KR890002181A - 7β-(치환된)아미노-3-치환 세팔로스포란산 및 에스테르 - Google Patents

7β-(치환된)아미노-3-치환 세팔로스포란산 및 에스테르 Download PDF

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KR890002181A
KR890002181A KR1019870007330A KR870007330A KR890002181A KR 890002181 A KR890002181 A KR 890002181A KR 1019870007330 A KR1019870007330 A KR 1019870007330A KR 870007330 A KR870007330 A KR 870007330A KR 890002181 A KR890002181 A KR 890002181A
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amino
methyl
thia
ene
thio
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지크 리이 빙
빈센트 커어런 윌리암
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원본미기재
아메리칸 사이아나밋드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용없음

Description

7β-(치환된)아미노-3-치환 세팔로스포란산 및 에스테르
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (16)

  1. 하기 일반식을 갖는 화합물 :
    여기서 R1은 수소, 알킬(C1-C6), 폴리플루오르화된 알킬(C1-C|6), 페닐 치환체가 알킬(C1-C6)알콕시(C1-C6)염소, 불소, 및 트리플루오르메틸로 부터 선택되는 다중 치환된 페닐, 알킬(C1-C6), 나프틸, 티에닐, 페닐티오, 테트라히드로피라닐, 벤질 및 -COOC2H5로 구성된 군에서 선택되고 ; R2는 수소, 디페닐메틸,-아실옥시알킬, t-부틸, 벤질, 4-니트로벤질과 4-메톡시벤질 및 제약학상 허용되는 염(나트륨 및 칼륨)으로 구성된 군에서 선택되고 ; R3는 수소,
    , (여기서 R5는 페닐, 치환된 페닐, 2-티에닐, 2-푸릴, 트리 플루오르 메틸티오메틸, 4-(2-아미노티아졸릴), 5-(2-아미노티아졸릴) 및 시아노메틸 티오메틸로 구성된 군에서 선택되고, R6는 우레이도, 카르복시아미도, 4-알킬(또는 아릴)-2,3-디옥소피페라진-1-카로보닐 및 수소로 구성된 군에서 선택됨),(X는 OH, SO3H, COOH 및 테트라졸릴로 구성된 군에서 선택됨) 이종 환형 아세틸, 페닐 아세틸로 구성된 군에서 선택되며 ; R4는 수소, -O-알킬, -S-알킬 및 포름 아미도로 구성된 군에서 선택된다.
  2. 제1항에 있어서, (Z)-7-[[(2-아미노-4-티아졸릴)(메톡시이미노)아세틸]아미노]-3-[[5-페닐-1,2,3-티아디아졸-4-일)티오]메틸]-8-옥소-5-티아-1-아자비시클로[4.2.0]옥트-2-엔-카르복실산인 화합물.
  3. 제1항에 있어서, (Z)-7-[[(2-아미노-4-티아졸릴)(메톡시이미노)아세틸]아미노]-3-[[[5-[4-(1,1-디메틸에틸)페닐]-1,2,3-티아디아졸-4-일)티오]메틸]-8-옥소-5-티아-1-아자비시클로[4.2.0]옥트-2-엔-카르복실산인 화합물.
  4. 제1항에 있어서, 7-아미노-3-[[[5-(1,1-디메틸에틸)-1,2,3-티아디아졸-4-일]티오]메틸]-8-옥소-5-티아-1-아자비시클로[4.2.0]옥트-2-엔-2-카르복실산인 화합물.
  5. 제1항에 있어서, 7-아미노-3-[[[5-(1,1-디메틸에틸)-1,2,3-티아디아졸-4-일]티오]메틸]-8-옥소-5-티아-1-아자비시클로[4.2.0]옥트-2-엔-2-카르복실산, 디페닐메틸 에스테르인 화합물.
  6. 제1항에 있어서, (Z)-3-[[[5-(1,1-디메틸에틸)-1,2,3-티아디아졸-4-일]티오]메틸]-7-[[(메톡시이미노)[2-[(트리페닐메틸)아미노]-4-티아졸릴]아세틸]아미노]-8-옥소-5-티아-1-아자비시클로[4.2.0]옥트-2-엔-카르복실산, 디페닐 메틸 에스테르인 화합물.
  7. 제1항에 있어서, (Z)-7-[[(2-아미노-4-티아졸릴)(메톡시이미노)아세틸]아미노]-3-[[[5-(1,1-디메틸에틸)-1,2,3-티아디아졸-4-일]티오]메틸]-8-옥소-5-티아-1-아자비시클로[4.2.0]옥트-2-엔-2-카르복실산인 화합물.
  8. 제1항에 있어서, (6R-트랜스)-3-[[(5-메틸-1,2,3-티아디아졸-4-일]티오]메틸]-8-옥소-7-[(2-티에닐아세틸)아미노]-5-티아-1-아자비시클로[4.2.0]옥트-2-엔-2-카르복실산, 1,1-디메틸에틸 에스테르인 화합물.
  9. 제1항에 있어서, (6R-트랜스)-3-[[(5-메틸-1,2,3-티아디아졸-4-일)티오]메틸]-8-옥소-[7-(2-티에닐 아세틸)아미노]-5-티아-1-아자비시클로-[4.2.0]옥트-2-엔-2-카르복실산인 화합물.
  10. 제1항에 있어서, (6R-트랜스)-3-[[(5-에틸-1,2,3-티아디아졸-4-일)티오]메틸]-8-옥소-[7-(2-티에닐 아세틸)아미노]-5-티아-1-아자비시클로-[4.2.0]옥트-2-엔-2-카르복실산, 1,1-디메틸에틸 에스테르인 화합물.
  11. 제1항에 있어서, (6R-트랜스)-3-[[(5-메틸-1,2,3-티아디아졸-4-일)티오]메틸-8-옥소-7-[(2-티에닐아세틸)아미노]-5-티아-1-아자비시클로-[4.2.0]옥트-2-엔-2-카르복실산인 화합물.
  12. 제1항에 있어서, (6R-트랜스)-3-[[[(2-트리페닐 메틸아미노)-4-티아졸릴](메틸아미노)아세틸]아미노]-3-[[(5-메틸-1,2,3-티아디아졸-4-일)티오]메틸]-8-옥소-5-티아-1-아자비시클로-[4.2.0]옥트-2-엔-2-카르복실산, 1,1-디메틸에틸 에스테르인 화합물.
  13. 제1항에 있어서, (6R-[6,7(Z)]]-7-[[(2-아미노-4-티아졸릴(메톡시이미노)아세틸]아미노]-3-[[(5-메틸-1,2,3-티아디아졸-4-일)티오]메틸]-8-옥소-5-티아-1-아자비 시클로 [4.2.0]옥트-2-엔-2-카르복실산인 화합물.
  14. 제1항에 있어서, (6R-트랜스)-7-[[[(2-(트리페닐 메틸아미노)-4-티아졸릴]-(메톡시이미노)아세틸]아미노-3-[[[5-에틸-1,2,3-티아디아졸-4-일)티오]메틸]-8-옥소-5-티아-1-아자비시클로-[4.2.0]옥트-2-엔-2-카르복실산, 1,1-디메틸에틸 에스테르인 화합물.
  15. 제1항에 있어서, (6R-[6,7(Z)]]-7-[[(2-아미노-4-티아졸릴)(메톡시이미노)아세틸]아미노]-3-[[(5-에틸-1,2,3-티아디아졸-4-일)티오]메틸]-8-옥소-5-티아-1-아자비 시클로 [4.2.0]옥트-2-엔-2-카르복실산인 화합물.
  16. 제1항에 있어서, (Z)-7-[[(2-아미노-4-티아졸릴)메톡시이미노)아세틸]아미노]-3-[[[5-에틸-1,2,3-티아디아졸-4-일]티오]메틸]-8-옥소-5-티아-1-아자비시클로[4.2.0]옥트-2-엔-2-카르복실산, 아세톡시메틸 에스테르인 화합물.
    ※ 참고사항: 최초출원 내용에 의하여 공개하는 것임.
KR1019870007330A 1986-07-08 1987-07-08 7β-(치환된)아미노-3-치환 세팔로스포란 산 및 에스테르 KR950008320B1 (ko)

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AU (1) AU599676B2 (ko)
CA (1) CA1284147C (ko)
DK (1) DK349687A (ko)
FI (1) FI88042C (ko)
HU (1) HU198070B (ko)
IL (1) IL83119A (ko)
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
KR20160050089A (ko) * 2013-09-06 2016-05-10 테일러 커 (커플링스) 리미티드 동적 축방향 구속 시스템을 구비한 파이프 결합구

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US4803280A (en) * 1986-07-08 1989-02-07 American Cyanamid Company Substituted 1,2,3-thia-diazole-4-thiolates

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US4399132A (en) * 1980-08-11 1983-08-16 American Cyanamid Company 7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-acetamido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C1 -C6 alkyl derivatives thereof
US4914091A (en) * 1984-04-02 1990-04-03 American Cyanamid Company Esters of cephalosporin derivitives
EP0168177A3 (en) * 1984-06-28 1987-04-01 Pfizer Limited Cephalosporin antibiotics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160050089A (ko) * 2013-09-06 2016-05-10 테일러 커 (커플링스) 리미티드 동적 축방향 구속 시스템을 구비한 파이프 결합구

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AU7531187A (en) 1988-01-14
IL83119A0 (en) 1987-12-31
NZ220995A (en) 1989-10-27
NO171726C (no) 1993-04-28
IL83119A (en) 1993-04-04
PT85276B (pt) 1990-03-30
DK349687D0 (da) 1987-07-07
DK349687A (da) 1988-01-09
EP0252473A2 (en) 1988-01-13
JPH0813820B2 (ja) 1996-02-14
FI88042B (fi) 1992-12-15
FI872999A0 (fi) 1987-07-07
NO872825D0 (no) 1987-07-07
FI872999A (fi) 1988-01-09
NO872825L (no) 1988-01-11
FI88042C (fi) 1993-03-25
PH24324A (en) 1990-05-29
ZA874941B (en) 1988-02-24
AU599676B2 (en) 1990-07-26
CA1284147C (en) 1991-05-14
HU198070B (en) 1989-07-28
JPS6388188A (ja) 1988-04-19
EP0252473A3 (en) 1989-07-05
KR950008320B1 (ko) 1995-07-27
PT85276A (en) 1987-08-01
HUT45070A (en) 1988-05-30
NO171726B (no) 1993-01-18

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