoppani Luigi Spa Addotti di composti vitaminici del tipo k e vitamine stabilizzanti,loro preparazione e addotti stabilizzati cosi' ottenuti
US4533674A (en) * 1983-10-24 1985-08-06 Basf Wyandotte Corporation Process for preparing a sugar and starch free spray-dried vitamin C powder containing 90 percent ascorbic acid
DE3443270A1 (de) * 1984-11-28 1986-05-28 Basf Ag, 6700 Ludwigshafen Menadioncholinbisulfit-addukt und verfahren zu dessen herstellung
US4740373A (en) * 1986-05-27 1988-04-26 Usv Pharmaceutical Corporation Stabilization of multivitamin/trace elements formulations

Also Published As

Publication number Publication date
US5128151A (en) 1992-07-07
KR950013449B1 (ko) 1995-11-08
JPS63198656A (ja) 1988-08-17
CA1305059C (en) 1992-07-14
DE3700812A1 (de) 1988-07-28
EP0275880A1 (de) 1988-07-27
EP0275880B1 (de) 1991-07-24
DE3863779D1 (de) 1991-08-29
IL85052A0 (en) 1988-06-30
JPH0774191B2 (ja) 1995-08-09
IL85052A (en) 1993-01-31
ES2038698T3 (es) 1995-04-01

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