KR880001719B1 - 1,4,9,10-테트라하이드로-피라졸로[4,3-e]-피리도[3,2-b][1,4]디아제핀-10-온의 제조 방법 - Google Patents

1,4,9,10-테트라하이드로-피라졸로[4,3-e]-피리도[3,2-b][1,4]디아제핀-10-온의 제조 방법 Download PDF

Info

Publication number
KR880001719B1
KR880001719B1 KR8202494A KR820002494A KR880001719B1 KR 880001719 B1 KR880001719 B1 KR 880001719B1 KR 8202494 A KR8202494 A KR 8202494A KR 820002494 A KR820002494 A KR 820002494A KR 880001719 B1 KR880001719 B1 KR 880001719B1
Authority
KR
South Korea
Prior art keywords
alkyl group
carbon atoms
hydrogen atom
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8202494A
Other languages
English (en)
Korean (ko)
Other versions
KR840000543A (ko
Inventor
슈미트 권테르
엥겔 볼프강
에베르라인 볼프강
트룸리츠 귄테르
엥겔하르트 귄테르
Original Assignee
라우디엔, 좀머
닥터. 칼 토매 게젤샤프트 미트 베슈랭크터 하프퉁
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 라우디엔, 좀머, 닥터. 칼 토매 게젤샤프트 미트 베슈랭크터 하프퉁 filed Critical 라우디엔, 좀머
Publication of KR840000543A publication Critical patent/KR840000543A/ko
Application granted granted Critical
Publication of KR880001719B1 publication Critical patent/KR880001719B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR8202494A 1981-06-06 1982-06-03 1,4,9,10-테트라하이드로-피라졸로[4,3-e]-피리도[3,2-b][1,4]디아제핀-10-온의 제조 방법 Expired KR880001719B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19813122670 DE3122670A1 (de) 1981-06-06 1981-06-06 "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
DE?3,122,670.1? 1981-06-06
DEP3122670.1 1981-06-06

Publications (2)

Publication Number Publication Date
KR840000543A KR840000543A (ko) 1984-02-25
KR880001719B1 true KR880001719B1 (ko) 1988-09-08

Family

ID=6134176

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8202494A Expired KR880001719B1 (ko) 1981-06-06 1982-06-03 1,4,9,10-테트라하이드로-피라졸로[4,3-e]-피리도[3,2-b][1,4]디아제핀-10-온의 제조 방법

Country Status (27)

Country Link
US (1) US4381303A (https=)
EP (1) EP0066774B1 (https=)
JP (1) JPS57212182A (https=)
KR (1) KR880001719B1 (https=)
AR (1) AR229124A1 (https=)
AT (1) ATE10744T1 (https=)
AU (1) AU552765B2 (https=)
CA (1) CA1167440A (https=)
CS (1) CS226743B2 (https=)
DD (1) DD202574A5 (https=)
DE (2) DE3122670A1 (https=)
DK (1) DK253382A (https=)
ES (1) ES8304571A1 (https=)
FI (1) FI71560C (https=)
GB (1) GB2117755B (https=)
GR (1) GR76438B (https=)
HU (1) HU186067B (https=)
IE (1) IE53067B1 (https=)
IL (1) IL65977A (https=)
NO (1) NO158063C (https=)
NZ (1) NZ200859A (https=)
PH (1) PH17719A (https=)
PL (1) PL135845B1 (https=)
PT (1) PT75016B (https=)
SU (1) SU1103795A3 (https=)
YU (1) YU118282A (https=)
ZA (1) ZA823919B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3643666A1 (de) * 1986-12-20 1988-06-30 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4749788A (en) * 1987-04-13 1988-06-07 A. H. Robins Company, Incorporated Process for the preparation of aryl-pyrido(1,4) benzodiazepines
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
EP0410148B1 (en) * 1989-06-28 1994-04-06 Boehringer Ingelheim Pharmaceuticals Inc. Novel 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-ones and thiones and their use in the prevention or treatment of AIDS
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines
HUT74682A (en) * 1993-12-29 1997-01-28 Pfizer Diazabicyclic neurokinin antagonists and pharmaceutical compositions containing them
CO4340691A1 (es) * 1994-02-18 1996-07-30 Boehringer Ingelheim Pharma 2-HETEROARIL-5,11-DIHIDRO-6H-DIPIRIDO(3,2-b:2´, 3´ -e) (1, 4)-DIAZEPINAS .
ES2137113B1 (es) 1997-07-29 2000-09-16 Almirall Prodesfarma Sa Nuevos derivados de triazolo-piridazinas heterociclicos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450694A (en) * 1966-02-23 1969-06-17 Abbott Lab Substituted benzoxazepines and benzothiazepines
DE2707269A1 (de) * 1977-02-19 1978-08-24 Hoechst Ag Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung
EP0023707B1 (de) * 1979-08-03 1986-04-30 Byk Gulden Lomberg Chemische Fabrik GmbH Substituierte Tetraazatricyclen, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Arzneimittel

Also Published As

Publication number Publication date
YU118282A (en) 1986-04-30
FI821992A0 (fi) 1982-06-04
IE53067B1 (en) 1988-05-25
AR229124A1 (es) 1983-06-15
NZ200859A (en) 1985-08-16
KR840000543A (ko) 1984-02-25
GR76438B (https=) 1984-08-10
ZA823919B (en) 1984-02-29
ATE10744T1 (de) 1984-12-15
NO158063B (no) 1988-03-28
PL236742A1 (en) 1984-03-26
ES512846A0 (es) 1983-03-01
ES8304571A1 (es) 1983-03-01
PH17719A (en) 1984-11-21
NO821882L (no) 1982-12-07
EP0066774A1 (de) 1982-12-15
NO158063C (no) 1988-07-06
CS226743B2 (en) 1984-04-16
GB2117755A (en) 1983-10-19
FI71560C (fi) 1987-01-19
FI71560B (fi) 1986-10-10
IE821350L (en) 1982-12-06
DD202574A5 (de) 1983-09-21
PT75016A (de) 1982-07-01
AU552765B2 (en) 1986-06-19
AU8460582A (en) 1982-12-16
GB2117755B (en) 1985-01-30
DE3122670A1 (de) 1982-12-23
DE3261530D1 (en) 1985-01-24
IL65977A0 (en) 1982-09-30
IL65977A (en) 1984-12-31
HU186067B (en) 1985-05-28
SU1103795A3 (ru) 1984-07-15
JPS57212182A (en) 1982-12-27
PL135845B1 (en) 1985-12-31
US4381303A (en) 1983-04-26
DK253382A (da) 1982-12-07
EP0066774B1 (de) 1984-12-12
CA1167440A (en) 1984-05-15
PT75016B (de) 1985-05-17

Similar Documents

Publication Publication Date Title
KR940010034B1 (ko) 헤테로사이클릭 퀴녹살린 화합물의 제조방법
US4110337A (en) Triazolobenzodiazepines
DE60219672T2 (de) Imidazopyridine, -pyrimidine und -triazine als gaba-a alpha 5 rezeptor subtyp liganden zur verbesserung kognitiver eigenschaften
EP0503349B1 (en) Hydrazone derivatives, their preparation and use
JP3212758B2 (ja) キノキサリン−２，３−（１ｈ，４ｈ）−ジオン
DE3935514A1 (de) Neue bicyclo-imidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US6124285A (en) Indole-2,3-dione-3-oxime derivatives
EP0104522B1 (en) New pyrazolo(3,4-b)pyridine derivatives and process for producing them
KR880001719B1 (ko) 1,4,9,10-테트라하이드로-피라졸로[4,3-e]-피리도[3,2-b][1,4]디아제핀-10-온의 제조 방법
DE69318563T2 (de) 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONE DERIVATE, IHRE HERSTELLUNG UND DIE SIE ENTHALTENDEN ARZNEIMITTEL
DD253821A5 (de) Verfahren zur herstellung von pyrrolo-benzimidozolen, pyrrolo-benzooxazolen und pyrrolo-benzthiozole
WO1998003511A1 (de) Neue triazolopurine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2740836A1 (de) Anellierte indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US6395905B1 (en) Tetrahydroindazole derivatives as ligands for GABA-A α 5 receptors
US3632605A (en) Pyrroline derivatives
US4053600A (en) Tricyclic 1,2,4-triazolo-quinazolines
US5843945A (en) AMPA antagonists and a method of treatment
EP1423378B1 (en) Aminopyrrole compounds as antiinflammatory agents
CA1171083A (en) Tricyclic pyrroles, a process for their preparation, their use, and medicaments containing them
AU2002331179A1 (en) Aminopyrrole compounds as antiinflammatory agents
US3740413A (en) 2-benzimidazolecarboxamides
DD234012A5 (de) Verfahre zur herstellung neuer imidazolderivaten
DE3519735A1 (de) Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0089426B1 (en) 2-amino-6-biphenylacetic acids
KR800000088B1 (ko) 치환된 6-아릴-4H-s-트리아졸로-[3, 4c]-티에노-[2, 3e]-1, 4-디아제핀의 제조방법

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19910909

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19910909