KR880008808A - 비경구투여용 현탁액 - Google Patents

비경구투여용 현탁액 Download PDF

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Publication number
KR880008808A
KR880008808A KR1019880000740A KR880000740A KR880008808A KR 880008808 A KR880008808 A KR 880008808A KR 1019880000740 A KR1019880000740 A KR 1019880000740A KR 880000740 A KR880000740 A KR 880000740A KR 880008808 A KR880008808 A KR 880008808A
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KR
South Korea
Prior art keywords
anhydrous
diclofenac
salt
pharmaceutically acceptable
finely divided
Prior art date
Application number
KR1019880000740A
Other languages
English (en)
Inventor
겔러 레오
글란쯔만 피터
Original Assignee
아놀드 자일러, 에른스트 알테르
시바-가이기 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아놀드 자일러, 에른스트 알테르, 시바-가이기 에이지 filed Critical 아놀드 자일러, 에른스트 알테르
Publication of KR880008808A publication Critical patent/KR880008808A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

내용 없음.

Description

비경구투여용 현탁액
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 디클로페낙(diclofenac)의 약제학적으로 허용되고 미분된(micronised)염 및 임의의 약제학적으로 허용되는 보조제를 함유하는, 염 형태인 디클로페낙의 안정한 수성 현탁액을 제조하기 위한 무수제형.
  2. 제1항에 있어서, 동결건조에 의해 수득 가능한 무수제형.
  3. 제1항 또는 제2항에 있어서, 평균입자 크기가 50㎛미만인 디클로페낙 염을 함유하는 무수제형
  4. 제3항에 있어서, 평균입자 크기가 20㎛미만인 디클로페낙나염을 함유하는 무수제형.
  5. 제3항에 있어서, 평균입자가 크기가 20㎛미만인 디클로페낙나트륨을 함유하는 무수제형.
  6. 임의의 약제학적으로 허용되는 보조제를 함유하는 현탁매질중에 미분된 형태의 디클로페탁염을 현탁시키고, 상기 현탁매질을 제거함을 특징으로 하여, 제1항 내지 4항중 어느 한 항에 따른 무수제형을 제조하는 방법.
  7. 제6항에 있어서, 등장 성분을 함유하는 수성 현탁 매질중에 미분된 형태의 디클로페낙염을 현탁시키고, 물을 제거함을 특징으로 하는 방법.
  8. 제6항에 있어서, 인지질을 함유하는 유기 현탁매질중에 미분된 형태의 디클로페낙염을 현탁시키고, 용매를 제거함을 특징으로하는 방법.
  9. 비경구 투여용 수성 현탁액을 제조하기 위한, 디클로페낙의 약제학적으로 허용되고 미분된 염 및 약제학적으로 허용되는 보조제를 함유하는 제1항 내지 5항중 어느 한 항에 따른 무수제형의 용도.
  10. 인체 또는 동물체를 치료하는 방법에 사용하기 위한 제1항 내지 5항중 어느 한 항에 따른 무수제형.
  11. 염증성 질환을 치료하기 위한 제1항 내지 5항중 어느 한 항에 따른 무수제형
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880000740A 1987-01-30 1988-01-29 비경구투여용 현탁액 KR880008808A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH350/87A CH673395A5 (ko) 1987-01-30 1987-01-30
CH350/87-4 1987-01-30

Publications (1)

Publication Number Publication Date
KR880008808A true KR880008808A (ko) 1988-09-13

Family

ID=4185019

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880000740A KR880008808A (ko) 1987-01-30 1988-01-29 비경구투여용 현탁액

Country Status (26)

