KR870005650A - 활성 물질의 신규 저제성 전달계 - Google Patents

활성 물질의 신규 저제성 전달계 Download PDF

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KR870005650A
KR870005650A KR860010928A KR860010928A KR870005650A KR 870005650 A KR870005650 A KR 870005650A KR 860010928 A KR860010928 A KR 860010928A KR 860010928 A KR860010928 A KR 860010928A KR 870005650 A KR870005650 A KR 870005650A
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delivery system
drugs
mixtures
active substance
substance
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KR860010928A
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KR900007468B1 (ko
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케이. 양 로버트
씨. 샤마 슈리
슈 샨-샨
제이.쇼 제임스
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토마스 디. 몰리터노
워너-램버트 컴패니
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Confectionery (AREA)

Abstract

내용 없음

Description

활성 물질의 신규 저제성 전달계
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (22)

  1. (가) 레시틴, 연쇄길이가 탄소원자수로 4개 이하인 폴리옥시알킬렌, 융점이 100℃ 이하인 글리세리드, 분자량이 3700 이하인 폴리알킬렌글리콜, 천연왁스와 합성왁스 및 이들의 혼합물 중에서 선택되는 최소한 한가지 물질로 예비 코우팅한 활성 물질과,
    (나)글리세린과 이것의 저급아킬(C2-7)에스테르 유도체 중에서 선택되는 보습제, 젤라틴, 감미제 및 수분 약 1-약30중량%로 된 결합제 계를 함유하는 저제성 메트릭스로 된 활성 물질의 씹을 수 있는 전달계.
  2. 제1항에 있어서, 활성 물질의 예비 코우팅에 사용되는 물질의 량이 총전달계에 대해 약 1-약 10중량%인 전달계.
  3. 제1항에 있어서, 코우팅물대 활성물질의 비가 중량부로 약 1:3-약 1:8인 전달계
  4. 제1항에 있어서, 활성 물질의 예비 코우팅용 물질의 폴리옥시에틸렌, 폴리옥시프로필네, 폴리옥시부틸렌, 이들의 공중합체 및 이들의 혼합물중에서 선택되는 전달계.
  5. 제1항에 있어서, 폴리알킬렌글리콜이 폴리에틸렌글리콜, 폴리프로필렌글리콜, 폴리부틸렌글리콜 및 이들의 혼합물 중에서 선택되는 전달계.
  6. 제1항에 있어서, 젤라틴 약 0.1-약 5.0%와 보습제 약 0.1-약25%된 결합제 계를 사용하는 전달계.
  7. 제6항에 있어서, 글리세린, 트리아세린, 트리부티린 및 이들의 혼합물 중에서 선택한 보습제를 사용하는 전달계.
  8. 제1항에 있어서, 바이온계 히드로클로이드검을 추가로 첨가하게 되는 전달계.
  9. 제8항에 있어서, 구아 검, 로우커스트 콩 검 및 이들의 혼합물 주에서 선택한 검을 사용하는 전달계.
  10. 제1항에 있어서, 펙틴, 감미제, 향미료, 색소, 보습제, 충전제, 유화제, 증점제 및 이들의 혼합물 중에서 선택한 물질을 추가로 첨가해서 되는 전달계.
  11. 제1항에 있어서, 활성 물질이 식이용 섬유인 전달계.
  12. 제1항에 있어서, 식이용 섬유가 천염검, 재질검, 펙틴, 점액제, 개질전분, 비셀롤로오스성 다당류, 조류 다당류 및 이들의 혼합물 중에서 선택되는 불용성 섬유인 전달계.
  13. 제1항에 있어서, 활성 물질이 무기첨가제, 진통약, 해열제, 항부정맥약, 이온교환수지, 식용억제제, 비타민류, 소염물질, 관상혈관확장제, 뇌혈관확장제, 말초혈관이완약, 감염방지제, 정신병치료약, 항조병제, 흥분제, 항히스타민제, 완하약, 충혈방지제, 위장진정제, 지사제, 협심증치료제, 혈관이완약, 항고혈압제, 혈관수축약, 편두통치료제, 항생제, 안정제, 항종양제, 항응고제, 항혈전제, 수면제, 진정제, 진토약, 항구토제, 항경련약, 신경근약, 과혈당증제, 저혈당증제, 갑상선제, 항갑상선제, 이뇨제, 진경약, 자궁이완제, 영양첨가제, 비만증치료제, 동화작용약, 조혈제, 천식약, 기침억제제 중에서 선택되는 약물인 전달계.
  14. 제1항에 있어서, 활성 물질이 염화칼륨, 탄화칼슘, 산화 마그네슘, N-아세틸프로카인아미드 및 이들의 혼합물 중에서 선택되는 전달계.
  15. 제1항에 있어서, 활성 물질이 콜레스티타민인 전달계.
  16. 제1항에 있어서, 예비 코우팅된 활성 물질이 최종 제품의 약 15-약30%를 차지하는 전달계.
  17. 제1항에 있어서, 활성 물질이 식이용 섬유와 약물의 혼합물인 전달계.
  18. 제15항의 전달계를 치료유효량으로 투여하는 과콜레스테롤혈증과 관련 장애의 치료방법.
  19. (가) 레시틴, 탄소원자수가 4개 이하인 폴리옥시알킬렌, 분자량이 3700 이하인 폴리알킬렌그리콜 및 이들의 혼합물중에서 선택한 최소한 한가지 물질로 섬유가 약물을 코우팅해서 된 폴레스티라민 수지와 식이용 섬유와의 조합물과,
    (나)글리세린 및 이것의 저급알킬(C2-7)에스테르 유도체 중에서 선택한 보습물질, 감미제, 물 약 1-30중량%, 및 젤라틴으로 된 결합제제를 함유하는 제제성 메트릭스로 된 전달계를 치료유효량을 투여하는 과콜레스테롤혈증과 관련장애의 치료방법.
  20. 활성물질이 쳄피브로질인 제1항의 전달계를 치료유효량을 부여하는 과콜레스테로혈증 치료방법.
  21. (가)레시틴, 탄소원자수가 4개 이하인 연쇄길이를 가진 폴리옥시알킬렌, 융점이 100℃이하인 글리세리드, 분자량이 3700 이하인 폴리알킬렌글리콜, 합성왁스, 천연왁스, 및 이들의 혼합물중에서 선택한 최소한 한가지의 물질을 사용해서 활성물질의 기능이나 방출성을 저해하지 않는 예비 코우팅을 활성물질에 해주고,
    (난)글리세린 및 이것의 저급알킬((C2-7)에스테르 유도체 중에서 선택한 보습물질, 감미제, 젤라틴 및 물 약 1-30중량부로 된 용액을 만들어주는 단계로 된 저제성 메트릭스를 제조하고
    (다)(가)와 (나)단계의 혼합물을 혼합해서
    (라)여기서 제조된 전달계를 일정한 형상으로 성형하는 활성물질의 전달계 제조방법.
  22. 제19항에 있어서, 예비코우팅을 실온에서 실시하고, 단순혼합법, 분무코우팅법, 분무응고별 또는 유동층 과립법중 한가지 방법을 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860010928A 1985-12-20 1986-12-19 활성 물질의 신규 당과성 전달 조성물 KR900007468B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US811601 1985-12-20
US06/811,601 US4778676A (en) 1985-12-20 1985-12-20 Confectionery delivery system for actives
US811.601 1985-12-20

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KR870005650A true KR870005650A (ko) 1987-07-06
KR900007468B1 KR900007468B1 (ko) 1990-10-10

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KR1019860010928A KR900007468B1 (ko) 1985-12-20 1986-12-19 활성 물질의 신규 당과성 전달 조성물

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Country Link
US (1) US4778676A (ko)
EP (1) EP0227603A3 (ko)
JP (1) JPS62155212A (ko)
KR (1) KR900007468B1 (ko)
CN (1) CN1010549B (ko)
AU (1) AU572036B2 (ko)
CA (1) CA1282700C (ko)
DE (1) DE227603T1 (ko)
DK (1) DK618186A (ko)
ES (1) ES2000071A4 (ko)
FI (1) FI865109A (ko)
GR (1) GR880300019T1 (ko)
NO (1) NO865202L (ko)
PH (1) PH25290A (ko)
PT (1) PT83976B (ko)
ZA (1) ZA869066B (ko)

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CN86108429A (zh) 1988-01-20
EP0227603A3 (en) 1988-06-15
CA1282700C (en) 1991-04-09
AU572036B2 (en) 1988-04-28
FI865109A (fi) 1987-06-21
DK618186D0 (da) 1986-12-19
ZA869066B (en) 1987-07-29
US4778676A (en) 1988-10-18
DE227603T1 (de) 1988-02-25
DK618186A (da) 1987-06-21
KR900007468B1 (ko) 1990-10-10
PT83976B (pt) 1989-01-17
NO865202D0 (no) 1986-12-19
GR880300019T1 (en) 1988-10-18
JPS62155212A (ja) 1987-07-10
NO865202L (no) 1987-06-22
ES2000071A4 (es) 1987-11-16
EP0227603A2 (en) 1987-07-01
PT83976A (en) 1987-01-01
AU6657286A (en) 1987-06-25
PH25290A (en) 1991-04-30
FI865109A0 (fi) 1986-12-15
CN1010549B (zh) 1990-11-28

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