JPS5618591A - Production of substance capable of differentiation and multiplication of stem cells of human granulocyte - Google Patents

Production of substance capable of differentiation and multiplication of stem cells of human granulocyte

Info

Publication number
JPS5618591A
JPS5618591A JP9235579A JP9235579A JPS5618591A JP S5618591 A JPS5618591 A JP S5618591A JP 9235579 A JP9235579 A JP 9235579A JP 9235579 A JP9235579 A JP 9235579A JP S5618591 A JPS5618591 A JP S5618591A
Authority
JP
Japan
Prior art keywords
multiplication
separated
stem cells
human
glycoprotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9235579A
Other languages
Japanese (ja)
Other versions
JPS6237605B2 (en
Inventor
Shima Takaku
Katsuhiro Ogasa
Morio Kuboyama
Nobuya Yanagiuchi
Muneo Yamada
Yoshiteru Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morinaga Milk Industry Co Ltd
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Morinaga Milk Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan, Morinaga Milk Industry Co Ltd filed Critical Green Cross Corp Japan
Priority to JP9235579A priority Critical patent/JPS5618591A/en
Priority to US06/169,107 priority patent/US4342828A/en
Priority to GB8023347A priority patent/GB2058081B/en
Priority to CA356,422A priority patent/CA1128881A/en
Priority to DE19803027105 priority patent/DE3027105A1/en
Priority to CH550580A priority patent/CH644520A5/en
Priority to SE8005256A priority patent/SE451850B/en
Priority to FR8015923A priority patent/FR2461500A1/en
Publication of JPS5618591A publication Critical patent/JPS5618591A/en
Publication of JPS6237605B2 publication Critical patent/JPS6237605B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PURPOSE: Monocytes and macrophages separated from human venous blood are cultured in a medium containing a protein which is separated from human urine and capable of multiplying granulocytes in vivo, thus producing a substance having activity of promoting differentiation and multiplication of stem cells.
CONSTITUTION: Monocytes and macrophages separated from human venous blood are cultured in a medium for tissue culture containing a glycoprotein which has been separated from human urine and can multiply granulocytes in vivo to produce the effective component, which is collected from the medium, thus producing the substance capable of promoting differentiation and multiplication of stem cells of granulocyte. The glycoprotein is obtained by adding diluted acid or alkali to human urine to adjust the pH to 6W9, removing impurities in the urine by centrifugation, adsorbing the supernatant on silica gel eluting the purified glycoprotein with an aqueous alkali. The resultant liquid product is used directly for injection or powdery product is dissolved in sterilized water and the solution is injected.
COPYRIGHT: (C)1981,JPO&Japio
JP9235579A 1979-07-20 1979-07-20 Production of substance capable of differentiation and multiplication of stem cells of human granulocyte Granted JPS5618591A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP9235579A JPS5618591A (en) 1979-07-20 1979-07-20 Production of substance capable of differentiation and multiplication of stem cells of human granulocyte
US06/169,107 US4342828A (en) 1979-07-20 1980-07-15 Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells
GB8023347A GB2058081B (en) 1979-07-20 1980-07-17 Method of producing a substance for curing human granulocytopoenia
CA356,422A CA1128881A (en) 1979-07-20 1980-07-17 Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells
DE19803027105 DE3027105A1 (en) 1979-07-20 1980-07-17 METHOD FOR PRODUCING A FACTOR STIMULATING THE PROLIFERATION AND DIFFERENTIATION OF HUMAN GRANULOPOETIC STEM CELLS
CH550580A CH644520A5 (en) 1979-07-20 1980-07-18 METHOD FOR PRODUCING A FACTOR STIMULATING PROLIFERATION AND DIFFERENTIATION OF HUMAN GRANULOPOETIC STEM CELLS.
SE8005256A SE451850B (en) 1979-07-20 1980-07-18 SET TO MAKE A GLYCOPROTEIN WITH KNOWN ABILITY TO STIMULATE EDUCATION AND DIFFERENTIZATION OF HUMAN GRANULOCYTES
FR8015923A FR2461500A1 (en) 1979-07-20 1980-07-18 PROCESS FOR PRODUCING A SUBSTANCE CAPABLE OF STIMULATING THE PROLIFERATION AND DIFFERENTIATION OF HUMAN GRANULOPOIETIC STEM CELLS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9235579A JPS5618591A (en) 1979-07-20 1979-07-20 Production of substance capable of differentiation and multiplication of stem cells of human granulocyte

Publications (2)

Publication Number Publication Date
JPS5618591A true JPS5618591A (en) 1981-02-21
JPS6237605B2 JPS6237605B2 (en) 1987-08-13

Family

ID=14052084

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9235579A Granted JPS5618591A (en) 1979-07-20 1979-07-20 Production of substance capable of differentiation and multiplication of stem cells of human granulocyte

Country Status (1)

Country Link
JP (1) JPS5618591A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62174026A (en) * 1985-10-04 1987-07-30 Chugai Pharmaceut Co Ltd Remedy for leukpenia

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62174026A (en) * 1985-10-04 1987-07-30 Chugai Pharmaceut Co Ltd Remedy for leukpenia

Also Published As

Publication number Publication date
JPS6237605B2 (en) 1987-08-13

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