KR890701542A - 페닐카르복시산 유도체 및 그 염 - Google Patents

페닐카르복시산 유도체 및 그 염

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Publication number
KR890701542A
KR890701542A KR1019890701126A KR890701126A KR890701542A KR 890701542 A KR890701542 A KR 890701542A KR 1019890701126 A KR1019890701126 A KR 1019890701126A KR 890701126 A KR890701126 A KR 890701126A KR 890701542 A KR890701542 A KR 890701542A
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KR
South Korea
Prior art keywords
group
phenyl
halogen atom
salt
alkylene
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KR1019890701126A
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English (en)
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KR970006890B1 (ko
Inventor
세쓰로 후지
히로유끼 가와무라
신니찌 와다나베
Original Assignee
오스카 아끼히꼬
오스카 세이야꾸 가부시끼가이샤
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Publication of KR890701542A publication Critical patent/KR890701542A/ko
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Publication of KR970006890B1 publication Critical patent/KR970006890B1/ko

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/44—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/46—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C07C217/86—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
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    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/25—Aminoacetonitriles
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
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    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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Abstract

내용 없음

Description

페닐카르복시산 유도체 및 그 염
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (24)

  1. 일반식
    [상기식에서, R1및R2는 각각 수소원자, 할로겐원자, C1-C6알킬기, 할로겐원자를 갖는 C1-C6알킬기, C1-C6알카노일기, C3-C8의 시클로알킬기, 니트로기, 아미노기, -O-D-R5(여기서, D는 C1-C6알킬렌기, R5는 수소원자, 아미노기, 모르폴리노기, 카르복시기, 프탈이미도기, 페닐기 또는를 나타냄), 페닐고리상에 치환기로서 할로겐원자 또는 C1-C6알킬기를 선택적으로 갖　 페녹시기, 페닐고리상에 치환기로서 C1-C4알킬렌디옥시기를 선택적으로 갖는 페닐 C1-C6알킬아미노기, 또는 카르복시기를 갖는 C2-C6알케닐기를 나타내거나, 또는 양작용기기 인접 탄소원자에 결합한 C1-C4알킬렌 디옥시기를 나타낸다. R3은 수소원자, -E-R5(여기서, E는 C1-C6알킬렌기를, R6은 수소원자, 카르복시기, 시아노기, 수산기, 페닐 C1-C6알콕시기, 할로겐원자를 갖는 페닐기, 또는 할로겐원자를 갖는 페닐 카르바모일기를 나타냄), -CO-G-R7(여기서, G는 C1-C6알킬렌기를, R7은 수소원자, 카르복시기 또는 할로겐원자를 갖는 페닐카르바 모일기를 나타냄), 페닐고리상에 치환기로서 C1-C4-알킬렌디옥시기, 할로겐원자 또는 C1-C6알킬기를 선택적으로 갖는 벤조일기, C2-C6알케닐기, 카르바모일기, 페닐기, 또는 할로겐원자를 갖는 페닐기를 나타낸다. R4는 수소원자 또는 C1-C6알킬기를 나타낸다. A는 C1-C6알킬렌기, CC4-C8시클로 알킬기가 축합한 C2-C6알킬렌기, 또는 C2-C6알케닐렌기를 나타낸다. B는 C1-C6알킬렌기 또는C2-C6알케닐렌기를 나타낸다. 1은 0또는 1을 나타낸다]로 표시되는 페닐카르복시산 유도체 및 그 염.
  2. 제 1 항에 있어서, A가 C1-C6알킬렌기인 페닐카르복시산 유도체 및 그 염.
  3. 제 1 항에 있어서, A가 C3-C8시클로 알킬고리가 축합한 C2-C6알킬렌기 또는 C2-C6알케닐렌기인 페닐카르복시산 유도체 및 그 염.
  4. 제 2 항에 있어서, R3이 수소원자 또는 -E-R5(여기서 E는 C1-C6알킬렌기, R6은 수소원자임)인 페닐카르복시산 유도체 및 그 염.
  5. 제 2 항에 있어서, R3이 -E-R6(여기서, E는 C1-C6알킬렌기, R6은 카르복시기, 시아노기, 수산기, 페닐 C1-C6알콕시기, 할로겐원자를 갖는 페닐기, 또는 할로겐원자를 갖는 페닐카르바모일기를 나타냄), -CO-G-R7(여기서 G는 C1-C6알킬렌기를, R7은 수소원자, 카르복시기, 또는 할로겐원자를 갖는 페닐카르바 모일기를 나타냄), 페닐고리상에 치환기로써, C1-C4알킬렌디옥시기, 할로겐원자 또는 C1-C6알킬기를 선택적으로 갖는 벤조일기, 카르바모일기, 페닐기, 또는 할로겐원자를 갖는 페닐기인 페닐카르복시산 유도체 및 그 염.
  6. 제 4 항에 있어서, R1이 수소원자, R2가 수소원자, 할로겐원자, C1-C6알킬기, 할로겐원자를 갖는 C1-C6알킬기, C1-C6알카노일기, C3-C8시클로 알킬기, 니트로기, 아미노기, -C-D-R5(여기서, D는 C1-C6알킬렌기, R5는 수소원자, 아미노기, 모르폴리노기, 카르복시기, 프탈이미도기, 페닐기 또는를 나타냄), 페닐고리상에 치환기로서 할로겐원자 또는 C1-C6알킬기를 선택적으로 갖는페녹시기, 페닐고리상에 치환기로서 C1-C4알킬렌디옥시기를 선택적으로 갖는 페닐 C1-C6알킬아미노기, 또는 카르복시기를 갖는 C2-C6알케닐기를 나타내는 페닐 카르복시산 유도체 및 그 염.
  7. 제 4 항에 있어서, R1및 R2가 각각 할로겐원자, C1-C4알킬기, 할로겐원자를 갖는C1-C6알킬기, C1-C6알카노일기, C3-C8시클로알킬기, 니트로기, 아미노기, -O-D-R5(여기서, D는 C1-C6알킬렌기를, R5은 수소원자, 아미노기, 모르폴리노기, 카르복시기, 프탈이미도기, 페닐기, 또는기를 나타냄), 페닐고리상에 치환기로서 할로겐원자 또는 C1-C6알킬기를 선택적으로 갖는 페녹시기, 페닐고리상에 치환기로서 C1-C4알킬렌 디옥시기를 선택적으로 갖는 페닐 C1-C6알킬아미노기 또는 카르복시기를 갖는 C2-C6알케닐기를 나타내거나, 또는 양 작용기가 인접 탄소원자에 결합한 C1-C4알킬렌 디옥시기를 나타내는 페닐카르복시산 유도체 및 그 염.
  8. 제 6 항에 있어서, 1이 0인 페닐카르복시산 유도체 및 그 염.
  9. 제 8 항에 있어서, R2가 할로겐원자 또는 C1-C6알킬기인 페닐카르복시산 유도체 및 그 염.
  10. 제 8 항에 있어서, R2가 할로겐원자를 갖는 C1-C6알킬기, C1-C6알카노일기, C3-C6시클로알킬기,니트로기, 아미노기, -O-D- R5(여기서, D는 C1-C6알킬렌기를 R5는 수소원자, 아미노기, 모르폴리노기,카르복시기 프탈이미노기, 페닐기 또는기를 나타냄), 페닐고리상에 치환기로서 할로겐원자 또는 C1-C6알킬기를 선택적으로 갖는 페녹시기, 페놀고리상에 치환기로서 C1-C4알킬렌디옥시기를 선택적으로 갖는 페닐 C1-C6알킬아미노기, 떠는 카르복시기를 갖는 C2-C6알케닐기를 나타내는 페닐카르복시산 유도체 및 그 염.
  11. 제 9 항에 있어서, R4가 수소원자인 페닐카르복시산 유도체 및 그 염.
  12. 제 9 항에 있어서, R4가 C1-C6알킬기인 페닐카르복시산 유도체 및 그 염.
  13. 제 11 항에 있어서, R3이 수소원자인 페닐카르복시산 유도체 및 그 염.
  14. 제 11 항에 있어서, R3이 -E-R6(여기서, E는 C1-C6알킬렌기를, R6은 수소원자를 나타냄)인 페닐카르복시산 유도체 및 그 염.
  15. 제 13 항에 있어서, R2이 할로겐원자인 페닐카르복시산 및 그 염.
  16. 제 13 항에 있어서, R2이 C1-C6알킬기인 페닐카르복시산 및 그 염.
  17. 제 6 항에 있어서, I 이 1이고, B가 C1-C6알케닐렌기인 페닐카르복시산 및 그 염.
  18. 제 17 항에 있어서, R2가 할로겐원자 또는 C1-C6알킬기인 페닐카르복시산 및 그 염.
  19. 제 6 항에 있어서, 1이 1이고, B가 C1-C6알케닐렌기인 페닐카르복시산 및 그 염.
  20. 제 19항에 있어서, R2가 할로겐원자 또는 C1-C6알킬기인 페닐카르복시산 및 그 염.
  21. 제 1 항에 있어서, 다음 화합물.
    4-[3-[N-(4-클로로페닐)아미노]프로폭시]벤조산.
    4-[3-[N-(4-클로로페닐)아미노]부톡시]벤조산.
    4-[3-[N-(4-클로로페닐)아미노]프로폭시]벤조산 염산염.
    4-[3-[N-(4-클로로페닐)아미노]프로폭시]-α-메틸신남산.
    4-[3-[N-(4-클로로페닐)-N-메틸아미노]프로폭시]벤조산.
    4-[3-[N-(4-클로로페닐)-N-이소프로필아미노]프로폭시]벤조산 및 4-[3-[N-(4-클로로페닐)아미노]-2-메틸프로폭시]벤조산으로부터 선택된 페닐카르복시산 유도체 및 그 염.
  22. 제 1 항에 있어서, 다음 공정,
    a) 일반식
    (상기식에서, A, B, R4및 1은 특허청구의 범위 제 1 항에 기재한 바와 같으며, X는 할로겐원자, 치환기를 선택적으로 갖는 C1-C6알칸술포닐옥시기, 또는 치환기를 선택적으로 갖는 아릴술포닐 옥시기를 나타냄)로 표시되는 화합물을 염기성 화합물의 존재하에, 일반식
    (상기식에서, R1, R2및 R3은 특허청구의 범위 제 1 항에 기재한 바와 같음)로 표시되는 화합물과 반응시켜, b) 일반식
    (상기식에서, B, R4및 1 은 특허청구의 범위 제 1 항에 기재한 바와 같으며, A1은 주사슬의 탄소수가 1개 적은점을 제외하고는 특허청구의 범위 제 1항에 정의한 A와 같음)로 표시되는 화합물을, 일반식
    (상기식에서, R1및 R2는 특허청구의 범위 제 1 항에 기재한 바와 같음)로 표시되는 화합물과 반응시켜, 일반식,
    (상기식에서, R1, R2, B, R4및 I은 특허청구의 범위 제1항에 정의한 바와 같으며, A1는 앞서 기술한 바와 같음)로 표시되는 화합물 얻고,
    C) 일반식
    (상기식에서, R1, R2, A,B 및 1은 특허청구의 범위 제 1 항에 기재한 바와 같으며, R4a는 C1-C6알킬기를 나타냄)으로 표시되는 화합물을 얻고, 일반식 R3aOH
    [상기식에서, R3a는 -CO-G-R7기(여기서 G 및 R7은 특허청구의 범위 제 1 항에 정의한 바와 같음), 또는 페닐고리상에 치환기로서 C1-C4알킬렌디옥시기, 할로겐원자 또는 C1-C6알킬기를 갖는 벤조일기를 나타냄]로 표시되는 카르복시기가 활성화된 화합물 또는 그 카르복시기가 활성화된 화합물을 반응시켜,
    일반식
    (상기식에서, R1, R2, A, B 및 1은 특허청구의 범위 제 1 항에 정의한 바와 같으며, R3a및R4a는 앞서 기술한 바와 같음)로 표시되는 화합물을 얻고,
    d) 일반식(1b)의 화합물에, 일반식
    R3b-X
    [상기식에서, X는 앞서 기술한 바와 같으며, R3a-E-R6(여기서, E 및 R6은 특허청구의 범위 제 1 항에 기재한 바와 같음) C2-C6알케닐기 또는 할로겐원자를 갖는 페닐기를 나타냄]로 표시되는 화합물을 반응시켜,
    일반식
    (상기식에서, R1, R2, A, B 및 1은 특허청구의 범위 제 1 항에 정의한 바와 같으며, 및 R4a는 앞서 기술한 바와 같음)로 표시되는 화합물을 얻고,
    e) 일반식
    (상기식에서, R1, R2, R3및 A는 특허청구의 범위 제 1 항에 정의한 바와 같고, X는 앞서 기술한 바와 같음)로 표시되는 화합물을, 일반식
    (상기식에서, B,R4및 1은 특허청구의 범위 제 1 항에 정의한 바와 같음)으로 표시되는 화합물과 반응시키고, 또는
    f)일반식(1e)의 화합물을 탈 에스테르화 반응하여, 일반식
    (상기식에서, R1, R2, R3, A, B 및 1은 특허청구의 범위 제 1 항에 정의한 바와 같음)으로 표시되는 화합물로 유도하는, 것으로된 페닐카르복시산 유도체 및 그 염의 제조방법.
  23. 제 1 항에 기재한 화합물 또는 그 염을 유효성분으로 함유하는 혈증지질저하용 조성물.
  24. 제 1 항에 기재한 화합물 또는 그 염의 유효량을 환자에게 투여하는 고 지질혈증의 치료방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890701126A 1987-10-20 1988-10-20 페닐카르복시산 유도체 및 그 염 KR970006890B1 (ko)

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EP0394440A1 (en) 1990-10-31
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WO1989003819A1 (en) 1989-05-05
DE3889545D1 (en) 1994-06-16
KR970006890B1 (ko) 1997-04-30
DE3889545T2 (de) 1994-10-13

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