KR870003717A - 탄수화물 및 알콜의 염소화방법 - Google Patents

탄수화물 및 알콜의 염소화방법 Download PDF

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Publication number
KR870003717A
KR870003717A KR860008784A KR860008784A KR870003717A KR 870003717 A KR870003717 A KR 870003717A KR 860008784 A KR860008784 A KR 860008784A KR 860008784 A KR860008784 A KR 860008784A KR 870003717 A KR870003717 A KR 870003717A
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KR
South Korea
Prior art keywords
penta
sucrose
thionyl chloride
agent
chlorinating agent
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KR860008784A
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English (en)
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KR940000483B1 (ko
Inventor
에이. 오브라이언 엘리노어
오코너 토머스
알. 제이. 튜이트 매도우
이 하이 리로
Original Assignee
데이비드 제이. 레비
맥네일랩, 인코포레이티드
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Publication of KR870003717A publication Critical patent/KR870003717A/ko
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Publication of KR940000483B1 publication Critical patent/KR940000483B1/ko

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen

Abstract

내용 없음

Description

탄수화물 및 알콜의 염소화방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 알콜을 티오닐 클로라이드 또는 포스젠 존재하에 트리아릴푸스핀옥사이드 도는 트리아릴포스핀 설파이드로 구성된 염소화제와 반응시킴을 특징으로 하는, 알콜의 염소화 방법.
  2. 제1항에 있어서, 염소화제가 트리페닐포스핀옥사이드/티오닐 클로라이드인 방법.
  3. 제1항에 있어서, 알콜이 탄수화물인 방법.
  4. 제1항에 있어서, 슈크로오즈의 2, 3, 6, 3′, 4′-펜타 에스테르를 제1항에서 정의한 바와 같은 염소화제로 염소화시키고, 염소화 생성물을 탈에스테르화하여, 1, 6-디클로로-1, 6-디데옥시-β-D-프럭토푸라노실-4-클로로-4-데옥시-α-갈락토피라노사이드를 제조하는 방법.
  5. 제4항에 있어서, 염소화제가 트리페닐포스핀옥사이드/티오닐 클로라이드인 방법.
  6. 제1항에 있어서, (a)슈크로오즈를 트리틸화제와 반응시키고, (b)트리틸화된 반응 생성물을 아세틸화제로 아세틸화시켜 6, 1′, 6′- 트리-O-트리틸슈크로오즈펜타-아세테이트를 수득하고, (c)상기 6, 1′, 6′-트리-O-트리틸슈크로오즈펜타-아세테이트를 탈트리틸화시켜 2, 3, 4, 3′, 4′-펜타-O-아세틸슈크로오즈를 수득하고, (d) 상기 2, 3, 4, 3′, 4′-펜타-O-아세틸슈크로오즈를 이성체화시켜 2, 3, 6.3′4′-펜타-O-아세틸슈크로오즈를 수득하고, (e) 2, 3, 6.3′,4′-펜타-O-아세틸슈크로오즈를, 트리페닐포스핀옥사이드/티오닐클로라이드, 트리페닐포스핀 옥사이드/포스젠, 트리페닐포스핀 설파이드/티오닐 클로라이드 및 트리페닐포스핀 설파이드/포스젠 중에서 선택된 염소화제로 염소화시켜 4, 1′6′-트리클로로-4,1′6′-트리데옥시갈락토슈크로오즈 펜타 아세테이트를 수득하고, (f)염소화된 생성물을 탈아세틸화시켜 1, 6-디클로로-1, 6-디데옥시-β-D-프럭토푸라노실-4-클로로-4-데옥시-α-갈락토피라노사이드를 제조하는 방법.
  7. 제6항에 있어서, 단계(a)에서 트리틸화제가 트리틸클로라이드인 방법.
  8. 제6항에 있어서, 단계(b)에서 아세틸화제가 아세트산 무수물인 방법.
  9. 제6항에 있어서, 단계(d)에서 이성체화가 약염기를 사용한 비-수성용매중에서 수행되는 방법.
  10. 제9항에 있어서, 약염기가 3급-부틸아민, 트리에틸아민, 피롤리딘, 디-N-프로필아민, 디-이소프로필아민, 모르폴린, n-부틸아민, 이소프로필아민, 피페리딘 및 디에틸아민 중에서 선택되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860008784A 1985-10-21 1986-10-20 탄수화물 및 알콜의 염소화방법 KR940000483B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8525954 1985-10-21
GB858525954A GB8525954D0 (en) 1985-10-21 1985-10-21 Chlorination of carbohydrates &c alcohols
GB8525954 1985-10-21

Publications (2)

Publication Number Publication Date
KR870003717A true KR870003717A (ko) 1987-05-04
KR940000483B1 KR940000483B1 (ko) 1994-01-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860008784A KR940000483B1 (ko) 1985-10-21 1986-10-20 탄수화물 및 알콜의 염소화방법

Country Status (21)

Country Link
US (1) US4783526A (ko)
EP (1) EP0223421B1 (ko)
JP (1) JPH0830073B2 (ko)
KR (1) KR940000483B1 (ko)
AR (1) AR243197A1 (ko)
AT (1) ATE101856T1 (ko)
AU (1) AU595250B2 (ko)
CA (1) CA1284495C (ko)
DE (1) DE3689662T2 (ko)
DK (1) DK174926B1 (ko)
ES (1) ES2051262T3 (ko)
FI (1) FI88912C (ko)
GB (2) GB8525954D0 (ko)
IE (1) IE59558B1 (ko)
IL (1) IL80370A (ko)
MX (1) MX171629B (ko)
NO (1) NO167034C (ko)
NZ (1) NZ218009A (ko)
PT (1) PT83580B (ko)
SU (1) SU1634139A3 (ko)
ZA (1) ZA867948B (ko)

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Also Published As

Publication number Publication date
IE862762L (en) 1987-04-21
EP0223421A2 (en) 1987-05-27
GB8625108D0 (en) 1986-11-26
NO167034B (no) 1991-06-17
FI88912C (fi) 1993-07-26
DK503186D0 (da) 1986-10-20
FI864236A0 (fi) 1986-10-20
IL80370A0 (en) 1987-01-30
JPH0830073B2 (ja) 1996-03-27
IE59558B1 (en) 1994-03-09
ZA867948B (en) 1988-05-25
ATE101856T1 (de) 1994-03-15
GB2182039A (en) 1987-05-07
NO864191L (no) 1987-04-22
GB2182039B (en) 1989-10-25
NO864191D0 (no) 1986-10-20
EP0223421A3 (en) 1988-12-07
DK174926B1 (da) 2004-03-01
JPS62135487A (ja) 1987-06-18
IL80370A (en) 1992-01-15
PT83580A (en) 1986-11-01
DE3689662D1 (de) 1994-03-31
FI88912B (fi) 1993-04-15
US4783526A (en) 1988-11-08
NO167034C (no) 1991-09-25
FI864236A (fi) 1987-04-22
DK503186A (da) 1987-04-22
AU6421386A (en) 1987-04-30
DE3689662T2 (de) 1994-06-23
KR940000483B1 (ko) 1994-01-21
ES2051262T3 (es) 1994-06-16
GB8525954D0 (en) 1985-11-27
AU595250B2 (en) 1990-03-29
EP0223421B1 (en) 1994-02-23
PT83580B (pt) 1989-05-31
SU1634139A3 (ru) 1991-03-07
NZ218009A (en) 1988-11-29
MX171629B (es) 1993-11-10
CA1284495C (en) 1991-05-28
AR243197A1 (es) 1993-07-30

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