DE69503213D1 - Baccatin-Derivate und Verfahren zu deren Herstellung - Google Patents
Baccatin-Derivate und Verfahren zu deren HerstellungInfo
- Publication number
- DE69503213D1 DE69503213D1 DE69503213T DE69503213T DE69503213D1 DE 69503213 D1 DE69503213 D1 DE 69503213D1 DE 69503213 T DE69503213 T DE 69503213T DE 69503213 T DE69503213 T DE 69503213T DE 69503213 D1 DE69503213 D1 DE 69503213D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- substituted
- unsubstituted
- residue
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP28378094 | 1994-11-17 | ||
JP25118595 | 1995-09-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69503213D1 true DE69503213D1 (de) | 1998-08-06 |
DE69503213T2 DE69503213T2 (de) | 1998-10-22 |
Family
ID=26540092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69503213T Expired - Fee Related DE69503213T2 (de) | 1994-11-17 | 1995-11-16 | Baccatin-Derivate und Verfahren zu deren Herstellung |
Country Status (9)
Country | Link |
---|---|
US (2) | US5589502A (de) |
EP (1) | EP0712854B1 (de) |
KR (1) | KR960017653A (de) |
CN (1) | CN1129217A (de) |
AT (1) | ATE167860T1 (de) |
CA (1) | CA2162759A1 (de) |
DE (1) | DE69503213T2 (de) |
DK (1) | DK0712854T3 (de) |
ES (1) | ES2120686T3 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6335362B1 (en) | 1991-09-23 | 2002-01-01 | Florida State University | Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them |
US6521660B2 (en) | 1991-09-23 | 2003-02-18 | Florida State University | 3′-alkyl substituted taxanes and pharmaceutical compositions containing them |
US5973160A (en) * | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
ATE234800T1 (de) | 1997-08-21 | 2003-04-15 | Univ Florida State | Verfahren zur synthese von taxanen |
CN1186340C (zh) | 2000-02-02 | 2005-01-26 | 佛罗里达州立大学研究基金有限公司 | 用作抗肿瘤剂的c10碳酸酯取代的紫杉烷 |
MXPA03002494A (es) * | 2000-09-22 | 2004-05-24 | Bristol Myers Squibb Co | Metodo para reducir toxicidad de quimio terapias combinadas. |
CA2354478A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 carbonate substituted taxanes |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6013775A (ja) * | 1983-07-05 | 1985-01-24 | Sawai Seiyaku Kk | 光学活性3−(p−アルコキシフエニル)グリシツド酸アルカリ金属塩の製造法 |
JPS6013776A (ja) * | 1983-07-05 | 1985-01-24 | Sawai Seiyaku Kk | 光学活性3−(p−アルコキシフエニル)グリシツド酸誘導体の製造法 |
US4825688A (en) * | 1987-07-02 | 1989-05-02 | Kraus Jr Robert P | Apparatus for sensing of mass in baths |
FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
JPH0678B2 (ja) * | 1988-09-02 | 1994-01-05 | 田辺製薬株式会社 | 光学活性3―フェニルグリシッド酸エステル類化合物の製法 |
US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
US5059699A (en) * | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
CA2098478C (en) * | 1991-09-23 | 1999-09-14 | Robert A. Holton | Preparation of substituted isoserine esters using metal alkoxides and .beta.-lactams |
US5284865A (en) * | 1991-09-23 | 1994-02-08 | Holton Robert A | Cyclohexyl substituted taxanes and pharmaceutical compositions containing them |
US5283253A (en) * | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5430160A (en) * | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
WO1993010076A1 (en) * | 1991-11-22 | 1993-05-27 | The University Of Mississippi | Synthesis and optical resolution of the taxol side chain and related compounds |
US5272171A (en) * | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
IT1254517B (it) * | 1992-03-06 | 1995-09-25 | Indena Spa | 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico |
WO1993021173A1 (en) * | 1992-04-17 | 1993-10-28 | Abbott Laboratories | Taxol derivatives |
JPH069600A (ja) * | 1992-05-06 | 1994-01-18 | Bristol Myers Squibb Co | タクソールのベンゾエート誘導体 |
JPH064607A (ja) * | 1992-06-18 | 1994-01-14 | Ricoh Co Ltd | データ表示装置 |
GB9213077D0 (en) * | 1992-06-19 | 1992-08-05 | Erba Carlo Spa | Polymerbound taxol derivatives |
US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
JPH0651689A (ja) * | 1992-07-27 | 1994-02-25 | Meiji Toshiyo Shuppan Kk | 学習テキスト対応コンピュータ・ソフト |
CA2100808A1 (en) * | 1992-10-01 | 1994-04-02 | Vittorio Farina | Deoxy paclitaxels |
WO1994010997A1 (en) * | 1992-11-13 | 1994-05-26 | Florida State University | Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them |
CA2119261C (en) * | 1992-12-23 | 2006-01-31 | Michael A. Poss | Novel sidechain-bearing taxanes and intermediates thereof |
CA2111527C (en) * | 1992-12-24 | 2000-07-18 | Jerzy Golik | Phosphonooxymethyl ethers of taxane derivatives |
AU682173B2 (en) * | 1993-01-15 | 1997-09-25 | Florida State University | Process for the preparation of 10-desacetoxybaccatin III |
IL108316A (en) * | 1993-01-15 | 2006-10-31 | Univ Florida State | History of C-10 Texan and pharmaceuticals containing them |
IL108443A0 (en) * | 1993-01-29 | 1994-04-12 | Univ Florida State | C7 taxane derivatives and pharmaceutical compositions containing them |
IL108444A0 (en) * | 1993-01-29 | 1994-04-12 | Univ Florida State | C2 taxane derivatives and pharmaceutical compositions containing them |
ZA94128B (en) * | 1993-02-01 | 1994-08-19 | Univ New York State Res Found | Process for the preparation of taxane derivatives and betalactam intermediates therefor |
EP1260507A1 (de) * | 1993-02-05 | 2002-11-27 | Bryn Mawr College | Synthese von Taxol, Analogen und Zwischenverbindungen mit veränderlichen A-ring Seiten Ketten |
EP0688212B1 (de) * | 1993-03-05 | 2002-06-12 | Florida State University | C9 taxanderivate und diese enthaltende pharmazeutische zusammensetzungen |
JP3892481B2 (ja) * | 1993-03-05 | 2007-03-14 | フロリダ・ステート・ユニバーシティー | 9−デスオキソタキサンの製法 |
AU686148B2 (en) * | 1993-03-22 | 1998-02-05 | Florida State University | Taxanes having an amino substituted side-chain |
DE69434373T2 (de) * | 1993-03-22 | 2006-03-09 | Florida State University, Tallahassee | Beta-laktame zur Herstellung von Taxanen mit Furyl oder Thienyl substituierter Seitenkette |
US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
IL109926A (en) * | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
US5405972A (en) * | 1993-07-20 | 1995-04-11 | Florida State University | Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes |
JPH07177879A (ja) * | 1993-07-27 | 1995-07-18 | Nippon Steel Corp | 微生物によるタキソール及びその類縁化合物の製造法 |
CA2129288C (en) * | 1993-08-17 | 2000-05-16 | Jerzy Golik | Phosphonooxymethyl esters of taxane derivatives |
FR2711370B1 (fr) * | 1993-10-18 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
FR2712288B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
IL127598A (en) * | 1994-01-28 | 2003-04-10 | Upjohn Co | Process for preparing isotaxol analogs |
US5395850A (en) * | 1994-03-10 | 1995-03-07 | Bristol-Myers Squibb Company | 6,7-epoxy paclitaxels |
GB9405400D0 (en) * | 1994-03-18 | 1994-05-04 | Erba Carlo Spa | Taxane derivatives |
JP3015398U (ja) | 1995-03-04 | 1995-08-29 | 西岡 璋 | 内燃機関等の排ガス浄化燃料節減装置 |
-
1995
- 1995-11-14 CA CA002162759A patent/CA2162759A1/en not_active Abandoned
- 1995-11-15 US US08/558,772 patent/US5589502A/en not_active Expired - Fee Related
- 1995-11-16 DK DK95308220T patent/DK0712854T3/da active
- 1995-11-16 ES ES95308220T patent/ES2120686T3/es not_active Expired - Lifetime
- 1995-11-16 EP EP95308220A patent/EP0712854B1/de not_active Expired - Lifetime
- 1995-11-16 AT AT95308220T patent/ATE167860T1/de not_active IP Right Cessation
- 1995-11-16 DE DE69503213T patent/DE69503213T2/de not_active Expired - Fee Related
- 1995-11-17 CN CN95117503A patent/CN1129217A/zh active Pending
- 1995-11-17 KR KR1019950041962A patent/KR960017653A/ko not_active Application Discontinuation
-
1996
- 1996-07-01 US US08/673,580 patent/US5608073A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK0712854T3 (da) | 1998-11-16 |
US5589502A (en) | 1996-12-31 |
CN1129217A (zh) | 1996-08-21 |
EP0712854B1 (de) | 1998-07-01 |
EP0712854A1 (de) | 1996-05-22 |
ATE167860T1 (de) | 1998-07-15 |
DE69503213T2 (de) | 1998-10-22 |
CA2162759A1 (en) | 1996-05-18 |
KR960017653A (ko) | 1996-06-17 |
ES2120686T3 (es) | 1998-11-01 |
US5608073A (en) | 1997-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |