FR2518095B1 - Nouveaux l-oxa-, thia- et aza-spirocyclo-benzene-acetamides et benzamides, leur procede de preparation et composition pharmaceutique les contenant - Google Patents

Nouveaux l-oxa-, thia- et aza-spirocyclo-benzene-acetamides et benzamides, leur procede de preparation et composition pharmaceutique les contenant

Info

Publication number
FR2518095B1
FR2518095B1 FR8218888A FR8218888A FR2518095B1 FR 2518095 B1 FR2518095 B1 FR 2518095B1 FR 8218888 A FR8218888 A FR 8218888A FR 8218888 A FR8218888 A FR 8218888A FR 2518095 B1 FR2518095 B1 FR 2518095B1
Authority
FR
France
Prior art keywords
spirocyclo
acetamides
benzamides
thia
aza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8218888A
Other languages
English (en)
French (fr)
Other versions
FR2518095A1 (fr
Inventor
Lester Jay Kaplan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2518095A1 publication Critical patent/FR2518095A1/fr
Application granted granted Critical
Publication of FR2518095B1 publication Critical patent/FR2518095B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
    • C07C29/19—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds in six-membered aromatic rings
    • C07C29/20—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds in six-membered aromatic rings in a non-condensed rings substituted with hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
FR8218888A 1981-11-12 1982-11-10 Nouveaux l-oxa-, thia- et aza-spirocyclo-benzene-acetamides et benzamides, leur procede de preparation et composition pharmaceutique les contenant Expired FR2518095B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32063581A 1981-11-12 1981-11-12
US06/390,462 US4438130A (en) 1981-11-12 1982-06-21 Analgesic 1-oxa-, aza- and thia-spirocyclic compounds

Publications (2)

Publication Number Publication Date
FR2518095A1 FR2518095A1 (fr) 1983-06-17
FR2518095B1 true FR2518095B1 (fr) 1986-01-10

Family

ID=26982582

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8218888A Expired FR2518095B1 (fr) 1981-11-12 1982-11-10 Nouveaux l-oxa-, thia- et aza-spirocyclo-benzene-acetamides et benzamides, leur procede de preparation et composition pharmaceutique les contenant

Country Status (16)

