KR860001592A - 조정펩티드의 제어방출 미세캡슐 - Google Patents
조정펩티드의 제어방출 미세캡슐 Download PDFInfo
- Publication number
- KR860001592A KR860001592A KR1019850005514A KR850005514A KR860001592A KR 860001592 A KR860001592 A KR 860001592A KR 1019850005514 A KR1019850005514 A KR 1019850005514A KR 850005514 A KR850005514 A KR 850005514A KR 860001592 A KR860001592 A KR 860001592A
- Authority
- KR
- South Korea
- Prior art keywords
- solution
- peptide
- emulsified
- hydrocarbons
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003094 microcapsule Substances 0.000 title claims 6
- 238000013270 controlled release Methods 0.000 title claims 3
- 108091005601 modified peptides Proteins 0.000 title 1
- 239000000243 solution Substances 0.000 claims 6
- 229930195733 hydrocarbon Natural products 0.000 claims 5
- 150000002430 hydrocarbons Chemical class 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- WHBMMWSBFZVSSR-GSVOUGTGSA-N (R)-3-hydroxybutyric acid Chemical compound C[C@@H](O)CC(O)=O WHBMMWSBFZVSSR-GSVOUGTGSA-N 0.000 claims 4
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 108010037003 Buserelin Proteins 0.000 claims 1
- PYMDEDHDQYLBRT-DRIHCAFSSA-N Buserelin acetate Chemical compound CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 PYMDEDHDQYLBRT-DRIHCAFSSA-N 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229960005064 buserelin acetate Drugs 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000005191 phase separation Methods 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 229920002545 silicone oil Polymers 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
- B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP34.28372.2 | 1984-08-01 | ||
| DE19843428372 DE3428372A1 (de) | 1984-08-01 | 1984-08-01 | Mikrokapseln von regulatorischen peptiden mit kontrollierter freisetzung, verfahren zu ihrer herstellung und injektionszubereitungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR860001592A true KR860001592A (ko) | 1986-03-20 |
Family
ID=6242124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850005514A Withdrawn KR860001592A (ko) | 1984-08-01 | 1985-07-31 | 조정펩티드의 제어방출 미세캡슐 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0172422A3 (enExample) |
| JP (1) | JPS6143119A (enExample) |
| KR (1) | KR860001592A (enExample) |
| AU (1) | AU4567785A (enExample) |
| DE (1) | DE3428372A1 (enExample) |
| DK (1) | DK348185A (enExample) |
| ES (1) | ES8608313A1 (enExample) |
| GR (1) | GR851872B (enExample) |
| HU (1) | HU195108B (enExample) |
| IL (1) | IL75936A0 (enExample) |
| PT (1) | PT80890B (enExample) |
| ZA (1) | ZA855769B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3712095A1 (de) * | 1987-04-10 | 1988-10-20 | Lentia Gmbh | Bindemittelfreies granulat mit verzoegerter wirkstoffabgabe |
| NZ224549A (en) * | 1987-05-29 | 1990-04-26 | Ici Australia Operations | Controlled release polymer microspheres containing at least one active agent |
| JP2837675B2 (ja) * | 1987-09-22 | 1998-12-16 | 中外製薬株式会社 | 徐放性微粒製剤 |
| DE3738228A1 (de) * | 1987-11-11 | 1989-05-24 | Hoechst Ag | Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln |
| DE59006217D1 (de) * | 1989-11-30 | 1994-07-28 | Danubia Petrochem Polymere | Nicht wirkstoffretardierender Pressling, Verfahren zu dessen Herstellung und Verwendung von Polyhydroxybuttersäure zur Herstellung eines solchen Presslings. |
| JP2997488B2 (ja) * | 1989-12-25 | 2000-01-11 | 興研株式会社 | 腫瘍細胞増殖抑制剤 |
| DE4000155A1 (de) * | 1990-01-04 | 1991-07-11 | Chemie Linz Deutschland | Nicht wirkstoffretardierender pressling, verfahren zu dessen herstellung und verwendung von polyhydroxybuttersaeure zur herstellung eines solchen presslings |
| CA2046830C (en) * | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
| DE4041563A1 (de) * | 1990-12-22 | 1992-06-25 | Sanol Arznei Schwarz Gmbh | Verfahren zur herstellung wirkstoffhaltiger mikropartikel aus hydrolytisch abbaubaren polymeren |
| JPH0580599U (ja) * | 1992-04-03 | 1993-11-02 | 株式会社丸島アクアシステム | 閉鎖系水域における水質浄化装置 |
| DE4223169C1 (de) | 1992-07-10 | 1993-11-25 | Ferring Arzneimittel Gmbh | Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe |
| DE4427201C2 (de) * | 1993-11-26 | 1996-09-12 | Ges Innenhochdruckverfahren | Verfahren zur Herstellung von hohlen Nockenwellen |
| CN1278675C (zh) * | 2001-07-10 | 2006-10-11 | 佳能株式会社 | 含聚羟基烷醇酸酯的粒状体及其制备方法 |
| JP2004331750A (ja) | 2003-05-02 | 2004-11-25 | Canon Inc | ポリヒドロキシアルカノエートを含有する磁性構造体及びその製造方法ならびにその用途 |
| GB2470378A (en) * | 2009-05-20 | 2010-11-24 | Univ Westminster | A controlled release composition for intraocular delivery of a therapeutic agent |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH649217A5 (de) * | 1977-08-25 | 1985-05-15 | Sandoz Ag | Bromocriptin enthaltende mikrokapseln. |
| PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
| GB2108074A (en) * | 1981-10-28 | 1983-05-11 | Pa Management Consult | Preservation and projection of active substances |
-
1984
- 1984-08-01 DE DE19843428372 patent/DE3428372A1/de not_active Withdrawn
-
1985
- 1985-07-20 EP EP85109098A patent/EP0172422A3/de not_active Withdrawn
- 1985-07-25 HU HU852832A patent/HU195108B/hu unknown
- 1985-07-29 IL IL75936A patent/IL75936A0/xx unknown
- 1985-07-30 GR GR851872A patent/GR851872B/el unknown
- 1985-07-30 ES ES545723A patent/ES8608313A1/es not_active Expired
- 1985-07-31 KR KR1019850005514A patent/KR860001592A/ko not_active Withdrawn
- 1985-07-31 JP JP60167841A patent/JPS6143119A/ja active Pending
- 1985-07-31 AU AU45677/85A patent/AU4567785A/en not_active Abandoned
- 1985-07-31 PT PT80890A patent/PT80890B/pt unknown
- 1985-07-31 DK DK348185A patent/DK348185A/da not_active Application Discontinuation
- 1985-07-31 ZA ZA855769A patent/ZA855769B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU4567785A (en) | 1986-02-06 |
| HU195108B (en) | 1988-04-28 |
| ES8608313A1 (es) | 1986-07-01 |
| HUT41982A (en) | 1987-06-29 |
| PT80890A (de) | 1985-08-01 |
| GR851872B (enExample) | 1985-12-02 |
| EP0172422A3 (de) | 1986-05-07 |
| JPS6143119A (ja) | 1986-03-01 |
| EP0172422A2 (de) | 1986-02-26 |
| IL75936A0 (en) | 1985-12-31 |
| PT80890B (de) | 1987-03-24 |
| ZA855769B (en) | 1986-03-26 |
| DK348185D0 (da) | 1985-07-31 |
| DE3428372A1 (de) | 1986-02-13 |
| ES545723A0 (es) | 1986-07-01 |
| DK348185A (da) | 1986-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19850731 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |