KR890010211A - α-아미노아디피닐-모노아미노 화합물의 효소적 가수분해 방법 - Google Patents

α-아미노아디피닐-모노아미노 화합물의 효소적 가수분해 방법 Download PDF

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KR890010211A
KR890010211A KR1019880017019A KR880017019A KR890010211A KR 890010211 A KR890010211 A KR 890010211A KR 1019880017019 A KR1019880017019 A KR 1019880017019A KR 880017019 A KR880017019 A KR 880017019A KR 890010211 A KR890010211 A KR 890010211A
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South Korea
Prior art keywords
aminoadipinyl
cepam
formula
compound
monoamino
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KR1019880017019A
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KR0149656B1 (ko
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아레츠 베르네르
사우베르 클라우스
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베른하르트 벡크, 하인리히 벡커
훽스트 아크티엔게젤샤프트
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Publication of KR890010211A publication Critical patent/KR890010211A/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

내용 없음

Description

α-아미노아디피닐-모노아미노 화합물의 효소적 가수분해 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 분자량이 40,000 내지 80,000이고, pH 4.4 내지 5.9에서 등전점을 지니며, 기질이 L--글루타밀 파라니트로아닐리드일 경우, 최적 pH는 6.5 내지 10이고 pH 8에서 Km은 9 내지 36μM이며, 일반식(I)의 α-아미노아디피닐-모노아미노 화합물을 가수분해 시키는 특성을 지닌-글라타밀랜스펩티다제.
    상기식에서, R1은 아미노산, 디펩타이드, 세펨, 세팜 또는 이들의 유도체이다.
  2. 제1항에 있어서, 수도모나스(Pseudomonas), 프로테우스(Proteus), 아트로박터(Arthrobacter) 및 바실러스(Bacillus)속의 세균을 영양배지내에 상기의 N--GTP가 축적될때까지, 영양배지중에서 배양시킴을 특징으로 하여, 제1항 따른-글루타밀트렌스 펩티다제를 제2조하는 방법.
  3. 제2항에 있어서,-글루타밀트랜스펩티다제가 비.섭틸리스(B.subtilis) IFO 3025를 배양시킴으로써 수득되는 방법.
  4. 일반식(I)의 α-아미노아디피닐-모노아미노 화합물을 가수분해시키기 위한 제1항에 따른-글루타밀트랜스펩티아제의 용도.
    상기식에서, R1은 아미노산, 디펩타이드, 세팸, 세팜 또는 이들의 유도체를 나타낸다.
  5. 제4항에 있어서, R1이 라디칼(여기에서, R2는 수소, OH 또는이다)를 나타내는 일반식(I)의 화합물을 가수분해시키기 위한 용도.
  6. 제4항 또는 5항에 있어서, pH 6.6 내지 8.0에서 가수분해시키기 위한 용도.
  7. 제4항 내지 6항중 어느 한 항 이상에 있어서, 28 내지 38℃에서 가수분해시키기 위한 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880017019A 1987-12-21 1988-12-20 알파-아미노아디피닐-모노아미노 화합물의 효소적 가수분해 방법 KR0149656B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3743323.7 1987-12-21
DE19873743323 DE3743323A1 (de) 1987-12-21 1987-12-21 Verfahren zur enzymatischen hydrolyse von (alpha)-aminoadipinyl-monoaminoverbindungen

Publications (2)

Publication Number Publication Date
KR890010211A true KR890010211A (ko) 1989-08-07
KR0149656B1 KR0149656B1 (ko) 1998-08-17

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KR1019880017019A KR0149656B1 (ko) 1987-12-21 1988-12-20 알파-아미노아디피닐-모노아미노 화합물의 효소적 가수분해 방법

Country Status (14)

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EP (1) EP0321849B1 (ko)
JP (1) JP2816167B2 (ko)
KR (1) KR0149656B1 (ko)
AT (1) ATE91711T1 (ko)
AU (1) AU616450B2 (ko)
CA (1) CA1317246C (ko)
CZ (1) CZ283529B6 (ko)
DE (2) DE3743323A1 (ko)
DK (1) DK710588A (ko)
ES (1) ES2058224T3 (ko)
HU (1) HU202917B (ko)
IE (1) IE62566B1 (ko)
PT (1) PT89282B (ko)
ZA (1) ZA889442B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0275901B1 (de) * 1987-01-17 1993-06-09 Hoechst Aktiengesellschaft Verwendung von Gamma-Glutamyl-Transpeptidase
US5104800A (en) * 1989-06-27 1992-04-14 Merck & Co., Inc. One-step cephalosporin c amidase enzyme
US5229274A (en) * 1989-06-27 1993-07-20 Merck & Co., Inc. Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus
JP3036775B2 (ja) * 1990-02-07 2000-04-24 協和醗酵工業株式会社 ｒ―グルタミルトランスペプチダーゼの製造法
JPH04281787A (ja) * 1991-03-04 1992-10-07 Yoshihiro Asada γ−グルタミルトランスペプチターゼの製造方法
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6121097A (ja) * 1984-07-10 1986-01-29 Asahi Chem Ind Co Ltd ７−アミノセフアロスポラン酸及びその誘導体の製造法
EP0275901B1 (de) * 1987-01-17 1993-06-09 Hoechst Aktiengesellschaft Verwendung von Gamma-Glutamyl-Transpeptidase

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ATE91711T1 (de) 1993-08-15
DK710588D0 (da) 1988-12-20
EP0321849A2 (de) 1989-06-28
JP2816167B2 (ja) 1998-10-27
JPH01199576A (ja) 1989-08-10
CZ847388A3 (en) 1997-12-17
DE3743323A1 (de) 1989-06-29
CZ283529B6 (cs) 1998-04-15
AU2732388A (en) 1989-06-22
EP0321849A3 (en) 1990-09-12
IE883807L (en) 1989-06-21
DK710588A (da) 1989-06-22
ZA889442B (en) 1989-08-30
PT89282B (pt) 1993-07-30
PT89282A (pt) 1989-12-29
EP0321849B1 (de) 1993-07-21
CA1317246C (en) 1993-05-04
AU616450B2 (en) 1991-10-31
DE3882503D1 (de) 1993-08-26
HUT49168A (en) 1989-08-28
IE62566B1 (en) 1995-02-08
HU202917B (en) 1991-04-29
ES2058224T3 (es) 1994-11-01
KR0149656B1 (ko) 1998-08-17

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