DK164054C - N-benzoyl-n'-oe4-(2-pyrimidinyloxy)phenylaa-urinstofforbindelser, fremgangsmaade til fremstilling af samme samt antitumorpraeparater indeholdende disse - Google Patents
N-benzoyl-n'-oe4-(2-pyrimidinyloxy)phenylaa-urinstofforbindelser, fremgangsmaade til fremstilling af samme samt antitumorpraeparater indeholdende disseInfo
- Publication number
- DK164054C DK164054C DK596586A DK596586A DK164054C DK 164054 C DK164054 C DK 164054C DK 596586 A DK596586 A DK 596586A DK 596586 A DK596586 A DK 596586A DK 164054 C DK164054 C DK 164054C
- Authority
- DK
- Denmark
- Prior art keywords
- phenylaa
- pyrimidinyloxy
- benzoyl
- procedure
- preparations containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27818085 | 1985-12-11 | ||
| JP27818085 | 1985-12-11 | ||
| JP27988485 | 1985-12-12 | ||
| JP27988485 | 1985-12-12 | ||
| JP28069485 | 1985-12-13 | ||
| JP60280694 | 1985-12-13 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK596586D0 DK596586D0 (da) | 1986-12-11 |
| DK596586A DK596586A (da) | 1987-06-12 |
| DK164054B DK164054B (da) | 1992-05-04 |
| DK164054C true DK164054C (da) | 1992-09-28 |
Family
ID=27336532
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK596586A DK164054C (da) | 1985-12-11 | 1986-12-11 | N-benzoyl-n'-oe4-(2-pyrimidinyloxy)phenylaa-urinstofforbindelser, fremgangsmaade til fremstilling af samme samt antitumorpraeparater indeholdende disse |
| DK911183A DK118391D0 (da) | 1985-12-11 | 1991-06-18 | N-benzoylurinstofforbindelser, fremgangsmaade til fremstilling af samme samt antitumorsammensaetning indeholdende disse |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK911183A DK118391D0 (da) | 1985-12-11 | 1991-06-18 | N-benzoylurinstofforbindelser, fremgangsmaade til fremstilling af samme samt antitumorsammensaetning indeholdende disse |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4863924A (da) |
| EP (1) | EP0226104B1 (da) |
| JP (1) | JPH0745473B2 (da) |
| KR (1) | KR870006016A (da) |
| AR (1) | AR244667A1 (da) |
| AT (1) | ATE60760T1 (da) |
| AU (1) | AU594098B2 (da) |
| DE (1) | DE3677478D1 (da) |
| DK (2) | DK164054C (da) |
| ES (1) | ES2033675T3 (da) |
| GR (1) | GR3001905T3 (da) |
| IL (1) | IL80776A (da) |
| NZ (1) | NZ218440A (da) |
| PL (1) | PL151012B1 (da) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ212208A (en) * | 1984-06-15 | 1988-04-29 | Ishihara Sangyo Kaisha | N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions |
| JPS62185013A (ja) * | 1986-02-08 | 1987-08-13 | Green Cross Corp:The | 易吸収性医薬組成物 |
| US5166180A (en) * | 1988-01-11 | 1992-11-24 | Duphar International Research B.V. | Method of treating hematologic diseases and pharmaceutical composition to be used therefor |
| DK5489A (da) * | 1988-01-11 | 1989-07-12 | Duphar Int Res | Anvendelse af substituerede amidforbindelser til fremstilling af farmaceutiske praeparater til behandling af haematologiske sygdomme |
| JPH029855A (ja) * | 1988-03-31 | 1990-01-12 | Ishihara Sangyo Kaisha Ltd | 置換ベンゼン誘導体、それらの製造方法及びそれらを含有する抗癌性組成物 |
| US5202487A (en) * | 1988-09-13 | 1993-04-13 | L'oreal | 2-substituted para-aminophenols and their use for dyeing keratinous fibres |
| FR2637282B1 (fr) * | 1988-09-13 | 1990-12-07 | Oreal | Para-aminophenols 2-substitues et leur utilisation pour la teinture des fibres keratiniques |
| JPH02196719A (ja) * | 1989-01-24 | 1990-08-03 | Green Cross Corp:The | 粉末状医薬組成物 |
| NZ234551A (en) * | 1989-07-28 | 1991-10-25 | Ishihara Sangyo Kaisha | Benzoylurea derivatives and antitumour compositions |
| US6344476B1 (en) * | 1997-05-23 | 2002-02-05 | Bayer Corporation | Inhibition of p38 kinase activity by aryl ureas |
| US7329670B1 (en) * | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| US20080300281A1 (en) * | 1997-12-22 | 2008-12-04 | Jacques Dumas | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| US20080269265A1 (en) * | 1998-12-22 | 2008-10-30 | Scott Miller | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas |
| CA2359244C (en) | 1999-01-13 | 2013-10-08 | Bayer Corporation | .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| EP1140840B1 (en) | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| ME00275B (me) | 1999-01-13 | 2011-02-10 | Bayer Corp | ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE |
| US7235576B1 (en) | 2001-01-12 | 2007-06-26 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US7371763B2 (en) * | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
| EP1437344A4 (en) * | 2001-09-28 | 2006-09-20 | Takeda Pharmaceutical | BENZOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
