KR890007741A - 진통제 - Google Patents
진통제 Download PDFInfo
- Publication number
- KR890007741A KR890007741A KR1019880014833A KR880014833A KR890007741A KR 890007741 A KR890007741 A KR 890007741A KR 1019880014833 A KR1019880014833 A KR 1019880014833A KR 880014833 A KR880014833 A KR 880014833A KR 890007741 A KR890007741 A KR 890007741A
- Authority
- KR
- South Korea
- Prior art keywords
- alkoxy
- alkyl
- formula
- physiologically acceptable
- alkylthio
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 다음 일반식(I)의 피리미딘 유도체 및/또는 이의 생리학적으로 허용되는 하나를 함유하는 진통제.상기식에서 =A-B=는 =CH-CH= 또는 -N-CR2=이고, Alk는 탄소수 2 내지 4의 알킬렌 그룹이고, R1는 H, 디알킬아미노알킬, 카복시알킬, 알콕시;카보닐아킬, 카바모일알킬, N-알킬카바모일알킬 또는 N,N-디알킬카바모일알킬이고, Y는 CH 또는 N이고, Z는 결합 또는 -CO-이고, Ar은 비치환 되거나 또는 알킬, 알콕시, F, Cl, Br, II 및/또는 CF3로 한번 이상 치환된 페닐, 티에닐 또는 피리딜 그룹이고, R2는 H, 알킬, 알콕시 또는 알킬티오이며, 상기에서, 알킬, 알콕시 및 알킬티오 그룹은 각기 탄소수 1내지 4를 함유한다.
- 일반식(I)의 화합물 및/또는 이의 생리학적으로 허용되는 염중 하나를 적어도 1종의 고체, 액체 및/또는 반액체 비히클 또는 보조제와 함께, 필요에 따라 종이상의 다른 활성 화합물(들)과 조합하여 적합한 투여형태로 전환시키는 것을 특징으로 하는 제1항에 따른 진통제의 제조방법.
- 통증을 억제시키기 위한 제1항에 따른 일반식(I)의 화합물 및/또는 이들의 생리학적으로 허용되는 염의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873738844 DE3738844A1 (de) | 1987-11-16 | 1987-11-16 | Analgetikum |
DEP3738844.4 | 1987-11-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890007741A true KR890007741A (ko) | 1989-07-05 |
Family
ID=6340578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880014833A KR890007741A (ko) | 1987-11-16 | 1988-11-11 | 진통제 |
Country Status (15)
Country | Link |
---|---|
US (1) | US4950648A (ko) |
EP (1) | EP0316668B1 (ko) |
JP (1) | JPH01160919A (ko) |
KR (1) | KR890007741A (ko) |
AT (1) | ATE89481T1 (ko) |
AU (1) | AU616695B2 (ko) |
CA (1) | CA1317549C (ko) |
DE (2) | DE3738844A1 (ko) |
ES (1) | ES2069541T3 (ko) |
GR (1) | GR3007918T3 (ko) |
HU (1) | HU203199B (ko) |
IE (1) | IE61301B1 (ko) |
PH (1) | PH25353A (ko) |
PT (1) | PT89000B (ko) |
ZA (1) | ZA888574B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2807577B2 (ja) * | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | 環状アミド誘導体 |
US5095019A (en) * | 1990-08-27 | 1992-03-10 | Hoechst-Roussel Pharmaceuticals Inc. | 4-substituted dihydropyrido(4,3-D)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders |
US6166019A (en) * | 1998-07-16 | 2000-12-26 | Abbott Laboratories | Piperazinyl pyrimidine dione compounds selective for adrenoceptors |
US7074834B2 (en) * | 2000-05-24 | 2006-07-11 | University Of Kentucky Foundation | Long acting, reversible veterinary sedative and analgesic and method of use |
FR2832711B1 (fr) | 2001-11-26 | 2004-01-30 | Warner Lambert Co | Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation |
CA2544245A1 (en) * | 2003-10-30 | 2005-05-26 | Tioga Pharmaceuticals, Inc. | Use of selective opiate receptor modulators in the treatment of neuropathy |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB843073A (en) * | 1958-05-09 | 1960-08-04 | Toraude Lab | 2-methyl-3-orthotolyl-4-quinazolone and acid addition salts thereof |
FR1043M (fr) * | 1960-12-28 | 1962-02-09 | Soc Ind Fab Antibiotiques Sifa | Dérivé de la quinazolone et ses sels, utilisés en thérapeutique. |
US3919425A (en) * | 1971-04-09 | 1975-11-11 | Miles Lab | Method of producing vasodilation using certain 3-substituted-quinazoline derivatives |
DE2143117A1 (de) * | 1971-08-28 | 1973-03-08 | Troponwerke Dinklage & Co | Neue 2-methyl-3-geschweifte klammer auf 3- eckige klammer auf 4-phenylpiperazinyl(1) eckige klammer zu -2-hydroxypropyl geschweifte klammer zu chinazolinon-(4)derivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
DE3012837A1 (de) * | 1979-04-10 | 1980-10-30 | Sandoz Ag | Analgetische und myotonolytische praeparate |
US4485107A (en) * | 1982-11-01 | 1984-11-27 | Janssen Pharmaceutica N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones |
DE3601731A1 (de) * | 1986-01-22 | 1987-07-23 | Merck Patent Gmbh | Pyrimidinderivate |
-
1987
- 1987-11-16 DE DE19873738844 patent/DE3738844A1/de not_active Withdrawn
-
1988
- 1988-11-03 AT AT88118320T patent/ATE89481T1/de not_active IP Right Cessation
- 1988-11-03 DE DE8888118320T patent/DE3881164D1/de not_active Expired - Fee Related
- 1988-11-03 EP EP88118320A patent/EP0316668B1/de not_active Expired - Lifetime
- 1988-11-03 ES ES88118320T patent/ES2069541T3/es not_active Expired - Lifetime
- 1988-11-11 PT PT89000A patent/PT89000B/pt not_active IP Right Cessation
- 1988-11-11 KR KR1019880014833A patent/KR890007741A/ko not_active Application Discontinuation
- 1988-11-14 AU AU25107/88A patent/AU616695B2/en not_active Ceased
- 1988-11-14 CA CA000582914A patent/CA1317549C/en not_active Expired - Fee Related
- 1988-11-14 PH PH37810A patent/PH25353A/en unknown
- 1988-11-15 IE IE341788A patent/IE61301B1/en not_active IP Right Cessation
- 1988-11-15 HU HU885883A patent/HU203199B/hu not_active IP Right Cessation
- 1988-11-15 US US07/271,463 patent/US4950648A/en not_active Expired - Fee Related
- 1988-11-16 ZA ZA888574A patent/ZA888574B/xx unknown
- 1988-11-16 JP JP63287879A patent/JPH01160919A/ja active Pending
-
1993
- 1993-05-20 GR GR930400139T patent/GR3007918T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2069541T3 (es) | 1995-05-16 |
ATE89481T1 (de) | 1993-06-15 |
HU203199B (en) | 1991-06-28 |
DE3881164D1 (de) | 1993-06-24 |
AU616695B2 (en) | 1991-11-07 |
DE3738844A1 (de) | 1989-05-24 |
EP0316668A3 (en) | 1990-09-19 |
ZA888574B (en) | 1989-08-30 |
CA1317549C (en) | 1993-05-11 |
US4950648A (en) | 1990-08-21 |
EP0316668A2 (de) | 1989-05-24 |
PT89000A (pt) | 1988-12-01 |
AU2510788A (en) | 1989-05-18 |
PT89000B (pt) | 1993-02-26 |
IE883417L (en) | 1989-05-16 |
PH25353A (en) | 1991-05-13 |
JPH01160919A (ja) | 1989-06-23 |
GR3007918T3 (ko) | 1993-08-31 |
IE61301B1 (en) | 1994-10-19 |
EP0316668B1 (de) | 1993-05-19 |
HUT48818A (en) | 1989-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |