KR880002591B1 - 술폰아미드기를 함유하는 페녹시벤조산 유도체의 제조방법 - Google Patents
술폰아미드기를 함유하는 페녹시벤조산 유도체의 제조방법 Download PDFInfo
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- KR880002591B1 KR880002591B1 KR8203344A KR820003344A KR880002591B1 KR 880002591 B1 KR880002591 B1 KR 880002591B1 KR 8203344 A KR8203344 A KR 8203344A KR 820003344 A KR820003344 A KR 820003344A KR 880002591 B1 KR880002591 B1 KR 880002591B1
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- South Korea
- Prior art keywords
- formula
- reaction
- sulfonamide
- solvent
- alkyl
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 27
- PKRSYEPBQPFNRB-UHFFFAOYSA-N 2-phenoxybenzoic acid Chemical class OC(=O)C1=CC=CC=C1OC1=CC=CC=C1 PKRSYEPBQPFNRB-UHFFFAOYSA-N 0.000 title claims description 4
- 125000000565 sulfonamide group Chemical group 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 2
- 239000002253 acid Substances 0.000 claims abstract description 21
- 238000006243 chemical reaction Methods 0.000 claims abstract description 18
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 16
- 150000004820 halides Chemical class 0.000 claims abstract description 15
- 229940124530 sulfonamide Drugs 0.000 claims abstract description 14
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 3
- 239000002904 solvent Substances 0.000 claims description 12
- 150000003456 sulfonamides Chemical class 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 239000012429 reaction media Substances 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 5
- 125000005843 halogen group Chemical group 0.000 claims description 5
- RWGFKTVRMDUZSP-UHFFFAOYSA-N isopropyl-benzene Natural products CC(C)C1=CC=CC=C1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 3
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 2
- 230000003197 catalytic effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 239000006227 byproduct Substances 0.000 claims 1
- 125000002592 cumenyl group Chemical group C1(=C(C=CC=C1)*)C(C)C 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- -1 Phenoxy benzoic sulphonamides Chemical class 0.000 abstract description 9
- 125000003545 alkoxy group Chemical group 0.000 abstract description 8
- 229910052794 bromium Inorganic materials 0.000 abstract description 7
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract description 5
- 229910052736 halogen Inorganic materials 0.000 abstract description 5
- 150000002367 halogens Chemical class 0.000 abstract description 5
- 125000004663 dialkyl amino group Chemical group 0.000 abstract description 4
- 125000001188 haloalkyl group Chemical group 0.000 abstract description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract description 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract description 3
- 229910052740 iodine Inorganic materials 0.000 abstract description 3
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 abstract description 3
- 125000003342 alkenyl group Chemical group 0.000 abstract description 2
- 125000005907 alkyl ester group Chemical group 0.000 abstract description 2
- 125000000304 alkynyl group Chemical group 0.000 abstract description 2
- 125000004076 pyridyl group Chemical group 0.000 abstract description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 description 10
- 239000000047 product Substances 0.000 description 8
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 239000000460 chlorine Substances 0.000 description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 5
- 229910052731 fluorine Inorganic materials 0.000 description 5
- 239000011737 fluorine Substances 0.000 description 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 239000000370 acceptor Substances 0.000 description 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 3
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 3
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 3
- 239000012442 inert solvent Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000008096 xylene Substances 0.000 description 3
- 0 Bc(c(C)c(*)c(*)c1F)c1Oc1cc(*)c(*)cc1 Chemical compound Bc(c(C)c(*)c(*)c1F)c1Oc1cc(*)c(*)cc1 0.000 description 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 230000002363 herbicidal effect Effects 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- NFAVVNVCVMAAFC-UHFFFAOYSA-N 1-oxo-N-phenoxy-1-phenylmethanesulfonamide Chemical compound O(C1=CC=CC=C1)NS(=O)(=O)C(C1=CC=CC=C1)=O NFAVVNVCVMAAFC-UHFFFAOYSA-N 0.000 description 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- KGPHNHSAYAXSOW-UHFFFAOYSA-N 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoyl chloride Chemical compound C1=C(C(Cl)=O)C([N+](=O)[O-])=CC=C1OC1=CC=C(C(F)(F)F)C=C1Cl KGPHNHSAYAXSOW-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- MHABMANUFPZXEB-UHFFFAOYSA-N O-demethyl-aloesaponarin I Natural products O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C MHABMANUFPZXEB-UHFFFAOYSA-N 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- 229910001515 alkali metal fluoride Inorganic materials 0.000 description 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 description 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 description 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 125000005117 dialkylcarbamoyl group Chemical group 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 125000000018 nitroso group Chemical group N(=O)* 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N39/00—Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or, e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
- A01N39/02—Aryloxy-carboxylic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/04—Sulfonic acids; Derivatives thereof
- A01N41/06—Sulfonic acid amides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C301/00—Esters of sulfurous acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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Abstract
내용 없음.
Description
본 발명은 제초성을 갖는 술폰아미드기 함유 페녹시 벤조산 유도체의 개량된 제조 방법에 관한 것이다.
술폰아미드기 함유 페녹시벤조산의 제초성 유도체류는 유럽 특허출원 제3,416 및 23,392호에 공지되어 있다.
이들 특허출원에는 하기식(Ⅰ)의 생성물 및 그의 염이 기재되어 있다.
여기에서, A는 수소, 불소, 염소, 브롬, 요오드, 니트로기, -N=NCF3, PO3H2및 탄소원자수 1~4의 그의 알킬에스테르류, NH2, NHOH2, N+ 2, 카르복실기 또는 그의 기능 유도체중의 어느 하나, 모노알킬아미노 또는 디알킬아미노기, NH-CO-R1(여기서, R1은 알킬, 알콕시, 모노알킬아미노 또는 디알킬아미노기이다), 알킬기, 트리알킬암모니오, NHSO2R2(여기서, R2는 알킬 또는 페닐기이다), NHCONHSO2R2(여기서, R2는 전술한 바와 같음), 알킬티오, 알킬술피닐, 알킬술포닐, 디알킬술포니오, 시아노술포닐, 히드록실, 알카노일옥시, 알콕시, 알콕시카르보닐로 치환된 알콕시, SH, 니트로소, -SCN, 아지드, CF3,또는 아실이고 ; B는 수소, 불소, 염소, 브롬, 요오드, 알킬, 알콕시, 알킬술피닐 또는 알킬술포닐기, CF3, NO2, CN, NH2, NHCOR1(여기서, R1은 전술한 바와 같음), 또는 CONH2이고 ; C는 수소, 할로겐 또는 알킬 또는 디알킬아미노기이고 ; D는 불소, 염소, 브롬, 요오드 또는 CF3, 알킬티오, 알킬술피닐, 알킬술포닐, 할로게노알킬, 술파모일, 포르밀, 알킬카르보닐, CN 또는 디메틸아미노기이며 ; E는 수소, 할로게노알킬, 알콕시, 알킬술피닐 또는 알킬술포닐기, CN, CF3, NH2, CONH2또는 NH-CO-R1(여기서, R1은 전술한 바와 같음)이고 ; F는 B에서 주어진 의미중의 하나이며 ; R은 -CON(R4)SO2R3이고, 여기서, R4는 수소 또는 탄소원자수 1~4의 알킬기이고, R3는 페닐, 피리딜 또는 1개 이상의 할로겐원자로 임의로 치환되는 티에닐기, 알킬기 또는 니트로기, 탄소원자수 2~4의 알케닐 또는 알키닐기 또는 탄소원자수 1~4의 알킬기[1개 이상의 불소, 염소, 브롬 또는 요오드 원자, 바람직하게는 CF3에 의해 치환되거나, 카르복실, 탄소원자수 2~5의 알콕시카르보닐, 탄소원자수 2~5의 알킬카르보닐, 모노알킬카르바모일 또는 디알킬카르바모일(여기서, 알킬기는 탄소원자수 1~4의 탄소원자임), 탄소원자수 2~5의 알킬카르보닐옥시, 탄소원자수 2~5의 알킬카르보닐아미노 또는 시아노에 의해 치환됨]를 나타낸다.
공지의 방법에 있어서, 상기 식(Ⅰ)의 생성물은 중간 물질인 하기식(Ⅱ)의 산 할로겐화물과 하기식(Ⅲ)의 술폰아미드를 산 수용체(특히, N,N-디메틸아닐린 또는 피리딘과 같은 3급 아민, 무수탄산칼륨과 같은 알칼리금속탄산염, 또는 플로오르화 칼슘과 같은 알칼리금속 플로오르화 물)존재하에서 25~140℃로 반응시켜 제조할 수 있다.
상기 식중, X는 염소, 브롬 또는 요오드이고, A, B, C, D, E, F 및 R3는 전술한 바와 같다.
R4가 수소원자인 상기 식(Ⅰ)의 화합물은 예를 들어 탄소원자수 1~4의 디아조알칸과 반응시키는 공지의 방법에 의해 알킬화 시켜 R4가 탄소원자수 1~4의 알킬기인 상응 화합물을 얻을 수 있다.
일반식(Ⅱ) 및 (Ⅲ)의 생성물의 축합 방법은 다수의 결점을 가지고 있다. 즉, 수율이 평범하다(예 ; 유럽 특허출원 제23,392호의 실시예 14에서는 수율이 27%이고, 실시예 34에서는 9.5%이다). 그 이유는 디아실화 반응을 증진시킴으로써 수율을 저하시키는 산 수용체의 존재에 기인하는 것으로 추측된다. 또한, 산 수용체를 사용하게 되면 최종 생성물의 분리 및 정제가 어렵고 값이 비싸게 든다.
본 발명의 한가지 목적은 이들 결점을 극복하는 것이다.
본 발명에 다른 방법은 산 할로겐화물(바람직하게는 염화물, 브롬화물 또는 요오드화물)과 일반식(Ⅲ)의 술폰 아미드를 산수용체 부재하에서 할로겐화 수소산이 생성되는 경우 일반식(Ⅰ)의 반응생성물이 분해되지 않고 반응 매질로부터 할로겐화 수소산(HCl, HBr, HI)이 기체상태로 제거되는 온도에서 반응시키는 것으로 구성된다.
본 발명의 방법에 의해, 공지의 방법보다 더욱 간단한 방법에 의해 최종 생성물을 회수 및 정제하여 페녹시 벤조산의 술폰아미드 유도체류가 실질적으로 더 높은 수율로 수득될 수 있다(에 ; 약 30%이상, 통상의 경우 50%이상).
실제로는, 본 발명에서 사용되는 산 할로겐화물은 일반식(Ⅱ)의 산 할로겐화물이고, A가 NO2기 또는 플루오르, 염소, 브롬 또는 요오드 원자이고, B는 할로겐원자이고, C, E 및 F가 수소원자이며, D가 CF3기인식(Ⅱ)의 할로겐화물을 사용하는 것이 바람직하다. 또한, R3가 알킬기, 특히 CH3또는 CF3기인 식(Ⅲ)의 화합물의 술폰아미드류를 사용하는 것도 바람직하다.
본 발명 방법이 수행되는 온도는, 특히 일반식(Ⅱ)의 산 할로겐화물 또는 일반식(Ⅲ)의 술폰아미드가 과량이거나, 촉매 성질을 갖는 용매가 사용 또는 사용되지 않는가에 따라 다르다.
따라서, 만약 산 할로겐화물(Ⅱ)의 과량, 즉(Ⅱ)/(Ⅲ )의 몰비가 약 1.5~5인 경우에는 산 할로겐화물(Ⅱ)은 반응의 용매로서 작용하고, 반응 온도는 80~200℃이고, 바람직하게는 90~160℃이다.
미반응 산 할로겐화물(Ⅱ)은 특히 펜탄, 헥산, 헵탄, 시클로펜탄, 시클로헥산, 시클로헵탄, 벤젠, 톨루엔 또는 크실렌과 같은 탄화수소, 또 클로로벤젠류와 같은 할로겐화 탄화수소, CS2, 테트라히드로푸란, 디옥산 등과 같은 불활성 용매로 세척시킴으로써 반응 매질로부터 회수될 수 있다.
과량의 술폰아미드가 사용되는 경우, 즉 화합물(Ⅲ )/(Ⅱ)의 몰비가 1.5~5인 경우에는 반응 온도가 보통 90~200℃이고, 바람직하게는 140~160℃이다. 어느 경우에서나, 최소한 반응 매질을 용융시키기에 충분해야 한다. 과량의 술폰아미드(Ⅲ)은 물 또는 이 반응물(Ⅲ)에 비활성인 용매로 세척시켜 반응 매질로부터 회수될 수 있다.
반응물은 반응 온도 이상의 b.p.점을 갖는 불활성 용매(즉, 염소화 또는 비염소화 액체탄화수소, 예 ; 벤젠, 톨루엔, 크실렌, 크실렌 또는 큐멘의 혼합물)중에 용해시킬 수가 있는데, 이런 경우 최대 반응 온도가 용매의 b.p.점 바로 아래의 온도가 유리하다. 따라서, 약 153℃에서 비등하는 큐멘의 경우에는 반응은 130~150℃에서 바람직하게 수행된다. 불활성 용매를 사용하여 공업적인 규모로 제조하는 경우에는 열 전달이 더욱 양호하다는 실제적인 잇점에 있고, 또한 반응 매질의 국소 과열을 피할 수도 있다.
본 발명의 또 다른 변형에 따라 산 할라이드(Ⅱ)와 술폰아미드(Ⅲ)의 반응으로 페녹시벤조일 술폰아미드(Ⅰ)를 수득하는데 있어서 촉매작용을 갖는 용매를 사용한다. 디메틸포름아미드(=DMF, 약 154℃에서 비등) 및 디메틸아세타미드(=DMAC, 약 164℃에서 비등)는 특히 이 경우에 유리하고, 비교적 저온(예 : 80~120℃, 바람직하게는 90~110℃) 또는 이들 용매의 b.p.점 바로 아래의 고온에서도 사용할 수 있으며, 반응 속도는 더욱 빠르다.
실시예가 하기에 주어지는데, 여기에서는 본 발명을 제한함이 없이 설명되고, 본 발명이 어떻게 수행되는가가 예시된다.
[실시예 1]
메탄술폰아미드(2g ; 0.021몰)를 5-[2'-클로로-4'-(트리플루오로메틸)-페녹시]-2-니트로벤조일클로라이드(3.8g ; 0.01몰)와 섞는다. 이 혼합물을 150℃에서 20분간 가열시킨다. 염화수소가 생성되었을 때 이를 반응매질로부터 방출시킨다. 매질을 냉각시켜 블랙 오일을 수득하고 ; 이를 수산화나트륨 수용액에 용해시키고 ; 용액을 여과시키고, 여액을 묽은 HCl로 산성화하고, 일반식(Ⅳ)의 생성물은 침전시킨다. 이에 따라, 195~197℃에서 용융하고, 적외선 흡수 밴드를 1,692㎝-1(C=O 기)에서 갖는 생성물(3.1g)이 71%의 수율로 수득된다. 이 생성물은 하기 구조식을 갖는다.
[실시예 2]
250g의 산 염화물 및 130g의 메탄술폰아미드를 사용하는 것을 제외하고, 실시예 1의 방법을 반복 실시한다. 혼합물을 냉각시킨 후에 이소프로판올로 재결정시키는 것에 의해 반응 생성물을 직접 분리시킨다. 이에따라, 일반식(Ⅳ)의 생성물이 64%(185g)의 수율로 수득된다. 이 생성물의 구조는 적외선(흡수밴드 : 1,692㎝-1) 및 핵자기 공명(단일선 3.5ppm, 다중선 8.07ppm)에 의해 확인된다.
산 수용체로서 피리딘을 사용하는 유럽 특허출원 제23,392호의 실시예의 방법을 이용하는 경우에는, 수율을 단지 25%이다.
Claims (16)
- 제 1 항에 있어서, 반응이 과량의 식(Ⅱ)의 산 할로겐화물 존재하 수행됨을 특징으로 하는 방법.
- 제 2 항에 있어서, 식(Ⅱ)의 산 할로겐화물/식(Ⅲ)의 술폰아미드의 몰비가 1.5~5임을 특징으로 하는 방법.
- 제2 또는 3항에 있어서, 반응 온도가 80~200℃임을 특징으로 하는 방법.
- 제 1 항에 있어서, 반응이 과량의 술폰아미드 존재하 수행됨을 특징으로 하는 방법.
- 제 5 항에 있어서, 식(Ⅲ)의 술폰아미드/식(Ⅱ)의 산 할라이드의 몰비가 1.5~5임을 특징으로 하는 방법.
- 제5 또는 6항에 잇어서, 반응 온도가 90~200℃임을 특징으로 하는 방법.
- 제 7 항에 있어서, 반응이 반응 온도 이상의 비점을 용매 존재하 수행됨을 특징으로 하는 방법.
- 제 8 항에 있어서, 용매가 탄화수소임을 특징으로 하는 방법.
- 제 9 항에 있어서, 용매가 큐멘이고 온도가 130~150℃임을 특징으로 하는 방법.
- 제 8 항에 있어서, 반응이 각 반응에서 촉매성질을 갖는 용매 존재하 수행됨을 특징으로 하는 방법.
- 제11항에 있어서, 용매가 디메틸포름아미드 또는 디메틸아세타미드이고, 온도가 80℃~ 용매의 비점임을 특징으로 하는 방법.
- 제12항에 있어서, 온도가 90℃ 이상임을 특징으로 하는 방법.
- 제13항에 있어서, 식(Ⅰ) 및 (Ⅱ)에서 B 및 X는 염소원자이고, A는 염소원자 또는 NO2이고, C,E 및 F는 수소원자이고, D는 CF3임을 특징으로 하는 방법.
- 제 7 항에 있어서, 술폰아미드는 R3가 C1~C4의 알킬기 임을 특징으로 하는 방법.
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- 1982-06-25 FR FR8211332A patent/FR2510105A1/fr active Granted
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- 1982-07-23 IT IT22545/82A patent/IT1198399B/it active
- 1982-07-26 DE DE19823227847 patent/DE3227847A1/de not_active Withdrawn
- 1982-07-26 DK DK333282A patent/DK333282A/da not_active Application Discontinuation
- 1982-07-26 HU HU822401A patent/HU191186B/hu not_active IP Right Cessation
- 1982-07-26 BE BE0/208676A patent/BE893940A/fr not_active IP Right Cessation
- 1982-07-26 PT PT75322A patent/PT75322B/pt unknown
- 1982-07-26 ES ES514352A patent/ES8306108A1/es not_active Expired
- 1982-07-26 JP JP57130216A patent/JPS5826860A/ja active Granted
- 1982-07-26 GB GB08221574A patent/GB2103611B/en not_active Expired
- 1982-07-26 IE IE1786/82A patent/IE53978B1/en unknown
- 1982-07-26 CA CA000408056A patent/CA1194472A/en not_active Expired
- 1982-07-26 LU LU84295A patent/LU84295A1/fr unknown
- 1982-07-26 BR BR8204357A patent/BR8204357A/pt unknown
- 1982-07-26 NL NL8202994A patent/NL8202994A/nl not_active Application Discontinuation
- 1982-07-26 SU SU823467843A patent/SU1215620A3/ru active
- 1982-07-27 KR KR8203344A patent/KR880002591B1/ko active
- 1982-07-27 AT AT0290082A patent/AT385985B/de not_active IP Right Cessation
- 1982-07-27 RO RO108286A patent/RO85388B/ro unknown
Also Published As
Publication number | Publication date |
---|---|
JPH0149262B2 (ko) | 1989-10-24 |
AT385985B (de) | 1988-06-10 |
IE821786L (en) | 1983-01-27 |
NL8202994A (nl) | 1983-02-16 |
IT1198399B (it) | 1988-12-21 |
PL136683B1 (en) | 1986-03-31 |
IL66197A (en) | 1985-11-29 |
DD203716A5 (de) | 1983-11-02 |
RO85388A (ro) | 1984-11-25 |
PT75322A (fr) | 1982-08-01 |
RO85388B (ro) | 1984-11-30 |
IL66197A0 (en) | 1982-11-30 |
GB2103611A (en) | 1983-02-23 |
GB2103611B (en) | 1985-04-03 |
ES514352A0 (es) | 1983-05-01 |
ATA290082A (de) | 1987-11-15 |
IT8222545A0 (it) | 1982-07-23 |
CA1194472A (en) | 1985-10-01 |
BE893940A (fr) | 1983-01-26 |
IT8222545A1 (it) | 1984-01-23 |
FR2510105A1 (fr) | 1983-01-28 |
BR8204357A (pt) | 1983-07-19 |
IE53978B1 (en) | 1989-05-10 |
FR2510105B1 (ko) | 1984-09-07 |
HU191186B (en) | 1987-01-28 |
LU84295A1 (fr) | 1984-03-22 |
CH652384A5 (fr) | 1985-11-15 |
KR840000466A (ko) | 1984-02-22 |
PT75322B (fr) | 1985-11-29 |
JPS5826860A (ja) | 1983-02-17 |
DK333282A (da) | 1983-01-28 |
ES8306108A1 (es) | 1983-05-01 |
PL237639A1 (en) | 1983-05-23 |
SU1215620A3 (ru) | 1986-02-28 |
DE3227847A1 (de) | 1983-02-10 |
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