Country Link
US (1) US4438130A (enExample)
KR (1) KR890000385B1 (enExample)
AU (1) AU552467B2 (enExample)
CA (1) CA1187082A (enExample)
CH (1) CH652718A5 (enExample)
DE (1) DE3241933A1 (enExample)
ES (1) ES8404342A1 (enExample)
FR (1) FR2518095B1 (enExample)
GB (1) GB2111488B (enExample)
GR (1) GR77790B (enExample)
IT (1) IT1154574B (enExample)
MX (1) MX157171A (enExample)
NL (1) NL8204279A (enExample)
NZ (1) NZ202086A (enExample)
PH (1) PH17634A (enExample)
SE (1) SE453501B (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598088A (en) * 1983-05-18 1986-07-01 The Upjohn Company 2-pyrrolyl-cycloalkyl-amide analgesics
US4560767A (en) * 1983-06-17 1985-12-24 The Upjohn Company N-(2-amino-cycloalkenyl)benzeneacetamide and -benzamide analgesics and tritiated kappa agonists therefrom
US4588591A (en) * 1984-05-25 1986-05-13 The Upjohn Company Analgesic 2-oxa-spirocyclic compounds
US4632935A (en) * 1984-05-30 1986-12-30 The Upjohn Company Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and cycloalkenyl amides as analgesics
US4618621A (en) * 1984-09-21 1986-10-21 The Upjohn Company Method for treating medical conditions involving cerebral ischemia
US4737493A (en) 1985-07-01 1988-04-12 Warner-Lambert Company 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents
US4876269A (en) * 1986-09-10 1989-10-24 E. I. Du Pont De Nemours And Company Benoz-fused cycloalkane trans-1,2-diamine derivatives
US5010085A (en) * 1986-09-10 1991-04-23 E. I. Du Pont De Nemours And Company Benzo-fused cycloalkane and oxa- and thia-cycloalkane trans-1,2-diamine derivatives
ZA876778B (en) * 1986-09-10 1989-05-30 Du Pont Benzo-fused cycloalkane and oxa-and thia-,cycloalkane trans-1,2-diamine derivatives
FR2608598B1 (fr) * 1986-12-23 1989-04-14 Roussel Uclaf Nouveaux derives de l'indane, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant
US5051428A (en) * 1988-12-06 1991-09-24 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
US5506257A (en) * 1992-03-26 1996-04-09 University Of British Columbia Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
ATE211135T1 (de) * 1993-09-24 2002-01-15 Univ British Columbia Aminocyclohexylester und ihre anwendung
US6303611B1 (en) 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6057323A (en) * 1996-03-08 2000-05-02 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
USRE38133E1 (en) * 1996-03-08 2003-06-03 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5688955A (en) * 1996-03-08 1997-11-18 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6750216B2 (en) * 1996-03-08 2004-06-15 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6133307A (en) * 1997-04-30 2000-10-17 Warner-Lambert Company Certain benzofuranyl-N-[pyrrolidin-1-YL]-N-methyl-acetamide derivatives useful as opioid agonists
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
NZ500438A (en) * 1997-07-14 2001-11-30 Adolor Corp Compositions containing a compound having kappa opioid agonist activity for treatment of pruritis (itchiness)
US6852713B2 (en) * 2003-04-16 2005-02-08 Adolor Corporation Lactam derivatives and methods of their use
US6992193B2 (en) 2003-06-10 2006-01-31 Adolor Corporation Sulfonylamino phenylacetamide derivatives and methods of their use
US7034051B2 (en) * 2003-08-28 2006-04-25 Adolor Corporation Fused bicyclic carboxamide derivatives and methods of their use
US7160902B2 (en) * 2003-11-14 2007-01-09 Adolor Corporation Amide derivatives and methods of their use
USD540702S1 (en) * 2004-12-13 2007-04-17 Euro-Celtique S.A. Analog scale for measuring pain
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
AR053713A1 (es) * 2005-04-20 2007-05-16 Xenon Pharmaceuticals Inc Compuestos heterociclicos y sus usos como agentes terapeuticos
CL2007002950A1 (es) * 2006-10-12 2008-02-01 Xenon Pharmaceuticals Inc Uso de compuestos derivados de espiro-oxindol en el tratamiento de hipercolesterolemia, hiperplasia benigna de prostata, pruritis, cancer
BRPI0719857A2 (pt) * 2006-10-12 2014-06-03 Xenon Pharmaceuticals Inc Compostos espiro-oxindol úteis no tratamento de doenças ou condições mediadas por canal de sódio.
MX2009003874A (es) * 2006-10-12 2009-04-22 Xenon Pharmaceuticals Inc Derivados de espiro-oxindol triciclicos y sus usos como agentes terapeuticos.
EP2020413A1 (de) 2007-08-02 2009-02-04 Bayer CropScience AG Oxaspirocyclische-spiro-substituierte Tetram- und Tetronsäure-Derivate
US8101647B2 (en) * 2008-10-17 2012-01-24 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
CN105175433A (zh) * 2008-10-17 2015-12-23 泽农医药公司 螺羟吲哚化合物及其作为治疗剂的用途
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
PH12012500726A1 (en) 2009-10-14 2019-07-10 Xenon Pharmaceuticals Inc Synthetic methods for spiro-oxindole compounds
RU2596488C2 (ru) 2010-02-26 2016-09-10 Ксенон Фармасьютикалз Инк. Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов
EP2621902B1 (en) 2010-09-28 2017-04-12 Panacea Biotec Ltd 3-azabicyclo[3.1.0]hexane compounds useful for the treatment of cns disorders
US9682033B2 (en) 2015-02-05 2017-06-20 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
US10343991B2 (en) 2016-11-02 2019-07-09 Council Of Scientific & Industrial Research C5, C6 substituted and/or fused oxindoles as anti-cancer agents and process for preparation thereof
CA3127453A1 (en) 2019-01-28 2020-08-06 Mitochondria Emotion, Inc. Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof
EP3917508A4 (en) 2019-01-28 2022-12-21 Mitochondria Emotion, Inc. EAAT2 ACTIVATORS AND METHODS OF USE THEREOF

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065573A (en) 1976-06-03 1977-12-27 The Upjohn Company 4-Amino-4-phenylcyclohexanone ketal compositions and process of use
US4098904A (en) 1976-11-12 1978-07-04 The Upjohn Company Analgesic n-(2-aminocycloaliphatic)benzamides
US4145435A (en) 1976-11-12 1979-03-20 The Upjohn Company 2-aminocycloaliphatic amide compounds
US4212878A (en) 1978-01-26 1980-07-15 The Upjohn Company Phenylacetamide derivative analgesics
GB2096607B (en) * 1981-04-09 1985-02-27 Upjohn Co Aminocycloalkyl amides

Also Published As

Publication number Publication date
NL8204279A (nl) 1983-06-01
FR2518095A1 (fr) 1983-06-17
PH17634A (en) 1984-10-18
DE3241933A1 (de) 1983-05-26
GR77790B (enExample) 1984-09-25
US4438130A (en) 1984-03-20
AU552467B2 (en) 1986-06-05
SE453501B (sv) 1988-02-08
IT8224200A1 (it) 1984-05-11
KR890000385B1 (ko) 1989-03-16
CH652718A5 (de) 1985-11-29
GB2111488A (en) 1983-07-06
MX157171A (es) 1988-10-31
AU8879282A (en) 1983-05-19
SE8206386D0 (sv) 1982-11-10
SE8206386L (sv) 1983-05-13
GB2111488B (en) 1985-11-06
CA1187082A (en) 1985-05-14
IT1154574B (it) 1987-01-21
KR840002376A (ko) 1984-06-25
ES517166A0 (es) 1984-05-01
IT8224200A0 (it) 1982-11-11
ES8404342A1 (es) 1984-05-01
NZ202086A (en) 1986-01-24

Similar Documents

Publication Publication Date Title
FR2518095B1 (fr) Nouveaux l-oxa-, thia- et aza-spirocyclo-benzene-acetamides et benzamides, leur procede de preparation et composition pharmaceutique les contenant
FR2505835B1 (fr) Nouvelles 1,2-diaminocyclobutene-3,4-diones, leur procede de preparation et composition pharmaceutique les contenant
BE882113A (fr) Nouveaux 3-(1-imidazolylalkyl) indoles, leur procede de production et composition pharmaceutique les contenant
FR2495154B1 (fr) 5'-aminoalkyl-4', 4, 8-trialkylpsoralenes, leur procede de production et composition pharmaceutique les contenant
BE885269A (fr) Nouveaux tensio-actifs non ioniques, leur procede de preparation et composition les contenant
FR2510572B1 (fr) Nouvelles thiazolidinediones, leur procede de production et preparation pharmaceutique les contenant
BE868173A (fr) Nouveaux hexahydro-1-hydroxy-9-hydroxymethyl-6h-dibenzo-(b,d)pyranes substitues en position 3, leur procede de preparation et composition pharmaceutique les contenant
FR2522324B1 (fr) Pyrrole-acetamides, leur procede de preparation et composition therapeutique les contenant
BE885268A (fr) Nouveaux n-propionyl-sarcosine-anilides, procede pour leur preparation et medicaments les contenant
FR2567519B1 (fr) Nouvelles isoindolinyl-alcoyl-piperazines, compositions pharmaceutiques les contenant, et leur procede de preparation
BE892552A (fr) Nouveaux amido-aminoacides, compositions pharmaceutiques les contenant et procede de preparation de ces amido-aminoacides
BE885156A (fr) Psoralenes, leur procede de preparation et compositions pharmaceutiques les contenant
FR2286643A1 (fr) Nouveaux triiodocarbanilates, leur procede de preparation et composition pharmaceutique les contenant
LU79684A1 (fr) Nouveaux trans-5-aryl-2,3,4a,5,9b-hexahydro-1h-pyrido(4,3-b)indoles,leur procede de preparation et composition pharmaceutique les contenant
BE884083A (fr) Nouveaux oxime-ethers, leur procede de preparation et compositions pharmaceutiques les contenant
FR2510575B1 (fr) Nouveaux composes bicycliques, leur procede de preparation et composition pharmaceutique les renfermant
BE884620A (fr) Nouveaux derives d'halovincamone, leur procede de preparation et medicaments les contenant
FR2303559A1 (fr) Nouveaux derives d'histidine, leur procede de preparation et composition pharmaceutique les contenant
BE889990A (fr) Nouveaux composes cytostatiques, leur procede de preparation et composition pharmaceutique les contenant
FR2601951B1 (fr) Nouvelles tetrahydrocarbazolones, composition pharmaceutique les contenant et leur procede de preparation
FR2503161B1 (fr) Nouvelles fluoroprostacyclines, leur preparation et leur application pharmaceutique
FR2513994B1 (fr) Tripeptides anorexigenes, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2551440B1 (fr) Aminocyclopentanes, leur procede de preparation et compositions pharmaceutiques les contenant
FR2517672B1 (fr) Thioalcanoyl-carnitines, procede pour leur preparation et composition pharmaceutique les contenant
LU79600A1 (fr) Nouveaux derives de phenylglycine,leur procede de preparation et composition pharmaceutique les contenant

Legal Events

Date Code Title Description
ST Notification of lapse