KR850000529A - 안트라사이클린 유도체의 제조방법 - Google Patents
안트라사이클린 유도체의 제조방법 Download PDFInfo
- Publication number
- KR850000529A KR850000529A KR1019840003590A KR840003590A KR850000529A KR 850000529 A KR850000529 A KR 850000529A KR 1019840003590 A KR1019840003590 A KR 1019840003590A KR 840003590 A KR840003590 A KR 840003590A KR 850000529 A KR850000529 A KR 850000529A
- Authority
- KR
- South Korea
- Prior art keywords
- rod
- roa
- sugar combination
- sugar
- acu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims 16
- 229940045799 anthracyclines and related substance Drugs 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 235000015097 nutrients Nutrition 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- 241000187410 Streptomyces purpurascens Species 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000008351 acetate buffer Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000003463 adsorbent Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000013375 chromatographic separation Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000004440 column chromatography Methods 0.000 claims 1
- 238000004185 countercurrent chromatography Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 239000002024 ethyl acetate extract Substances 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 229930182470 glycoside Natural products 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000741 silica gel Substances 0.000 claims 1
- 229910002027 silica gel Inorganic materials 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 238000004809 thin layer chromatography Methods 0.000 claims 1
- 235000013619 trace mineral Nutrition 0.000 claims 1
- 239000011573 trace mineral Substances 0.000 claims 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3323025.0 | 1983-06-25 | ||
| DE3323025A DE3323025A1 (de) | 1983-06-25 | 1983-06-25 | Anthracyclin-derivate, ein mikrobiologisches verfahren zu ihrer herstellung und ihre verwendung als cytostatika |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR850000529A true KR850000529A (ko) | 1985-02-27 |
Family
ID=6202458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019840003590A Ceased KR850000529A (ko) | 1983-06-25 | 1984-06-25 | 안트라사이클린 유도체의 제조방법 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4713371A (enExample) |
| EP (1) | EP0131181B1 (enExample) |
| JP (1) | JPS6036437A (enExample) |
| KR (1) | KR850000529A (enExample) |
| AT (1) | ATE50776T1 (enExample) |
| AU (1) | AU578615B2 (enExample) |
| CA (1) | CA1244364A (enExample) |
| DE (2) | DE3323025A1 (enExample) |
| DK (1) | DK306584A (enExample) |
| ES (1) | ES8601230A1 (enExample) |
| FI (1) | FI80071C (enExample) |
| GR (1) | GR81630B (enExample) |
| HU (1) | HU195979B (enExample) |
| IL (1) | IL72214A0 (enExample) |
| MX (1) | MX7303E (enExample) |
| NO (1) | NO160011C (enExample) |
| NZ (1) | NZ208622A (enExample) |
| PH (1) | PH22276A (enExample) |
| PT (1) | PT78784B (enExample) |
| ZA (1) | ZA844742B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3325957A1 (de) * | 1983-07-19 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Anthracyclin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als cytostatika |
| JPS6117597A (ja) * | 1984-07-03 | 1986-01-25 | Microbial Chem Res Found | アントラサイクリン化合物 |
| DE3524117A1 (de) * | 1985-07-05 | 1987-02-05 | Hoechst Ag | Neue anthracyclin-tetrasaccharide, ein verfahren zu ihrer herstellung und ihre verwendung als cytostatik |
| DE3706175A1 (de) * | 1987-02-26 | 1988-09-08 | Behringwerke Ag | Verwendung von lipophilen anthracyclinen zur behandlung "sekundaer" anthracyclin-resistenter tumoren, mittel enthaltend ein lipophiles anthracyclin und verfahren zu seiner herstellung |
| DE3712350A1 (de) * | 1987-04-11 | 1988-10-20 | Behringwerke Ag | Semisynthetische rhodomycine, verfahren zu ihrer herstellung und ihre verwendung als zytostatika |
| US4918172A (en) * | 1987-10-06 | 1990-04-17 | Sanraku Incorporated | Anthracycline antibiotics |
| DE3842836A1 (de) * | 1988-12-20 | 1990-06-21 | Behringwerke Ag | Rhodomycine mit einer modifizierten kohlenhydrat-einheit |
| DE3920062A1 (de) * | 1989-06-20 | 1991-01-10 | Hoechst Ag | Neue anthracyclin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| FI93860C (fi) * | 1991-03-25 | 1995-06-12 | Leiras Oy | Menetelmä antibioottien tuottamiseksi, siinä käyttökelpoisia DNA-jaksoja, yhdistelmä-DNA-konstruktioita ja näitä sisältäviä mikrobikantoja |