| ES2275931T5 (es) * | 2001-12-03 | 2018-10-23 | Bayer Healthcare Llc | Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos |
| US20040023961A1 (en) * | 2002-02-11 | 2004-02-05 | Bayer Corporation | Aryl ureas with raf kinase and angiogenisis inhibiting activity |
| WO2003068229A1 (en) * | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
| DK1478358T3 (da) | 2002-02-11 | 2013-10-07 | Bayer Healthcare Llc | Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese |
| WO2003068746A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Aryl ureas as kinase inhibitors |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| PT1626714E (pt) | 2003-05-20 | 2007-08-24 | Bayer Pharmaceuticals Corp | Diarilureias para doenças mediadas por pdgfr |
| ES2297490T3 (es) | 2003-07-23 | 2008-05-01 | Bayer Pharmaceuticals Corporation | Omega-carboxiarildifenilurea fluoro sustituida para el tratamiento y prevencion de enfermadades y afecciones. |
| EP1689376A2 (en) * | 2003-11-28 | 2006-08-16 | Novartis AG | Diaryl urea derivatives in the treatment of protein kinase dependent diseases |
| JP5304241B2 (ja) | 2005-03-07 | 2013-10-02 | バイエル・ヘルスケア・エルエルシー | 癌の処置用のオメガ−カルボキシアリール置換ジフェニルウレアを含む医薬組成物 |
| KR102381581B1 (ko) | 2014-01-16 | 2022-04-04 | 에프엠씨 코포레이션 | 제초제로서의 피리미디닐옥시 벤젠 유도체 |
| CA2969816C (en) | 2015-03-18 | 2022-03-01 | E I Du Pont De Nemours And Company | Substituted pyrimidinyloxy pyridine derivatives as herbicides |
| TWI713530B (zh) * | 2015-06-05 | 2020-12-21 | 美商艾佛艾姆希公司 | 作為除草劑之嘧啶氧基苯衍生物 |
| AU2016292811B2 (en) | 2015-07-13 | 2021-02-18 | Fmc Corporation | Aryloxypyrimidinyl ethers as herbicides |
| WO2018204164A1 (en) | 2017-05-02 | 2018-11-08 | Fmc Corporation | Pyrimidinyloxy benzo-fused compounds as herbicides |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5615272A (en) * | 1979-07-17 | 1981-02-14 | Ishihara Sangyo Kaisha Ltd | N-benzoyl-n'-phenylurea compound, its preparation, and insecticide containing the same |
| CA1233822A (en) * | 1982-12-30 | 1988-03-08 | David T. Chou | Pesticidal benzoyl ureas and process for preparation |
| NZ212208A (en) * | 1984-06-15 | 1988-04-29 | Ishihara Sangyo Kaisha | N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions |
| JPS6133176A (ja) * | 1984-07-24 | 1986-02-17 | Ishihara Sangyo Kaisha Ltd | Ｎ−ニトロベンゾイル−ｎ’−ピリダジニルオキシフエニルウレア系化合物、それらの製造方法及びそれらを含有する抗癌剤 |
| JPS6193163A (ja) * | 1984-10-12 | 1986-05-12 | Ishihara Sangyo Kaisha Ltd | Ｎ−ベンゾイル−ｎ′−フエニルウレア系化合物、それらの製造方法並びにそれらを含有する抗癌剤 |
| US4727077A (en) * | 1985-02-20 | 1988-02-23 | Ishihara Sangyo Kaisha Ltd. | Benzoyl urea compounds, process for their production, and antitumorous compositions containing them |
-
1986
- 1986-11-20 AU AU65581/86A patent/AU594098B2/en not_active Ceased
- 1986-11-26 IL IL80776A patent/IL80776A/xx unknown
- 1986-11-28 EP EP86116595A patent/EP0226104B1/en not_active Expired - Lifetime
- 1986-11-28 AT AT86116595T patent/ATE60760T1/de not_active IP Right Cessation
- 1986-11-28 DE DE8686116595T patent/DE3677478D1/de not_active Expired - Fee Related
- 1986-11-28 ES ES198686116595T patent/ES2033675T3/es not_active Expired - Lifetime
- 1986-11-28 NZ NZ218440A patent/NZ218440A/xx unknown
- 1986-12-05 AR AR86306114A patent/AR244667A1/es active
- 1986-12-08 US US06/939,025 patent/US4863924A/en not_active Expired - Fee Related
- 1986-12-08 JP JP29192186A patent/JPH0745473B2/ja not_active Expired - Lifetime
- 1986-12-10 KR KR860010558A patent/KR870006016A/ko not_active Application Discontinuation
- 1986-12-10 PL PL1986262901A patent/PL151012B1/pl unknown
- 1986-12-11 DK DK596586A patent/DK164054C/da not_active IP Right Cessation
-
1991
- 1991-05-03 GR GR91400577T patent/GR3001905T3/el unknown
- 1991-06-18 DK DK911183A patent/DK118391D0/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU594098B2 (en) | 1990-03-01 |
| GR3001905T3 (en) | 1992-11-23 |
| PL262901A1 (en) | 1988-09-29 |
| EP0226104A2 (en) | 1987-06-24 |
| EP0226104A3 (en) | 1988-09-07 |
| KR870006016A (ko) | 1987-07-08 |
| AU6558186A (en) | 1987-06-18 |
| NZ218440A (en) | 1989-06-28 |
| DE3677478D1 (de) | 1991-03-14 |
| DK596586A (da) | 1987-06-12 |
| PL151012B1 (en) | 1990-07-31 |
| ATE60760T1 (de) | 1991-02-15 |
| AR244667A1 (es) | 1993-11-30 |
| JPH0745473B2 (ja) | 1995-05-17 |
| DK118391A (da) | 1991-06-18 |
| JPS6399056A (ja) | 1988-04-30 |
| US4863924A (en) | 1989-09-05 |
| IL80776A (en) | 1991-03-10 |
| IL80776A0 (en) | 1987-02-27 |
| DK596586D0 (da) | 1986-12-11 |
| DK118391D0 (da) | 1991-06-18 |
| DK164054B (da) | 1992-05-04 |
| EP0226104B1 (en) | 1991-02-06 |
| ES2033675T3 (es) | 1993-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |