KR870003792A - 백혈구 감소증치료제 - Google Patents

백혈구 감소증치료제 Download PDF

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Publication number
KR870003792A
KR870003792A KR1019860008292A KR860008292A KR870003792A KR 870003792 A KR870003792 A KR 870003792A KR 1019860008292 A KR1019860008292 A KR 1019860008292A KR 860008292 A KR860008292 A KR 860008292A KR 870003792 A KR870003792 A KR 870003792A
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Prior art keywords
granulocyte colony
human granulocyte
leukopenia
polypeptide
therapeutic agent
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KR1019860008292A
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English (en)
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KR960000394B1 (ko
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마사히꼬 다무라
히또시 노무라
구니히로 하또리
마사요시 오노
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우에노 기미오
쥬우가이세이야꾸 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음

Description

백혈구 감소증치료제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 세가지 서로 다른 탐침, IWQ,A 및 LC의 서열을 나타낸다.
제4도는 발현용 제조합 벡터 pTN-G4의 제작과정을 나타낸다.

Claims (9)

  1. 인체과립구 콜로니 자극인자를 유효성분으로 하는 백혈구 감소증치료제제.
  2. 제1항에 있어서, 인체과립구 콜로니자극 인자가 호중구 콜로니 자극인자임을 특징으로 하는 백혈구 감소증 치료제.
  3. 제1항에 있어서, 인체과립구 콜로니 자극인자가 인체과립구 콜로니 자극인자 생산세포의 배양 상동액으로부터 얻어진 것임을 특징으로 하는 백혈구 감소증 치료제.
  4. 제3항에 있어서, 인체과립구 콜로니 자극인자가 다음의 생리학적 성질을 갖는 것임을 특징으로 하는 백혈구 감소증 치료제.
    [이화학적 성질]
    ① 분자량 : 도던실 황산나트륨-폴리아크릴아미드겔 전기영동법에 의한 측정으로 19,000±1,000의 분자량을 갖는다.
    ② 동전점 : pI=505±0.1, pI=5.8±0.1, pI=6.1±0.1의 3개의 동전점중 적어도 하나를 갖는다.
    ③ 자외부흡수 : 280nm에 극대흡수를 갖고, 250nm에 극소치를 갖는다.
    ④ N말단으로부터 21 잔기째까지의 아미노산 서열이 다음과 같다.
  5. 제1항에 있어서, 인체과립구 콜로니 자극인자가 인체과립구 콜로니 자극인자 활성을 갖는 폴리펩판드를 코오딩하는 유전자를 할유하는 제조합벡터를 함유하는 형질전환체로부터 생산된 인체과립구 콜로니 자극인자 활성을 갖는 폴리펩티드 또는 당 단백질임을 특징으로 하는 백혈구 감소증 치료제.
  6. 제5항에 있어서, 인체과립구 콜로니 자극인자 활성을 갖는 폴리펩티드를 코오딩하는 유전자가 제2도에 나타낸 염기서열 또는 그 일부를 갖는 백혈구 감소증 치료제.
  7. 제5항에 있어서, 인체 과립구 콜로니 자극인자 활성을 갖는 폴리펩티드를 코오딩하는 유전자가 제도에 나타낸 염기서열 또는 그 일부를 갖는 백혈구 감소증 치료제.
  8. 제5항에 있어서, 인체과립구 콜로니 자극인자 활성을 갖는 폴리펩티드가 다음의 아미노산서열 또는 그 일부로 나타내지는 백혈구 감소증 치료제.
    (단 m은 0 또는 1이고, n은 0 또는 1이다)
  9. 제5항에 있어서, 인체과립구 콜로니 자극인자 활성을 갖는 당단백질이 다음의 아미노산 서열 또는 그 일부로 나타내지는 폴리펩티드와 당쇄부를 갖는 백혈구 감소증 치료제.
    (단 m은 0 또는 1이다)
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860008292A 1985-10-04 1986-10-02 백혈구 감소증 치료제의 제조방법 KR960000394B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP60-220450 1985-10-04
JP22045085 1985-10-04
JP220450/85 1985-10-04
JP125660/86 1986-06-02
JP61125660A JPH0618778B2 (ja) 1985-10-04 1986-06-02 白血球減少症治療剤
JP60-125660 1986-06-02

Publications (2)

