KR830003462A - 치환된 옥시란 카르복실릭 산류의 제조방법 - Google Patents

치환된 옥시란 카르복실릭 산류의 제조방법 Download PDF

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KR830003462A
KR830003462A KR1019800003519A KR800003519A KR830003462A KR 830003462 A KR830003462 A KR 830003462A KR 1019800003519 A KR1019800003519 A KR 1019800003519A KR 800003519 A KR800003519 A KR 800003519A KR 830003462 A KR830003462 A KR 830003462A
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암슈레르 헤르만
이스테테르 크라우스
루드비그 게르하르드
라프 엔리흐
볼트 호르스트
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귄테르 미첼, 쿠르트 크렘
비크 굴덴 롬베르그 케미쉬 파브리크 쥐엠비 에이츠
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Abstract

내용 없음

Description

치환된 옥시란 카르복실릭 산류의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (89)

  1. 일반구조식 Ⅰ의 치환된 옥시란카르복실릭산류와 카르복실릭산류의 염류
  3. 상기식에서
  4. R1은 수소원자, 할로겐원자, 하이드록실그룹, 저급알킬그룹, 저급알콕시그룹 또는 트리플루오로메틸 그룹
  5. R2는 R1에서 언급한 것중 하나
  6. R3는 수소원자 또는 저급 알킬그룹이고
  7. n은 1내지 8의 정수
  8. 일반구조식 Ⅰ이 다음과 같은 것을 특징으로하는 청구범위 1에 따른 치환된 옥시란 카르복실릭산류와 카르복실산류의 염류
  10. 상기식에서
  11. R1*와 R2*는 메타-위치 또는 파라-위치이고
  12. R1*은 수소원자, 염소원자, 메틸그룹, 메톡시그룹 또는 트리플루오로메틸그룹,
  13. R2*는 수소원자 또는 염소원자,
  14. R3*는 수소원자 또는 저급알킬그룹이고
  15. n*는 3내지 7의 정수
  16. 다음 n*가 3내지 5정수이고 R1*, R2*와 R3*가 청구범위 2에서 언급한 것인 청구범위 2에 따른 화합물
  17. 일반구조식 Ⅰ**과 무기 또는 유기염기류인 카르복실릭산류의 약학적으로 받아들여 질 수 있는 염류로 특징이 있는 청구범위1에 따른 치환된 옥시란 카르복실릭산류
  19. 상기식에서
  20. R1**와 R2**는 메타-위치 또는 파라-위치이고
  21. R1**은 수소원자, 염소원자 또는 트리플루오로 메틸그룹,
  22. R2**는 수소원자,
  23. R3**는 수소원자, 메틸그룹 또는 에틸그룹이고
  24. n**는 3 또는 4
  25. R1**이 수소원자 또는 염소원자이고 R2**, R3**와 n**는 청구범위 4에서 언급한것인 청구범위 4에 따른 화합물
  26. 다음 일반구조식 Ⅰ***과 무기 또는 유기염기류인 카르복실릭산류의 약학적으로 받아들여질 수 있는 염류로 특징이 있는 청구범위 1에 따른치환된 옥시란 카르복실릭산류
  28. 상기식에서
  29. R1***와 R2***는 메타-위치 또는 파라-위치이고
  30. R1***는 수소원자, 염소원자 또는 트리플루오로메틸그룹,
  31. R2***는 수소원자,
  32. R3***는 수소원자, 메틸그룹 또는 에틸그룹이고
  33. n***는 5이다.
  34. 2-[3-(1-클로로페닐)-프로필]-옥시란-2-카르복실릭산, 이들 에틸 에스 테르와 무기와 유기염기류인 약학적으로 받아들여질수 있는 염류
  35. 2-[3-(4-클로로페닐)-프로필]-옥시란-2-카르복실릭산, 이들 에틸에스테르와 무기와 유기염기류인 약학적으로 받아들여질수 있는 염류
  36. 2-[3-(3-트리플루오로 메틸페닐)-프로필]-옥시란-2-카르복실릭산, 이들 에스테르와 무기와 유기염기류인 약학적으로 받아들여질수 있는 염류
  37. 2-(5-페닐펜틸)-옥시란-2-카르복실릭산, 이들 에틸에스테르와 무기와 유기염기류인 약학적으로 받아들여질 수 있는 염류
  38. 2-[5-(4-클로로페닐)-펜틸]-옥시란-2-카르복실릭산, 이들 에틸에스테르와 무기와 유기염기류인 약학적으로 받아들여질수 있는 염류
  39. 다음 일반구조식 Ⅰ의 치환된 옥시란카르복실릭산류의 하나 또는 다수 활성성분 또는 무기 또는 유기염기류인 산류의 약학적으로 받아들여질 수 있는 염류를 포함하는 약제
  41. 상기식에서
  42. R1은 수소원자, 할로겐원자, 하이드록실그룹, 저급알킬그룹, 저급알콕시그룹 또는 트리플루오로 메틸그룹,
  43. R2는 R1에서 언급한 것중 하나
  44. R3는 수소원자 또는 저급알킬그룹이고
  45. n은 1내지 8의 정수
  46. 청구범위 2 또는 청구범위 4 또는 청구범위 6에 따른 일반구조식 Ⅰ*, Ⅰ**또는 Ⅰ***의 하나 또는 다수치환된 옥시란 카르복실릭산류 또는 유기염기류인 약학적으로 받아들여질 수 있는 염류를 활성성분으로서 포함하는 약제
  47. 하나 또는 다수 고체 또는 액체 약학적으로 받아들여질 수 있는 담체인 혼합물에서 청구범위 1내지 11에 따른 적어도 하나 화합물의 전체혼합물 중량 1내지 95%를 포함하는 약학적 제제
  48. 다음 일반구조식(Ⅱ)의 치환된 α-메틸렌카르복실릭산류를 산화시키고 생성저급알킬 에스 테르를 임의로 사포닌화시키거나 또는 생성산류를 임의로 염류 또는 저급알킬 에스테르류로 전환시키는 것을 특징으로 하는 다음 일반구조식 Ⅰ의 치환된 옥시란 카르복실릭산류와 산류의 염류를 제조하는 방법.
  51. 상기 식에서
  52. R1은 수소원자, 할로겐원자, 하이드록실그룹, 저급알킬그룹, 저급알콕시그룹 또는 트리트리플 루오로메틸 그룹,
  53. R2는 R1에서 언급한것중 하나
  54. R3는 수소원자 또는 저급알킬그룹이고
  55. n은 1내지 8의 정수이다.
  56. 다음 일반구조식Ⅱ*의 α-메틸렌카르복실릭산류를 사용하여 청구범위 2에 따른 일반 구조식 Ⅰ*의 치환된 옥시란카르복실릭산류를 제조하는 것을 특징으로 하는 청구범위 15에 따른 공정
  58. 상기식에서
  59. R1*, R2*, R3*와 n*은 청구범위 2에서 언급한 것이다.
  60. n*가 3내지 5이고 R1*, R2*와 R3*가 청구범위 2에서 언급한것인 일반구조식Ⅱ*의 α-메틸렌카르복실릭산류를 사용하는 것을 특징으로 하는 청구범위 60에 따른 공정
  61. 다음 일반구조식Ⅱ**의 α-메틸렌 카르복실릭산류를 사용하여 청구범위 4에 따른 일반구조식Ⅰ**의 치환된 옥시란 카르복실릭산류를 제조하는 것을 특징으로하는 청구범위 15에 따른 공정.
  63. 상기식에서
  64. R1**, R2**, R3**는 청구범위 4에서 언급한 것이다.
  65. R1*이 수소원자 또는 염소원자이고 R2**, R3**와 n**가 청구범위 4에서 언급한 것인 일반구조식Ⅱ**의 α-메틸렌카르복실릭산류를 사용하는 것을 특징으로 하는 청구범위 18에 따른 공정.
  66. 일반구조식 Ⅱ***의 α-메틸렌카르복실릭산류를 사용하여 청구범위 6에 따른 일반구조식 Ⅰ***의 치환된 옥시란카르복실릭산류를 제조하는 것을 특징으로하는 청구범위15에 따른 공정.
  68. 상기식에서
  69. R1***, R2***, R3***와 n***가 청구범위 6에서 언급한 것이다.
  70. 전에 언급한 상세한 실시예로 전반적으로 기술된 청구범위 1의 치환된 옥시란카르복실릭산류를 제조하는 방법.
  71. 일반구조식 Ⅱ**의 α-메틸렌 카르복실릭산류와 무기 또는 유기염기류인 카르복실릭산류의 약학적으로 받아들여질 수 있는 염류
  73. 상기식에서
  74. R1**와 R2**는 메타-위치 또는 파라-위치,
  75. R1**는 염소원자,
  76. R2**는 수소원자,
  77. R3**는 수소원자, 메틸그룹 또는 에틸그룹이고
  78. n**는 3 또는 4
  79. 다음 일반구조식 Ⅱ***의 α-메틸렌카르복실릭산류와 무기 또는 유기염기류인 카르복실릭산류의 약학적으로 받아들여질 수 있는 염류
  81. 상기식에서
  82. R1***와 R2***는 메타-위치 또는 파라-위치,
  83. R1***는 수소원자, 염소원자 또는 트리플루오로메틸그룹,
  84. R2***는 수소원자,
  85. R3***는 수소원자, 메틸그룹 또는에틸그룹이고
  86. n***는 5이다.
  87. 청구범위 22 또는 23에 따른 화합물을 활성성분으로 포함하는 약제
  88. 하나 또는 다수고체 또는 액체 약학적으로 받아들여질 수 있는 담체와 혼합물에서 청구범위 22 또는 23에 따른 적어도 하나 화합물의 전체혼합물의 중량 1내지 95%를 포함하는 약학적 제제.
  89. * 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800003519A 1979-09-07 1980-09-05 치환된 옥시란카복실산의 제조방법 KR840002306B1 (ko)

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JPS57501478A (ko) * 1980-08-29 1982-08-19
IL66365A0 (en) * 1981-07-24 1982-11-30 Byk Gulden Lomberg Chem Fab Phenylalkyloxiranecarboxylic acids,a process for their preparation,their use,and medicaments containing them
DE3525284A1 (de) * 1985-07-16 1987-01-29 Boehringer Mannheim Gmbh Neue carbonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung sowie arzneimittel, die diese verbindungen enthalten
WO1987000751A2 (en) * 1985-08-02 1987-02-12 Byk Gulden Lomberg Chemische Fabrik Gmbh Use of oxirancarboxylic acids for the treatment of hyperlipemia
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PT87988B (pt) * 1987-07-16 1995-05-04 Byk Gulden Lomberg Chem Fab Processo para a preparacao de diazois e de composicoes farmaceuticas que os contem
US4788304A (en) * 1987-12-07 1988-11-29 American Home Products Corporation Phospholipase A2 inhibitors
US5545672A (en) * 1993-02-11 1996-08-13 The University Of Texas System Treatment of insulin resistance and type 2 diabetes mellitus with a thiol protease inhibitor
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
WO1998000422A1 (en) * 1996-07-02 1998-01-08 Sang Sup Jew Oxirane carboxylic acid derivative and its manufacturing method
KR19980028082A (ko) * 1996-10-21 1998-07-15 김박광 혈당 강하 작용을 갖는 신규 옥시란 카복실산의 유도체, 그 제조방법 및 이를 함유하는 당뇨병 치료제
DE19705718A1 (de) * 1997-02-14 1998-08-20 Horst P O Dr Wolf Neue Oxirancarbonsäuren zur Behandlung des Diabetes Typ 2 und anderer insulinresistenter Zustände
WO2004071458A2 (en) * 2003-02-13 2004-08-26 Albert Einstein College Of Medicine Of Yeshiva University REGULATION OF FOOD INTAKE AND GLUCOSE PRODUCTION BY MODULATION OF LONG-CHAIN FATTY ACYL-CoA LEVELS IN THE HYPOTHALAMUS
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AU6209880A (en) 1981-03-12
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ATE3291T1 (de) 1983-05-15
US4324796A (en) 1982-04-13
GR69822B (ko) 1982-07-13
DK380680A (da) 1981-03-08
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IL60975A0 (en) 1980-11-30
FI802790A (fi) 1981-03-08
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