KR870006016A - N-벤조일 우레아 화합물, 이를 함유하는 항종양 조성물 및 그의 제조 방법 - Google Patents
N-벤조일 우레아 화합물, 이를 함유하는 항종양 조성물 및 그의 제조 방법 Download PDFInfo
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- KR870006016A KR870006016A KR860010558A KR860010558A KR870006016A KR 870006016 A KR870006016 A KR 870006016A KR 860010558 A KR860010558 A KR 860010558A KR 860010558 A KR860010558 A KR 860010558A KR 870006016 A KR870006016 A KR 870006016A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (15)
- 하기 일반식(I)의 N-벤조일 우레아 화합물.[상기 식중, X는 수소원자, 할로겐원자 또는 니트로기이며, n은 1-3의 정수이고, Q는(식중, Y1은 치환 또는 비치환알킬기, 또는 알킬부가 치환 또는 비치환된 알콕시 또는 알콕시 카르보닐기이며, Y2는 수소원자, 할로겐원자, 니트로기, 치환 또는 비치환 알킬기 또는 알킬부가 치환 또는 비치환된 알콕시 또는 알콕시카르보닐기이고, Z는 수소원자, 할로겐원자, 트리플루오로메틸기 또는 니트로기이며, A 및 B중의 하나는 =CH-이고 다른 하나는 질소원자라는 조건하에 A 및 B는 각각 =CH-또는 질소원자이다)이며, 단(1) Q가여기서 X가 수소원자이고, Y1이 알킬기일때, Z는 수소원자, 할로겐원자 또는 트리플루오로 메틸기가 아니며, (2) Q가(식중, A는 질소원자이고. Y1은 트리플루오로메틸기이다)일때, Y2는 수소원자 이외의 기이다].
- 제1항에 있어서, Q가인 N-벤조일 우레아 화합물.
- 제2항에 있어서, X가 질소원자 또는 할로겐원자이고, Y1이 할로겐으로 치환될 수 있는 알킬기이며, Y2가 수소원자이고, Z가 할로겐원자인 N-벤조일 우레아 화합물.
- 제1항에 있어서, Q가인 N-벤조일 우레아 화합물.
- 제4항에 있어서, Y2가 할로겐으로 치환될 수 있는 알킬기이고, A가 소원자이며, B가 =CH-이고, Z가 할로겐원자인 N-벤조일 우레아 화합물.
- 제2항에 있어서, N-(2-니트로벤조일)-N'-[4-(5-클로로-2-피리미디닐옥시)-3-메틸페닐]우레아인 화합물.
- 제2항에 있어서, N-(2-니트로벤조일)-N'-[4-(5-브로모-2-피리미디닐옥시)-3-메틸페닐]우레아인 화합물.
- 제4항에 있어서, N-(2-니트로벤조일)-N'-[3-(5-클로로-2-피리미디닐옥시)-4-메틸페닐]우레아인 화합물.
- 하기 일반식(II)의 화합물을 하기 일반식(III) 또는 (IV)의 화합물과 반응시킴을 특징으로 하는, 하기 일반식(I)의 N-벤조일 우레아 화합물의 제조 방법.[상기 식중, X는 수소원자, 할로겐원자 또는 니트로기 이며; n은 1-3의 정수이고; Q는(식중, Y1은 치환 또는 비치환 알킬기, 또는 알킬부가 치환 또는 비치환된 알콕시 또는 알콕 시카르보닐기이며, Y2는 수소원자, 할로겐원자, 니트로기, 치환 또는 비치환 알킬기 또는 알킬부가 치환 또는 비치환된 알콕시 또는 알콕시카 로보닐기이고, Z는 수소원자, 할로겐원자, 트리플루오로메틸기 또는 니트로기이며, A 및 B중의 하나는 =CH-이고 다른 하나는 질소원자라는 조건하에 A 및 B는 각각 =CH-또는 질소원자이다)이며, 단(1) Q가여기서 X가 수소원자이고, Y1이 알킬기일때, Z는 수소원자, 할로겐원자 또는 트리플루오로메틸기가 아니며, (2) Q가식중, A는 질소원자이고, Y1은 트리플루오로메틸기이다)일때, Y2는 수소원자 이외의 기이며; R1은 이소시아네이트기, 아미노기,이고 R2는(식중, Y1및 Y2는 상기에서 정의한 바와 같고, R3는 R1과는 상이한 아미노기 또는 이소시아네이트기이다)또는 할로겐 원자이며, 단 R1이일 때, R2는 할로겐원자 이고, R1이 이소시아네이트기 또는 아미노기 일때, R2는이다.]
- 제9항에 있어서,와 반응시키는 N-벤조일 우레아 화합물의 제조 방법.
- 제10항에 있어서, R1이 이소시아네이트기 또는 아미노기이고, R2가인 N-벤조일 우레아 화합물의 제조 방법.
- 제9항에 있어서,와 반응시키는 N-벤조일 우레아 화합물의 제조 방법.
- 제12항에 있어서, R1이 이소시아네이트기 또는 아미노기 이고, R2가인 N-벤조일 우레아 화합물의 제조 방법.
- 치료에 유효한량의 제1항에 정의된 N-벤조일 우레아 화합물 및 약학적으로 수용 가능한 보조제를 함유한 항종양 조성물.
- 치료에 유효한량의 제1항에 정의된 N-벤조일 우레아 화합물을 질병에 걸린 대상에 투여함을 특징으로 하는 암의 치료방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP27818085 | 1985-12-11 | ||
JP60-178180 | 1985-12-11 | ||
JP279884 | 1985-12-12 | ||
JP27988485 | 1985-12-12 | ||
JP280694 | 1985-12-13 | ||
JP60280694 | 1985-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR870006016A true KR870006016A (ko) | 1987-07-08 |
Family
ID=27336532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR860010558A KR870006016A (ko) | 1985-12-11 | 1986-12-10 | N-벤조일 우레아 화합물, 이를 함유하는 항종양 조성물 및 그의 제조 방법 |
Country Status (14)
Country | Link |
---|---|
US (1) | US4863924A (ko) |
EP (1) | EP0226104B1 (ko) |
JP (1) | JPH0745473B2 (ko) |
KR (1) | KR870006016A (ko) |
AR (1) | AR244667A1 (ko) |
AT (1) | ATE60760T1 (ko) |
AU (1) | AU594098B2 (ko) |
DE (1) | DE3677478D1 (ko) |
DK (2) | DK164054C (ko) |
ES (1) | ES2033675T3 (ko) |
GR (1) | GR3001905T3 (ko) |
IL (1) | IL80776A (ko) |
NZ (1) | NZ218440A (ko) |
PL (1) | PL151012B1 (ko) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ212208A (en) * | 1984-06-15 | 1988-04-29 | Ishihara Sangyo Kaisha | N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions |
JPS62185013A (ja) * | 1986-02-08 | 1987-08-13 | Green Cross Corp:The | 易吸収性医薬組成物 |
ZA89135B (en) * | 1988-01-11 | 1989-10-25 | Duphar Int Res | Method of treating hematologic diseases and pharmaceutical composition to be used therefor |
US5166180A (en) * | 1988-01-11 | 1992-11-24 | Duphar International Research B.V. | Method of treating hematologic diseases and pharmaceutical composition to be used therefor |
JPH029855A (ja) * | 1988-03-31 | 1990-01-12 | Ishihara Sangyo Kaisha Ltd | 置換ベンゼン誘導体、それらの製造方法及びそれらを含有する抗癌性組成物 |
US5202487A (en) * | 1988-09-13 | 1993-04-13 | L'oreal | 2-substituted para-aminophenols and their use for dyeing keratinous fibres |
FR2637282B1 (fr) * | 1988-09-13 | 1990-12-07 | Oreal | Para-aminophenols 2-substitues et leur utilisation pour la teinture des fibres keratiniques |
JPH02196719A (ja) * | 1989-01-24 | 1990-08-03 | Green Cross Corp:The | 粉末状医薬組成物 |
NZ234551A (en) * | 1989-07-28 | 1991-10-25 | Ishihara Sangyo Kaisha | Benzoylurea derivatives and antitumour compositions |
US6344476B1 (en) * | 1997-05-23 | 2002-02-05 | Bayer Corporation | Inhibition of p38 kinase activity by aryl ureas |
US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
US20080300281A1 (en) * | 1997-12-22 | 2008-12-04 | Jacques Dumas | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas |
US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
US20080269265A1 (en) * | 1998-12-22 | 2008-10-30 | Scott Miller | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas |
RU2319693C9 (ru) | 1999-01-13 | 2008-08-20 | Байер Копэрейшн | Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты) |
JP2002534468A (ja) | 1999-01-13 | 2002-10-15 | バイエル コーポレイション | p38キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素 |
US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
WO2000042012A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
US7235576B1 (en) | 2001-01-12 | 2007-06-26 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US7371763B2 (en) * | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
JPWO2003029199A1 (ja) * | 2001-09-28 | 2005-01-13 | 武田薬品工業株式会社 | ベンゼン誘導体、その製造法および用途 |
US20030232765A1 (en) * | 2001-12-03 | 2003-12-18 | Bayer Corporation | Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers |
US20030216396A1 (en) * | 2002-02-11 | 2003-11-20 | Bayer Corporation | Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors |
WO2003068228A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
US20040023961A1 (en) * | 2002-02-11 | 2004-02-05 | Bayer Corporation | Aryl ureas with raf kinase and angiogenisis inhibiting activity |
AU2003209118A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Aryl ureas as kinase inhibitors |
US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
PT1636585E (pt) | 2003-05-20 | 2008-03-27 | Bayer Pharmaceuticals Corp | Diarilureias com actividade inibidora de cinase |
US8637553B2 (en) | 2003-07-23 | 2014-01-28 | Bayer Healthcare Llc | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
PE20051046A1 (es) * | 2003-11-28 | 2006-01-11 | Novartis Ag | Derivados de diaril-urea en el tratamiento de enfermedades dependientes de la quinasa de proteina |
JP5304241B2 (ja) | 2005-03-07 | 2013-10-02 | バイエル・ヘルスケア・エルエルシー | 癌の処置用のオメガ−カルボキシアリール置換ジフェニルウレアを含む医薬組成物 |
JP6541667B2 (ja) | 2014-01-16 | 2019-07-10 | エフ エム シー コーポレーションFmc Corporation | 除草剤としてのピリミジニルオキシベンゼン誘導体 |
EP3271350B1 (en) | 2015-03-18 | 2022-05-25 | FMC Corporation | Substituted pyrimidinyloxy pyridine derivatives as herbicides |
TWI713530B (zh) * | 2015-06-05 | 2020-12-21 | 美商艾佛艾姆希公司 | 作為除草劑之嘧啶氧基苯衍生物 |
CA2990839A1 (en) | 2015-07-13 | 2017-01-19 | E.I. Du Pont De Nemours & Company | Aryloxypyrimidinyl ethers as herbicides |
WO2018204164A1 (en) | 2017-05-02 | 2018-11-08 | Fmc Corporation | Pyrimidinyloxy benzo-fused compounds as herbicides |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5615272A (en) * | 1979-07-17 | 1981-02-14 | Ishihara Sangyo Kaisha Ltd | N-benzoyl-n'-phenylurea compound, its preparation, and insecticide containing the same |
CA1233822A (en) * | 1982-12-30 | 1988-03-08 | David T. Chou | Pesticidal benzoyl ureas and process for preparation |
NZ212208A (en) * | 1984-06-15 | 1988-04-29 | Ishihara Sangyo Kaisha | N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions |
JPS6133176A (ja) * | 1984-07-24 | 1986-02-17 | Ishihara Sangyo Kaisha Ltd | N−ニトロベンゾイル−n’−ピリダジニルオキシフエニルウレア系化合物、それらの製造方法及びそれらを含有する抗癌剤 |
JPS6193163A (ja) * | 1984-10-12 | 1986-05-12 | Ishihara Sangyo Kaisha Ltd | N−ベンゾイル−n′−フエニルウレア系化合物、それらの製造方法並びにそれらを含有する抗癌剤 |
US4727077A (en) * | 1985-02-20 | 1988-02-23 | Ishihara Sangyo Kaisha Ltd. | Benzoyl urea compounds, process for their production, and antitumorous compositions containing them |
-
1986
- 1986-11-20 AU AU65581/86A patent/AU594098B2/en not_active Ceased
- 1986-11-26 IL IL80776A patent/IL80776A/xx unknown
- 1986-11-28 DE DE8686116595T patent/DE3677478D1/de not_active Expired - Fee Related
- 1986-11-28 EP EP86116595A patent/EP0226104B1/en not_active Expired - Lifetime
- 1986-11-28 NZ NZ218440A patent/NZ218440A/xx unknown
- 1986-11-28 AT AT86116595T patent/ATE60760T1/de not_active IP Right Cessation
- 1986-11-28 ES ES198686116595T patent/ES2033675T3/es not_active Expired - Lifetime
- 1986-12-05 AR AR86306114A patent/AR244667A1/es active
- 1986-12-08 JP JP29192186A patent/JPH0745473B2/ja not_active Expired - Lifetime
- 1986-12-08 US US06/939,025 patent/US4863924A/en not_active Expired - Fee Related
- 1986-12-10 KR KR860010558A patent/KR870006016A/ko not_active Application Discontinuation
- 1986-12-10 PL PL1986262901A patent/PL151012B1/pl unknown
- 1986-12-11 DK DK596586A patent/DK164054C/da not_active IP Right Cessation
-
1991
- 1991-05-03 GR GR91400577T patent/GR3001905T3/el unknown
- 1991-06-18 DK DK911183A patent/DK118391D0/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL80776A0 (en) | 1987-02-27 |
DK118391A (da) | 1991-06-18 |
AU594098B2 (en) | 1990-03-01 |
US4863924A (en) | 1989-09-05 |
AR244667A1 (es) | 1993-11-30 |
NZ218440A (en) | 1989-06-28 |
DK596586D0 (da) | 1986-12-11 |
DK596586A (da) | 1987-06-12 |
DK118391D0 (da) | 1991-06-18 |
JPH0745473B2 (ja) | 1995-05-17 |
ES2033675T3 (es) | 1993-04-01 |
DK164054B (da) | 1992-05-04 |
AU6558186A (en) | 1987-06-18 |
IL80776A (en) | 1991-03-10 |
EP0226104A2 (en) | 1987-06-24 |
GR3001905T3 (en) | 1992-11-23 |
JPS6399056A (ja) | 1988-04-30 |
EP0226104A3 (en) | 1988-09-07 |
DE3677478D1 (de) | 1991-03-14 |
DK164054C (da) | 1992-09-28 |
EP0226104B1 (en) | 1991-02-06 |
PL151012B1 (en) | 1990-07-31 |
PL262901A1 (en) | 1988-09-29 |
ATE60760T1 (de) | 1991-02-15 |
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