KR880008808A - 비경구투여용 현탁액 - Google Patents
비경구투여용 현탁액 Download PDFInfo
- Publication number
- KR880008808A KR880008808A KR1019880000740A KR880000740A KR880008808A KR 880008808 A KR880008808 A KR 880008808A KR 1019880000740 A KR1019880000740 A KR 1019880000740A KR 880000740 A KR880000740 A KR 880000740A KR 880008808 A KR880008808 A KR 880008808A
- Authority
- KR
- South Korea
- Prior art keywords
- anhydrous
- diclofenac
- salt
- pharmaceutically acceptable
- finely divided
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- 디클로페낙(diclofenac)의 약제학적으로 허용되고 미분된(micronised)염 및 임의의 약제학적으로 허용되는 보조제를 함유하는, 염 형태인 디클로페낙의 안정한 수성 현탁액을 제조하기 위한 무수제형.
- 제1항에 있어서, 동결건조에 의해 수득 가능한 무수제형.
- 제1항 또는 제2항에 있어서, 평균입자 크기가 50㎛미만인 디클로페낙 염을 함유하는 무수제형
- 제3항에 있어서, 평균입자 크기가 20㎛미만인 디클로페낙나염을 함유하는 무수제형.
- 제3항에 있어서, 평균입자가 크기가 20㎛미만인 디클로페낙나트륨을 함유하는 무수제형.
- 임의의 약제학적으로 허용되는 보조제를 함유하는 현탁매질중에 미분된 형태의 디클로페탁염을 현탁시키고, 상기 현탁매질을 제거함을 특징으로 하여, 제1항 내지 4항중 어느 한 항에 따른 무수제형을 제조하는 방법.
- 제6항에 있어서, 등장 성분을 함유하는 수성 현탁 매질중에 미분된 형태의 디클로페낙염을 현탁시키고, 물을 제거함을 특징으로 하는 방법.
- 제6항에 있어서, 인지질을 함유하는 유기 현탁매질중에 미분된 형태의 디클로페낙염을 현탁시키고, 용매를 제거함을 특징으로하는 방법.
- 비경구 투여용 수성 현탁액을 제조하기 위한, 디클로페낙의 약제학적으로 허용되고 미분된 염 및 약제학적으로 허용되는 보조제를 함유하는 제1항 내지 5항중 어느 한 항에 따른 무수제형의 용도.
- 인체 또는 동물체를 치료하는 방법에 사용하기 위한 제1항 내지 5항중 어느 한 항에 따른 무수제형.
- 염증성 질환을 치료하기 위한 제1항 내지 5항중 어느 한 항에 따른 무수제형※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH350/87A CH673395A5 (ko) | 1987-01-30 | 1987-01-30 | |
CH350/87-4 | 1987-01-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR880008808A true KR880008808A (ko) | 1988-09-13 |
Family
ID=4185019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880000740A KR880008808A (ko) | 1987-01-30 | 1988-01-29 | 비경구투여용 현탁액 |
Country Status (26)
Country | Link |
---|---|
JP (1) | JPS63192716A (ko) |
KR (1) | KR880008808A (ko) |
AT (1) | AT397460B (ko) |
AU (1) | AU612343B2 (ko) |
BE (1) | BE1000442A4 (ko) |
CA (1) | CA1305058C (ko) |
CH (1) | CH673395A5 (ko) |
DE (1) | DE3802357A1 (ko) |
DK (1) | DK45588A (ko) |
ES (1) | ES2008420A6 (ko) |
FI (1) | FI880368A (ko) |
FR (1) | FR2611498B1 (ko) |
GB (1) | GB2201089B (ko) |
GR (1) | GR880100041A (ko) |
IE (1) | IE60453B1 (ko) |
IT (1) | IT1224241B (ko) |
LU (1) | LU87115A1 (ko) |
MY (1) | MY102662A (ko) |
NL (1) | NL8800231A (ko) |
NO (1) | NO880403L (ko) |
NZ (1) | NZ223343A (ko) |
PH (1) | PH23652A (ko) |
PT (1) | PT86644B (ko) |
SE (1) | SE8800228L (ko) |
YU (1) | YU15488A (ko) |
ZA (1) | ZA88638B (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH675537A5 (ko) * | 1988-03-25 | 1990-10-15 | Ciba Geigy Ag | |
MX9201782A (es) * | 1991-04-19 | 1992-10-01 | Sandoz Ag | Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene. |
DE4140184C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Akutform für ein Flurbiprofen enthaltendes Arzneimittel |
DE4140185C2 (de) * | 1991-12-05 | 1996-02-01 | Alfatec Pharma Gmbh | Ein 2-Arylpropionsäurederivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung |
DE4140183C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Retardform für ein Flurbiprofen enthaltendes Arzneimittel |
GB9212450D0 (en) * | 1992-06-11 | 1992-07-22 | Indena Spa | New derivatives of non-steroidal anti-inflammatory,analgesic and/or antipyretic substances,their use and pharmaceutical formulations containing them |
ZA949182B (en) * | 1993-12-02 | 1995-07-26 | South African Druggists Ltd | Pharmaceutical composition |
US6447806B1 (en) | 1999-02-25 | 2002-09-10 | Novartis Ag | Pharmaceutical compositions comprised of stabilized peptide particles |
FR2793418B1 (fr) * | 1999-05-11 | 2001-07-27 | Synthelabo | Formulations galeniques d'agents antithrombotiques pour administration sous-cutanee |
GB0207529D0 (en) * | 2002-04-02 | 2002-05-08 | Norbrook Lab Ltd | Injectable veterinary composition for small animals |
JO3352B1 (ar) * | 2005-06-17 | 2019-03-13 | Apr Applied Pharma Res Sa | صيغ دايكلوفيناك وطرق استخدامه |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1373913A (en) * | 1970-12-17 | 1974-11-13 | Glaxo Lab Ltd | Pharmaceutical compositions |
DE2914788A1 (de) * | 1979-04-11 | 1980-10-16 | Nattermann A & Cie | Parenteral applizierbare, stabile arzneimittelloesungen mit entzuendungshemmender wirkung |
DE3324193A1 (de) * | 1983-07-05 | 1985-01-17 | Troponwerke Gmbh & Co Kg | Depot-antiphlogistika |
DE3328401A1 (de) * | 1983-08-05 | 1985-02-21 | Merckle GmbH, 7902 Blaubeuren | Injizierbare loesung zur behandlung von entzuendungen |
EP0152379A3 (de) * | 1984-02-15 | 1986-10-29 | Ciba-Geigy Ag | Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen enthaltend unilamellare Liposomen |
DE3421468A1 (de) * | 1984-06-08 | 1985-12-19 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US5002940A (en) * | 1984-11-06 | 1991-03-26 | Ciba-Geigy Corporation | Solid drug formulations and stable suspensions |
DE3446873A1 (de) * | 1984-12-21 | 1986-07-10 | Merckle Gmbh | Fluessige diclofenac-zubereitungen |
IT1207994B (it) * | 1986-01-03 | 1989-06-01 | Therapicon Srl | Sali idrosulubili di composti adattivita' antiinfiammatoria ed analgesica, loro preparazione ed utilizzo in composizioni farmaceutiche. |
DE3607339A1 (de) * | 1986-03-06 | 1987-09-10 | Merck Patent Gmbh | Pharmazeutische zubereitung |
-
1987
- 1987-01-30 CH CH350/87A patent/CH673395A5/de not_active IP Right Cessation
-
1988
- 1988-01-19 MY MYPI88000041A patent/MY102662A/en unknown
- 1988-01-25 SE SE8800228A patent/SE8800228L/ not_active Application Discontinuation
- 1988-01-27 DE DE3802357A patent/DE3802357A1/de not_active Ceased
- 1988-01-27 FI FI880368A patent/FI880368A/fi not_active IP Right Cessation
- 1988-01-27 GB GB8801737A patent/GB2201089B/en not_active Expired - Lifetime
- 1988-01-27 YU YU00154/88A patent/YU15488A/xx unknown
- 1988-01-27 PH PH36414A patent/PH23652A/en unknown
- 1988-01-27 LU LU87115A patent/LU87115A1/de unknown
- 1988-01-28 FR FR888800972A patent/FR2611498B1/fr not_active Expired - Lifetime
- 1988-01-28 CA CA000557536A patent/CA1305058C/en not_active Expired - Lifetime
- 1988-01-28 NZ NZ223343A patent/NZ223343A/xx unknown
- 1988-01-28 JP JP63016006A patent/JPS63192716A/ja active Pending
- 1988-01-28 PT PT86644A patent/PT86644B/pt not_active IP Right Cessation
- 1988-01-29 IE IE25088A patent/IE60453B1/en not_active IP Right Cessation
- 1988-01-29 AU AU11102/88A patent/AU612343B2/en not_active Ceased
- 1988-01-29 DK DK045588A patent/DK45588A/da not_active Application Discontinuation
- 1988-01-29 NO NO880403A patent/NO880403L/no unknown
- 1988-01-29 AT AT0018588A patent/AT397460B/de not_active IP Right Cessation
- 1988-01-29 ES ES8800262A patent/ES2008420A6/es not_active Expired
- 1988-01-29 ZA ZA88638A patent/ZA88638B/xx unknown
- 1988-01-29 GR GR880100041A patent/GR880100041A/el unknown
- 1988-01-29 BE BE8800109A patent/BE1000442A4/fr not_active IP Right Cessation
- 1988-01-29 NL NL8800231A patent/NL8800231A/nl not_active Application Discontinuation
- 1988-01-29 KR KR1019880000740A patent/KR880008808A/ko not_active Application Discontinuation
- 1988-08-21 IT IT47557/88A patent/IT1224241B/it active
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |