KR880005139A - 펜엠의 제조방법 - Google Patents
펜엠의 제조방법 Download PDFInfo
- Publication number
- KR880005139A KR880005139A KR870011366A KR870011366A KR880005139A KR 880005139 A KR880005139 A KR 880005139A KR 870011366 A KR870011366 A KR 870011366A KR 870011366 A KR870011366 A KR 870011366A KR 880005139 A KR880005139 A KR 880005139A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- group
- formula
- enzyme
- enzymatic hydrolysis
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/883—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a substituted hydrocarbon radical attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
- C12N1/185—Saccharomyces isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/85—Saccharomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pens And Brushes (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 하기 일반식(II)의 화합물을 그의 2-치환체의 에스테르 그룹을 선택적으로 가수분해시킬 수 있는 효소를 사용하여 가수분해시킴을 특징으로 하여, 하기 일반식(I)의 화합물을 제조하는 방법.상기식에서, R은 탄소수 1 내지 18의 알킬, 알케닐 또는 페닐 알킬그룹이고, R1은 하이드록시 보호그룹이며, R2는 카복시 보호그룹이다.
- 제1항에 있어서, R1이 P-니트로벤질옥시카보닐, 트리메틸실릴 또는 피라닐그룹이고 ; R2가 알릴, 벤질 또는 P-니트로벤질그룹이며 ; R이 메틸, 에틸, 프로필 또는 부틸그룹인 방법.
- 제1항 또는 2항에 있어서, 효소적 가수분해를 리파아제, 프로테아제, 판크레아틴 또는 스테앞신을 사용하여 수행하는 방법.
- 제1항 내지 3항중 어느 한 항에 있어서, 효소적 가수분해를 상기 효소를 분비하는 미생물 세포의 존재하에 수행하거나, 상기 효소를 분리시킨 다음 분리된 효소를 일반식(II)의 화합물에 작용시켜 수행하는 방법.
- 제4항에 있어서, 미생물 세포 또는 분리된 효소를 불활성 기질상에 고정화시키거나, 가교결합에 의해 불용성화시키는 방법.
- 제5항에 있어서, 일반식(I)의 최종화합물을 불활성 기질상에 흡착시킨 다음, 적합한 용매로 기질을 간단하게 세척하여 순수한 형태로 회수하는 방법.
- 제1항 내지 6항중 어느 한 항에 있어서, 효소적 가수분해를 임의로는 소량의 탄화수소 존재하에 pH 5 내지 9로 완충된, 일반식(II)화합물의 농도가 1 내지 100g/ι 인 수용액중 10°내지 50℃에서 0.5 내지 48시간동안 수행하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8624686 | 1986-10-15 | ||
GB868624686A GB8624686D0 (en) | 1986-10-15 | 1986-10-15 | Preparing penems |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880005139A true KR880005139A (ko) | 1988-06-28 |
KR950012694B1 KR950012694B1 (ko) | 1995-10-20 |
Family
ID=10605770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870011366A KR950012694B1 (ko) | 1986-10-15 | 1987-10-14 | 펜엠의 제조방법 |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0265166B1 (ko) |
JP (1) | JP2688053B2 (ko) |
KR (1) | KR950012694B1 (ko) |
AT (1) | ATE66961T1 (ko) |
AU (1) | AU590455B2 (ko) |
CA (1) | CA1300539C (ko) |
DE (1) | DE3772703D1 (ko) |
ES (1) | ES2026548T3 (ko) |
FI (1) | FI90994C (ko) |
GB (1) | GB8624686D0 (ko) |
GR (1) | GR3003059T3 (ko) |
HU (1) | HU198098B (ko) |
IE (1) | IE60493B1 (ko) |
IL (1) | IL84148A (ko) |
NZ (1) | NZ222141A (ko) |
PT (1) | PT85915B (ko) |
SU (1) | SU1625333A3 (ko) |
ZA (1) | ZA877682B (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8713515D0 (en) * | 1987-06-10 | 1987-07-15 | Erba Farmitalia | Methoxymethyl compounds |
GB2206578B (en) * | 1987-07-07 | 1991-07-03 | Erba Carlo Spa | Process for the preparation of penems |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES436565A1 (es) * | 1974-06-05 | 1977-04-01 | Bristol Myers Co | Un procedimiento para la preparacion de acidos acetamidope- nicilanicos. |
US4414328A (en) * | 1980-07-21 | 1983-11-08 | Fujisawa Pharmaceutical Co., Ltd. | Process for the preparation of deacetylcephalosporin C |
-
1986
- 1986-10-15 GB GB868624686A patent/GB8624686D0/en active Pending
-
1987
- 1987-10-12 FI FI874469A patent/FI90994C/fi not_active IP Right Cessation
- 1987-10-12 IL IL84148A patent/IL84148A/xx not_active IP Right Cessation
- 1987-10-12 JP JP62257028A patent/JP2688053B2/ja not_active Expired - Fee Related
- 1987-10-12 NZ NZ222141A patent/NZ222141A/xx unknown
- 1987-10-12 IE IE272187A patent/IE60493B1/en not_active IP Right Cessation
- 1987-10-12 AU AU79575/87A patent/AU590455B2/en not_active Ceased
- 1987-10-13 CA CA000549083A patent/CA1300539C/en not_active Expired - Fee Related
- 1987-10-13 SU SU874203495A patent/SU1625333A3/ru active
- 1987-10-13 PT PT85915A patent/PT85915B/pt not_active IP Right Cessation
- 1987-10-13 ZA ZA877682A patent/ZA877682B/xx unknown
- 1987-10-14 DE DE8787309078T patent/DE3772703D1/de not_active Expired - Fee Related
- 1987-10-14 EP EP87309078A patent/EP0265166B1/en not_active Expired - Lifetime
- 1987-10-14 ES ES198787309078T patent/ES2026548T3/es not_active Expired - Lifetime
- 1987-10-14 AT AT87309078T patent/ATE66961T1/de not_active IP Right Cessation
- 1987-10-14 KR KR1019870011366A patent/KR950012694B1/ko active IP Right Grant
- 1987-10-14 HU HU974639A patent/HU198098B/hu not_active IP Right Cessation
-
1991
- 1991-11-04 GR GR91401667T patent/GR3003059T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT85915A (en) | 1987-11-01 |
HUT45262A (en) | 1988-06-28 |
GR3003059T3 (en) | 1993-02-17 |
DE3772703D1 (de) | 1991-10-10 |
ES2026548T3 (es) | 1992-05-01 |
GB8624686D0 (en) | 1986-11-19 |
AU7957587A (en) | 1988-04-21 |
HU198098B (en) | 1989-07-28 |
EP0265166B1 (en) | 1991-09-04 |
JPS63105696A (ja) | 1988-05-10 |
AU590455B2 (en) | 1989-11-02 |
IL84148A (en) | 1992-05-25 |
EP0265166A1 (en) | 1988-04-27 |
FI90994C (fi) | 1994-04-25 |
JP2688053B2 (ja) | 1997-12-08 |
IE60493B1 (en) | 1994-07-27 |
SU1625333A3 (ru) | 1991-01-30 |
ZA877682B (en) | 1988-04-19 |
IL84148A0 (en) | 1988-03-31 |
FI874469A0 (fi) | 1987-10-12 |
IE872721L (en) | 1988-04-15 |
KR950012694B1 (ko) | 1995-10-20 |
FI874469A (fi) | 1988-04-16 |
NZ222141A (en) | 1989-03-29 |
ATE66961T1 (de) | 1991-09-15 |
CA1300539C (en) | 1992-05-12 |
PT85915B (pt) | 1990-07-31 |
FI90994B (fi) | 1994-01-14 |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
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NORF | Unpaid initial registration fee |