ES2033675T3 - Un procedimiento para preparar un compuesto de n-benzoil urea. - Google Patents

Un procedimiento para preparar un compuesto de n-benzoil urea.

Info

Publication number
ES2033675T3
ES2033675T3 ES198686116595T ES86116595T ES2033675T3 ES 2033675 T3 ES2033675 T3 ES 2033675T3 ES 198686116595 T ES198686116595 T ES 198686116595T ES 86116595 T ES86116595 T ES 86116595T ES 2033675 T3 ES2033675 T3 ES 2033675T3
Authority
ES
Spain
Prior art keywords
group
formula
substituted
benzoil
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686116595T
Other languages
English (en)
Inventor
Haga Takahiro
Yamada Nobutoshi
Sugi Hideo
Koyanagi Toru
Okada Hiroshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ishihara Sangyo Kaisha Ltd
Original Assignee
Ishihara Sangyo Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishihara Sangyo Kaisha Ltd filed Critical Ishihara Sangyo Kaisha Ltd
Application granted granted Critical
Publication of ES2033675T3 publication Critical patent/ES2033675T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • C07D213/6432-Phenoxypyridines; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/34One oxygen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

COMPRENDEN LA FORMULA (I) DONDE X ES H, UN ATOMO DE HALOGENO O UN GRUPO NITRO, N ES UN ENTERO ENTRE 1 Y 3 Y Q ES LA FORMULA (II) O LA FORMULA (III) DONDE Y ES UN GRUPO ALQUIL SUSTITUIDO O NO SUSTITUIDO, O UN ALCOXIDO O UN GRUPO ALCOXIDOCARBONIL CON SU MOLECULA DE ALQUIL SUSTITUIDA O NO SUSTITUIDA, Y2 ES H, UN ATOMO DE HALOGENO, UN GRUPO NITRO O UN GRUPO ALQUIL SUSTITUIDO O NO SUSTITUIDO, O UN ALCOXIDO O UN GRUPO ALCOXIDOCARBONIL, CON SU MOLECULA DE ALQUIL SUSTITUIDA O NO SUSTITUIDA, Z ES H, UN ATOMO DE HALOGENO, UN GRUPO TRIFLUOROMETILO O UN GRUPO NITRO, Y CADA A Y B ES =CH O UN ATOMO DE NITROGENO, CON TAL DE QUE UNO DE A Y B SEA =CH - Y EL OTRO SEA UN ATOMO DE HIDROGENO, CON LAS SALVEDADES (1) DE QUE CUANDO Q ES LA FORMULA (IV) A ES =CH -, LA FORMULA (V) O LA FORMULA (VI), DONDE X ES H E Y1 ES UN GRUPO ALQUIL, Z NO ES H NI UN ATOMO DE HALOGENO NI UN GRUPO TRIFLUOROMETILO, Y (2) QUE CUANDO Q ES LA FORMULA (VII) DONDE A ES H E Y1 ES UN GRUPO TRIFLUOROMETILO, Y2 ES DISTINTO DE H.
ES198686116595T 1985-12-11 1986-11-28 Un procedimiento para preparar un compuesto de n-benzoil urea. Expired - Lifetime ES2033675T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27818085 1985-12-11
JP27988485 1985-12-12
JP60280694 1985-12-13

Publications (1)

Publication Number Publication Date
ES2033675T3 true ES2033675T3 (es) 1993-04-01

Family

ID=27336532

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686116595T Expired - Lifetime ES2033675T3 (es) 1985-12-11 1986-11-28 Un procedimiento para preparar un compuesto de n-benzoil urea.

Country Status (14)

Country Link
US (1) US4863924A (es)
EP (1) EP0226104B1 (es)
JP (1) JPH0745473B2 (es)
KR (1) KR870006016A (es)
AR (1) AR244667A1 (es)
AT (1) ATE60760T1 (es)
AU (1) AU594098B2 (es)
DE (1) DE3677478D1 (es)
DK (2) DK164054C (es)
ES (1) ES2033675T3 (es)
GR (1) GR3001905T3 (es)
IL (1) IL80776A (es)
NZ (1) NZ218440A (es)
PL (1) PL151012B1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212208A (en) * 1984-06-15 1988-04-29 Ishihara Sangyo Kaisha N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions
JPS62185013A (ja) * 1986-02-08 1987-08-13 Green Cross Corp:The 易吸収性医薬組成物
EP0324521A3 (en) * 1988-01-11 1991-11-27 Duphar International Research B.V Method of treating haematologic diseases and pharmaceutical compositions to be used therefor
US5166180A (en) * 1988-01-11 1992-11-24 Duphar International Research B.V. Method of treating hematologic diseases and pharmaceutical composition to be used therefor
JPH029855A (ja) * 1988-03-31 1990-01-12 Ishihara Sangyo Kaisha Ltd 置換ベンゼン誘導体、それらの製造方法及びそれらを含有する抗癌性組成物
FR2637282B1 (fr) * 1988-09-13 1990-12-07 Oreal Para-aminophenols 2-substitues et leur utilisation pour la teinture des fibres keratiniques
US5202487A (en) * 1988-09-13 1993-04-13 L'oreal 2-substituted para-aminophenols and their use for dyeing keratinous fibres
JPH02196719A (ja) * 1989-01-24 1990-08-03 Green Cross Corp:The 粉末状医薬組成物
NZ234551A (en) * 1989-07-28 1991-10-25 Ishihara Sangyo Kaisha Benzoylurea derivatives and antitumour compositions
US6344476B1 (en) 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US7329670B1 (en) * 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
ME00275B (me) * 1999-01-13 2011-02-10 Bayer Corp ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
ATE556713T1 (de) 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1140840B1 (en) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
JPWO2003029199A1 (ja) * 2001-09-28 2005-01-13 武田薬品工業株式会社 ベンゼン誘導体、その製造法および用途
WO2003047579A1 (en) * 2001-12-03 2003-06-12 Bayer Pharmaceuticals Corporation Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers
AU2003210969A1 (en) * 2002-02-11 2003-09-04 Bayer Corporation Aryl ureas with raf kinase and angiogenesis inhibiting activity
WO2003068746A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Aryl ureas as kinase inhibitors
AU2003209116A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
WO2003068229A1 (en) * 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
PT1636585E (pt) 2003-05-20 2008-03-27 Bayer Pharmaceuticals Corp Diarilureias com actividade inibidora de cinase
JP4777887B2 (ja) 2003-07-23 2011-09-21 バイエル、ファーマシューテイカルズ、コーポレイション 病気および状態の処置および防止のためのフロロ置換オメガカルボキシアリールジフェニル尿素
TW200529849A (en) * 2003-11-28 2005-09-16 Novartis Ag Diaryl urea derivatives in the treatment of protein kinase dependent diseases
EP1868579B1 (en) 2005-03-07 2010-09-29 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer
PL3094631T3 (pl) 2014-01-16 2019-07-31 Fmc Corporation Pochodne pirymidynyloksy-benzenu jako środki chwastobójcze
MX2017009792A (es) 2015-03-18 2017-10-27 Du Pont Derivados de pirimidiniloxipiridina sustituidos como herbicidas.
TW202400564A (zh) 2015-06-05 2024-01-01 美商艾佛艾姆希公司 作為除草劑之嘧啶氧基苯衍生物
CA2990839A1 (en) 2015-07-13 2017-01-19 E.I. Du Pont De Nemours & Company Aryloxypyrimidinyl ethers as herbicides
US11427549B2 (en) 2017-05-02 2022-08-30 Fmc Corporation Pyrimidinyloxy benzo-fused compounds as herbicides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5615272A (en) * 1979-07-17 1981-02-14 Ishihara Sangyo Kaisha Ltd N-benzoyl-n'-phenylurea compound, its preparation, and insecticide containing the same
CA1233822A (en) * 1982-12-30 1988-03-08 David T. Chou Pesticidal benzoyl ureas and process for preparation
NZ212208A (en) * 1984-06-15 1988-04-29 Ishihara Sangyo Kaisha N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions
JPS6133176A (ja) * 1984-07-24 1986-02-17 Ishihara Sangyo Kaisha Ltd N−ニトロベンゾイル−n’−ピリダジニルオキシフエニルウレア系化合物、それらの製造方法及びそれらを含有する抗癌剤
JPS6193163A (ja) * 1984-10-12 1986-05-12 Ishihara Sangyo Kaisha Ltd N−ベンゾイル−n′−フエニルウレア系化合物、それらの製造方法並びにそれらを含有する抗癌剤
US4727077A (en) * 1985-02-20 1988-02-23 Ishihara Sangyo Kaisha Ltd. Benzoyl urea compounds, process for their production, and antitumorous compositions containing them

Also Published As

Publication number Publication date
DK118391A (da) 1991-06-18
EP0226104A2 (en) 1987-06-24
AU6558186A (en) 1987-06-18
US4863924A (en) 1989-09-05
DK164054C (da) 1992-09-28
IL80776A0 (en) 1987-02-27
GR3001905T3 (en) 1992-11-23
JPS6399056A (ja) 1988-04-30
DK118391D0 (da) 1991-06-18
KR870006016A (ko) 1987-07-08
JPH0745473B2 (ja) 1995-05-17
PL262901A1 (en) 1988-09-29
ATE60760T1 (de) 1991-02-15
NZ218440A (en) 1989-06-28
DK596586A (da) 1987-06-12
IL80776A (en) 1991-03-10
PL151012B1 (en) 1990-07-31
DK164054B (da) 1992-05-04
AR244667A1 (es) 1993-11-30
DK596586D0 (da) 1986-12-11
DE3677478D1 (de) 1991-03-14
AU594098B2 (en) 1990-03-01
EP0226104A3 (en) 1988-09-07
EP0226104B1 (en) 1991-02-06

Similar Documents

Publication Publication Date Title
ES2033675T3 (es) Un procedimiento para preparar un compuesto de n-benzoil urea.
ES2039369T3 (es) Un procedimiento para la produccion de nuevos derivados de acido picolinico.
UA7140A1 (uk) Спосіб отримання похідних піридіну
FI953523A (fi) Fenyyli-3-dimetyyliamino-propaaniyhdisteet, joilla on farmakologista vaikutusta
ES2021027T5 (es) Un procedimiento para producir un compuesto de piridinsulfonamida sustituido.
ES2028101T3 (es) Una composicion que comprende un acido carboxilico y una amina.
JPS5373294A (en) Cationic polyurethane emulsion coposition
BR7701457A (pt) Processo para preparacao de derivados do acido 4,5-dicloroimidazol 2-carboxilico e composicoes praguicidas a base destes
JPS51118781A (en) Phthalazine derivatives or their salts and method for preparing them
ES2094812T3 (es) Un procedimiento mejorado para la preparacion de derivados sustituidos de indolona.
ES2039241T3 (es) Metodo para producir derivados de benzoilurea.
DE3666805D1 (en) Improved process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
ES422906A1 (es) Un procedimiento para preparar nuevos derivados de 2-amino-indano.
ES457805A1 (es) Un procedimiento para la preparacion de derivados de tiou- rea.
IT8026657A0 (it) Procedimento per il ricupero dell'acido borico da un concentrato di acque di scarico di una centrale di energia nucleare.
ES2079486T3 (es) Procedimiento para preparar resinas fenolicas que contienen cianato.
DE3565552D1 (en) Unwetting composition based on fluorochlorohydrocarbon, surface active agent and carboxylic acid
ES2042850T3 (es) Nuevo procedimiento para la preparacion de oxalil- y oxamil-hidracidas.
ES550040A0 (es) Un metodo para producir derivados de acido 2-(4-amino susti-tuido-3-oxo-2-isoxazolidinil)-5-oxo-2-tetrahidrofuran-carbo-xilico
ATE22285T1 (de) Verfahren zur herstellung sekundaerer amine.
JPS52152932A (en) Fluorescent brighteners for resin treatment
IT1212821B (it) Derivati dell'acido fenil-etil-acetico ad attivita'antiinfiammatoria.
ES540117A0 (es) Un metodo de preparar sales de metal alcalino de diaminas organicas.
ES2017607T3 (es) Sales de amina de 2-alcoxi-2-oxidos del acido 1,4,2-oxazafosfolidin-4-acetico.
JPS5634674A (en) Isoxazolin-3-one derivative

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 226104

Country of ref document: ES