Country Link
JP (1) JPS63192716A (ko)
KR (1) KR880008808A (ko)
AT (1) AT397460B (ko)
AU (1) AU612343B2 (ko)
BE (1) BE1000442A4 (ko)
CA (1) CA1305058C (ko)
CH (1) CH673395A5 (ko)
DE (1) DE3802357A1 (ko)
DK (1) DK45588A (ko)
ES (1) ES2008420A6 (ko)
FI (1) FI880368A (ko)
FR (1) FR2611498B1 (ko)
GB (1) GB2201089B (ko)
GR (1) GR880100041A (ko)
IE (1) IE60453B1 (ko)
IT (1) IT1224241B (ko)
LU (1) LU87115A1 (ko)
MY (1) MY102662A (ko)
NL (1) NL8800231A (ko)
NO (1) NO880403L (ko)
NZ (1) NZ223343A (ko)
PH (1) PH23652A (ko)
PT (1) PT86644B (ko)
SE (1) SE8800228L (ko)
YU (1) YU15488A (ko)
ZA (1) ZA88638B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH675537A5 (ko) * 1988-03-25 1990-10-15 Ciba Geigy Ag
MX9201782A (es) * 1991-04-19 1992-10-01 Sandoz Ag Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
DE4140184C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Flurbiprofen enthaltendes Arzneimittel
DE4140185C2 (de) * 1991-12-05 1996-02-01 Alfatec Pharma Gmbh Ein 2-Arylpropionsäurederivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung
DE4140183C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Retardform für ein Flurbiprofen enthaltendes Arzneimittel
GB9212450D0 (en) * 1992-06-11 1992-07-22 Indena Spa New derivatives of non-steroidal anti-inflammatory,analgesic and/or antipyretic substances,their use and pharmaceutical formulations containing them
ZA949182B (en) * 1993-12-02 1995-07-26 South African Druggists Ltd Pharmaceutical composition
US6447806B1 (en) 1999-02-25 2002-09-10 Novartis Ag Pharmaceutical compositions comprised of stabilized peptide particles
FR2793418B1 (fr) * 1999-05-11 2001-07-27 Synthelabo Formulations galeniques d'agents antithrombotiques pour administration sous-cutanee
GB0207529D0 (en) * 2002-04-02 2002-05-08 Norbrook Lab Ltd Injectable veterinary composition for small animals
JO3352B1 (ar) * 2005-06-17 2019-03-13 Apr Applied Pharma Res Sa صيغ دايكلوفيناك وطرق استخدامه

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1373913A (en) * 1970-12-17 1974-11-13 Glaxo Lab Ltd Pharmaceutical compositions
DE2914788A1 (de) * 1979-04-11 1980-10-16 Nattermann A & Cie Parenteral applizierbare, stabile arzneimittelloesungen mit entzuendungshemmender wirkung
DE3324193A1 (de) * 1983-07-05 1985-01-17 Troponwerke Gmbh & Co Kg Depot-antiphlogistika
DE3328401A1 (de) * 1983-08-05 1985-02-21 Merckle GmbH, 7902 Blaubeuren Injizierbare loesung zur behandlung von entzuendungen
EP0152379A3 (de) * 1984-02-15 1986-10-29 Ciba-Geigy Ag Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen enthaltend unilamellare Liposomen
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5002940A (en) * 1984-11-06 1991-03-26 Ciba-Geigy Corporation Solid drug formulations and stable suspensions
DE3446873A1 (de) * 1984-12-21 1986-07-10 Merckle Gmbh Fluessige diclofenac-zubereitungen
IT1207994B (it) * 1986-01-03 1989-06-01 Therapicon Srl Sali idrosulubili di composti adattivita' antiinfiammatoria ed analgesica, loro preparazione ed utilizzo in composizioni farmaceutiche.
DE3607339A1 (de) * 1986-03-06 1987-09-10 Merck Patent Gmbh Pharmazeutische zubereitung

Also Published As

Publication number Publication date
IT8847557A0 (it) 1988-08-21
PT86644A (pt) 1988-02-01
SE8800228L (sv) 1988-07-31
PT86644B (pt) 1992-01-31
FR2611498B1 (fr) 1991-06-14
NZ223343A (en) 1990-03-27
CH673395A5 (ko) 1990-03-15
IE60453B1 (en) 1994-07-13
DK45588D0 (da) 1988-01-29
ZA88638B (en) 1989-10-25
NO880403L (no) 1988-08-01
LU87115A1 (fr) 1989-03-08
JPS63192716A (ja) 1988-08-10
FI880368A (fi) 1988-07-31
GB8801737D0 (en) 1988-02-24
NO880403D0 (no) 1988-01-29
ATA18588A (de) 1993-09-15
NL8800231A (nl) 1988-08-16
PH23652A (en) 1989-09-27
GB2201089A (en) 1988-08-24
GR880100041A (el) 1988-12-16
IE880250L (en) 1988-07-30
YU15488A (en) 1989-10-31
AU1110288A (en) 1988-08-04
ES2008420A6 (es) 1989-07-16
IT1224241B (it) 1990-09-26
BE1000442A4 (fr) 1988-12-06
FI880368A0 (fi) 1988-01-27
AU612343B2 (en) 1991-07-11
DK45588A (da) 1988-07-31
AT397460B (de) 1994-04-25
CA1305058C (en) 1992-07-14
GB2201089B (en) 1990-05-16
MY102662A (en) 1992-08-17
FR2611498A1 (fr) 1988-09-09
SE8800228D0 (sv) 1988-01-25
DE3802357A1 (de) 1988-08-11

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