Publication Number Publication Date
KR870003792A true KR870003792A (ko) 1987-05-04
KR960000394B1 KR960000394B1 (ko) 1996-01-06

Family

ID=26462024

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KR1019860008292A KR960000394B1 (ko) 1985-10-04 1986-10-02 백혈구 감소증 치료제의 제조방법

Country Status (11)

Country Link
EP (1) EP0217404B2 (ko)
JP (1) JPH0618778B2 (ko)
KR (1) KR960000394B1 (ko)
AT (1) ATE71662T1 (ko)
AU (1) AU596997C (ko)
DE (1) DE3683430D1 (ko)
DK (1) DK172204B1 (ko)
ES (1) ES2055684T5 (ko)
FI (1) FI863971A (ko)
HK (1) HK65693A (ko)
NO (1) NO863918L (ko)

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ATE79761T1 (de) * 1985-11-27 1992-09-15 Genetics Inst Behandlung einer krankheit vom aids-typ.
JPH0618779B2 (ja) * 1986-01-22 1994-03-16 中外製薬株式会社 造血機能回復促進剤
GR871067B (en) * 1986-07-18 1987-11-19 Chugai Pharmaceutical Co Ltd Process for producing stable pharmaceutical preparation containing granulocyte colony stimulating factor
CA1329119C (en) * 1988-03-29 1994-05-03 Milton David Goldenberg Cytotoxic therapy
NZ243953A (en) * 1989-01-30 1997-06-24 Schering Corp Gm-csf composition for treating leukocyte dysfunction
EP0565722A1 (en) * 1990-12-25 1993-10-20 Kyowa Hakko Kogyo Co., Ltd. Pharmaceutical preparation for pernasal administration
US5686578A (en) 1994-08-05 1997-11-11 Immunomedics, Inc. Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
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US7423007B2 (en) 2002-08-27 2008-09-09 Biokine Therapeutics Ltd. Cxcr4 antagonist and use thereof
KR100638453B1 (ko) * 2004-11-19 2006-10-24 씨제이 주식회사 포장용 박스 및 포장용 박스 접는방법
ES2842210T3 (es) 2006-12-21 2021-07-13 Biokine Therapeutics Ltd 4F-benzoil-TN14003 para la movilización de células progenitoras hematopoyéticas con vistas al trasplante
WO2010092571A2 (en) 2009-02-11 2010-08-19 Yeda Research And Development Co. Ltd. Short beta-defensin-derived peptides
KR101719339B1 (ko) 2009-06-14 2017-03-23 바이오카인 테라퓨틱스 리미티드 혈소판 수준을 증가시키는 펩타이드 요법
EP2841084B1 (en) 2012-04-24 2018-05-30 Biokine Therapeutics Ltd. Cxcr4 antagonist peptide for use in the treatment of large cell lung cancer
EP3744340A3 (en) 2015-07-16 2021-03-03 Biokine Therapeutics Ltd. Compositions and methods for treating cancer
AU2017222495B2 (en) 2016-02-23 2019-08-08 Biolinerx Ltd. Methods of treating acute myeloid leukemia
CN112175906B (zh) * 2019-07-05 2023-09-29 中国科学院生物物理研究所 胸腺嘧啶核苷诱导成纤维细胞转分化在中性粒细胞减少症治疗中的应用

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Also Published As

Publication number Publication date
AU596997C (en) 1993-01-21
ES2055684T3 (es) 1994-09-01
ATE71662T1 (de) 1992-02-15
HK65693A (en) 1993-07-16
ES2055684T5 (es) 1999-06-16
JPS62174026A (ja) 1987-07-30
NO863918D0 (no) 1986-10-02
EP0217404A3 (en) 1988-07-13
EP0217404B1 (en) 1992-01-15
KR960000394B1 (ko) 1996-01-06
NO863918L (no) 1987-04-06
DK471386A (da) 1987-04-05
DE3683430D1 (de) 1992-02-27
EP0217404B2 (en) 1999-01-07
EP0217404A2 (en) 1987-04-08
DK172204B1 (da) 1998-01-05
AU596997B2 (en) 1990-05-24
FI863971A (fi) 1987-04-05
DK471386D0 (da) 1986-10-02
AU6312186A (en) 1987-04-09
FI863971A0 (fi) 1986-10-01
JPH0618778B2 (ja) 1994-03-16

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