KR890010559A - 크로마토그래피 결합분석 장치 및 방법 - Google Patents

크로마토그래피 결합분석 장치 및 방법 Download PDF

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KR890010559A
KR890010559A KR1019880017084A KR880017084A KR890010559A KR 890010559 A KR890010559 A KR 890010559A KR 1019880017084 A KR1019880017084 A KR 1019880017084A KR 880017084 A KR880017084 A KR 880017084A KR 890010559 A KR890010559 A KR 890010559A
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chromatography material
immobilized
test sample
trapping agent
indicator
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KR1019880017084A
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머피 디버록스 샤론
엘.윌콕스 제임스
프레드릭 홀쯔만 토마스
고돈 줄리안
샨펀칭
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조셉엠.버닉
애보트 래보러토리스
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing

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Abstract

내용 없음

Description

크로마토그래피 결합분석 장치 및 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 선택적이며 바람직한 양태를 갖는 본 발명 장치의 확대 도면이다.

Claims (22)

  1. 시험샘플이 모세관 작용에 의해 근위 말단부로부터 원위 말단부까지 이동할 수 있는 근위 말단부 및 원위 말단부를 가지며, 포착 위치에 고정화되어 분석물, 보조적 특이 결합원 및 지시제로 이루어진 그룹중에서 선택되는 일웜(member)과 결합할 수 있는 포착제를 함유하는 크로마토그래피 물질 ; 및 크로마토그래피 물질의 근위 말단부에 유액 유동상으로 접해 있으며, 시험샘플을 수용하고, 적용패드로부터 크로마토그래피 물질까지 이동할 수 있으며, 분석물, 보조적 특이 결합원 및 포착제로 이루어진 그룹중에서 선택되는 일원과 결합할 수 있는 확산 지시제(여기에서, 지시제의 결합은 상기 포착 위치에서 검출가능한 신호를 발생시킴으로써 시험샘플중 분석물의 존재 또는 양을 나타낸다)를 함유하는, 적용 패드를 함유함을 특징으로 하는, 시험 샘플중의 분석물의 존재 또는 양을 측정하는 분석장치.
  2. 제1항에 있어서, 포착제가 크로마토그래피 물질내에 일정하게 고정화되어 포착위치를 형성하는 장치.
  3. 제1항에 있어서, 포착제가 크로마토그래피 물질내에 고정화되어, 크로마토그래피 물질보다 면적이 실질적으로 더 적은 적어도 하나의 분리된 포착위치를 형성하는 장치.
  4. 제1항에 있어서, 포착제가 크로마토그래피 물질내에 고정화되어 크로마토그래피 물질의 폭을 가로지르는 하나 이상의 분리된 평행 포착위치를 형성하는 장치.
  5. 제4항에 있어서, 지시제가 검출된 가장 낮은 분석물 농도보다 더 작은 해리상수를 갖는 콜로이드-표지된 항체인 장치.
  6. 제1항에 있어서, 포착제가 구배 양식으로 크로마토그래피 물질내에 고정화된 장치.
  7. 제1항에 있어서, 포착제가 크로마토그래피 물질내에 고정화되어 적어도 하나의 가느다란 스트라이프(stripe)를 형성하는 장치.
  8. 제1항에 있어서, 포착제가 미세입자에 결합되어 있고 이 미세입자가 크로마토그래피 물질에 고정화된 장치.
  9. 제1항에 있어서, 포착제가 바이오틴 및 아비딘, 탄수화물 및 렉틴, 상보적 뉴클레오타이드 서열, 상보적 펩타이드 서열, 효과인자 및 수용체 분자, 효소 보조인자 및 효소, 효소 억제제 및 효소, 서 및 면역반응물에 특이한 펩타이드 서열 및 항체로 이루어진 그룹중에서 선택되는 특이 결합쌍의 특이 결합원(specific binding member)인 장치.
  10. 제1항에 있어서, 지시제가 특이 결합원에 부착된 표지를 함유함을 특징으로 하는 장치.
  11. 제10항에 있어서, 표지가 크로마겐, 촉매, 형광 화합물, 화학발광 화합물, 방사성 동위원소, 콜로이드 금속성 입자, 셀레늄 입자, 염료 입자, 효소, 기질, 유기 중합체 라텍스 입자 및 리포좀 및 신호 발생 성분을 함유하는 다른 소낭으로 이루어진 그룹중에서 선택되는 일원을 함유함을 특징으로 하는 장치.
  12. 제1항에 있어서, 추가로 크로마토그래피 물질상에 포착제와 함께 고정화된 적어도 하나의 신호 발생성분을 함유함을 특징으로 하는 장치.
  13. 제1항에 있어서, 적용패드가 니트로셀룰로오즈, 폴리에틸렌 프릿 및 유리섬유 여과지로 이루어진 그룹중에서 선택되는 일원을 함유함을 특징으로 하는 장치.
  14. 제1항에 있어서, 크로마토그래피 물질이 셀룰로오즈, 셀룰로오즈 유도체, 니트로셀룰로오즈, 유리 섬유, 천, 다공성 겔, 다공 섬유성 매트릭스, 전분 기본의 물질, 세라믹 물질 및 필름으로 이루어진 그룹중에서 선택되는 일원을 함유함을 특징으로 하는 장치.
  15. 제1항에 있어서, 크로마토그래피 물질이 니트로 셀룰로오즈 막이고 적용패드가 유리섬유지인 장치.
  16. 제1항에 있어서, 추가로 시험샘플이 크로마토그래피 물질과 직접 접하지 못하도록 하고 시험샘플을 적용패드에 적용시키기 위한 수단을 갖는, 적용패드를 밀폐시키는 하우징(housing)을 함유함을 특징으로 하는 장치.
  17. 제1항에 있어서, 추가로 포착제 및 지시제중 적어도 하나가 보조적 특이 결합원에 대해 특이적인, 적어도 하나의 보조적 특이 결합원을 함유함을 특징으로 하는 장치.
  18. 제1항에 따른 크로마토그래피 장치를 사용하여 ; a. 분석물을 함유하는 것으로 생각되는 시험샘플을, 시험샘플을 지시제와 접하게 되며 시험샘플 및 지시제가 크로마토그래피 물질로 옮겨지도록 적용패드에 접촉시키고 ; b. 시험샘플 및 지시제를 크로마토그래피 물질을 통해 이동시키고 포착제와 접촉시킴으로써 포착 위치에서 검출가능한 신호를 발생시켜 ; c. 검출가능한 신호를 관찰하여 시험샘플중의 분석물의 존재 또는양을 측정하는 단계를 포함함을 특징으로 하여, 시험 샘플중의 분석물의 존재 또는 양을 측정하는 분석방법.
  19. 제18항에 있어서, 추가로 동시에 또는 연속적으로 적용패드에 시험샘플이 함유된 위킹(wicking)용액을 가함을 특징으로 하는 방법.
  20. 제18항에 있어서, 포착제가 크로마토그래피 물질내에 고정화되어 크로마토그래피 물질보다 면적이 실질적으로 더 적은 적어도 하나의 분리된 포착 위치를 형성하는 방법.
  21. 제18항에 있어서, 포착제가 크로마토그래피 물질내에 고정화되어 크로마토그래피 물질의 폭을 가로지르는 하나 이상의 분리된 평행 포착위치를 형성하는 방법.
  22. 제18항에 있어서, 포착제가 구배 양식으로 크로마토그래피 물질내에 고정화된 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880017084A 1987-12-21 1988-12-21 크로마토그래피 결합분석 장치 및 방법 KR890010559A (ko)

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Application Number Priority Date Filing Date Title
US13581087A 1987-12-21 1987-12-21
US135,810 1987-12-21
US28297888A 1988-12-14 1988-12-14
US282,978 1988-12-14

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KR890010559A true KR890010559A (ko) 1989-08-09

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EP (1) EP0323605B1 (ko)
JP (1) JPH01244370A (ko)
KR (1) KR890010559A (ko)
CN (1) CN1036078A (ko)
AU (1) AU619231B2 (ko)
CA (1) CA1312544C (ko)
DE (1) DE3887491T2 (ko)
ES (1) ES2050697T3 (ko)

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EP0323605A3 (en) 1989-08-09
DE3887491D1 (de) 1994-03-10
EP0323605A2 (en) 1989-07-12
AU619231B2 (en) 1992-01-23
ES2050697T3 (es) 1994-06-01
JPH01244370A (ja) 1989-09-28
DE3887491T2 (de) 1994-07-07
AU2709588A (en) 1989-06-29
CA1312544C (en) 1993-01-12
EP0323605B1 (en) 1994-01-26
CN1036078A (zh) 1989-10-04

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