KR840008817A - Bbm-1675, 새로운 항암 항생복합체 - Google Patents
Bbm-1675, 새로운 항암 항생복합체Info
- Publication number
- KR840008817A KR840008817A KR1019840002636A KR840002636A KR840008817A KR 840008817 A KR840008817 A KR 840008817A KR 1019840002636 A KR1019840002636 A KR 1019840002636A KR 840002636 A KR840002636 A KR 840002636A KR 840008817 A KR840008817 A KR 840008817A
- Authority
- KR
- South Korea
- Prior art keywords
- bbm
- strain
- silica gel
- berukosospora
- kfcc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003972 antineoplastic antibiotic Substances 0.000 title claims 19
- 238000000862 absorption spectrum Methods 0.000 claims description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 42
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 24
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 16
- 239000000741 silica gel Substances 0.000 claims 16
- 229910002027 silica gel Inorganic materials 0.000 claims 16
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 15
- 239000002904 solvent Substances 0.000 claims 15
- 241000187362 Actinomadura Species 0.000 claims 13
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 13
- 241000894006 Bacteria Species 0.000 claims 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 12
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 9
- 238000010521 absorption reaction Methods 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 230000002401 inhibitory effect Effects 0.000 claims 8
- 238000004809 thin layer chromatography Methods 0.000 claims 8
- 239000001963 growth medium Substances 0.000 claims 7
- 241000233866 Fungi Species 0.000 claims 6
- 229910021578 Iron(III) chloride Inorganic materials 0.000 claims 6
- RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims 6
- 208000032839 leukemia Diseases 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 238000002844 melting Methods 0.000 claims 6
- 230000008018 melting Effects 0.000 claims 6
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 claims 6
- 238000006243 chemical reaction Methods 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 5
- 230000035764 nutrition Effects 0.000 claims 5
- 235000016709 nutrition Nutrition 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 241001269524 Dura Species 0.000 claims 4
- 241000699670 Mus sp. Species 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 230000003287 optical effect Effects 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 238000001228 spectrum Methods 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 239000011593 sulfur Substances 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 230000014759 maintenance of location Effects 0.000 claims 2
- 238000004949 mass spectrometry Methods 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000005760 tumorsuppression Effects 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000004907 flux Effects 0.000 claims 1
- 230000001320 lysogenic effect Effects 0.000 claims 1
- 238000004321 preservation Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000008188 pellet Substances 0.000 description 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019890006047A KR920001366B1 (ko) | 1983-05-16 | 1989-05-04 | 새로운 항암 항생복합체 bbm-1675의 제조방법 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49523183A | 1983-05-16 | 1983-05-16 | |
| US495231 | 1983-05-16 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019890006047A Division KR920001366B1 (ko) | 1983-05-16 | 1989-05-04 | 새로운 항암 항생복합체 bbm-1675의 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840008817A true KR840008817A (ko) | 1984-12-19 |
Family
ID=23967812
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019840002636A Ceased KR840008817A (ko) | 1983-05-16 | 1984-05-16 | Bbm-1675, 새로운 항암 항생복합체 |
| KR1019890006047A Expired KR920001366B1 (ko) | 1983-05-16 | 1989-05-04 | 새로운 항암 항생복합체 bbm-1675의 제조방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019890006047A Expired KR920001366B1 (ko) | 1983-05-16 | 1989-05-04 | 새로운 항암 항생복합체 bbm-1675의 제조방법 |