| DE10029433A1 (de) * | 2000-06-15 | 2001-12-20 | Bioleads Gmbh | Rhodomycinon-Derivate |
| US8313760B2 (en) | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
| JP2005527302A (ja) | 2002-05-24 | 2005-09-15 | アンジオテック インターナショナル アーゲー | 医療用移植物をコーティングするための組成物および方法 |
| US20050059156A1 (en) * | 2003-08-06 | 2005-03-17 | Pharmacia Italia S.P.A. | Method for detecting contaminants in pharmaceutical products |
| WO2005051871A2 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Implantable sensors and implantable pumps and anti-scarring agents |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5323961A (en) * | 1976-08-16 | 1978-03-06 | Microbial Chem Res Found | Antitumors |
| JPS55120786A (en) * | 1979-03-14 | 1980-09-17 | Sanraku Inc | Variant capable of producing anthracycline glycoside |
| JPS6023679B2 (ja) * | 1979-07-13 | 1985-06-08 | メルシャン株式会社 | ロドマイシン群抗生物質とその製造法 |
| CH648327A5 (de) * | 1980-10-16 | 1985-03-15 | Hoffmann La Roche | Anthracycline. |
| JPS57114547A (en) * | 1981-01-07 | 1982-07-16 | Sanraku Inc | Anthracycline antibiotic substance and its preparation |
| JPS57176995A (en) * | 1981-04-23 | 1982-10-30 | Sanraku Inc | Novel anthracyclinone glycoside and its preparation |
| JPS5826895A (ja) * | 1981-08-11 | 1983-02-17 | Sanraku Inc | ２‐ヒドロキシアクラシノマイシンｂ |
| JPS5874694A (ja) * | 1981-10-29 | 1983-05-06 | Sanraku Inc | アントラサイクリン誘導体 |
| JPS5982395A (ja) * | 1982-11-02 | 1984-05-12 | Microbial Chem Res Found | アントラサイクリン化合物、その製造法およびその用途 |
| JPS59231023A (ja) * | 1983-11-11 | 1984-12-25 | Ajinomoto Co Inc | 抗腫瘍剤 |
-
1983
- 1983-06-25 DE DE3323025A patent/DE3323025A1/de not_active Withdrawn
-
1984
- 1984-06-18 HU HU842338A patent/HU195979B/hu not_active IP Right Cessation
- 1984-06-19 DE DE8484106995T patent/DE3481515D1/de not_active Expired - Fee Related
- 1984-06-19 AT AT84106995T patent/ATE50776T1/de active
- 1984-06-19 EP EP84106995A patent/EP0131181B1/de not_active Expired - Lifetime
- 1984-06-21 FI FI842523A patent/FI80071C/fi not_active IP Right Cessation
- 1984-06-22 NO NO842546A patent/NO160011C/no unknown
- 1984-06-22 DK DK306584A patent/DK306584A/da not_active Application Discontinuation
- 1984-06-22 ZA ZA844742A patent/ZA844742B/xx unknown
- 1984-06-22 GR GR75085A patent/GR81630B/el unknown
- 1984-06-22 AU AU29812/84A patent/AU578615B2/en not_active Ceased
- 1984-06-22 NZ NZ208622A patent/NZ208622A/en unknown
- 1984-06-22 ES ES533631A patent/ES8601230A1/es not_active Expired
- 1984-06-22 MX MX8411189U patent/MX7303E/es unknown
- 1984-06-22 JP JP59127644A patent/JPS6036437A/ja active Pending
- 1984-06-22 CA CA000457301A patent/CA1244364A/en not_active Expired
- 1984-06-25 IL IL72214A patent/IL72214A0/xx unknown
- 1984-06-25 KR KR1019840003590A patent/KR850000529A/ko not_active Ceased
- 1984-06-25 PT PT78784A patent/PT78784B/pt not_active IP Right Cessation
- 1984-06-25 PH PH30879A patent/PH22276A/en unknown
-
1986
- 1986-02-03 US US06/824,939 patent/US4713371A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MX7303E (es) | 1988-04-29 |
| FI842523A0 (fi) | 1984-06-21 |
| CA1244364A (en) | 1988-11-08 |
| NO842546L (no) | 1984-12-27 |
| DK306584A (da) | 1984-12-26 |
| FI842523A7 (fi) | 1984-12-26 |
| FI80071C (fi) | 1990-04-10 |
| NO160011B (no) | 1988-11-21 |
| US4713371A (en) | 1987-12-15 |
| JPS6036437A (ja) | 1985-02-25 |
| ES533631A0 (es) | 1985-10-16 |
| NZ208622A (en) | 1988-02-29 |
| PT78784B (de) | 1986-07-22 |
| EP0131181A2 (de) | 1985-01-16 |
| DE3481515D1 (de) | 1990-04-12 |
| AU578615B2 (en) | 1988-11-03 |
| PH22276A (en) | 1988-07-14 |
| ZA844742B (en) | 1985-02-27 |
| EP0131181A3 (en) | 1985-05-22 |
| DE3323025A1 (de) | 1985-01-10 |
| ATE50776T1 (de) | 1990-03-15 |
| NO160011C (no) | 1989-03-01 |
| EP0131181B1 (de) | 1990-03-07 |
| FI80071B (fi) | 1989-12-29 |
| AU2981284A (en) | 1985-01-03 |
| IL72214A0 (en) | 1984-10-31 |
| HUT44803A (en) | 1988-04-28 |
| DK306584D0 (da) | 1984-06-22 |
| HU195979B (en) | 1988-08-29 |
| PT78784A (de) | 1984-07-01 |
| ES8601230A1 (es) | 1985-10-16 |
| GR81630B (enExample) | 1984-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19840625 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19890531 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19840625 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19910701 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19920218 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19910701 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |