KR880000385A - 선스크린제, 선스크린 조성물 및 선번예방법 - Google Patents

선스크린제, 선스크린 조성물 및 선번예방법 Download PDF

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KR880000385A
KR880000385A KR1019870006643A KR870006643A KR880000385A KR 880000385 A KR880000385 A KR 880000385A KR 1019870006643 A KR1019870006643 A KR 1019870006643A KR 870006643 A KR870006643 A KR 870006643A KR 880000385 A KR880000385 A KR 880000385A
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skin
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다니엘 세베이텔리 안토니
앤 스퍼나크 조세핀
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더 프록터 앤드 갬블 캄파니
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Abstract

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Description

선스크린제, 선스크린 조성물 및 선번예방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (24)

  1. 다음 일반식(Ⅰ)을 갖는 선스크린 화합물
    X-Y-Z (Ⅰ)
    상기식에서
    (a) X는 다음의 일반식(i) 내지 (Ⅴ)로 구성되는 그룹으로부터 선택된 UVA 흡수잔기이고,
    (b) Z는 다음의 일반식(i)´ 내지 (Ⅴ)'로 구성되는 그룹으로부터 선택된 UVB 흡수잔기이고,
    상기식에서,
    A는 R, -OR, -NR2또는 -SO3H 또는 그의 약학적으로 허용되는 염 또는 에스테르로 구성된 그룹으로부터 독립적으로 선택한 치환체이고, A1는 각각 독립적으로 -CN 또는 -CO2R1이고, A2는 각각 독립적으로 -OR, 또는 -NR2이고, A3는 각각 독립적으로 H 또는 OH이고, A4및 A5는 각각 독립적으로 R 또는 OR이고, A3또는 A4는 OH이어야 하고, A6는 각각 독립적으로 H 또는 -SO3H 또는 그의 약학상 허용되는 염 또는 에스테르이고, A7는 각각 독립적으로 -OR, 또는 -O2C-R1이고, 단, A7및 A3은 OH가 아니고, R는 각각 독립적으로 H ,1 내지 20개의 탄소원자를 가지는 직쇄 또는 측쇄알킬,
    (CH2CH2O)p-H 또는 (CH2CH(CH3)O)p-H
    (여기에서 p는 1 내지 8 의 정수이다)이고, R1는 각각 독립적으로 1 내지 20개의 탄소원자를 가지는 직쇄 또는 측쇄알킬이고,
    (C) Y는 X자기와 Z잔기를 하나의 분자로 공유결합시키고, 또한 상기 잔기들의 전자시스템들이 직접 결합되지 못하도록 X잔기와 Z잔기를 분리시키는 결합잔기이다.
  2. 제 1 항에 있어서, Y결합잔기가 일반식
    -(-W1-(-CR2 2-)n-)m-W2-
    (여기에서 W1및 W2는 각각 독립적으로 단일결합으로 구성된 그룹으로부터 선택하거나, O 또는 NR의 그룹으로부터 선택한 원자이고, n는 1 이상의 정수이고, m는 1 이상의 정수이고, R2그룹은 각각 독립적으로 H, OH 또는 1 내지 20개의 탄소원자를 가지는 직쇄 또는 측쇄알킬로 구성되는 그룹으로부터 선택하고, R는 H 또는 1 내지 20개의 탄소원자를 가지는 직쇄 또는 측쇄알킬이다)을 가지는 선스크린 화합물.
  3. 제 1 항에 있어서,
    (a) X UVA 흡수잔기가 다음의 일반식(i) 및 (Ⅴ)로 구성되는 그룹으로부터 선택되고,
    (b) Z UVB 흡수잔기가 다음의 일반식 (i)' 및 (ⅱ)'로 구성된 그룹으로부터 선택되는 선스크린 화합물.
  4. 제 3 항에 있어서, 다음의 일반식을 갖는 선스크린 화합물.
  5. 제 4 항에 있어서, Y 결합잔기가 다음 일반식
    -O-(-CH-2)n-O- (여기에서 n는 1 내지 약 6의 정수이다),
    -NH-(-CH2-)n-NH- (여기에서 n는 1 내지 약 6의 정수이다),
    -(-O-CH2CH2-)n-O- (여기에서 n는 1 또는 2이다),
    -(-NH-CH2CH2-)n-NH (여기에서 n는 1 또는 2이다),
    (여기에서 n는 1 또는 2이다),
    (여기에서 n는 1 또는 2이다) 및
    (여기에서 n는 1 또는 2이다)로 구성되는 잔기의 그룹중에서 선택되고,
    A가 R그룹이고, A2가 -OR 또는 -NR2로부터 선택되는 선스크린 화합물.
  6. 제 5 항에 있어서, Y가 -O-(CH2-)n-O- (여기에서 n는 1 내지 6의 정수이다)이고, A가 H이며, A2가 -OCH3, -OCH2CH3, -OH 또는 -NR2 1이고, -NR2가 -NR2 1이고, -NR2 1그룹이 2개 이상의 탄소원자를 가지는 하나의 R1그룹을 함유하며 또다른 R1그룹이 메틸 또는 에틸인 선스크린 화합물.
  7. 제 5 항에 있어서, Y가 -O-(-CH-2)n-O- (여기에서 n는 1 내지 약 6의 정수이다)이고, A가 H이며, A2가 -OCH3, -OCH2CH3, -OH 또는 -NR2 1이고, -NR2가 -NR2 1이고, R1그룹이 모두 2-에틸-헥실인 선스크린 화합물.
  8. 제 1 항에 있어서, 2-히드록시-4-(2-히드록시에톡시)벤조페논의 4- N,N-디메틸아미노벤조산4-에스테르, 2-히드록시-4-(2-히드록시에톡시)-벤조페논의 4-메톡시신남신 4-에스테르, 2-히드록시-4-(2-히드록시에톡시) 벤조페논의4-(2-메틸프로폭시) 신남산 4-에스테르, 2-히드록시-4-(2-히드록시에톡시) 벤조페논의 4-N-데실아미노벤조산 4-에스테르, 2-히드록시-4-(2-히드록시에톡시) 벤조페논의 4-N,N-부틸메틸아미노벤조산 4-에스테르, 2-히드록시-4-(2-히드록시에톡시) 벤조페논의 4-N,N-부틸메틸아미노벤조산 에스테르, 4-(2-히드록시에톡시) 디벤조일메탄의 4-N,N-(2-에틸헥실) 메틸아미노벤조산 에스테르, 2-히드록시-4-(2-히드록시에톡시) 벤조페논의 N,N-디-(2-에틸헥실)-4-아미노벤조산 에스테르 및 4-(2-히드록시에톡시) 디벤조일메탄의 N,N-디-(2-에틸헥실)-4-아미노벤조산 에스테르로 구성되는 그룹으로부터 선택되는 선스크린 화합물.
  9. (a) 다음 일반식(Ⅰ)을 가지는 선스크린 화합물 및
    (b) 약학적으로 허용되는 선스크린 담체를 함유하는 선스크린 조성물.
    X-Y-Z (Ⅰ)
    상기식에서,
    (ⅰ) X는 분리된 분자내의 독립된 발색단잔기로서 320 내지 400mm의 범위내에서 적어도 9,000 이상의 몰흡광도를 가지는 적어도 하나 이상의 최대흡광을 나타내는 치환된 카르보닐함유 방향족환함유 발색단잔기이고,
    (ⅱ) Z는 분리된 분자내의 독립된 발색단잔기로서, 약 290 내지 약 320mm의 범위내에서 적어도 하나 이상의 파장에 대하여 적어도 4,000 이상의 몰흡광도를 나타내고, 또한 분리된 분자내의 독립된 발색단잔기로서, 320mm 이상의 파장에 대하여 9,000 이상의 물흡광도를 가지는 최대흡광을 나타내지 아니하는 치환된 카르보닐함유 방향족환함유 발색단잔기이고,
    (ⅲ) Y는 X잔기와 Z잔기를 하나의 분자로 공유결합시키고, 상기 잔기들의 전자시스템들이 직접 결합되지 못하도록 X잔기와 Z잔기를 분리시키는 결합잔기이다.
  10. 제 8 항에 있어서, 선스크린 화합물에 대한 일반식에서,
    (ⅰ) X가 분리된 분자내의 독립된 발색단잔기로서 320 내지 400mm의 범위내에서 적어도 20,000 이상의 몰흡광도를 가지는 적어도 하나 이상의 최대흡광을 나타내는 치환된 카르보닐 및 방향족환함유 발색단잔기이고,
    (ⅱ) Z 가 분리된 분자내의 독립된 발색단잔기로서, 290 내지 320mm의 범위내에서 적어도 15,000 이상의 몰흡광도를 가지는 적어도 하나 이상의 최대흡광을 나타내고, 분리된 분자내의 독립된 발색단잔기로서 320mm 이상의 파장에 대하여 9,000 이상의 몰흡광도를 가진 최대흡광을 나타내지 아니하는 치환된 카르보닐 및 방향족환함유 발색단 잔기인 선스크린 조성물.
  11. (a) 제 1 항에 의한 선스크린 화합물과
    (b) 약학적으로 허용되는 선스크린 담체를 함유하는 선스크린 조성물.
  12. (a) 제 3 항에 의한 선스크린 화합물과
    (b) 약학적으로 허용되는 선스크린 담체를 함유하는 선스크린 조성물.
  13. (a) 제 4 항에 의한 선스크린 화합물과
    (b) 약학적으로 허용되는 선스크린 담체를 함유하는 선스크린 조성물.
  14. (a) 제 6 항에 의한 선스크린 화합물과
    (b) 약학적으로 허용되는 선스크린 담체를 함유하는 선스크린 조성물.
  15. (a) 제 7 항에 의한 선스크린 화합물과
    (b) 약학적으로 허용되는 선스크린 담체를 함유하는 선스크린 조성물.
  16. (a) 제 8 항에 의한 선스크린 화합물과
    (b) 약학적으로 허용되는 선스크린 담체를 함유하는 선스크린 조성물.
  17. UVA 및 UVB 파장방사선의 영향으로부터 인간 또는 하등동물의 피부를 보호하고 방법에 있어서, 인간 또는 하등동물의 피부에 제 8 항에 의한 선스크린 조성물의 유효코팅을 국부적으로 적용시킴을 특징으로 하는 방법.
  18. UVA 및 UVB 파장방사선의 영향으로부터 인간 또는 하등동물의 피부를 보호하고 방법에 있어서, 인간 또는 하등동물의 피부에 제10항에 의한 선스크린 조성물의 유효코팅을 국부적으로 적용시킴을 특징으로 하는 방법.
  19. UVA 및 UVB 파장방사선의 영향으로부터 인간 또는 하등동물의 피부를 보호하고 방법에 있어서, 인간 또는 하등동물의 피부에 제11항에 의한 선스크린 조성물의 유효코팅을 국부적으로 적용시킴을 특징으로 하는 방법.
  20. UVA 및 UVB 파장방사선의 영향으로부터 인간 또는 하등동물의 피부를 보호하고 방법에 있어서, 인간 또는 하등동물의 피부에 제12항에 의한 선스크린 조성물의 유효코팅을 국부적으로 적용시킴을 특징으로 하는 방법.
  21. UVA 및 UVB 파장방사선의 영향으로부터 인간 또는 하등동물의 피부를 보호하고 방법에 있어서, 인간 또는 하등동물의 피부에 제13항에 의한 선스크린 조성물의 유효코팅을 국부적으로 적용시킴을 특징으로 하는 방법.
  22. UVA 및 UVB 파장방사선의 영향으로부터 인간 또는 하등동물의 피부를 보호하고 방법에 있어서, 인간 또는 하등동물의 피부에 제14항에 의한 선스크린 조성물의 유효코팅을 국부적으로 적용시킴을 특징으로 하는 방법.
  23. UVA 및 UVB 파장방사선의 영향으로부터 인간 또는 하등동물의 피부를 보호하고 방법에 있어서, 인간 또는 하등동물의 피부에 제15항에 의한 선스크린 조성물의 유효코팅을 국부적으로 적용시킴을 특징으로 하는 방법.
  24. UVA 및 UVB 파장방사선의 영향으로부터 인간 또는 하등동물의 피부를 보호하고 방법에 있어서, 인간 또는 하등동물의 피부에 제16항에 의한 선스크린 조성물의 유효코팅을 국부적으로 적용시킴을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870006643A 1986-06-27 1987-06-27 일광차단 화합물 및 일광차단 조성물 KR960002370B1 (ko)

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US87972586A 1986-06-27 1986-06-27
US879,725 1986-06-27
US54046 1987-06-02
US07/054,046 US4999186A (en) 1986-06-27 1987-06-02 Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn
US054,046 1987-06-02
US879725 1997-06-20

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CA (1) CA1324153C (ko)
DE (1) DE3781061T2 (ko)
DK (1) DK330087A (ko)
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FI89592C (fi) 1993-10-25
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US4999186A (en) 1991-03-12
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IE59767B1 (en) 1994-03-23
PH30468A (en) 1997-05-28
AU7474287A (en) 1988-01-07
DK330087D0 (da) 1987-06-26
DE3781061D1 (de) 1992-09-17
KR960002370B1 (ko) 1996-02-16
DK330087A (da) 1987-12-28
FI89592B (fi) 1993-07-15
AU612579B2 (en) 1991-07-18
FI872842A0 (fi) 1987-06-26
DE3781061T2 (de) 1992-12-17
IE871719L (en) 1987-12-27
JPS6354315A (ja) 1988-03-08
GR3005687T3 (ko) 1993-06-07
NZ220879A (en) 1990-08-28
JP2675006B2 (ja) 1997-11-12
EP0255157A3 (en) 1988-06-15
EP0255157A2 (en) 1988-02-03

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