KR890008072A - 벤조사이클로헵텐 유도체 - Google Patents

벤조사이클로헵텐 유도체 Download PDF

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KR890008072A
KR890008072A KR1019880014556A KR880014556A KR890008072A KR 890008072 A KR890008072 A KR 890008072A KR 1019880014556 A KR1019880014556 A KR 1019880014556A KR 880014556 A KR880014556 A KR 880014556A KR 890008072 A KR890008072 A KR 890008072A
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propenyl
tetrahydro
benzocyclohepten
benzoate
compound
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클라우스 미카엘
모어 페너
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쟝-쟈크 오가이, 프리돌린 클라우스너
에프. 호프만-라 로슈 앤드 캄파니 아크티엔게젤샤프트
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Publication of KR890008072A publication Critical patent/KR890008072A/ko

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Abstract

내용 없음

Description

벤조사이크로헵텐 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (20)

  1. 하기 일반식 (I)의 화합물 및 일반식 (I)의 카복실산의 생리학적으로 허용되는 염
    상기식에서 R¹은 하이드록시, 저급-알콕시, 아미노, 모노 또는 디 - 저급 - 알킬아미노이고 : R²은 수소, 알킬, 알콕시 또는 할로겐이며 : R3,R4,R5,R6,R11및 R12는 각각 독립적으로 수소 또는 저급 - 알킬이고 : R³ 및 R5가 함께는 메틸렌 또는 하이드록시-메틸렌 그룹이며, R7,R8,R9및 R10은 수소 또는 저급 알킬이고 : R11및 R12가 함께는 옥소그룹 또는 스피로-사이클로-저급 알킬이거나, 또는 R11은 수소이며, R12는 하이드록시 또는 아세톡시이고, 잔기 R13및 R14중 하나는 수소이며, 다른 하나는 저급-알킬 또는 트리플루오르메틸이다
  2. 제 1 항에 있어서, R¹이 하이드록시, 저급 - 알콕시, 아미노, 모노-또는 디 - 저급 -알킬아미노이고 : R²는 수소, 알킬, 알콕시 또는 할로겐이며 : R3,R4,R5,R6,R11및 R12는 각각 독립적으로 수소 또는 저급 - 알킬이고 : R³ 및 R⁴가 함께는 메틸렌 그룹이며 : R7,R8,R9및 R10은 수소 또는 저급 - 일킬이고 : R11및 Rg함께는 옥소 그룹이거나, 또는 R11은 수소이며, R12는 하이드록시이고 : 잔기 R13및 R14중 하나는 수소이며, 다른 하나는 저급 - 알킬 또는 트리플루오로메틸인 일반식(I)의 화합물, 및 일반식(I)의 카복실산의 생리학적으로 허용되는 염
  3. 제 1 항 또는 제 2 항에 있어서, R¹이 하이드록시 또는 저급- 알콕시인 화합물
  4. 제 1 항 내지 제 3 항중 어느 한 항에 있어서, R²가 수소인 화합물
  5. 제 1 항 내지 제 4항중 어느 한 항에 있어서, R3,R4,R5,R6,R7,R8,R9,R10,R11및 R12가 수소 또는 저급 - 알킬인 화합물
  6. 제 1 항 내지 제 4 항중 어느 한 항에 있어서, 잔기 R³내지 R12중 적어도 하나가 저급 - 알킬인 화합물
  7. 제 1 항 내지 제 4 항 중 어느 한 항에 있어서 R¹ 및 R12가 하이드록시인 화합물
  8. 제 1 항 내지 제 4항중 어느 한 항에 있어서 R11이 수소이고, R12가 하이드록시인 화합물
  9. 제 1 항 내지 제 4 항중 어느 한 항에 있어서, R³ 및 (R5) 가 함께는 메틸렌 그룹인 화합물
  10. 에틸 P-[(E)-2-(6,7,8,9-테트라하이드로-9,9-디메틸-5H-벤조사이클로헵텐-2-일)프로페닐]벤조에이트
  11. 에틸 P-[(E)-2-(6,7,8,9- 테트라하이드로 -9,9-디메틸-5H-벤조사이클로헵텐-2-일)프로페닐]벤조에이트 : 에틸 P-[(E)-2-2(6,7,8,9-테트라하이드로 -5,5-디메틸 -5H-벤조사이클로헵텐-2-일)프로페닐] 벤조에이트: 에틸 P-[(E)-2-(6,7,8,9-테트라하이드로-5,9,9-트리메틸-5H-벤조사이크로헵텐-2-일)프로페닐]벤조에이트:P-[(E)-2-(6,7,8,9-테트라하이드로 - 5,5,9-트리메틸-5H-벤조사이클로헵텐-2-일)프로페닐]벤조에이트 : 에틸 P-[(E)-2-2(6,7,8,9-테트라하이드로-5,5,9,9-테트라메틸-5H-벤조사이클로헵텐- 2-일)프로페닐]벤조에이트 : 에틸 P-[(E)-2-(6,7,8,9-테트라하이드로 - 7,7,9-테트라메틸-5H-벤조사이클로헵텐-2-일)프로페닐]벤조에이트 : 메틸 P-[(E)-2-(6,7,8,9-테트라하이드로 - 7,7,9,9-테트라메틸 - 5H-벤조사이클로헵텐-2-일)프로페닐]벤조에이트 : 에틸 P-[(E)-2-(7-에틸-6,7,8,9-테트라하이드로- 7-메틸-5H- 벤조사이클로헵텐-2-일)프로페닐]벤조에이트: P-[(E)-6,7,8,9-테트라하이드로-5H-벤조사이클로헵텐-2-일)프로페닐]벤조산 : P-[(E)-2-(6,7,8,9-테트라하이드로-7,7-디메틸-5H-벤조사이클로헵텐-2-일)프로페닐]벤조산 :P-[(E)-2-(6,7,8,9-테트라하이드로--5,5,9,9-디메틸-5H-벤조사이클로헵텐-2-일)프로페닐]벤조산 : 에틸 P-[(E)-2-(6,7,8,9-테트라하이드로-7-메틸-5H-벤조사이클로헵텐 -2-일)프로페닐]벤조에이트 : P-[(E)-2-(6,7,8,9-테트라하이드로 - 6,6,8,8-테트라메틸 - 5H-벤조사이클로헵텐-2-일)프로페닐]벤조산 : 메틸 P-[(E)-2-(6,7,8,9-테트라하이드로-3,7,7-트리메틸-5H-벤조시이클로헵텐-2-일)프로페닐]벤조에이트 : 에틸 P-[(E)-2-(6,7,8,9-테트라하이드로-9-메틸-5H-벤조사이클로헵텐-2-일)프로페닐]벤조에이트: P-[(E)-2-(6,7,8,9-테트라하이드로-7,7,9,9-테트라메틸-5H-벤조사이클로헵텐-2-일)프로페닐]벤조산 : P-[(ZX)-2-(6,7,8,9-테트라하이드로-7,7-디메틸-3-옥틸-5H-벤조사이클로헵텐-2-일)프로페닐]벤조산 : P-[(Z)-2-(3-브로모-6,7,8,9-테트라하이드로-7,7-디메틸-5H-벤조사이클로헵텐-2-일)프로페닐]벤조산 : P-[(Z)-2-(6,7,8,9-테트라하이드로-3,7,7-트리메틸-5H-벤조사이클로헵텐-2-일)프로페닐]벤조산 : 및 에틸 P-[(E)-2-(6,7,8,9-테트라하이드로-5H-벤조사이클로헵텐-2-일)프로페닐]벤조에이트로 이루어진 그룹중에서 선택되는 화합물
  12. 에틸 P-[(E)-2-[5,6,8,9-테트라하이드로스피로-[7H-벤조사이클로헵텐-7,1-사이클로프로판]-2-일]프로페닐]벤조에이트로 이루어진 그룹중에서 선택되는 화합물
  13. 에틸 P-[(E)-2-(6,7,8,9-테트라하이드로-7-옥소-5H-벤조사이클로헵텐-2-일)프로페닐]벤조에이트 : 및 에틸 P-[(E)-2-(6,7,8,9-테트라하이드로-6,6,8,8,-테트라메틸7-5H-벤조사이클로헵텐-2-일)프로페닐]벤조에이트로 이루어진 그룹중에서 선택되는 화합물
  14. 에틸 P-[(E)-2-(6,7,8,9-테트라하이드로-10-아세톡시-5,9-디메틸-5,9-메타노-5H-벤조사이클로헵텐-2-일)프로페닐]벤조에이트 : P-[(E)-2-(6,7,8,9-테트라하이드로-10-하이드록시-5,9-디메틸-5,9-메타노-5H-벤조시아클로헵텐-2-일)프로페닐]벤조산 : 에틸 P-[(E)-2-(6,7,8,9-테트라하이드로-5,9-디메틸-5,9-메타노-5H-벤조사이클로헵텐-2-일)프로페닐]벤조에이트 및 P-[(E)-2-(6,7,8,9-테트라하이드로-5,9-디메틸-5,0-메티노-5H-벤조사이클로헵텐-2-일)프로페닐]벤조산으로 이루어진 그룹중에서 선택되는 화합물
  15. 제 1 항 내지 제14항중 어느 한 항에 있어서 약제학적으로 하기 위한 화합물
  16. 일반식(II)의 화합물과 일반식(III)의 화합물을 반응시키고, 존재할 수 있는 하이드록시 또는 옥소 보호그룹을 축합 생성물로부터 분해 제거하고, 필요한 경우, 이렇게 하여 수득된 일반식(I)의 화합물의 에스테르 그룹-COR′을 비누화(saponifying)시키거나, 또는 카복스 아미노그룹 또는 N-모노 또는 디알킬화 카복스 아미노 그룹으로 전환시키거나, 또는 일반식(I)의 카복실신을 생리학적으로 허용하되는 염으로 전환시킴을 특징으로 하여, 일반식(I)의 화합물 및 일반식(I)의 카복실산의 생리학적으로 허용되는 염을 제조하는 방법.
    상기식에서, A는 잔기 -CH(R13)P+(Q)3Y- 이고, B는 잔기 -CO(R14)- 이거나, 또는 A는 잔기 -CO(R13)-이고 B는 잔기 -PO(OAlk)₂ 이며 : Q는 아릴이고 Y-유기산 또는 무기산의 음이온이며: Alk는 저급 알킬 그룹이고 : R¹내지 R14는 상기 정의한 바와 같으며, 이중에는 R12또는R11및 R12로서 존재하는 하이드록시 또는 옥소그룹은 보호된 형태로 존재한다
  17. 제 1 항에서 청구된 화합물 및 통상의 담체 물질을 함유하는 약제학적 조성물
  18. 제16항의 방법에 의해 또는 이의 명백한 화학적 등가 방법에 의해 제조된 제 1 항 내지 제14항중 어느한 항에서 청구된 화합물
  19. 지루-치료, 각화-치료, 종량-치료, 항알레르기 및 소염활성을 갖는 약제학적 조성물중에서 활성물질로서 사용하기 위한 제1항 내지 제14항중 어느 한 항에서 청구된 화합물
  20. 실질적으로 본 명세서에 기술되어 있는 신규한 화합물 조성물 및 제조방법
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880014556A 1987-11-06 1988-11-05 벤조사이클로헵텐 유도체 KR890008072A (ko)

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IL88239A (en) 1993-03-15
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PH25523A (en) 1991-07-24
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IE883339L (en) 1989-05-06
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