ES2033675T3 - Un procedimiento para preparar un compuesto de n-benzoil urea. - Google Patents

Un procedimiento para preparar un compuesto de n-benzoil urea.

Info

Publication number
ES2033675T3
ES2033675T3 ES198686116595T ES86116595T ES2033675T3 ES 2033675 T3 ES2033675 T3 ES 2033675T3 ES 198686116595 T ES198686116595 T ES 198686116595T ES 86116595 T ES86116595 T ES 86116595T ES 2033675 T3 ES2033675 T3 ES 2033675T3
Authority
ES
Spain
Prior art keywords
group
formula
substituted
benzoil
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686116595T
Other languages
English (en)
Inventor
Haga Takahiro
Yamada Nobutoshi
Sugi Hideo
Koyanagi Toru
Okada Hiroshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ishihara Sangyo Kaisha Ltd
Original Assignee
Ishihara Sangyo Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishihara Sangyo Kaisha Ltd filed Critical Ishihara Sangyo Kaisha Ltd
Application granted granted Critical
Publication of ES2033675T3 publication Critical patent/ES2033675T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

COMPRENDEN LA FORMULA (I) DONDE X ES H, UN ATOMO DE HALOGENO O UN GRUPO NITRO, N ES UN ENTERO ENTRE 1 Y 3 Y Q ES LA FORMULA (II) O LA FORMULA (III) DONDE Y ES UN GRUPO ALQUIL SUSTITUIDO O NO SUSTITUIDO, O UN ALCOXIDO O UN GRUPO ALCOXIDOCARBONIL CON SU MOLECULA DE ALQUIL SUSTITUIDA O NO SUSTITUIDA, Y2 ES H, UN ATOMO DE HALOGENO, UN GRUPO NITRO O UN GRUPO ALQUIL SUSTITUIDO O NO SUSTITUIDO, O UN ALCOXIDO O UN GRUPO ALCOXIDOCARBONIL, CON SU MOLECULA DE ALQUIL SUSTITUIDA O NO SUSTITUIDA, Z ES H, UN ATOMO DE HALOGENO, UN GRUPO TRIFLUOROMETILO O UN GRUPO NITRO, Y CADA A Y B ES =CH O UN ATOMO DE NITROGENO, CON TAL DE QUE UNO DE A Y B SEA =CH - Y EL OTRO SEA UN ATOMO DE HIDROGENO, CON LAS SALVEDADES (1) DE QUE CUANDO Q ES LA FORMULA (IV) A ES =CH -, LA FORMULA (V) O LA FORMULA (VI), DONDE X ES H E Y1 ES UN GRUPO ALQUIL, Z NO ES H NI UN ATOMO DE HALOGENO NI UN GRUPO TRIFLUOROMETILO, Y (2) QUE CUANDO Q ES LA FORMULA (VII) DONDE A ES H E Y1 ES UN GRUPO TRIFLUOROMETILO, Y2 ES DISTINTO DE H.
ES198686116595T 1985-12-11 1986-11-28 Un procedimiento para preparar un compuesto de n-benzoil urea. Expired - Lifetime ES2033675T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27818085 1985-12-11
JP27988485 1985-12-12
JP60280694 1985-12-13

Publications (1)

Publication Number Publication Date
ES2033675T3 true ES2033675T3 (es) 1993-04-01

Family

ID=27336532

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686116595T Expired - Lifetime ES2033675T3 (es) 1985-12-11 1986-11-28 Un procedimiento para preparar un compuesto de n-benzoil urea.

Country Status (14)

Country Link
US (1) US4863924A (es)
EP (1) EP0226104B1 (es)
JP (1) JPH0745473B2 (es)
KR (1) KR870006016A (es)
AR (1) AR244667A1 (es)
AT (1) ATE60760T1 (es)
AU (1) AU594098B2 (es)
DE (1) DE3677478D1 (es)
DK (2) DK164054C (es)
ES (1) ES2033675T3 (es)
GR (1) GR3001905T3 (es)
IL (1) IL80776A (es)
NZ (1) NZ218440A (es)
PL (1) PL151012B1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212208A (en) * 1984-06-15 1988-04-29 Ishihara Sangyo Kaisha N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions
JPS62185013A (ja) * 1986-02-08 1987-08-13 Green Cross Corp:The 易吸収性医薬組成物
ZA89135B (en) * 1988-01-11 1989-10-25 Duphar Int Res Method of treating hematologic diseases and pharmaceutical composition to be used therefor
US5166180A (en) * 1988-01-11 1992-11-24 Duphar International Research B.V. Method of treating hematologic diseases and pharmaceutical composition to be used therefor
JPH029855A (ja) * 1988-03-31 1990-01-12 Ishihara Sangyo Kaisha Ltd 置換ベンゼン誘導体、それらの製造方法及びそれらを含有する抗癌性組成物
FR2637282B1 (fr) * 1988-09-13 1990-12-07 Oreal Para-aminophenols 2-substitues et leur utilisation pour la teinture des fibres keratiniques
US5202487A (en) * 1988-09-13 1993-04-13 L'oreal 2-substituted para-aminophenols and their use for dyeing keratinous fibres
JPH02196719A (ja) * 1989-01-24 1990-08-03 Green Cross Corp:The 粉末状医薬組成物
NZ234551A (en) * 1989-07-28 1991-10-25 Ishihara Sangyo Kaisha Benzoylurea derivatives and antitumour compositions
US6344476B1 (en) * 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US7329670B1 (en) * 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
IL144144A0 (en) 1999-01-13 2002-05-23 Bayer Ag Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
WO2000042012A1 (en) 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
ME00275B (me) * 1999-01-13 2011-02-10 Bayer Corp ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
WO2003029199A1 (fr) * 2001-09-28 2003-04-10 Takeda Chemical Industries, Ltd. Derives de benzene et procede de preparation et d'utilisation associe
EP1450799B2 (en) * 2001-12-03 2018-07-11 Bayer HealthCare LLC Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers
US8110587B2 (en) * 2002-02-11 2012-02-07 Bayer Healthcare Llc Aryl ureas as kinase inhibitors
US20040023961A1 (en) * 2002-02-11 2004-02-05 Bayer Corporation Aryl ureas with raf kinase and angiogenisis inhibiting activity
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
EP2324825A1 (en) 2002-02-11 2011-05-25 Bayer Healthcare LLC Aryl ureas with angiogenesis inhibiting activity
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
ATE384264T1 (de) 2003-05-20 2008-02-15 Bayer Pharmaceuticals Corp Diaryl-harnstoffe mit kinasehemmender wirkung
NZ580384A (en) 2003-07-23 2011-03-31 Bayer Pharmaceuticals Corp 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
TW200529849A (en) * 2003-11-28 2005-09-16 Novartis Ag Diaryl urea derivatives in the treatment of protein kinase dependent diseases
KR101335932B1 (ko) 2005-03-07 2013-12-04 바이엘 헬스케어 엘엘씨 암의 치료를 위한 오메가-카르복시아릴 치환된 디페닐우레아를 포함하는 제약 조성물
ES2719410T3 (es) 2014-01-16 2019-07-10 Fmc Corp Derivados del pirimidiniloxi benceno como herbicidas
MX2017009792A (es) 2015-03-18 2017-10-27 Du Pont Derivados de pirimidiniloxipiridina sustituidos como herbicidas.
TW202400564A (zh) * 2015-06-05 2024-01-01 美商艾佛艾姆希公司 作為除草劑之嘧啶氧基苯衍生物
US10485235B2 (en) 2015-07-13 2019-11-26 Fmc Corporation Aryloxypyrimidinyl ethers as herbicides
US11427549B2 (en) 2017-05-02 2022-08-30 Fmc Corporation Pyrimidinyloxy benzo-fused compounds as herbicides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5615272A (en) * 1979-07-17 1981-02-14 Ishihara Sangyo Kaisha Ltd N-benzoyl-n'-phenylurea compound, its preparation, and insecticide containing the same
CA1233822A (en) * 1982-12-30 1988-03-08 David T. Chou Pesticidal benzoyl ureas and process for preparation
NZ212208A (en) * 1984-06-15 1988-04-29 Ishihara Sangyo Kaisha N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions
JPS6133176A (ja) * 1984-07-24 1986-02-17 Ishihara Sangyo Kaisha Ltd Ｎ−ニトロベンゾイル−ｎ’−ピリダジニルオキシフエニルウレア系化合物、それらの製造方法及びそれらを含有する抗癌剤
JPS6193163A (ja) * 1984-10-12 1986-05-12 Ishihara Sangyo Kaisha Ltd Ｎ−ベンゾイル−ｎ′−フエニルウレア系化合物、それらの製造方法並びにそれらを含有する抗癌剤
US4727077A (en) * 1985-02-20 1988-02-23 Ishihara Sangyo Kaisha Ltd. Benzoyl urea compounds, process for their production, and antitumorous compositions containing them

Also Published As

Publication number Publication date
JPH0745473B2 (ja) 1995-05-17
AU6558186A (en) 1987-06-18
EP0226104B1 (en) 1991-02-06
DK118391A (da) 1991-06-18
IL80776A (en) 1991-03-10
IL80776A0 (en) 1987-02-27
DK118391D0 (da) 1991-06-18
JPS6399056A (ja) 1988-04-30
PL262901A1 (en) 1988-09-29
NZ218440A (en) 1989-06-28
DK596586D0 (da) 1986-12-11
EP0226104A2 (en) 1987-06-24
EP0226104A3 (en) 1988-09-07
ATE60760T1 (de) 1991-02-15
DK164054C (da) 1992-09-28
KR870006016A (ko) 1987-07-08
DK596586A (da) 1987-06-12
US4863924A (en) 1989-09-05
DE3677478D1 (de) 1991-03-14
AR244667A1 (es) 1993-11-30
DK164054B (da) 1992-05-04
AU594098B2 (en) 1990-03-01
GR3001905T3 (en) 1992-11-23
PL151012B1 (en) 1990-07-31

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