KR870008887A - 방향족 ω-알킬이미노- 테트라하이드로-6H-1,3-티아진-6-온 유도체 - Google Patents

방향족 ω-알킬이미노- 테트라하이드로-6H-1,3-티아진-6-온 유도체 Download PDF

Info

Publication number
KR870008887A
KR870008887A KR870001907A KR870001907A KR870008887A KR 870008887 A KR870008887 A KR 870008887A KR 870001907 A KR870001907 A KR 870001907A KR 870001907 A KR870001907 A KR 870001907A KR 870008887 A KR870008887 A KR 870008887A
Authority
KR
South Korea
Prior art keywords
tetrahydro
compound
aromatic
thiazin
alkylimino
Prior art date
Application number
KR870001907A
Other languages
English (en)
Other versions
KR900000676B1 (ko
Inventor
이베르 마르셀
기또스 모리스 두블메
Original Assignee
개리 디. 스트리트
메렐 다우 파마슈티칼스 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 개리 디. 스트리트, 메렐 다우 파마슈티칼스 인코포레이티드 filed Critical 개리 디. 스트리트
Publication of KR870008887A publication Critical patent/KR870008887A/ko
Application granted granted Critical
Publication of KR900000676B1 publication Critical patent/KR900000676B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

방향족 ω-알킬아미노-테트라하이드로-6H-1,3-티아진-6-온 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 다음 일반식⑴의 방향족 ω-알킬아미노-테트라하이드로-6H-1,3-티아진-6-온 및 약제학적으로 무독한 이의 산 부가염.
    상기식에서,
    n은 2 내지 5의 정수이고,
    R1및 R2는 각각 메틸이거나, 함께 테트라메틸렌 또는 펜타메틸렌 환을 형성하며,
  2. 제 1 항에 있어서, X가
  3. 제 1 항에 있어서, 2-[4-(2,3-디하이드로-1,4-벤조디옥신-2-일) 메틸아미노] 부틸이미노]-테트라하이드로-4,4-디메틸-6H-1,3-티아진-6-온인 화합물.
  4. 제 1 항에 있어서, X가
    라디칼인 화합물.
  5. 제 1 항에 있어서, 2-[4-[4-(2-피리미디닐)-1-피페라지닐]부틸이미노]-테트라하이드로-4,4-디메틸-6H-1,3-티아진-6-온인 화합물.
  6. 제 1 항에 있어서, 2-[4-[4-(2-피리미디닐)-1-피페라지닐] 부틸이미노]-테트라하이드로-4,4-테트라메틸렌-6H-1,3-티아진-6-온인 화합물.
  7. 다음 일반식⑵의 3-이소티오시아노프로피온산의 알킬 에스테르를 용액중에서 다음 일반식⑶의 알킬아민과 축합시켜 다음 일반식⑷의 3-[(N-알킬) 티오우레이도] 프로피온산의 알킬 에스테르를 형성시키고, 생성된 N-방향족-티오우레아-알킬에스테르를 자발적으로 폐환시킨 다음, 방향족 ω-알킬이미노-테트라하이드로-6H-1,3-티아진-6-온 또는 약제학적으로 무독한 이의 염을 분리함을 특징으로 하여, 다음 일반식(Ⅰ)의 방향족 ω-알킬이미노-테트라하이드로-6H-1,3-티아진-6-온 화합물 또는 이의 약제학적 염을 제조하는 방법.
    상기식에서,
    n은 2 내지 5의 정수이고,
    R1및 R2는 각각 메틸이거나, 함께 테트라메틸렌 또는 펜타메틸렌 환을 형성하며,
    X는또는
    라디칼이고,
    R3는 탄소수 1 내지 4의 저급 알킬그룹이다.
  8. 불안해소에 유효한 양의 제 1 항의 화합물을 불안증세가 있는 환자에게 투여함을 특징으로 하여, 불안증상의 해소를 요하는 환자에게 있어서 불안증상을 경감시키는 방법.
  9. 불안해소에 유효한 양의 제 1 항에 따르는 화합물 또는 약제학적으로 무독한 이의 산 부가염과 약제학적으로 무독한 담체 또는 희석제와의 혼합물로 이루어짐을 특징으로 하는, 불안해소 제 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870001907A 1986-03-05 1987-03-04 방향족 w-알킬이미노-테트라하이드로-6h-1,3-티아진-6-온 유도체 KR900000676B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83627586A 1986-03-05 1986-03-05
US836.275 1986-03-05
US836275 1986-03-05

Publications (2)

Publication Number Publication Date
KR870008887A true KR870008887A (ko) 1987-10-21
KR900000676B1 KR900000676B1 (ko) 1990-02-02

Family

ID=25271603

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870001907A KR900000676B1 (ko) 1986-03-05 1987-03-04 방향족 w-알킬이미노-테트라하이드로-6h-1,3-티아진-6-온 유도체

Country Status (18)

Country Link
EP (1) EP0236931B1 (ko)
JP (1) JPH0667933B2 (ko)
KR (1) KR900000676B1 (ko)
CN (1) CN1021825C (ko)
AR (1) AR241162A2 (ko)
AT (1) ATE99309T1 (ko)
AU (1) AU589256B2 (ko)
CA (1) CA1288101C (ko)
DE (1) DE3788581T2 (ko)
DK (1) DK111887A (ko)
ES (1) ES2061445T3 (ko)
FI (1) FI89919C (ko)
HU (1) HU201546B (ko)
IL (2) IL81718A0 (ko)
NO (1) NO166182C (ko)
PH (1) PH25227A (ko)
PT (1) PT84406B (ko)
ZA (1) ZA871449B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116970A (en) * 1988-02-18 1992-05-26 New James S Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
DE2727469A1 (de) * 1977-06-18 1978-12-21 Hoechst Ag Neue hexahydropyrimidine, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
CA1244418A (en) * 1984-07-30 1988-11-08 Marcel Hibert Glutarimide antianxiety and antihypertensive agents

Also Published As

Publication number Publication date
CA1288101C (en) 1991-08-27
AU6960587A (en) 1987-09-10
ZA871449B (en) 1987-08-20
AR241162A2 (en) 1991-12-30
HUT47105A (en) 1989-01-30
PH25227A (en) 1991-03-27
AU589256B2 (en) 1989-10-05
EP0236931A2 (en) 1987-09-16
CN87101690A (zh) 1987-12-30
NO166182B (no) 1991-03-04
EP0236931A3 (en) 1990-01-17
IL81718A0 (en) 1987-10-20
NO870889L (no) 1987-09-07
JPH0667933B2 (ja) 1994-08-31
EP0236931B1 (en) 1993-12-29
DK111887D0 (da) 1987-03-04
FI89919B (fi) 1993-08-31
NO870889D0 (no) 1987-03-04
NO166182C (no) 1991-06-12
ES2061445T3 (es) 1994-12-16
DK111887A (da) 1987-09-06
IL81738A0 (en) 1987-10-20
HU201546B (en) 1990-11-28
DE3788581D1 (de) 1994-02-10
PT84406A (en) 1987-04-01
FI870924A0 (fi) 1987-03-03
ATE99309T1 (de) 1994-01-15
DE3788581T2 (de) 1994-04-28
CN1021825C (zh) 1993-08-18
FI870924A (fi) 1987-09-06
PT84406B (pt) 1989-10-04
FI89919C (fi) 1993-12-10
KR900000676B1 (ko) 1990-02-02
JPS62221683A (ja) 1987-09-29

Similar Documents

Publication Publication Date Title
MX9300031A (es) Derivados de piperazina, procedimiento para su preparacion y composicion farmaucetica que los contiene.
KR890003671A (ko) 신규 항우울제
FI96857B (fi) Menetelmä valmistaa farmakologisesti käyttökelpoista tiatsoliyhdistettä
FI943775A0 (fi) Hypolipideemiset bentsotiatsepiiniyhdisteet
KR890003720A (ko) 벤조티아졸 및 그를 유효성분으로 함유하는 항류머티스제
KR870008880A (ko) 방향족 2-아미노알킬-1,2-벤조 이소 티아졸-3(2h)온-1,1-디옥사이드 유도체
KR920700939A (ko) 감광성 내식막-패턴된 금속층용 부식제 용액
EP0193148A3 (en) 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides
KR920018028A (ko) 콜레스테롤 생합성 억제제로서의 신규 아자데칼린 아미드 및 티오아미드
KR950000663A (ko) 트리테르펜 유도체 및 이를 함유하는 엔도텔린-수용체 길항물질
DE3762860D1 (de) 2-thiazolylimidazo(1,2-a)pyrimidine und ihre salze, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
DE69423528T2 (de) Arzneimittel enthaltend Argatroban Analoga
KR910006309A (ko) 인지질 및 인지질 유도체를 유효 성분으로 하는 항비루스성 약제
KR870008887A (ko) 방향족 ω-알킬이미노- 테트라하이드로-6H-1,3-티아진-6-온 유도체
KR880003941A (ko) 4,5-디하이드로옥사졸 유도체, 그의 제조방법 및 용도
TNSN92017A1 (fr) Procede de preparation, d'un derive de benzothiazole, et d'une composition pharmaceutique le contenant et procede de traitement en comportant application
FI834800A (fi) Foerfarande foer framstaellning av dialkylaminoalkoxibensylalkohol-derivat.
PL295932A1 (en) Method of obtaining novel bezazepine compounds
KR900016178A (ko) 2-치환 n,n'-디트리메톡시벤조일 피페라진, 그의 제조 방법 및 그를 함유하는 치료 조성물
KR880007494A (ko) 5-아릴-3h-1,2,4-트리아졸-3-온 및 진경제로서의 그들의 용도
NO178025C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive (benzhydryloksyetylpiperidyl)alifatiske syrederivater
KR870008834A (ko) 아실-보효소 a:클레스테롤 아실 전이 효소의 억제제로서의 올레인산, 리놀산 또는 리놀렌산의 치환 아닐리드
KR910015301A (ko) 수면 무호흡증의 치료방법
KR880005138A (ko) 신규 화합물들
KR870006043A (ko) 피라진유도체 그 제조방법 및 약제조성물

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20030128

Year of fee payment: 14

LAPS Lapse due to unpaid annual fee