KR860000067A - 고체다환식 약물의 용해도를 증진시키는 방법 - Google Patents

고체다환식 약물의 용해도를 증진시키는 방법 Download PDF

Info

Publication number
KR860000067A
KR860000067A KR1019850003860A KR850003860A KR860000067A KR 860000067 A KR860000067 A KR 860000067A KR 1019850003860 A KR1019850003860 A KR 1019850003860A KR 850003860 A KR850003860 A KR 850003860A KR 860000067 A KR860000067 A KR 860000067A
Authority
KR
South Korea
Prior art keywords
mixture
beads
drug
water
binder
Prior art date
Application number
KR1019850003860A
Other languages
English (en)
Inventor
죤 해리슨(외 2) 폴
Original Assignee
제이므즈 에이취 루우서
스터어링 드럭그 인코포레이팃드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 제이므즈 에이취 루우서, 스터어링 드럭그 인코포레이팃드 filed Critical 제이므즈 에이취 루우서
Publication of KR860000067A publication Critical patent/KR860000067A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

Abstract

내용 없음

Description

고체다환식 약물의 용해도를 증진시키는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예 8제제와 비교제 제2의 화합물 D의 방출속도를 비교해 놓은 그래프이다.

Claims (11)

  1. 미세하게 분할된 입자형태의 다환식 약물을 통상적으로 위장관에서 발견되는 pH에서 수성매체 및 상기 매체에 가용성인 결합제와 혼합해준 후, 상기 혼합물로부터 비이드를 형성하고, 상기 비이드를 건조시키는 것으로 구성된, 주위온도에서 물 또는 기타 수성매체 5000 중량부 당 약 1중량부 이하의 용해도를 갖고있는 고체다환식 약물의 용해도를 증신시키는 방법.
  2. 제1항에 있어서, 상기 혼합물이 중심(core)에 결합될 수 있도록 상기 혼합물로 중심입자를 코팅해줌으로써 비이드가 형성되는 방법.
  3. 제2항에 있어서, 미세하게 분할된 약물입자의 상기 결합제 수용액중 현탁액을 상기한 입자 중심물질을 구성하는 논퍼렐에 피복해준 후 이렇게 형성된 피복된 비이드를 건조시키는 방법.
  4. 제1항에 있어서, 상기한 미세하게 분할된 약물입자, 물 또는 기타 수성매체 및 결합제로 된 습윤혼합물을 제조한 후 혼합물을 압출하고 상기한 비이드를 생성시키기 위해 압출된 혼합물을 분쇄해줌으로써 비이드가 생성되는 방법.
  5. 제1항 내지 제4항중 어느 하나에 있어서, 고체약물이 17α-프레그나-2,4-디엔-20-인오[2,3-d]-이속사졸-17-올인 방법.
  6. 제1항 내지 제4항중 어느 하나에 있어서, 고체 약물이 17β-하이드록시-17α-메틸안드로스타노 [3,2-c] 피라졸; 17β-하이드록시-17α-에리닐-4-안드로스테노 [3,2-c]-2'-(파라-플루오로페닐)피라졸; 4α,5α-에폭시-17β-하이드록시-4,17-디메틸-3-옥소안드로스탄-2α-카보니트릴 및 4α,5α-에폭시-17β-하이드록시-3-옥소안드로스탄-2α-카보닐니트릴로부터 선택되는 방법.
  7. 제1항 내지 제6항중 어느 하나에 있어서, 상기 비이드 단위제형 용량을 의액-용해성 물질내에 밀폐시키는 것이 포함된 방법.
  8. 제1항 내지 제7항중 어느 하나에 있어서, 결합제가 하이드록시프로필메틸셀룰로오즈, 하이드록시프로필메틸셀룰로오즈프탈레이트, 폴리비닐피롤라돈, 또는 그 혼합물로 구성되어 있는 방법.
  9. 제1항 내지 제8항중 어느 하나에 있어서, 결합제가 수용성 다당류 또는 당시럽으로부터 유도된 당으로 구성되어 있는 방법.
  10. 제1항 내지 제9항중 어느 하나에 있어서, 상기 약물의 수용해도가 물 10000중량부당 약 1부 이하인 방법.
  11. 제1항 내지 제10항중 어느 하나에 있어서, 통상적으로 위장관에서 발견되는 pH치가 1.5내지 7의 범위인 방법.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019850003860A 1984-06-04 1985-06-03 고체다환식 약물의 용해도를 증진시키는 방법 KR860000067A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB14221 1984-06-04
GB848414221A GB8414221D0 (en) 1984-06-04 1984-06-04 Unit dosage form

Publications (1)

Publication Number Publication Date
KR860000067A true KR860000067A (ko) 1986-01-25

Family

ID=10561913

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850003860A KR860000067A (ko) 1984-06-04 1985-06-03 고체다환식 약물의 용해도를 증진시키는 방법

Country Status (20)

Country Link
US (1) US4717569A (ko)
EP (1) EP0164967B1 (ko)
JP (1) JPS611613A (ko)
KR (1) KR860000067A (ko)
AT (1) ATE56357T1 (ko)
AU (1) AU578474B2 (ko)
CA (1) CA1242646A (ko)
DE (1) DE3579631D1 (ko)
DK (1) DK164355C (ko)
ES (1) ES8608865A1 (ko)
FI (1) FI84783C (ko)
GB (1) GB8414221D0 (ko)
GR (1) GR851355B (ko)
IL (1) IL75372A (ko)
MX (1) MX161943A (ko)
NO (1) NO166918C (ko)
NZ (1) NZ212255A (ko)
PH (1) PH22173A (ko)
PT (1) PT80584B (ko)
ZA (1) ZA854115B (ko)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3440288A1 (de) * 1984-11-05 1986-05-07 Gergely, Gerhard, Dr.-Ing., Wien Pharmazeutische zubereitung mit einem gehalt an mindestens einer schleimhautreizenden substanz oder dergleichen, insbesondere profen, sowie verfahren zu ihrer herstellung
GB2176999B (en) * 1985-06-22 1989-07-12 Stanley Stewart Davis Sustained release medicament
US4833133A (en) * 1986-05-22 1989-05-23 Sterling Drug Inc. Method of regulating fertility in cattle using epostane
US4870068A (en) * 1986-05-22 1989-09-26 Sterling Drug Inc. Method of regulating fertility in swine using epostane
JP2680614B2 (ja) * 1988-08-01 1997-11-19 日清製粉株式会社 ダナゾール組成物
JP2773895B2 (ja) * 1989-04-25 1998-07-09 東京田辺製薬株式会社 ダナゾール組成物
JP2542122B2 (ja) * 1990-04-18 1996-10-09 旭化成工業株式会社 球状核、球形顆粒およびその製造方法
EP0452862B1 (en) * 1990-04-18 1995-07-19 Asahi Kasei Kogyo Kabushiki Kaisha Spherical seed cores, spherical granules and process for production thereof
US5223268A (en) * 1991-05-16 1993-06-29 Sterling Drug, Inc. Low solubility drug-coated bead compositions
US5547948A (en) * 1995-01-17 1996-08-20 American Home Products Corporation Controlled release of steroids from sugar coatings
US5573783A (en) * 1995-02-13 1996-11-12 Nano Systems L.L.C. Redispersible nanoparticulate film matrices with protective overcoats
FR2758459B1 (fr) * 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US7863331B2 (en) * 1999-07-09 2011-01-04 Ethypharm Pharmaceutical composition containing fenofibrate and method for the preparation thereof
FR2795961B1 (fr) 1999-07-09 2004-05-28 Ethypharm Lab Prod Ethiques Composition pharmaceutique contenant du fenofibrate micronise, un tensioactif et un derive cellulosique liant et procede de preparation
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
JP3386052B2 (ja) * 2001-02-13 2003-03-10 トヨタ自動車株式会社 ポンプ装置
GB2375958B (en) * 2001-04-09 2005-03-02 George Margetts The use of steroids to lower the levels of cortisol
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2842736B1 (fr) * 2002-07-26 2005-07-22 Flamel Tech Sa Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)
GB2400554B (en) * 2003-04-16 2007-04-18 George Margetts Treatment of angiotensin II-induced cardiovascular disease
NZ546183A (en) * 2003-09-26 2011-04-29 Alza Corp Controlled release formulations exhibiting an ascending rate of release
ATE504288T1 (de) * 2003-09-26 2011-04-15 Alza Corp Oros-push-stick für die kontrollierte abgabe von wirkstoffen
JP5563731B2 (ja) * 2003-09-26 2014-07-30 アルザ・コーポレーシヨン オピオイドおよび非オピオイド鎮痛薬の制御放出製剤
JP4919801B2 (ja) * 2003-09-26 2012-04-18 アルザ・コーポレーシヨン 高い薬剤配合量を提供する薬剤コーティング及びそれを提供する方法
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
FR2885526B1 (fr) * 2005-05-13 2007-07-27 Flamel Technologies Sa Medicament oral a base d'inhibiteur de pompe a protons
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
EP2018437A2 (en) * 2006-05-02 2009-01-28 Allozyne, Inc. Non-natural amino acid substituted polypeptides
US20080096819A1 (en) * 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
CA2707840A1 (en) 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
EP2257220B1 (en) * 2008-03-13 2017-06-14 Liebel-Flarsheim Company LLC Multi-function, foot-activated controller for imaging system
US8883176B2 (en) 2008-09-25 2014-11-11 Isp Investments Inc. Smooth, high solids tablet coating composition
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US20140030346A1 (en) * 2010-12-27 2014-01-30 Masashi Konishi Disintegrable core particle for pharmaceutical preparation
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US11559530B2 (en) 2016-11-28 2023-01-24 Lipocine Inc. Oral testosterone undecanoate therapy