Country Status (28)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR78648B (enrdf_load_stackoverflow) * | 1982-07-26 | 1984-09-27 | Bristol Myers Co | |
| IL79519A0 (en) * | 1985-08-27 | 1986-10-31 | Bristol Myers Co | Bbm-1675c and d antitumor antibiotics |
| US4837206A (en) * | 1987-04-29 | 1989-06-06 | Bristol-Myers Company | Esperamicin derivatives |
| US4996305A (en) * | 1988-02-29 | 1991-02-26 | American Cyanamid Company | Process for producing the antibiotic and antitumor agents LL-E33288.epsilon.ε-Br |
| CA2027601A1 (en) * | 1989-11-06 | 1991-05-07 | Koko Sugawara | Antitumor antibiotic bu-3983t |
| GB0016020D0 (en) * | 2000-06-29 | 2000-08-23 | Inst Biomar Sa | New polyciclic xanthones and their use |
| US12194393B2 (en) * | 2021-03-17 | 2025-01-14 | Nissui Corporation | Method of purification and purified products |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4195079A (en) * | 1979-01-31 | 1980-03-25 | Pfizer Inc. | New polycyclic ether antibiotic |
| JPS56113791A (en) * | 1980-02-15 | 1981-09-07 | Kaken Pharmaceut Co Ltd | Novel antibiotic and its preparation |
| GR78648B (enrdf_load_stackoverflow) * | 1982-07-26 | 1984-09-27 | Bristol Myers Co | |
| US4539203A (en) * | 1984-11-13 | 1985-09-03 | Warner-Lambert Company | CL-1577D And CL-1577E antibiotic/antitumor compounds, their production and use |
-
1984
- 1984-05-01 NZ NZ208013A patent/NZ208013A/en unknown
- 1984-05-08 AU AU27791/84A patent/AU569294B2/en not_active Ceased
- 1984-05-08 CA CA000453762A patent/CA1241282A/en not_active Expired
- 1984-05-08 GR GR74646A patent/GR81581B/el unknown
- 1984-05-11 ZA ZA843591A patent/ZA843591B/xx unknown
- 1984-05-11 FI FI841906A patent/FI81114C/fi not_active IP Right Cessation
- 1984-05-14 IL IL71824A patent/IL71824A/xx unknown
- 1984-05-14 ES ES532476A patent/ES8700267A1/es not_active Expired
- 1984-05-15 GB GB08412368A patent/GB2141425B/en not_active Expired
- 1984-05-15 SU SU843744582A patent/SU1344249A3/ru active
- 1984-05-15 LU LU85362A patent/LU85362A1/fr unknown
- 1984-05-15 DK DK239784A patent/DK163127C/da not_active IP Right Cessation
- 1984-05-15 DE DE19843418023 patent/DE3418023A1/de active Granted
- 1984-05-15 IT IT20928/84A patent/IT1175498B/it active
- 1984-05-15 IE IE1200/84A patent/IE57444B1/en not_active IP Right Cessation
- 1984-05-15 FR FR8407477A patent/FR2547594B1/fr not_active Expired
- 1984-05-15 BE BE0/212942A patent/BE899667A/fr not_active IP Right Cessation
- 1984-05-15 SE SE8402619A patent/SE460364B/sv not_active IP Right Cessation
- 1984-05-15 HU HU841877A patent/HU193928B/hu not_active IP Right Cessation
- 1984-05-16 YU YU849/84A patent/YU43846B/xx unknown
- 1984-05-16 NL NL8401572A patent/NL8401572A/nl not_active Application Discontinuation
- 1984-05-16 PT PT78590A patent/PT78590A/pt not_active IP Right Cessation
- 1984-05-16 AT AT0160984A patent/AT393691B/de not_active IP Right Cessation
- 1984-05-16 JP JP59096758A patent/JPS59232094A/ja active Granted
- 1984-05-16 KR KR1019840002636A patent/KR840008817A/ko not_active Ceased
-
1988
- 1988-11-21 KE KE3846A patent/KE3846A/xx unknown
-
1989
- 1989-02-02 HK HK98/89A patent/HK9889A/xx unknown
- 1989-05-04 KR KR1019890006047A patent/KR920001366B1/ko not_active Expired
- 1989-07-21 CY CY1465A patent/CY1465A/en unknown
- 1989-08-24 JP JP1216009A patent/JPH02128693A/ja active Granted
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19840516 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19870303 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19840516 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19880806 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19890228 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19880806 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |
|
| J2X1 | Appeal (before the patent court) |
Free format text: APPEAL AGAINST DECISION TO DECLINE REFUSAL |
|
| PJ2001 | Appeal |
Appeal kind category: Appeal against decision to decline refusal Decision date: 19891230 Appeal identifier: 1989201000272 Request date: 19890404 |