MX157171A - Procedimiento para preparar compuestos 1-oxa,aza-y tia-espirociclos - Google Patents
Procedimiento para preparar compuestos 1-oxa,aza-y tia-espirociclosInfo
- Publication number
- MX157171A MX157171A MX194919A MX19491982A MX157171A MX 157171 A MX157171 A MX 157171A MX 194919 A MX194919 A MX 194919A MX 19491982 A MX19491982 A MX 19491982A MX 157171 A MX157171 A MX 157171A
- Authority
- MX
- Mexico
- Prior art keywords
- spyrocicles
- aunt
- aza
- oxa
- procedure
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
- C07C29/19—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds in six-membered aromatic rings
- C07C29/20—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds in six-membered aromatic rings in a non-condensed rings substituted with hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/05—Alcohols containing rings other than six-membered aromatic rings
- C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32063581A | 1981-11-12 | 1981-11-12 | |
| US06/390,462 US4438130A (en) | 1981-11-12 | 1982-06-21 | Analgesic 1-oxa-, aza- and thia-spirocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX157171A true MX157171A (es) | 1988-10-31 |
Family
ID=26982582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX194919A MX157171A (es) | 1981-11-12 | 1982-10-25 | Procedimiento para preparar compuestos 1-oxa,aza-y tia-espirociclos |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4438130A (es) |
| KR (1) | KR890000385B1 (es) |
| AU (1) | AU552467B2 (es) |
| CA (1) | CA1187082A (es) |
| CH (1) | CH652718A5 (es) |
| DE (1) | DE3241933A1 (es) |
| ES (1) | ES8404342A1 (es) |
| FR (1) | FR2518095B1 (es) |
| GB (1) | GB2111488B (es) |
| GR (1) | GR77790B (es) |
| IT (1) | IT1154574B (es) |
| MX (1) | MX157171A (es) |
| NL (1) | NL8204279A (es) |
| NZ (1) | NZ202086A (es) |
| PH (1) | PH17634A (es) |
| SE (1) | SE453501B (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4598088A (en) * | 1983-05-18 | 1986-07-01 | The Upjohn Company | 2-pyrrolyl-cycloalkyl-amide analgesics |
| US4560767A (en) * | 1983-06-17 | 1985-12-24 | The Upjohn Company | N-(2-amino-cycloalkenyl)benzeneacetamide and -benzamide analgesics and tritiated kappa agonists therefrom |
| US4588591A (en) * | 1984-05-25 | 1986-05-13 | The Upjohn Company | Analgesic 2-oxa-spirocyclic compounds |
| US4632935A (en) * | 1984-05-30 | 1986-12-30 | The Upjohn Company | Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and cycloalkenyl amides as analgesics |
| US4618621A (en) * | 1984-09-21 | 1986-10-21 | The Upjohn Company | Method for treating medical conditions involving cerebral ischemia |
| US4737493A (en) | 1985-07-01 | 1988-04-12 | Warner-Lambert Company | 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents |
| US4876269A (en) * | 1986-09-10 | 1989-10-24 | E. I. Du Pont De Nemours And Company | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
| MY101368A (en) * | 1986-09-10 | 1991-09-05 | Bristol Myers Squibb Pharma Company | Benzo-fused cyclaolkane and oxa-and thai,cycloalkane trans-1, 2-daimine derivatives |
| US5043350A (en) * | 1986-09-10 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Benzo-fused cycloalkane and oxa- and thia-, cycloalkane trans-1,2-diamine derivatives |
| FR2608598B1 (fr) * | 1986-12-23 | 1989-04-14 | Roussel Uclaf | Nouveaux derives de l'indane, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
| US5051428A (en) * | 1988-12-06 | 1991-09-24 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
| US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
| US5506257A (en) * | 1992-03-26 | 1996-04-09 | University Of British Columbia | Aminocyclohexylamides for antiarrhythmic and anaesthetic uses |
| DE69429524T2 (de) * | 1993-09-24 | 2002-08-08 | The University Of British Columbia, Vancouver | Aminocyclohexylester und ihre anwendung |
| US6057323A (en) * | 1996-03-08 | 2000-05-02 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6750216B2 (en) * | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5763445A (en) * | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6303611B1 (en) | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| USRE38133E1 (en) * | 1996-03-08 | 2003-06-03 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5688955A (en) * | 1996-03-08 | 1997-11-18 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| AU7133098A (en) * | 1997-04-30 | 1998-11-24 | Warner-Lambert Company | Kappa opioid agonists |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| JP2003526594A (ja) * | 1997-07-14 | 2003-09-09 | アドラー コーポレーション | カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法 |
| US6852713B2 (en) * | 2003-04-16 | 2005-02-08 | Adolor Corporation | Lactam derivatives and methods of their use |
| US6992193B2 (en) | 2003-06-10 | 2006-01-31 | Adolor Corporation | Sulfonylamino phenylacetamide derivatives and methods of their use |
| US7034051B2 (en) * | 2003-08-28 | 2006-04-25 | Adolor Corporation | Fused bicyclic carboxamide derivatives and methods of their use |
| US7160902B2 (en) * | 2003-11-14 | 2007-01-09 | Adolor Corporation | Amide derivatives and methods of their use |
| USD540702S1 (en) * | 2004-12-13 | 2007-04-17 | Euro-Celtique S.A. | Analog scale for measuring pain |
| MY145694A (en) * | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
| MY158766A (en) * | 2005-04-11 | 2016-11-15 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| AR053713A1 (es) * | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
| CN103271906A (zh) * | 2006-10-12 | 2013-09-04 | 泽农医药公司 | 螺-吲哚酮化合物作为治疗剂的用途 |
| MX2009003874A (es) * | 2006-10-12 | 2009-04-22 | Xenon Pharmaceuticals Inc | Derivados de espiro-oxindol triciclicos y sus usos como agentes terapeuticos. |
| US20110294842A9 (en) * | 2006-10-12 | 2011-12-01 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
| EP2020413A1 (de) | 2007-08-02 | 2009-02-04 | Bayer CropScience AG | Oxaspirocyclische-spiro-substituierte Tetram- und Tetronsäure-Derivate |
| WO2010045197A1 (en) * | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| NZ592275A (en) | 2008-10-17 | 2013-04-26 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their use as therapeutic agents |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| WO2011047173A2 (en) * | 2009-10-14 | 2011-04-21 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| MY165579A (en) | 2009-10-14 | 2018-04-05 | Xenon Pharmaceuticals Inc | Synthetic methods for spiro-oxindole compounds |
| CN105726531A (zh) | 2010-02-26 | 2016-07-06 | 泽农医药公司 | 用于局部给药的螺-羟吲哚化合物的药物组合物及其作为治疗剂的用途 |
| JP2013542929A (ja) | 2010-09-28 | 2013-11-28 | パナセア バイオテック リミテッド | 新規ビシクロ環化合物 |
| TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
| US10343991B2 (en) | 2016-11-02 | 2019-07-09 | Council Of Scientific & Industrial Research | C5, C6 substituted and/or fused oxindoles as anti-cancer agents and process for preparation thereof |
| JP2022523702A (ja) | 2019-01-28 | 2022-04-26 | ミトコンドリア エモーション， インク． | トランス－４－ヒドロキシシクロヘキシルフェニルアミドマイトフュージン活性化物質及びその使用方法 |
| EP3917508A4 (en) | 2019-01-28 | 2022-12-21 | Mitochondria Emotion, Inc. | EAAT2 ACTIVATORS AND METHODS OF USE THEREOF |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
| GB2096607B (en) * | 1981-04-09 | 1985-02-27 | Upjohn Co | Aminocycloalkyl amides |
-
1982
- 1982-06-21 US US06/390,462 patent/US4438130A/en not_active Expired - Lifetime
- 1982-09-28 AU AU88792/82A patent/AU552467B2/en not_active Ceased
- 1982-10-05 NZ NZ202086A patent/NZ202086A/en unknown
- 1982-10-05 CA CA000412863A patent/CA1187082A/en not_active Expired
- 1982-10-25 MX MX194919A patent/MX157171A/es unknown
- 1982-11-04 NL NL8204279A patent/NL8204279A/nl unknown
- 1982-11-05 ES ES517166A patent/ES8404342A1/es not_active Expired
- 1982-11-05 KR KR8204989A patent/KR890000385B1/ko active
- 1982-11-10 PH PH28120A patent/PH17634A/en unknown
- 1982-11-10 FR FR8218888A patent/FR2518095B1/fr not_active Expired
- 1982-11-10 SE SE8206386A patent/SE453501B/sv not_active IP Right Cessation
- 1982-11-11 GB GB08232210A patent/GB2111488B/en not_active Expired
- 1982-11-11 IT IT24200/82A patent/IT1154574B/it active
- 1982-11-11 GR GR69789A patent/GR77790B/el unknown
- 1982-11-12 DE DE19823241933 patent/DE3241933A1/de not_active Withdrawn
- 1982-11-12 CH CH6620/82A patent/CH652718A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL8204279A (nl) | 1983-06-01 |
| GB2111488A (en) | 1983-07-06 |
| ES517166A0 (es) | 1984-05-01 |
| SE8206386L (sv) | 1983-05-13 |
| FR2518095A1 (fr) | 1983-06-17 |
| IT1154574B (it) | 1987-01-21 |
| FR2518095B1 (fr) | 1986-01-10 |
| AU552467B2 (en) | 1986-06-05 |
| NZ202086A (en) | 1986-01-24 |
| CH652718A5 (de) | 1985-11-29 |
| SE8206386D0 (sv) | 1982-11-10 |
| GR77790B (es) | 1984-09-25 |
| IT8224200A0 (it) | 1982-11-11 |
| SE453501B (sv) | 1988-02-08 |
| PH17634A (en) | 1984-10-18 |
| AU8879282A (en) | 1983-05-19 |
| US4438130A (en) | 1984-03-20 |
| CA1187082A (en) | 1985-05-14 |
| KR890000385B1 (ko) | 1989-03-16 |
| GB2111488B (en) | 1985-11-06 |
| KR840002376A (ko) | 1984-06-25 |
| ES8404342A1 (es) | 1984-05-01 |
| DE3241933A1 (de) | 1983-05-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX157171A (es) | Procedimiento para preparar compuestos 1-oxa,aza-y tia-espirociclos | |
| MX8481A (es) | Procedimiento para preparar compuestos de carboestirilo. | |
| ES507715A0 (es) | Procedimiento para preparar derivados de 1-sulfo-2-oxoazetidina . | |
| ES514016A0 (es) | Procedimiento para preparar derivados de n-fenilpirazol. | |
| ES507493A0 (es) | Procedimiento de preparar compuestos benzoheterociclicos. | |
| ES507126A0 (es) | Procedimiento para preparar derivados de piridona. | |
| ES516154A0 (es) | Procedimiento para preparar polipeptidos. | |
| ES514796A0 (es) | Procedimiento para preparar compuestos tetrakisazoicos. | |
| ES507545A0 (es) | Procedimiento de preparar compuestos carbostirilicos. | |
| ES523733A0 (es) | Procedimiento para preparar acilanilidas. | |
| ES519709A0 (es) | Procedimiento para preparar derivados de ciclohexeno-1,2-diona 5-aril-sustituidos. | |
| ES512295A0 (es) | Procedimiento para preparar derivados de piridina. | |
| MX158200A (es) | Procedimiento para preparar dimetileter | |
| ES509044A0 (es) | Procedimiento para preparar derivados de fenilsulfonilurea sustituidos. | |
| ES510258A0 (es) | Procedimiento para preparar derivados de quanadina. | |
| ES517333A0 (es) | Procedimientos para preparar derivados piridazinona. | |
| ES506842A0 (es) | Procedimiento para preparar derivados 3-aminopropoxifenili- cos. | |
| AR226634A1 (es) | Procedimiento para preparar cligolaldehido | |
| ES519961A0 (es) | Procedimiento de preparar compuestos piridinicos. | |
| MX6975E (es) | Procedimiento para preparar s,s-dialquil-fosforoditioatos de o-alquilo | |
| ES527945A0 (es) | Procedimiento para preparar derivados de bencilcarbamoilpiridina. | |
| ES511317A0 (es) | Procedimiento para preparar derivados de imidazol. | |
| ES509734A0 (es) | Procedimiento para preparar derivados de benzotiadiazol-amina. | |
| ES525333A0 (es) | Procedimiento para preparar derivados de sulfamoilbenzofenona. | |
| ES517646A0 (es) | Procedimiento para preparar nuevos compuestos anti-helminticos. |