KR880002528A - 뇌세포 보호작용을 가지는 의약 조성물 - Google Patents

뇌세포 보호작용을 가지는 의약 조성물 Download PDF

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Publication number
KR880002528A
KR880002528A KR870009076A KR870009076A KR880002528A KR 880002528 A KR880002528 A KR 880002528A KR 870009076 A KR870009076 A KR 870009076A KR 870009076 A KR870009076 A KR 870009076A KR 880002528 A KR880002528 A KR 880002528A
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South Korea
Prior art keywords
pharmaceutical composition
carbon atoms
group
hydrogen
composition according
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KR870009076A
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KR950009095B1 (ko
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고구레규야
미쓰오 마사끼
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나까무라 하루후미
닛뽕케미화가부시끼가이샤
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Publication of KR880002528A publication Critical patent/KR880002528A/ko
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Publication of KR950009095B1 publication Critical patent/KR950009095B1/ko

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

뇌세포 보호작용을 가지는 의약 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기 일반식을 갖는 피페라진 유도체를 활성성분으로 함유하는 뇌세포 보호용 의약 조성물.
    (상기식에서 R3은 수소 또는 저급알킬기이고, R2는 히드록실, 아르알킬옥시기, 1∼5개의 탄소원자를 갖는 저급 알콕시기 또는 3∼5개의 탄소원자를 갖는 저급알케닐옥시기이며, R3은 수소, 아르알킬옥시기, 1∼5개의 탄소원자를 갖는 저급알콕시기 또는 3∼5개의 탄소원자를 갖는 저급알케닐옥시기이고, R4는 수소 또는 1∼5개의 탄소원자를 갖는 저급 알콕시기이다).
  2. 제 1 항에 있어서, 활성성분이 1-(3,4-디메톡시페닐)-2(4-디페닐메틸피페라지닐) 에탄올인 의약 조성물.
  3. 제 1 항에 있어서, 피페라진 유도체가 의약적으로 수용 가능한 산과의 염형태인 의약 조성물.
  4. 제 1 항에 있어서, 펠릿, 캡슐, 과립 또는 주사제의 형태인 의약 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870009076A 1986-08-20 1987-08-19 뇌세포 보호 작용을 가지는 의약 조성물 KR950009095B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP61194925A JPH08776B2 (ja) 1986-08-20 1986-08-20 脳細胞保護作用を有する医薬組成物
JP194925 1986-08-20
JP61-194925 1986-08-20

Publications (2)

Publication Number Publication Date
KR880002528A true KR880002528A (ko) 1988-05-09
KR950009095B1 KR950009095B1 (ko) 1995-08-14

Family

ID=16332624

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870009076A KR950009095B1 (ko) 1986-08-20 1987-08-19 뇌세포 보호 작용을 가지는 의약 조성물

Country Status (7)

Country Link
US (1) US4835155A (ko)
EP (1) EP0256890B1 (ko)
JP (1) JPH08776B2 (ko)
KR (1) KR950009095B1 (ko)
AU (1) AU603373B2 (ko)
DE (1) DE3781483T2 (ko)
DK (1) DK169055B1 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2614021B1 (fr) * 1987-04-14 1991-03-01 Andre Buzas Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant
JPH07121864B2 (ja) * 1987-06-26 1995-12-25 日本ケミファ株式会社 脳障害抑制作用を有する医薬組成物
PT90619B (pt) * 1988-05-23 1994-10-31 Glaxo Group Ltd Processo para a preparacao de compostos de piperazina
NZ232493A (en) * 1989-02-14 1992-06-25 Toyama Chemical Co Ltd Aryl- or heterocyclyl-substituted 1,2-ethanediol derivatives and pharmaceutical compositions
US5280032A (en) * 1989-02-14 1994-01-18 Toyama Chemical Co., Ltd. 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same
JP2679872B2 (ja) * 1989-04-28 1997-11-19 明治製菓株式会社 N−置換ピペラジン誘導体を含む脳機能障害改善剤
US5116842A (en) * 1989-05-18 1992-05-26 Glaxo Group Limited Chemical compounds
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2820937A1 (de) * 1978-05-12 1979-11-15 Dolorgiet Arzneimittelfabrik Arzneimittel
EP0067897A1 (en) * 1981-06-22 1982-12-29 Tanabe Seiyaku Co., Ltd. A pharmaceutical composition for use in raised intracranial pressure
JPS58124776A (ja) * 1982-01-21 1983-07-25 Nippon Chemiphar Co Ltd 新規ピペラジン誘導体およびその製造法ならびにこれを含有する脳循環改善剤
JPS59101475A (ja) * 1982-12-02 1984-06-12 Nippon Chemiphar Co Ltd 新規ピペラジン誘導体およびその製造法ならびにこれを含有する脳循環改善剤
FR2588188B1 (fr) * 1985-10-04 1988-01-08 Delalande Sa Comprime de sel(s) hydrosoluble(s) de cinepazide a liberation programmee et son procede de preparation

Also Published As

Publication number Publication date
US4835155A (en) 1989-05-30
JPH08776B2 (ja) 1996-01-10
DK427887A (da) 1988-02-21
AU7720487A (en) 1988-02-25
EP0256890A3 (en) 1990-02-14
DE3781483D1 (de) 1992-10-08
DK169055B1 (da) 1994-08-08
DK427887D0 (da) 1987-08-17
JPS6351328A (ja) 1988-03-04
EP0256890B1 (en) 1992-09-02
DE3781483T2 (de) 1993-04-22
EP0256890A2 (en) 1988-02-24
AU603373B2 (en) 1990-11-15
KR950009095B1 (ko) 1995-08-14

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