GB742007A - Improvements in or relating to method of forming coated pharmaceutical pellets - Google Patents
Improvements in or relating to method of forming coated pharmaceutical pelletsInfo
- Publication number
- GB742007A GB742007A GB9045/53A GB904553A GB742007A GB 742007 A GB742007 A GB 742007A GB 9045/53 A GB9045/53 A GB 9045/53A GB 904553 A GB904553 A GB 904553A GB 742007 A GB742007 A GB 742007A
- Authority
- GB
- United Kingdom
- Prior art keywords
- medicament
- pellets
- cores
- solution
- dextro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
In the production of sustained release pharmaceutical pellets, substantially spherical innocuous cores, e.g. of sugar, synthetic resin or nitrocellulose, or naturally-occurring seeds, are coated with a medicament, the cores are subdivided into groups, each group is provided with a slowly digestible coating to produce pellets of 0,1-2 mm. diameter to provide different times of release of the medicament on ingestion, and the pellets are combined e.g. by enclosure in a gelatin capsule, if desired with uncoated pellets. The cores are first wetted in a coating pan with gelatin &c.-sugar solution, and sprinkled with medicament, the operation being repeated as necessary; alternatively, the adhesive solution may contain dissolved or suspended medicament. The time delay material may be applied as a solution in various specified organic solvents of glyceryl monostearate and a wax, beeswax being preferred, or wax-like substances such as chlolesterol. Fatty acids and alcohols may be used in place of glyceryl monostearate. The various delay times may be provided by varying the thickness of the coatings, or by using different coating materials. Medicaments specified are salts of racemic and dextro-amphetamine, racemic and dextro-desoxyephedrine, and 2-amino-1-(4 methylphenyl)-propane sulphate, or potassium iodide. The medicament may be extended with calcium sulphate dehydrate, starch, acacia. Specifications 523,594, as open to inspection under Sect. 91, and 715,305 are referred to.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9045/53A GB742007A (en) | 1953-04-01 | 1953-04-01 | Improvements in or relating to method of forming coated pharmaceutical pellets |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9045/53A GB742007A (en) | 1953-04-01 | 1953-04-01 | Improvements in or relating to method of forming coated pharmaceutical pellets |
Publications (1)
Publication Number | Publication Date |
---|---|
GB742007A true GB742007A (en) | 1955-12-14 |
Family
ID=9864333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9045/53A Expired GB742007A (en) | 1953-04-01 | 1953-04-01 | Improvements in or relating to method of forming coated pharmaceutical pellets |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB742007A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1091289B (en) * | 1956-01-25 | 1960-10-20 | Hans Lowey | Process for the production of an orally used drug form with a longer duration of action |
DE1094929B (en) * | 1956-04-19 | 1960-12-15 | Pfizer & Co C | Process for coating sugar kernels |
DE2740286A1 (en) * | 1977-06-01 | 1978-12-07 | Ici Ltd | PHARMACEUTICAL COMPOSITION WITH DELAYED DELIVERY OF ACTIVE SUBSTANCE |
GB2159714A (en) * | 1984-06-04 | 1985-12-11 | Sterwin Ag | Pharmaceutical composition of sparingly soluble medicament and method for its preparation |
US4717569A (en) * | 1984-06-04 | 1988-01-05 | Sterling Drug Inc. | Unit dosage form of sparingly soluble medicaments |
GB2167374B (en) * | 1984-11-06 | 1989-06-01 | Long Island University | Aspirin or acetaminophen drug in bead form and process for preparing same. |
US4867984A (en) * | 1984-11-06 | 1989-09-19 | Nagin K. Patel | Drug in bead form and process for preparing same |
-
1953
- 1953-04-01 GB GB9045/53A patent/GB742007A/en not_active Expired
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1091289B (en) * | 1956-01-25 | 1960-10-20 | Hans Lowey | Process for the production of an orally used drug form with a longer duration of action |
DE1094929B (en) * | 1956-04-19 | 1960-12-15 | Pfizer & Co C | Process for coating sugar kernels |
DE2740286A1 (en) * | 1977-06-01 | 1978-12-07 | Ici Ltd | PHARMACEUTICAL COMPOSITION WITH DELAYED DELIVERY OF ACTIVE SUBSTANCE |
GB2159714A (en) * | 1984-06-04 | 1985-12-11 | Sterwin Ag | Pharmaceutical composition of sparingly soluble medicament and method for its preparation |
US4717569A (en) * | 1984-06-04 | 1988-01-05 | Sterling Drug Inc. | Unit dosage form of sparingly soluble medicaments |
GB2167374B (en) * | 1984-11-06 | 1989-06-01 | Long Island University | Aspirin or acetaminophen drug in bead form and process for preparing same. |
US4867984A (en) * | 1984-11-06 | 1989-09-19 | Nagin K. Patel | Drug in bead form and process for preparing same |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR870003778A (en) | Manufacturing method of new drug | |
GB935602A (en) | Sustained release type of pharmaceutical vehicles | |
AR193271A1 (en) | ESTERS OF CYCLOPROPROPANOCARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND INSECTICIDE COMPOSITIONS THAT CONTAIN THEM | |
GB742007A (en) | Improvements in or relating to method of forming coated pharmaceutical pellets | |
JPS557241A (en) | Artificial granules and their preparation | |
GB953626A (en) | Enteric-coated tablets of dextran sulphate ester and method of preparation thereof | |
NO975993L (en) | Process for the preparation of an oral preparation which is provided externally with an enteric coating, as well as oral preparation obtained by the method | |
ATE110267T1 (en) | PROCESS FOR MANUFACTURE OF TABLETS CONTAINING SPRAY DRIED NAPROXEN OR NAPROXEN SODIUM SALT. | |
US2816061A (en) | Sodium carboxymethyl cellulose tablet coating | |
US2816062A (en) | Hydroxyethyl cellulose tablet coating | |
CA922982A (en) | Gelatine capsule coatings and a process for their manufacture | |
GB793808A (en) | Sustained action pill | |
GB1072028A (en) | Anthelmintic compositions and their preparation | |
BR7303782D0 (en) | PROCESS FOR THE PREPARATION OF AN ACID ESTER CYCLE CARBOXYLIC INSECTICIDE COMPOSITION AND PROCESS TO COMBAT INSECTS | |
US2433244A (en) | Enteric coating | |
ATE9957T1 (en) | PROCESS FOR PREPARING AN ENCLOSED ACETYLSALICYL ACID PREPARATION. | |
AT320634B (en) | Process for the production of new indolecarboxylic acids, their esters and salts | |
AT317433B (en) | Process for the production of a framework drug form with controllable release of active ingredients | |
DE1924647C3 (en) | Process for the production of gelatine capsules which are resistant to gastric juice and soluble in the small intestine | |
GB857550A (en) | Improvements in or relating to the coating of shaped medical preparations | |
GB835956A (en) | Process for coating tablets | |
AT313888B (en) | Process for the production of new β-phenyl fatty acids, their esters, amides and / or salts | |
AT196557B (en) | Process for the production of plant extracts, in particular drug extracts suitable for preparation for infusion, in powder or tablet form | |
KR900000075A (en) | Method for preparing enteric granules | |
FR1066792A (en) | Product against the fermentation of plant and animal materials, artificial cellulose-based materials, and its manufacturing process |