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB742007A (en) * 1953-04-01 1955-12-14 Smith Kline & French Internat Improvements in or relating to method of forming coated pharmaceutical pellets
GB765086A (en) * 1954-11-19 1957-01-02 Smith Kline & French Internat Anticholinergic preparation
GB785262A (en) * 1955-09-23 1957-10-23 Smith Kline & French Internat Improvements in or relating to hypotensive and sedative preparations
GB844772A (en) * 1956-04-19 1960-08-17 Pfizer & Co C Granular pharmaceutical compositions and process for preparing same
US3328256A (en) * 1963-05-27 1967-06-27 William E Gaunt Spherical beads and their production
DE2010416B2 (de) * 1970-03-05 1979-03-29 Hoechst Ag, 6000 Frankfurt Oral anwendbare Arzneiform mit Retardwirkung
DE2336218C3 (de) * 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Orale Arzneiform
AT336190B (de) * 1974-07-23 1977-04-25 Hurka Wilhelm Verfahren zur herstellung von mikropellets zur behandlung von erkrankungen des mund- und rachenraumes
GB1561301A (en) * 1976-01-02 1980-02-20 Beecham Group Ltd Orally administrable pharmaceutical composition
DD146547A5 (de) * 1978-07-15 1981-02-18 Boehringer Sohn Ingelheim Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen
DE3000979A1 (de) * 1980-01-12 1981-07-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue dipyridamol-retardformen und verfahren zu ihrer herstellung
IT1144911B (it) * 1981-03-19 1986-10-29 Pharmatec Spa Composizione farmaceutica a rilascio controllato contenente ibuprofen
DE3126703A1 (de) * 1981-07-07 1983-01-27 Dr. Karl Thomae Gmbh, 7950 Biberach Bromhexin-retardform und verfahren zu ihrer herstellung
FR2510582B1 (fr) * 1981-07-30 1986-05-30 Sipsy Steroides esterifies en la position 17 et thio-esterifies en la position 21, leur procede de preparation et leur application comme medicament
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4415547A (en) * 1982-06-14 1983-11-15 Sterling Drug Inc. Sustained-release pharmaceutical tablet and process for preparation thereof

Also Published As

Publication number Publication date
ATE56357T1 (de) 1990-09-15
DK247485A (da) 1985-12-05
NO166918B (no) 1991-06-10
JPS611613A (ja) 1986-01-07
FI852236A0 (fi) 1985-06-04
GR851355B (ko) 1985-11-25
EP0164967A3 (en) 1986-12-30
IL75372A (en) 1989-08-15
DE3579631D1 (de) 1990-10-18
ES8608865A1 (es) 1986-07-16
CA1242646A (en) 1988-10-04
NO852226L (no) 1985-12-05
PT80584A (en) 1985-07-01
PT80584B (pt) 1987-09-18
AU4323785A (en) 1985-12-12
AU578474B2 (en) 1988-10-27
GB8414221D0 (en) 1984-07-11
IL75372A0 (en) 1985-09-29
EP0164967B1 (en) 1990-09-12
MX161943A (es) 1991-03-08
ES543828A0 (es) 1986-07-16
FI84783C (fi) 1992-01-27
EP0164967A2 (en) 1985-12-18
DK164355B (da) 1992-06-15
FI852236L (fi) 1985-12-05
DK247485D0 (da) 1985-06-03
DK164355C (da) 1992-11-02
US4717569A (en) 1988-01-05
ZA854115B (en) 1986-01-29
FI84783B (fi) 1991-10-15
NO166918C (no) 1991-09-18
NZ212255A (en) 1988-06-30
PH22173A (en) 1988-06-28

Similar Documents

Publication Publication Date Title
KR860000067A (ko) 고체다환식 약물의 용해도를 증진시키는 방법
KR910018017A (ko) 구형시드코어, 구형과립 및 그의 제조방법
GR3007626T3 (ko)
ID27586A (id) Komposisi aerosol
KR970700202A (ko) 다공성 입자 응집체 및 이의 제조방법(porous particle aggregate and method therefor)
WO1989011154A1 (en) Encapsulated superparamagnetic particles
KR910003036A (ko) 소판형 기재
KR900001363A (ko) 서방성(徐放性) 마이크로캡슐
TW362113B (en) Process for manufacturing thermosetting resin particles for powder coating use
KR880000123A (ko) 광물성 멤브레인의 제조방법
NO20012734L (no) Fremgangsmåte for fremstilling av agglomerater omfattende en kjerne-skallstruktur
DE69007455D1 (de) Magnetisierbare Polysilsesquioxanmikrokugeln, Verfahren zu ihrer Herstellung und ihre Verwendung in der Biologie.
JPS56143445A (en) Microencapsulated toner
KR880001732A (ko) 중합체-처리한 이온교환수지
KR910012168A (ko) 적색안료부착 형광체의 제조방법
CA2258224A1 (en) Resin encapsulated particles
KR850003559A (ko) 전착조성물
KR890016142A (ko) 은 활성화된 아연 설파이트 인광체를 착색 및 피복시키고 잘 휘저어 섞이는 능력을 부여하는 방법
JPS5674130A (en) Production of fine spherular particle of water-soluble high polymer
JPS5378986A (en) Pigment-attached fluorescent substance and production thereof
JPS557815A (en) Prevention of billsticking
NO921161D0 (no) Fremgangsmaate for innkapsling av hydrokarbonsystemer
JPS555953A (en) Remoistening adhesive paper
KR890006733A (ko) 분체성형용 수지와 그의 제조방법
IE35322L (en) Microencapsulating hydrophobic oil droplets.

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid