KR880003941A - 4,5-디하이드로옥사졸 유도체, 그의 제조방법 및 용도 - Google Patents

4,5-디하이드로옥사졸 유도체, 그의 제조방법 및 용도 Download PDF

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Publication number
KR880003941A
KR880003941A KR870009953A KR870009953A KR880003941A KR 880003941 A KR880003941 A KR 880003941A KR 870009953 A KR870009953 A KR 870009953A KR 870009953 A KR870009953 A KR 870009953A KR 880003941 A KR880003941 A KR 880003941A
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KR
South Korea
Prior art keywords
compound
formula
hydrogen
following general
dihydrooxazole
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Application number
KR870009953A
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English (en)
Inventor
빈더 디이터
로펜스키 프란쯔
페터 페르버 후베르트
Original Assignee
클라우스 만들, 디트후리트 글라이쓜러
케미린쯔 아크티엔게젤샤프트
디트후리트 글라이쓸러
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Application filed by 클라우스 만들, 디트후리트 글라이쓜러, 케미린쯔 아크티엔게젤샤프트, 디트후리트 글라이쓸러 filed Critical 클라우스 만들, 디트후리트 글라이쓜러
Publication of KR880003941A publication Critical patent/KR880003941A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)

Abstract

내용 없음

Description

4,5-디하이드로옥사졸 유도체, 그의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 다음 일반식(Ⅰ)의 4,5-디하이드로옥사졸,
    상기식에서, A는 -CH=CH- 또는 -S-이고, R1,R3및 R4는 각각 독립적으로 수소 또는 저급알킬이며, R2는 수소 또는 저급알콕시이고, n은 0또는 1이다.
  2. 제1항에 있어서, n이 1인 일반식(Ⅰ)의 화합물.
  3. 제1항 또는 2항에 있어서, R1,R3및 R4가 수소 또는 메틸이고, R2가 수소 또는 메톡시인 일반식(Ⅰ)의 화합물.
  4. (a) 다음 일반식(Ⅱ)의 화합물을, 적어도 2당량의 강염기 존재하에서, 다음 일반식(Ⅲ)의 화합물을 반응시킨 후, (b)이렇게 하여 수득된 n이 0인 일반식(Ⅰ)의 화합물을 , 경우에 따라 등량의 유기과산 또는 과산화수소와 반응시켜 n이 1인 일반식(Ⅰ)의 화합물을 생성 시킴을 특징으로 하여 일반식(Ⅰ)의 화합물을 제조하는 방법.
    상기식에서, A는 -CH=CH- 또는 -S-이고, R1,R3및 R4는 각각 독립적으로 수소 또는 저급알킬이며, R2는 수소 또는 저급알콕시이고, n은 0또는 1이며, X는 염소 또는 브롬이다.
  5. 통상적인 보조제 및 부형제와 함께 제1항의 일반식(Ⅰ)의 화합물을 함유하는 약제학적 제제.
  6. 위궤양 및 십이지장궤양과 같이 위액분비증가에 의해 야기되는 질병을 치료 및 예방하기 위한 약제의 활성 성분으로 사용하기 위한 제1항에 따르는 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870009953A 1986-09-10 1987-09-09 4,5-디하이드로옥사졸 유도체, 그의 제조방법 및 용도 KR880003941A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA2437/86 1986-09-10
AT243786 1986-09-10

Publications (1)

Publication Number Publication Date
KR880003941A true KR880003941A (ko) 1988-05-31

Family

ID=3534337

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870009953A KR880003941A (ko) 1986-09-10 1987-09-09 4,5-디하이드로옥사졸 유도체, 그의 제조방법 및 용도

Country Status (21)

Country Link
US (1) US4818760A (ko)
EP (1) EP0261478B1 (ko)
JP (1) JPS6377878A (ko)
KR (1) KR880003941A (ko)
AT (1) ATE62908T1 (ko)
AU (1) AU596869B2 (ko)
CA (1) CA1256109A (ko)
CS (1) CS268191B2 (ko)
DD (1) DD262230A5 (ko)
DE (1) DE3769563D1 (ko)
DK (1) DK165322C (ko)
ES (1) ES2028838T3 (ko)
FI (1) FI89267C (ko)
GR (1) GR3001842T3 (ko)
HU (1) HU198059B (ko)
MY (1) MY102003A (ko)
NO (1) NO165195C (ko)
NZ (1) NZ221723A (ko)
SG (1) SG39892G (ko)
SU (1) SU1574177A3 (ko)
ZA (1) ZA876740B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002510293A (ja) * 1997-05-30 2002-04-02 ドクター・レディーズ・リサーチ・ファウンデーション 抗潰瘍剤として新規なベンゾイミダゾール誘導体、それらの製造方法、及びそれらを含有する薬学的組成物
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
PT1187601E (pt) 1999-06-07 2005-11-30 Altana Pharma Ag Nova forma de preparacao e a administracao compreendendo um inibidor da bomba de protoes instavel em meio acido
EP1534278A4 (en) * 2002-08-01 2006-09-06 Nitromed Inc NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD
CA2529984C (en) 2003-06-26 2012-09-25 Isa Odidi Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors
RS52233B (en) * 2004-05-07 2012-10-31 Nycomed Gmbh THE PHARMACEUTICAL DOSAGE FORM CONTAINING GRANULES AND ITS PRODUCTION PROCEDURE
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
US9561188B2 (en) * 2006-04-03 2017-02-07 Intellipharmaceutics Corporation Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045564A (en) * 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
GB8305245D0 (en) * 1983-02-25 1983-03-30 Fujisawa Pharmaceutical Co Imidazo-heterocyclic compounds
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
FI861772A (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
ES2032394T3 (es) * 1986-02-20 1993-02-16 Hoechst Aktiengesellschaft Procedimiento para preparar derivados de tienoimidazol sustituidos.

Also Published As

Publication number Publication date
CS268191B2 (en) 1990-03-14
ES2028838T3 (es) 1992-07-16
NO873722D0 (no) 1987-09-07
SG39892G (en) 1992-10-02
US4818760A (en) 1989-04-04
DK165322B (da) 1992-11-09
DK165322C (da) 1993-03-29
NO873722L (no) 1988-03-11
FI873892A (fi) 1988-03-11
NO165195C (no) 1991-01-09
ATE62908T1 (de) 1991-05-15
EP0261478A1 (de) 1988-03-30
AU7817087A (en) 1988-03-17
DK469687D0 (da) 1987-09-09
DE3769563D1 (de) 1991-05-29
ZA876740B (en) 1988-03-14
JPS6377878A (ja) 1988-04-08
HUT47288A (en) 1989-02-28
NO165195B (no) 1990-10-01
EP0261478B1 (de) 1991-04-24
AU596869B2 (en) 1990-05-17
CS649787A2 (en) 1989-05-12
NZ221723A (en) 1989-11-28
MY102003A (en) 1992-02-29
GR3001842T3 (en) 1992-11-23
DD262230A5 (de) 1988-11-23
DK469687A (da) 1988-03-11
HU198059B (en) 1989-07-28
FI89267B (fi) 1993-05-31
CA1256109A (en) 1989-06-20
FI873892A0 (fi) 1987-09-09
FI89267C (fi) 1993-09-10
SU1574177A3 (ru) 1990-06-23

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