KR900001375A - 개선된 재흡수 가능한 뼈 왁스(ⅲ) - Google Patents

개선된 재흡수 가능한 뼈 왁스(ⅲ) Download PDF

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KR900001375A
KR900001375A KR1019890010521A KR890010521A KR900001375A KR 900001375 A KR900001375 A KR 900001375A KR 1019890010521 A KR1019890010521 A KR 1019890010521A KR 890010521 A KR890010521 A KR 890010521A KR 900001375 A KR900001375 A KR 900001375A
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wax
resorbable
weight
salt
salts
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KR1019890010521A
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KR970002612B1 (ko
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퓨즈 요한-프리드리히
리터 볼프강
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크리스토프 빌크, 요한 글라슬
헨켈 코만디트 게젤샤프트 아우프 아크티엔
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Lubricants (AREA)
  • Fats And Perfumes (AREA)
  • Developing Agents For Electrophotography (AREA)

Abstract

내용 없음

Description

개선된 재흡수 가능한 뼈 왁스(Ⅲ)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 올리고머 왁스중에 내재하는 유리 카르복실기의 상응하는 반응에 의해 형성되고 및/ 또는 첨가된 염으로서 왁스중에 균질 분포로 함입된 유기 및/ 또는 무기산의 생체 혼화성 염을 함유하는, 1가 및/ 또는 다가의 알코올 및/ 또는 상응하는 카르복실산과 글리콜산 및/ 또는 락트산의 올리고머 및 그 유도체 기재의, 경질생체조직, 더욱 특히 뼈상에서 혈액을 기계적으로 지혈하기에 적합한 재흡수 가능한, 점성 내지 고체 왁스.
  2. 제1항에 있어서, 알칼리, 알칼리 토금속 및/ 또는 알루미늄의 카르복실산 염의 기 및 특히 나트륨, 칼슘 및/ 또는 마그네슘의 카르복실산 염의 기를 함유하는 재흡수 가능한 왁스.
  3. 제1 또는 2항에 있어서, 가공성을 향상시키기 위해, 유기산의 염으로서 글리콜산 및/ 또는 락트산의 염 및/ 또는 무기산의 염으로서 특히 인산칼슘 기재의 생체-혼화성 세라믹 물질을 함유하고, 이 첨가된 염의 함량은 올리고머 왁스에 대해 약 30중량% 이하, 바람직하게는 약 20중량% 이하, 더욱 바람직하게는 약 10중량% 이하인 재흡수 가능한 왁스.
  4. 제1 내지 3항중 어느 한항에 있어서, 무기염으로서 재흡수 가능한 및/ 또는 재흡수 불가능한 칼슘 포스페이트, 특히 히드록실 아프티트 및/ 또는 트리칼슘 포스페이트를 함유하는 재흡수 가능한 왁스.
  5. 제1 내지 4항중 어느 한항에 있어서, 왁스중에 적어도 실질적으로 불용인 염의 입자 크기 약 250μm 이하, 바람직하게는 약 100μm 이하, 특히 염의 평균 입자크기 약 1 내지 50μm인 재흡수 가능한 왁스.
  6. 제1 내지 5항중 어느 한항에 있어서, 분자량을 조절하기 위해, 올리고머 성분이 특히 상대적으로 긴 사슬의 지방산과 그리세롤 및/또는 글리세롤 부분 에스테르를 사용하고, 필요하다면 반응 생성물중에 잔류하는 유리 카르복실 잔기에서 후속적으로 염을 형성하여 제조되는 재흡수 가능한 왁스.
  7. 제1 내지 6항중 어느 한항에 있어서, 락트산 및 글리콜산 잔류물의 합에 대해 적어도 35몰%, 바람직하게는 적어도 50몰% 락트산 잔류물을 하유하는 재흡수 가능한 왁스.
  8. 제1 내지 7항중 어느 한항에 있어서, 락트산의 혼합물 및 글리콜산의 혼합물의 올리고머를 함유하고, 락트산 올리고머의 함량이 올리고머 혼합물에 대해 적어도 35중량%, 바람직하게는 적어도 약 50중량%, 더욱 바람직하게는 약 75 내지 95중량%인 재흡수 가능한 왁스.
  9. 제1 내지 8항중 어느 한항에 있어서, 폴리에스테르의 평균 분자량이 약 200 내지 1,500, 바람직하게는 약 300 내지 1,000범위이내인 재흡수 가능한 왁스.
  10. 제1 내지 9항중 어느 한항에 있어서, 체온에서 풀-상 내지 연-분산성이거나 풀-상, 연-분산성 형태로 되고, 약 100℃ 이상의 온도로 잠시 가열하여도 거의 또는 전혀 가선을 나타내지 않는 재흡수 가능한 왁스.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890010521A 1988-07-25 1989-07-25 개선된 재흡수 가능한 뼈 왁스(ⅲ) KR970002612B1 (ko)

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Application Number Priority Date Filing Date Title
DEP3825211.2 1988-07-25
DE3825211A DE3825211A1 (de) 1988-07-25 1988-07-25 Verbesserte koerperresorbierbare knochenwachse (iii)

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KR970002612B1 KR970002612B1 (ko) 1997-03-06

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US (3) US5143730A (ko)
EP (1) EP0352588B1 (ko)
JP (1) JP2774824B2 (ko)
KR (1) KR970002612B1 (ko)
AT (1) ATE111748T1 (ko)
CA (1) CA1335109C (ko)
DE (2) DE3825211A1 (ko)
ES (1) ES2058409T3 (ko)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3825211A1 (de) * 1988-07-25 1990-02-01 Henkel Kgaa Verbesserte koerperresorbierbare knochenwachse (iii)
DE3826915A1 (de) * 1988-08-09 1990-02-15 Henkel Kgaa Neue werkstoffe fuer den knochenersatz und knochen- bzw. prothesenverbund
JP2833096B2 (ja) * 1990-01-31 1998-12-09 株式会社島津製作所 Ｌｃ／ｉｒ測定方法
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
DE4037516A1 (de) * 1990-11-26 1992-05-27 Henkel Kgaa Hochfeste und abbaubare werkstoffe und formkoerper fuer die implantation in den menschlichen und tierischen organismus
DE4112464A1 (de) * 1991-04-17 1992-10-22 Henkel Kgaa Verbesserte retard-systeme fuer die zeitverzoegerte freigabe medizinischer und/oder biologischer wertstoffe aus einem depot-traegermaterial
EP0544097A1 (de) * 1991-10-23 1993-06-02 Boehringer Ingelheim Kg Halbfeste Mischungen aus Oligomeren und/oder Polymeren auf der Basis von Milchsäure, Verfahren zur deren Herstellung und deren Verwendung als resorbierbare Implantate
US5489441A (en) * 1992-01-07 1996-02-06 Procept, Inc. Method for suppressing immune response associated with psoriasis, contact dermatitis and diabetes mellitus
US5522895A (en) * 1993-07-23 1996-06-04 Rice University Biodegradable bone templates
US5681873A (en) * 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US20020193338A1 (en) * 1994-02-18 2002-12-19 Goldstein Steven A. In vivo gene transfer methods for wound healing
US6074840A (en) * 1994-02-18 2000-06-13 The Regents Of The University Of Michigan Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
US5607686A (en) * 1994-11-22 1997-03-04 United States Surgical Corporation Polymeric composition
US5641502A (en) * 1995-06-07 1997-06-24 United States Surgical Corporation Biodegradable moldable surgical material
US6126919A (en) * 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
DE69840361D1 (de) 1997-07-30 2009-01-29 Univ Emory Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme
JP3483753B2 (ja) * 1997-12-29 2004-01-06 タキロン株式会社 生体内分解吸収性可塑性粘着物
ATE521277T1 (de) * 1998-06-03 2011-09-15 Masimo Corp Stereo puls oximeter
DE19841342A1 (de) * 1998-09-10 2000-04-20 Merck Patent Gmbh Neue Reaktivsysteme aus polymerisierbaren Monomeren , die Peroxide und stabilisierten Boralkylverbindungen enthalten
US20020160336A1 (en) * 1998-10-09 2002-10-31 Ernst Muhlbauer Kg Mixture for use as wound dressing
US7144414B2 (en) * 2000-06-27 2006-12-05 Smith & Nephew, Inc. Surgical procedures and instruments
US6620185B1 (en) * 2000-06-27 2003-09-16 Smith & Nephew, Inc. Surgical procedures and instruments
US7030127B2 (en) * 2001-06-29 2006-04-18 Ethicon, Inc. Composition and medical devices utilizing bioabsorbable polymeric waxes
US6967234B2 (en) * 2002-12-18 2005-11-22 Ethicon, Inc. Alkyd-lactone copolymers for medical applications
US7034037B2 (en) * 2001-06-29 2006-04-25 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
US6641394B2 (en) * 2001-08-13 2003-11-04 Ormco Corporation Fluid material delivery devices and methods
US7326426B2 (en) 2002-03-29 2008-02-05 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable liquid polymers
US7368125B2 (en) * 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
US7026374B2 (en) 2002-06-25 2006-04-11 Aruna Nathan Injectable microdispersions for medical applications
US7101566B2 (en) * 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
CZ294328B6 (cs) * 2002-08-22 2004-11-10 Pliva-Lachema A. S. Biodegradabilní kompozice s prolongovaným uvolňováním biologicky aktivní látky a způsob její výroby
US6872799B2 (en) * 2002-12-18 2005-03-29 Ethicon, Inc. Functionalized polymers for medical applications
US6866860B2 (en) 2002-12-19 2005-03-15 Ethicon, Inc. Cationic alkyd polyesters for medical applications
US20040120981A1 (en) * 2002-12-20 2004-06-24 Aruna Nathan Crosslinked alkyd polyesters for medical applications
US20060140904A1 (en) * 2003-02-12 2006-06-29 Tadeusz Wellisz Random alkylene oxide copolymers for medical and surgical utilities
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
EP1622691B1 (en) 2003-03-14 2011-05-25 The Trustees of Columbia University in the City of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US7572298B2 (en) * 2003-03-28 2009-08-11 Ethicon, Inc. Implantable medical devices and methods for making same
WO2005034726A2 (en) 2003-09-23 2005-04-21 Ortho Therapeutics, Llc Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
US7955616B2 (en) * 2003-09-23 2011-06-07 Orthocon, Inc. Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
JP2007506505A (ja) 2003-09-23 2007-03-22 オーソ・セラピューティクス・リミテッド・ライアビリティ・カンパニー 生体吸収性のパテ様止血性インプラント
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
US8603528B2 (en) * 2004-09-16 2013-12-10 Abyrx, Inc. Compositions and method for the reduction of post-operative pain
US8147246B2 (en) 2005-03-28 2012-04-03 Neubardt Seth L Surgical bone wax applicator
IL174531A0 (en) * 2005-04-06 2006-08-20 Given Imaging Ltd System and method for performing capsule endoscopy diagnosis in remote sites
US20060233849A1 (en) * 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material
US7621963B2 (en) * 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
WO2007137245A2 (en) 2006-05-22 2007-11-29 Columbia University Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
US7914819B1 (en) 2006-10-19 2011-03-29 Clemson University Research Foundation Polysaccharide-based biomaterials
US20090263346A1 (en) * 2006-12-05 2009-10-22 David Taft Systems and methods for delivery of drugs
US8956602B2 (en) * 2006-12-05 2015-02-17 Landec, Inc. Delivery of drugs
US20090246155A1 (en) * 2006-12-05 2009-10-01 Landec Corporation Compositions and methods for personal care
US8399007B2 (en) * 2006-12-05 2013-03-19 Landec Corporation Method for formulating a controlled-release pharmaceutical formulation
US8114883B2 (en) * 2007-12-04 2012-02-14 Landec Corporation Polymer formulations for delivery of bioactive materials
CA2714594A1 (en) 2008-02-04 2009-08-13 Edward F. Leonard Fluid separation devices, systems and methods
AU2009277252B2 (en) 2008-07-30 2014-01-16 Mesynthes Limited Tissue scaffolds derived from forestomach extracellular matrix
JP5835751B2 (ja) 2011-04-01 2015-12-24 珠海奥托沙医薬科技有限公司 医療用吸収性骨創傷止血材及びその調製方法
JP6901721B2 (ja) * 2017-03-30 2021-07-14 国立大学法人東海国立大学機構 骨髄止血剤
CN107519528B (zh) * 2017-08-30 2020-10-23 山东省立医院 一种生物可吸收的骨蜡及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2242867C3 (de) * 1972-08-31 1975-09-25 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur Herstellung implantierbarer, keramischer Knochenersatz-, Knochenverbund- oder Prothesenverankerung swerkstoffe
US3919773A (en) * 1973-12-20 1975-11-18 Sybron Corp Direct moldable implant material
US3918100A (en) * 1974-05-13 1975-11-11 Us Navy Sputtering of bone on prostheses
US4010196A (en) * 1975-06-25 1977-03-01 American Home Products Corporation Linear polyester salts
DE2620891A1 (de) * 1976-05-12 1977-11-17 Battelle Institut E V Resorbierbarer knochenersatz-, knochenverbund- oder prothesenverankerungswerkstoff
AT352867B (de) * 1976-05-12 1979-10-10 Battelle Institut E V Knochenersatz-knochenverbund-oder prothesen- verankerungswerkstoff und verfahren zu seiner herstellung
DE3229540A1 (de) * 1982-08-07 1984-02-09 Henkel KGaA, 4000 Düsseldorf Resorbierbare knochenwachse
US4443430A (en) * 1982-11-16 1984-04-17 Ethicon, Inc. Synthetic absorbable hemostatic agent
EP0115549B1 (de) * 1983-02-03 1987-11-25 Ethicon, Inc. Paste zur Blutstillung und temporären Defektüberbrückung bei Knochentrauma
DE3716302C2 (de) * 1987-05-15 1996-02-01 Henkel Kgaa Verbesserte resorbierbare Knochenwachse und ihre Verwendung
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4698375A (en) * 1985-02-19 1987-10-06 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US4645503A (en) * 1985-08-27 1987-02-24 Orthomatrix Inc. Moldable bone-implant material
DE3620685A1 (de) * 1986-06-20 1987-12-23 Henkel Kgaa Neue mittel zur abdeckung unverletzter und/oder verletzter bereiche menschlicher oder tierischer haut
JPH01163135A (ja) * 1987-12-18 1989-06-27 Taki Chem Co Ltd 徐放性基剤の製造方法
DE3825211A1 (de) * 1988-07-25 1990-02-01 Henkel Kgaa Verbesserte koerperresorbierbare knochenwachse (iii)

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EP0352588B1 (de) 1994-09-21
ES2058409T3 (es) 1994-11-01
US5308623A (en) 1994-05-03
KR970002612B1 (ko) 1997-03-06
DE3825211A1 (de) 1990-02-01
EP0352588A3 (en) 1990-06-20
EP0352588A2 (de) 1990-01-31
JP2774824B2 (ja) 1998-07-09
DE58908386D1 (de) 1994-10-27
CA1335109C (en) 1995-04-04
US5143730A (en) 1992-09-01
US5482717A (en) 1996-01-09
JPH0280054A (ja) 1990-03-20
ATE111748T1 (de) 1994-10-15

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