KR860000915B1 - 히단토인 유도체의 제조방법 - Google Patents

히단토인 유도체의 제조방법 Download PDF

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Publication number
KR860000915B1
KR860000915B1 KR1019840002240A KR840002240A KR860000915B1 KR 860000915 B1 KR860000915 B1 KR 860000915B1 KR 1019840002240 A KR1019840002240 A KR 1019840002240A KR 840002240 A KR840002240 A KR 840002240A KR 860000915 B1 KR860000915 B1 KR 860000915B1
Authority
KR
South Korea
Prior art keywords
spiro
fluoro
chroman
imidazolidine
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019840002240A
Other languages
English (en)
Korean (ko)
Other versions
KR840008355A (ko
Inventor
사쥐스 레인하아드
Original Assignee
화이자 인코퍼레이티드
테렌스 제이. 갈라쥐
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 화이자 인코퍼레이티드, 테렌스 제이. 갈라쥐 filed Critical 화이자 인코퍼레이티드
Publication of KR840008355A publication Critical patent/KR840008355A/ko
Application granted granted Critical
Publication of KR860000915B1 publication Critical patent/KR860000915B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1019840002240A 1983-04-27 1984-04-26 히단토인 유도체의 제조방법 Expired KR860000915B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/488,947 US4474967A (en) 1983-04-27 1983-04-27 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
US488947 1983-04-27
US488,947 1983-04-27

Publications (2)

Publication Number Publication Date
KR840008355A KR840008355A (ko) 1984-12-14
KR860000915B1 true KR860000915B1 (ko) 1986-07-18

Family

ID=23941785

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840002240A Expired KR860000915B1 (ko) 1983-04-27 1984-04-26 히단토인 유도체의 제조방법

Country Status (22)

Country Link
US (1) US4474967A (https=)
EP (1) EP0124327A3 (https=)
JP (1) JPS59205384A (https=)
KR (1) KR860000915B1 (https=)
AU (1) AU542142B2 (https=)
CA (1) CA1226866A (https=)
CS (1) CS250661B2 (https=)
DD (1) DD219772A5 (https=)
DK (1) DK208284A (https=)
ES (1) ES8607312A1 (https=)
FI (1) FI841657A7 (https=)
GR (1) GR81491B (https=)
HU (1) HU191755B (https=)
IL (1) IL71656A (https=)
NO (1) NO841627L (https=)
NZ (1) NZ207959A (https=)
PH (1) PH22869A (https=)
PL (1) PL142759B1 (https=)
PT (1) PT78476B (https=)
SU (1) SU1240362A3 (https=)
YU (1) YU43358B (https=)
ZA (1) ZA843091B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172719B1 (en) * 1984-08-20 1988-09-21 Pfizer Inc. Process for the production as asymmetric hydantoins
US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
US5059693A (en) * 1989-10-06 1991-10-22 Pfizer Inc. Process for making 3-aroyl-2-oxindole-1-carboxamides
GB9317764D0 (en) * 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
EP1004307B1 (en) * 1998-01-30 2002-09-04 R-Tech Ueno, Ltd. Ophthalmic composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation

Also Published As

Publication number Publication date
ZA843091B (en) 1985-12-24
PL142759B1 (en) 1987-11-30
CS250661B2 (en) 1987-05-14
DD219772A5 (de) 1985-03-13
PH22869A (en) 1989-01-19
YU43358B (en) 1989-06-30
EP0124327A2 (en) 1984-11-07
SU1240362A3 (ru) 1986-06-23
FI841657L (fi) 1984-10-28
IL71656A0 (en) 1984-07-31
NO841627L (no) 1984-10-29
AU2726384A (en) 1984-11-01
YU74184A (en) 1986-10-31
ES531873A0 (es) 1986-06-01
DK208284A (da) 1984-10-28
HU191755B (en) 1987-04-28
DK208284D0 (da) 1984-04-26
US4474967A (en) 1984-10-02
KR840008355A (ko) 1984-12-14
PT78476B (en) 1986-08-28
FI841657A0 (fi) 1984-04-26
EP0124327A3 (en) 1985-07-31
AU542142B2 (en) 1985-02-07
FI841657A7 (fi) 1984-10-28
IL71656A (en) 1987-10-20
HUT34197A (en) 1985-02-28
JPS59205384A (ja) 1984-11-20
PL247379A1 (en) 1985-03-26
GR81491B (https=) 1984-12-11
PT78476A (en) 1984-05-01
NZ207959A (en) 1987-04-30
CA1226866A (en) 1987-09-15
ES8607312A1 (es) 1986-06-01

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19840426

PA0201 Request for examination
PG1501 Laying open of application
PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19860620

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19861004