KR890000385B1 - 스피로사이클 벤젠아세트아미드 및-벤즈아미드 화합물 - Google Patents
스피로사이클 벤젠아세트아미드 및-벤즈아미드 화합물 Download PDFInfo
- Publication number
- KR890000385B1 KR890000385B1 KR8204989A KR820004989A KR890000385B1 KR 890000385 B1 KR890000385 B1 KR 890000385B1 KR 8204989 A KR8204989 A KR 8204989A KR 820004989 A KR820004989 A KR 820004989A KR 890000385 B1 KR890000385 B1 KR 890000385B1
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- pyrrolidinyl
- acid
- dec
- oxaspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 0 CC(CC(C)=CC1C)N1C(*)=* Chemical compound CC(CC(C)=CC1C)N1C(*)=* 0.000 description 5
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
- C07C29/19—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds in six-membered aromatic rings
- C07C29/20—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds in six-membered aromatic rings in a non-condensed rings substituted with hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/05—Alcohols containing rings other than six-membered aromatic rings
- C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32063581A | 1981-11-12 | 1981-11-12 | |
| US320635 | 1981-11-12 | ||
| US390462 | 1982-06-21 | ||
| US06/390,462 US4438130A (en) | 1981-11-12 | 1982-06-21 | Analgesic 1-oxa-, aza- and thia-spirocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840002376A KR840002376A (ko) | 1984-06-25 |
| KR890000385B1 true KR890000385B1 (ko) | 1989-03-16 |
Family
ID=26982582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR8204989A Expired KR890000385B1 (ko) | 1981-11-12 | 1982-11-05 | 스피로사이클 벤젠아세트아미드 및-벤즈아미드 화합물 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4438130A (enExample) |
| KR (1) | KR890000385B1 (enExample) |
| AU (1) | AU552467B2 (enExample) |
| CA (1) | CA1187082A (enExample) |
| CH (1) | CH652718A5 (enExample) |
| DE (1) | DE3241933A1 (enExample) |
| ES (1) | ES8404342A1 (enExample) |
| FR (1) | FR2518095B1 (enExample) |
| GB (1) | GB2111488B (enExample) |
| GR (1) | GR77790B (enExample) |
| IT (1) | IT1154574B (enExample) |
| MX (1) | MX157171A (enExample) |
| NL (1) | NL8204279A (enExample) |
| NZ (1) | NZ202086A (enExample) |
| PH (1) | PH17634A (enExample) |
| SE (1) | SE453501B (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4598088A (en) * | 1983-05-18 | 1986-07-01 | The Upjohn Company | 2-pyrrolyl-cycloalkyl-amide analgesics |
| US4560767A (en) * | 1983-06-17 | 1985-12-24 | The Upjohn Company | N-(2-amino-cycloalkenyl)benzeneacetamide and -benzamide analgesics and tritiated kappa agonists therefrom |
| US4588591A (en) * | 1984-05-25 | 1986-05-13 | The Upjohn Company | Analgesic 2-oxa-spirocyclic compounds |
| US4632935A (en) * | 1984-05-30 | 1986-12-30 | The Upjohn Company | Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and cycloalkenyl amides as analgesics |
| US4618621A (en) * | 1984-09-21 | 1986-10-21 | The Upjohn Company | Method for treating medical conditions involving cerebral ischemia |
| US4737493A (en) | 1985-07-01 | 1988-04-12 | Warner-Lambert Company | 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents |
| US4876269A (en) * | 1986-09-10 | 1989-10-24 | E. I. Du Pont De Nemours And Company | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
| US5043350A (en) * | 1986-09-10 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Benzo-fused cycloalkane and oxa- and thia-, cycloalkane trans-1,2-diamine derivatives |
| MY101368A (en) * | 1986-09-10 | 1991-09-05 | Bristol Myers Squibb Pharma Company | Benzo-fused cyclaolkane and oxa-and thai,cycloalkane trans-1, 2-daimine derivatives |
| FR2608598B1 (fr) * | 1986-12-23 | 1989-04-14 | Roussel Uclaf | Nouveaux derives de l'indane, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
| US5051428A (en) * | 1988-12-06 | 1991-09-24 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
| US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
| US5506257A (en) * | 1992-03-26 | 1996-04-09 | University Of British Columbia | Aminocyclohexylamides for antiarrhythmic and anaesthetic uses |
| ATE211135T1 (de) * | 1993-09-24 | 2002-01-15 | Univ British Columbia | Aminocyclohexylester und ihre anwendung |
| US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5763445A (en) * | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| USRE38133E1 (en) * | 1996-03-08 | 2003-06-03 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6750216B2 (en) * | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6057323A (en) * | 1996-03-08 | 2000-05-02 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5688955A (en) * | 1996-03-08 | 1997-11-18 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6303611B1 (en) | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| WO1998049141A1 (en) * | 1997-04-30 | 1998-11-05 | Warner-Lambert Company | Kappa opioid agonists |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| MXPA99011298A (es) * | 1997-07-14 | 2004-10-28 | Adolor Corp | Formulaciones farmaceuticas antiprurito de agonista kappa y metodo para tratar prurito con las mismas. |
| US6852713B2 (en) * | 2003-04-16 | 2005-02-08 | Adolor Corporation | Lactam derivatives and methods of their use |
| US6992193B2 (en) | 2003-06-10 | 2006-01-31 | Adolor Corporation | Sulfonylamino phenylacetamide derivatives and methods of their use |
| US7034051B2 (en) * | 2003-08-28 | 2006-04-25 | Adolor Corporation | Fused bicyclic carboxamide derivatives and methods of their use |
| US7160902B2 (en) * | 2003-11-14 | 2007-01-09 | Adolor Corporation | Amide derivatives and methods of their use |
| USD540702S1 (en) * | 2004-12-13 | 2007-04-17 | Euro-Celtique S.A. | Analog scale for measuring pain |
| MY145694A (en) * | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
| MY158766A (en) * | 2005-04-11 | 2016-11-15 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| AR053713A1 (es) * | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
| JP2010522690A (ja) * | 2006-10-12 | 2010-07-08 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 三環式スピロオキシインドール誘導体および治療薬としてのその使用 |
| CL2007002953A1 (es) * | 2006-10-12 | 2008-02-01 | Xenon Pharmaceuticals Inc | Compuestos derivados de espiro-oxindol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del dolor, cancer, prurito, hiperplasia prostatica benigna, hipercolesterolemia. |
| ATE545416T1 (de) * | 2006-10-12 | 2012-03-15 | Xenon Pharmaceuticals Inc | Verwendung von spiro-oxindol-verbindungen als therapeutika |
| EP2020413A1 (de) | 2007-08-02 | 2009-02-04 | Bayer CropScience AG | Oxaspirocyclische-spiro-substituierte Tetram- und Tetronsäure-Derivate |
| HRP20150882T1 (hr) | 2008-10-17 | 2015-09-25 | Xenon Pharmaceuticals Inc. | Spirooksindolski spojevi i njihova upotreba kao terapijska sredstva |
| WO2010045197A1 (en) * | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| MY165579A (en) * | 2009-10-14 | 2018-04-05 | Xenon Pharmaceuticals Inc | Synthetic methods for spiro-oxindole compounds |
| US20110086899A1 (en) * | 2009-10-14 | 2011-04-14 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| JP2013521232A (ja) | 2010-02-26 | 2013-06-10 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 局所投与のためのスピロオキシインドール化合物の医薬組成物および治療剤としてのその使用 |
| EP2621902B1 (en) | 2010-09-28 | 2017-04-12 | Panacea Biotec Ltd | 3-azabicyclo[3.1.0]hexane compounds useful for the treatment of cns disorders |
| TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
| US10343991B2 (en) | 2016-11-02 | 2019-07-09 | Council Of Scientific & Industrial Research | C5, C6 substituted and/or fused oxindoles as anti-cancer agents and process for preparation thereof |
| JP7734917B2 (ja) | 2019-01-28 | 2025-09-08 | ミトコンドリア エモーション， インク． | トランス－４－ヒドロキシシクロヘキシルフェニルアミドマイトフュージン活性化物質及びその使用方法 |
| JP7473565B2 (ja) | 2019-01-28 | 2024-04-23 | ミトコンドリア エモーション， インク． | マイトフュージン活性化物質及びその使用方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065573A (en) | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
| US4145435A (en) | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
| US4098904A (en) | 1976-11-12 | 1978-07-04 | The Upjohn Company | Analgesic n-(2-aminocycloaliphatic)benzamides |
| US4212878A (en) | 1978-01-26 | 1980-07-15 | The Upjohn Company | Phenylacetamide derivative analgesics |
| GB2096607B (en) * | 1981-04-09 | 1985-02-27 | Upjohn Co | Aminocycloalkyl amides |
-
1982
- 1982-06-21 US US06/390,462 patent/US4438130A/en not_active Expired - Lifetime
- 1982-09-28 AU AU88792/82A patent/AU552467B2/en not_active Ceased
- 1982-10-05 CA CA000412863A patent/CA1187082A/en not_active Expired
- 1982-10-05 NZ NZ202086A patent/NZ202086A/en unknown
- 1982-10-25 MX MX194919A patent/MX157171A/es unknown
- 1982-11-04 NL NL8204279A patent/NL8204279A/nl unknown
- 1982-11-05 KR KR8204989A patent/KR890000385B1/ko not_active Expired
- 1982-11-05 ES ES517166A patent/ES8404342A1/es not_active Expired
- 1982-11-10 FR FR8218888A patent/FR2518095B1/fr not_active Expired
- 1982-11-10 PH PH28120A patent/PH17634A/en unknown
- 1982-11-10 SE SE8206386A patent/SE453501B/sv not_active IP Right Cessation
- 1982-11-11 IT IT24200/82A patent/IT1154574B/it active
- 1982-11-11 GB GB08232210A patent/GB2111488B/en not_active Expired
- 1982-11-11 GR GR69789A patent/GR77790B/el unknown
- 1982-11-12 DE DE19823241933 patent/DE3241933A1/de not_active Withdrawn
- 1982-11-12 CH CH6620/82A patent/CH652718A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE453501B (sv) | 1988-02-08 |
| SE8206386D0 (sv) | 1982-11-10 |
| IT8224200A0 (it) | 1982-11-11 |
| IT1154574B (it) | 1987-01-21 |
| GB2111488A (en) | 1983-07-06 |
| CA1187082A (en) | 1985-05-14 |
| CH652718A5 (de) | 1985-11-29 |
| US4438130A (en) | 1984-03-20 |
| NL8204279A (nl) | 1983-06-01 |
| KR840002376A (ko) | 1984-06-25 |
| AU8879282A (en) | 1983-05-19 |
| ES517166A0 (es) | 1984-05-01 |
| DE3241933A1 (de) | 1983-05-26 |
| GR77790B (enExample) | 1984-09-25 |
| ES8404342A1 (es) | 1984-05-01 |
| PH17634A (en) | 1984-10-18 |
| MX157171A (es) | 1988-10-31 |
| IT8224200A1 (it) | 1984-05-11 |
| AU552467B2 (en) | 1986-06-05 |
| FR2518095B1 (fr) | 1986-01-10 |
| NZ202086A (en) | 1986-01-24 |
| GB2111488B (en) | 1985-11-06 |
| SE8206386L (sv) | 1983-05-13 |
| FR2518095A1 (fr) | 1983-06-17 |
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